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48-nm repeating structure of doublets from mouse sperm flagella
Chen Z, Shiozaki M, Haas KM, Skinner WM, Zhao S, Guo C, Polacco BJ, Yu Z, Krogan NJ, Lishko PV, Kaake RM, Vale RD, Agard DA
Cell (2023) 186 pp. 5041-5053.e19 [ DOI: doi:10.1016/j.cell.2023.09.017 Pubmed: 37865089 ]
- Protein flattop (20 kDa, Protein from Mus musculus)
- Tektin bundle-interacting protein 1 (23 kDa, Protein from Mus musculus)
- Coiled-coil domain-containing protein 105 (57 kDa, Protein from Mus musculus)
- Parkin coregulated gene protein homolog (27 kDa, Protein from Mus musculus)
- Tektin-1 (48 kDa, Protein from Mus musculus)
- Nucleoside diphosphate kinase 7 (44 kDa, Protein from Mus musculus)
- Tektin-5 (62 kDa, Protein from Mus musculus)
- Tubulin beta-4b chain (49 kDa, Protein from Mus musculus)
- Ef-hand calcium-binding domain-containing protein 6 (176 kDa, Protein from Mus musculus)
- Dual specificity protein phosphatase 3 (20 kDa, Protein from Mus musculus)
- Tektin-4 (52 kDa, Protein from Mus musculus)
- Sperm acrosome-associated protein 9 (19 kDa, Protein from Mus musculus)
- Cilia- and flagella-associated protein 45 (65 kDa, Protein from Mus musculus)
- Cilia- and flagella-associated protein 53 (62 kDa, Protein from Mus musculus)
- Cilia- and flagella-associated protein 107 (23 kDa, Protein from Mus musculus)
- Enkurin (29 kDa, Protein from Mus musculus)
- Cilia- and flagella-associated protein 141 (12 kDa, Protein from Mus musculus)
- Piercer of microtubule wall 2 protein (13 kDa, Protein from Mus musculus)
- Tektin-3 (56 kDa, Protein from Mus musculus)
- Cilia- and flagella- associated protein 210 (65 kDa, Protein from Mus musculus)
- Piercer of microtubule wall 1 protein (18 kDa, Protein from Mus musculus)
- Ef-hand domain-containing protein 1 (75 kDa, Protein from Mus musculus)
- Rib43a-like with coiled-coils protein 2 (45 kDa, Protein from Mus musculus)
- Cilia- and flagella-associated protein 276 (18 kDa, Protein from Mus musculus)
- Detyrosinated tubulin alpha-1a chain (50 kDa, Protein from Mus musculus)
- Ef-hand domain-containing family member c2 (87 kDa, Protein from Mus musculus)
- Tektin-2 (50 kDa, Protein from Mus musculus)
- Ef-hand domain-containing family member b (95 kDa, Protein from Mus musculus)
- Mouse sperm (Cell from Mus musculus)
- Cilia- and flagella-associated protein 95 (26 kDa, Protein from Mus musculus)
- Meiosis-specific nuclear structural protein 1 (60 kDa, Protein from Mus musculus)
- Cilia- and flagella-associated protein 52 (68 kDa, Protein from Mus musculus)
- Cilia- and flagella-associated protein 20 (22 kDa, Protein from Mus musculus)
- Protein fam166b (30 kDa, Protein from Mus musculus)
- Cilia- and flagella-associated protein 161 (34 kDa, Protein from Mus musculus)
- Sperm-associated antigen 8 (50 kDa, Protein from Mus musculus)
In situ structure of axonemal doublet microtubules in mouse sperm with 16-nm repeat
Resolution: 4.5 Å
EM Method: Subtomogram averaging
Fitted PDBs: 8i7o
Q-score: 0.248
Tai L, Yin G, Huang X, Sun F, Zhu Y
Cell Discov (2023) 9 pp. 116-116 [ Pubmed: 37989994 DOI: doi:10.1038/s41421-023-00606-3 ]
- Protein flattop (20 kDa, Protein from Mus musculus)
- Tektin bundle-interacting protein 1 (23 kDa, Protein from Mus musculus)
- Tubulin beta-4b chain (47 kDa, Protein from Mus musculus)
- Coiled-coil domain-containing protein 105 (57 kDa, Protein from Mus musculus)
- Parkin coregulated gene protein homolog (27 kDa, Protein from Mus musculus)
- Testis-expressed protein 43 (16 kDa, Protein from Mus musculus)
- Tektin-1 (48 kDa, Protein from Mus musculus)
- Tektin-5 (62 kDa, Protein from Mus musculus)
