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Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound MK-6892
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 8j6i
Q-score: 0.443
Zhu S, Yuan Q, Li X, He X, Shen S, Wang D, Li J, Cheng X, Duan X, Xu HE, Duan J
Cell Rep (2023) 42 pp. 113406-113406 [ DOI: doi:10.1016/j.celrep.2023.113406 Pubmed: 37952153 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (36 kDa, Protein from Homo sapiens)
- 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Complex of hydroxycarboxylic acid receptor 2 with mk-6892 (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound with GSK256073
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8j6j
Q-score: 0.425
Zhu S, Yuan Q, Li X, He X, Shen S, Wang D, Li J, Cheng X, Duan X, Xu HE, Duan J
Cell Rep (2023) 42 pp. 113406-113406 [ DOI: doi:10.1016/j.celrep.2023.113406 Pubmed: 37952153 ]
- Scfv16 (Complex)
- Hydroxycarboxylic acid receptor 2,hydroxycarboxylic acid receptor 2 (56 kDa, Protein from Homo sapiens)
- 8-chloranyl-3-pentyl-7h-purine-2,6-dione (256 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Complex of hydroxycarboxylic acid receptor 2 with gsk256073 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein (Complex)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
Focused refinement structure of GRK2 in NTSR1-GRK2-Galpha(q) complexes
Resolution: 2.81 Å
EM Method: Single-particle
Fitted PDBs: 8jpd
Q-score: 0.497
Duan J, Liu H, Zhao F, Yuan Q, Ji Y, Cai X, He X, Li X, Li J, Wu K, Gao T, Zhu S, Lin S, Wang MW, Cheng X, Yin W, Jiang Y, Yang D, Xu HE
Nature (2023) 620 pp. 676-681 [ Pubmed: 37532940 DOI: doi:10.1038/s41586-023-06395-9 ]
- Focused refinement structure of grk2 in ntsr1-grk2-galpha(q) complexes (Complex from Bos taurus)
- Beta-adrenergic receptor kinase 1 (79 kDa, Protein from Bos taurus)
- Staurosporine (466 Da, Ligand)
Cryo-EM structure of the PGF2-alpha-bound human PTGFR-Gq complex
Resolution: 2.67 Å
EM Method: Single-particle
Fitted PDBs: 8iuk
Q-score: 0.45
Wu C, Xu Y, He Q, Li D, Duan J, Li C, You C, Chen H, Fan W, Jiang Y, Eric Xu H
Nat Commun (2023) 14 pp. 2668-2668 [ Pubmed: 37160891 DOI: doi:10.1038/s41467-023-38411-x ]
- Nanobody nb35 (16 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cryo-em structure of the pgf2-alpha-bound human ptgfr-gq complex (160 kDa, Complex from Homo sapiens)
- (z)-7-[(1r,2r,3r,5s)-3,5-bis(oxidanyl)-2-[(e,3s)-3-oxidanyloct-1-enyl]cyclopentyl]hept-5-enoic acid (354 Da, Ligand)
- Antibody fragment scfv16 (26 kDa, Protein from Mus musculus)
- G subunit alpha (q) (41 kDa, Protein from Homo sapiens)
- Prostaglandin f2-alpha receptor (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of the latanoprost-bound human PTGFR-Gq complex
Resolution: 2.78 Å
EM Method: Single-particle
Fitted PDBs: 8iul
Q-score: 0.484
Wu C, Xu Y, He Q, Li D, Duan J, Li C, You C, Chen H, Fan W, Jiang Y, Eric Xu H
Nat Commun (2023) 14 pp. 2668-2668 [ Pubmed: 37160891 DOI: doi:10.1038/s41467-023-38411-x ]
- G subunit alpha (q) (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cryo-em structure of the latanoprost-bound human ptgfr-gq complex (160 kDa, Complex from Homo sapiens)
- Z-7-[(1r,2r,3r,5s)-3,5-bis(oxidanyl)-2-[(3r)-3-oxidanyl-5-phenyl-pentyl]cyclopentyl]hept-5-enoic acid (390 Da, Ligand)
- Antibody fragment scfv16 (26 kDa, Protein from Mus musculus)
- Prostaglandin f2-alpha receptor (40 kDa, Protein from Homo sapiens)
FSHR-Follicle stimulating hormone-compound 716340-Gs complex
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8i2g
Q-score: 0.363
Duan J, Xu P, Zhang H, Luan X, Yang J, He X, Mao C, Shen DD, Ji Y, Cheng X, Jiang H, Jiang Y, Zhang S, Zhang Y, Xu HE
Nat Commun (2023) 14 pp. 519-519 [ Pubmed: 36720854 DOI: doi:10.1038/s41467-023-36170-3 ]
- Chimera of guanine nucleotide-binding protein g(s) subunit alpha and guanine nucleotide-binding protein g(s) subunit alpha isoforms xlas (30 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Myristic acid (228 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Fshr-follicle stimulating hormone-compound 716340-gs complex (Complex from Homo sapiens)
