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Structure of Thyrotropin-Releasing Hormone Receptor bound with Taltirelin.
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 7x1t
Q-score: 0.462
Yang F, Zhang H, Meng X, Li Y, Zhou Y, Ling S, Sun D, Lv P, Liu L, Shi P, Tian C
Cell Res (2022) 32 pp. 858-861 [ Pubmed: 35352031 DOI: doi:10.1038/s41422-022-00646-6 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Scfv16 (26 kDa, Protein from Rattus norvegicus)
- Taltirelin (423 Da, Protein from synthetic construct)
- Thyrotropin-releasing hormone receptor (45 kDa, Protein from Homo sapiens)
- The thyrotropin-releasing hormone receptor and gq heterotrimer complex (Complex from Homo sapiens)
- Mini-g alpha q protein (28 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Bos taurus)
Structure of Thyrotropin-Releasing Hormone Receptor bound with an Endogenous Peptide Agonist TRH.
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 7x1u
Q-score: 0.445
Yang F, Zhang H, Meng X, Li Y, Zhou Y, Ling S, Sun D, Lv P, Liu L, Shi P, Tian C
Cell Res (2022) 32 pp. 858-861 [ Pubmed: 35352031 DOI: doi:10.1038/s41422-022-00646-6 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Scfv16 (26 kDa, Protein from Rattus norvegicus)
- Thyrotropin-releasing hormone receptor (45 kDa, Protein from Homo sapiens)
- Mini-g alpha q prtoein (28 kDa, Protein from Homo sapiens)
- The thyrotropin-releasing hormone receptor and gq heterotrimer complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Bos taurus)
- Endogenous peptide agonist trh (362 Da, Protein from synthetic construct)
Human Calcium-Sensing Receptor bound with calcium ions
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7dtt
Q-score: 0.442
Ling S, Shi P, Liu S, Meng X, Zhou Y, Sun W, Chang S, Zhang X, Zhang L, Shi C, Sun D, Liu L, Tian C
Cell Res (2021) 31 pp. 383-394 [ DOI: doi:10.1038/s41422-021-00474-0 Pubmed: 33603117 ]
- Full-lenth human calcium-sensing receptor bound with 20 mm calcium ions (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Extracellular calcium-sensing receptor (123 kDa, Protein from Homo sapiens)
Human Calcium-Sensing Receptor bound with L-Trp
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 7dtu
Q-score: 0.339
Ling S, Shi P, Liu S, Meng X, Zhou Y, Sun W, Chang S, Zhang X, Zhang L, Shi C, Sun D, Liu L, Tian C
Cell Res (2021) 31 pp. 383-394 [ DOI: doi:10.1038/s41422-021-00474-0 Pubmed: 33603117 ]
- Tryptophan (204 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human calcium-sensing receptor bound with l-trp (Complex from Homo sapiens)
- Extracellular calcium-sensing receptor (123 kDa, Protein from Homo sapiens)
Human Calcium-Sensing Receptor bound with L-Trp and calcium ions
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7dtv
Q-score: 0.483
Ling S, Shi P, Liu S, Meng X, Zhou Y, Sun W, Chang S, Zhang X, Zhang L, Shi C, Sun D, Liu L, Tian C
Cell Res (2021) 31 pp. 383-394 [ DOI: doi:10.1038/s41422-021-00474-0 Pubmed: 33603117 ]
- Human calcium-sensing receptor bound with l-trp and calcium ions (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Tryptophan (204 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Extracellular calcium-sensing receptor (123 kDa, Protein from Homo sapiens)
Human Calcium-Sensing Receptor in the inactive close-close conformation
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 7dtw
Q-score: 0.306