- Ef-hand calcium-binding domain-containing protein 6 (176 kDa, Protein from Mus musculus)
- Cilia and flagella-associated protein 77 (32 kDa, Protein from Mus musculus)
- Tektin-4 (52 kDa, Protein from Mus musculus)
- Dual specificity phosphatase 21 (21 kDa, Protein from Mus musculus)
- Sperm acrosome-associated protein 9 (19 kDa, Protein from Mus musculus)
- Mouse sperm (Cell from Mus musculus)
- Enkurin (29 kDa, Protein from Mus musculus)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Tektin-3 (56 kDa, Protein from Mus musculus)
- Ef-hand domain-containing protein 1 (75 kDa, Protein from Mus musculus)
- Cilia- and flagella-associated protein 276 (18 kDa, Protein from Mus musculus)
- Ef-hand domain-containing family member c2 (87 kDa, Protein from Mus musculus)
- Detyrosinated tubulin alpha-3 chain (48 kDa, Protein from Mus musculus)
- Tektin-2 (50 kDa, Protein from Mus musculus)
- Cilia- and flagella-associated protein 52 (68 kDa, Protein from Mus musculus)
- Cilia- and flagella-associated protein 20 (22 kDa, Protein from Mus musculus)
- Protein fam166a (36 kDa, Protein from Mus musculus)
- Protein fam166c (23 kDa, Protein from Mus musculus)
In situ structure of axonemal doublet microtubules in mouse sperm with 48-nm repeat
Resolution: 6.5 Å
EM Method: Subtomogram averaging
Fitted PDBs: 8i7r
Q-score: 0.173
Tai L, Yin G, Huang X, Sun F, Zhu Y
Cell Discov (2023) 9 pp. 116-116 [ Pubmed: 37989994 DOI: doi:10.1038/s41421-023-00606-3 ]
- Protein flattop (20 kDa, Protein from Mus musculus)
- Tektin bundle-interacting protein 1 (23 kDa, Protein from Mus musculus)
- Tubulin beta-4b chain (47 kDa, Protein from Mus musculus)
- Coiled-coil domain-containing protein 105 (57 kDa, Protein from Mus musculus)
- Parkin coregulated gene protein homolog (27 kDa, Protein from Mus musculus)
- Testis-expressed protein 43 (16 kDa, Protein from Mus musculus)
- Tektin-1 (48 kDa, Protein from Mus musculus)
- Nucleoside diphosphate kinase 7 (44 kDa, Protein from Mus musculus)
- Tektin-5 (62 kDa, Protein from Mus musculus)
- Ef-hand calcium-binding domain-containing protein 6 (176 kDa, Protein from Mus musculus)
- Cilia and flagella-associated protein 77 (32 kDa, Protein from Mus musculus)
- Tektin-4 (52 kDa, Protein from Mus musculus)
- Dual specificity phosphatase 21 (21 kDa, Protein from Mus musculus)
- Cilia- and flagella-associated protein 45 (65 kDa, Protein from Mus musculus)
- Mouse sperm (Cell from Mus musculus)
- Sperm acrosome-associated protein 9 (19 kDa, Protein from Mus musculus)
- Cilia- and flagella-associated protein 53 (62 kDa, Protein from Mus musculus)
- Cilia- and flagella-associated protein 107 (23 kDa, Protein from Mus musculus)
- Enkurin (29 kDa, Protein from Mus musculus)
- Cilia- and flagella-associated protein 141 (12 kDa, Protein from Mus musculus)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Piercer of microtubule wall 2 protein (13 kDa, Protein from Mus musculus)
- Tektin-3 (56 kDa, Protein from Mus musculus)
- Piercer of microtubule wall 1 protein (18 kDa, Protein from Mus musculus)
- Ef-hand domain-containing protein 1 (75 kDa, Protein from Mus musculus)
- Rib43a-like with coiled-coils protein 2 (45 kDa, Protein from Mus musculus)
- Cilia- and flagella-associated protein 276 (18 kDa, Protein from Mus musculus)
- Ef-hand domain-containing family member c2 (87 kDa, Protein from Mus musculus)
- Detyrosinated tubulin alpha-3 chain (48 kDa, Protein from Mus musculus)
- Tektin-2 (50 kDa, Protein from Mus musculus)
- Ef-hand domain-containing family member b (95 kDa, Protein from Mus musculus)
- Cilia- and flagella-associated protein 95 (26 kDa, Protein from Mus musculus)
- Meiosis-specific nuclear structural protein 1 (60 kDa, Protein from Mus musculus)