- Glycoprotein hormones alpha chain (10 kDa, Protein from Homo sapiens)
- Nb35 (13 kDa, Protein from Lama glama)
- Follitropin subunit beta (12 kDa, Protein from Homo sapiens)
- Follicle-stimulating hormone receptor (76 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- N-tert-butyl-n-ethyl-8-methoxy-9-propan-2-yloxy-1-thiophen-2-yl-5,6-dihydroimidazo[5,1-a]isoquinoline-3-carboxamide (467 Da, Ligand)
Cryo-EM structure of IRL1620-bound ETBR-Gi complex
Resolution: 2.99 Å
EM Method: Single-particle
Fitted PDBs: 8hbd
Q-score: 0.412
Ji Y, Duan J, Yuan Q, He X, Yang G, Zhu S, Wu K, Hu W, Gao T, Cheng X, Jiang H, Eric Xu H, Jiang Y
Nat Commun (2023) 14 pp. 1268-1268 [ Pubmed: 36882417 DOI: doi:10.1038/s41467-023-36998-9 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Irl1620 (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Irl1620-bound etbr-gi complex (Complex from Homo sapiens)
- Scfv16 (30 kDa, Protein from Mus musculus)
- Endothelin receptor type b,endothelin receptor type b,oplophorus-luciferin 2-monooxygenase catalytic subunit chimera (67 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
TSHR-thyroid stimulating hormone-Gs-ML109 complex
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 7xw5
Q-score: 0.482
Duan J, Xu P, Luan X, Ji Y, He X, Song N, Yuan Q, Jin Y, Cheng X, Jiang H, Zheng J, Zhang S, Jiang Y, Xu HE
Nature (2022) 609 pp. 854-859 [ Pubmed: 35940204 DOI: doi:10.1038/s41586-022-05173-3 ]
- Thyrotropin subunit beta (13 kDa, Protein from Homo sapiens)
- ~{n}-[4-[[2-methoxy-5-[(2~{s})-5-oxidanyl-4-oxidanylidene-3-(phenylmethyl)-1,2-dihydroquinazolin-2-yl]phenyl]methoxy]phenyl]ethanamide (523 Da, Ligand)
- Nanobody35 (14 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Glycoprotein hormones alpha chain (10 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Thyrotropin receptor (79 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (29 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- Tshr-thyroid stimulating hormone-gs-ml109 complex (Complex from Homo)
TSHR-Gs-M22 antibody-ML109 complex
Resolution: 2.78 Å
EM Method: Single-particle
Fitted PDBs: 7xw6
Q-score: 0.441
Duan J, Xu P, Luan X, Ji Y, He X, Song N, Yuan Q, Jin Y, Cheng X, Jiang H, Zheng J, Zhang S, Jiang Y, Xu HE
Nature (2022) 609 pp. 854-859 [ Pubmed: 35940204 DOI: doi:10.1038/s41586-022-05173-3 ]
- Cholesterol (386 Da, Ligand)
- ~{n}-[4-[[2-methoxy-5-[(2~{s})-5-oxidanyl-4-oxidanylidene-3-(phenylmethyl)-1,2-dihydroquinazolin-2-yl]phenyl]methoxy]phenyl]ethanamide (523 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- The complex was assembled by co-expression. (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Thyrotropin receptor (79 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Nanobody35 (14 kDa, Protein from Homo sapiens)
- M22 antibody heavy chain (13 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (29 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- M22 antibody light chain (11 kDa, Protein from Mus musculus)
Galanin-bound galanin receptor 1 in complex with Gi
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7wq3
Q-score: 0.312
Duan J, Shen DD, Zhao T, Guo S, He X, Yin W, Xu P, Ji Y, Chen LN, Liu J, Zhang H, Liu Q, Shi Y, Cheng X, Jiang H, Eric Xu H, Zhang Y, Xie X, Jiang Y
Nat Commun (2022) 13 pp. 1364- [ DOI: doi:10.1038/s41467-022-29072-3 ]
- Scfv16 (26 kDa, Protein from Mus musculus)
- Cholesterol (386 Da, Ligand)
- Galanin receptor type 1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Galanin (Complex)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (Complex from Rattus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Mus musculus)
- Galanin-gal1r-gi-scfv16 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Galanin (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Bos taurus)
- Scfv16 (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus)
- Galanin receptor type 1 (38 kDa, Protein from Homo sapiens)