- Cilia- and flagella-associated protein 52 (68 kDa, Protein from Mus musculus)
- Cilia- and flagella-associated protein 210 (65 kDa, Protein from Mus musculus)
- Cilia- and flagella-associated protein 20 (22 kDa, Protein from Mus musculus)
- Cilia- and flagella-associated protein 161 (34 kDa, Protein from Mus musculus)
- Protein fam166a (36 kDa, Protein from Mus musculus)
- Sperm-associated antigen 8 (50 kDa, Protein from Mus musculus)
- Protein fam166c (23 kDa, Protein from Mus musculus)
96nm repeat of human respiratory doublet microtubule and associated axonemal complexes
Walton T, Gui M, Velkova S, Fassad MR, Hirst RA, Haarman E, O'Callaghan C, Bottier M, Burgoyne T, Mitchison HM, Brown A
Nature (2023) 618 pp. 625-633 [ Pubmed: 37258679 DOI: doi:10.1038/s41586-023-06140-2 ]
- Cilia- and flagella-associated protein 161 (34 kDa, Protein from human)
- Calaxin (24 kDa, Protein from human)
- Dynein axonemal heavy chain 9 (512 kDa, Protein from human)
- Rib43a-like with coiled-coils protein 1 (44 kDa, Protein from human)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Dynein axonemal heavy chain 3 (471 kDa, Protein from human)
- Unknown (6 kDa, Protein from human)
- Cilia- and flagella-associated protein 100 (71 kDa, Protein from human)
- Cilia- and flagella-associated protein 52 (68 kDa, Protein from human)
- Probable inactive peptidyl-prolyl cis-trans isomerase-like 6 (35 kDa, Protein from human)
- Outer dynein arm-docking complex subunit 3 (69 kDa, Protein from human)
- Dynein axonemal heavy chain 7 (461 kDa, Protein from human)
- Cytochrome b5 domain-containing protein 1 (26 kDa, Protein from human)
- Dynein axonemal intermediate chain 2 (68 kDa, Protein from human)
- Cilia- and flagella-associated protein 251 (130 kDa, Protein from human)
- Ef-hand domain-containing family member b (93 kDa, Protein from human)
- Tubulin beta-4b chain (49 kDa, Protein from human)
- Nucleoside diphosphate kinase 7 (42 kDa, Protein from human)
- Outer dynein arm-docking complex subunit 1 (75 kDa, Protein from human)
- Iq and ubiquitin-like domain-containing protein (92 kDa, Protein from human)
- Axonemal dynein light intermediate polypeptide 1 (29 kDa, Protein from human)
- Dynein axonemal intermediate chain 1 (79 kDa, Protein from human)
- Morn repeat-containing protein 3 (27 kDa, Protein from human)
- Calmodulin-1 (16 kDa, Protein from human)
- Ropporin-1-like protein (26 kDa, Protein from human)
- Acta2 (42 kDa, Protein from human)
- Piercer of microtubule wall 2 protein (13 kDa, Protein from human)
- Dynein light chain tctex-type 1 (12 kDa, Protein from human)
- Tubulin alpha-1a chain (50 kDa, Protein from human)
- Ef-hand domain-containing protein 1 (74 kDa, Protein from human)
- Sperm-associated antigen 8 (51 kDa, Protein from human)
- Cilia- and flagella-associated protein 107 (23 kDa, Protein from human)
- Dynein regulatory complex subunit 2 (57 kDa, Protein from human)
- Dynll1 (10 kDa, Protein from human)
- Rib43a-like with coiled-coils protein 2 (45 kDa, Protein from human)
- Piercer of microtubule wall 1 protein (15 kDa, Protein from human)
- Cilia- and flagella- associated protein 210 (66 kDa, Protein from human)
- Protein fam166c (23 kDa, Protein from human)
- Cilia- and flagella-associated protein 141 (12 kDa, Protein from human)
- Uncharacterized protein cfap68 (17 kDa, Protein from human)
- Cilia- and flagella-associated protein 44 (214 kDa, Protein from human)
- Dynein light chain roadblock-type 2 (10 kDa, Protein from human)
- Cilia- and flagella-associated protein 299 (26 kDa, Protein from human)
- Dynein axonemal heavy chain 10 (529 kDa, Protein from human)
- Outer dynein arm-docking complex subunit 2 (115 kDa, Protein from human)
- Cilia- and flagella-associated protein 45 (65 kDa, Protein from human)
- Cilia- and flagella-associated protein 144 (16 kDa, Protein from human)
- Dynein axonemal heavy chain 6 (476 kDa, Protein from human)
- Dynein axonemal intermediate chain 7 (83 kDa, Protein from human)
- Axonemal complex (Complex from Homo sapiens)
- Cilia- and flagella-associated protein 73 (35 kDa, Protein from human)
- Dynein regulatory complex subunit 4 (56 kDa, Protein from human)
- Uncharacterized protein cfap90 (17 kDa, Protein from human)
- Cilia- and flagella-associated protein 77 (33 kDa, Protein from human)
- Cilia- and flagella-associated protein 95 (26 kDa, Protein from human)
- Coiled-coil domain-containing protein 96 (62 kDa, Protein from human)
- Dynein axonemal intermediate chain 3 (103 kDa, Protein from human)
- Coiled-coil domain-containing protein 40 (130 kDa, Protein from human)
- Dynein axonemal intermediate chain 4 (94 kDa, Protein from human)
- Dynein regulatory complex protein 10 (52 kDa, Protein from human)
- Coiled-coil domain-containing protein 39 (110 kDa, Protein from human)
- Parkin coregulated gene protein (29 kDa, Protein from human)
- Coiled-coil domain-containing protein 113 (44 kDa, Protein from human)
- Dynein axonemal heavy chain 2 (508 kDa, Protein from human)
- Dynein regulatory complex protein 9 (52 kDa, Protein from human)
- Dynein regulatory complex protein 1 (87 kDa, Protein from human)
- Dynein regulatory complex protein 11 (95 kDa, Protein from human)
- Cilia- and flagella-associated protein 53 (61 kDa, Protein from human)
- Cilia- and flagella-associated protein 20 (22 kDa, Protein from human)
- Sperm acrosome-associated protein 9 (25 kDa, Protein from human)
- Dynein axonemal heavy chain 1 (488 kDa, Protein from human)
- Dynein axonemal light chain 1 (21 kDa, Protein from human)
- Dynein light chain roadblock-type 1 (10 kDa, Protein from human)
- Leucine-rich repeat-containing protein 34 (51 kDa, Protein from human)
- Protein fam166b (30 kDa, Protein from human)
- Tektin-1 (48 kDa, Protein from human)
- Dynein regulatory complex subunit 7 (103 kDa, Protein from human)
- Cilia- and flagella-associated protein 61 (141 kDa, Protein from human)
- Tektin-2 (49 kDa, Protein from human)
- Radial spoke head protein 9 homolog (31 kDa, Protein from human)
- Enkurin (29 kDa, Protein from human)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Tetratricopeptide repeat protein 29 (55 kDa, Protein from human)
- Ef-hand domain-containing family member c2 (87 kDa, Protein from human)
- Dynein axonemal heavy chain 12 (454 kDa, Protein from human)
- Radial spoke head protein 4 homolog a (80 kDa, Protein from human)
- Dynein regulatory complex subunit 5 (55 kDa, Protein from human)
- Zinc finger mynd domain-containing protein 12 (41 kDa, Protein from human)
- Dpy30 domain-containing protein 2 (20 kDa, Protein from human)
- Thioredoxin domain-containing protein 6 (36 kDa, Protein from human)
- Radial spoke head 14 homolog (38 kDa, Protein from human)
- Cilia- and flagella-associated protein 57 (145 kDa, Protein from human)
- Outer dynein arm-docking complex subunit 4 (76 kDa, Protein from human)
- Dnaj homolog subfamily b member 13 (36 kDa, Protein from human)
- Radial spoke head 1 homolog (35 kDa, Protein from human)
- Dynein axonemal heavy chain 5 (529 kDa, Protein from human)
- Nucleoside diphosphate kinase homolog 5 (24 kDa, Protein from human)
- Cilia- and flagella-associated protein 276 (19 kDa, Protein from human)
- Dynein regulatory complex subunit 3 (61 kDa, Protein from human)
- Radial spoke head protein 3 homolog (63 kDa, Protein from human)
- Meiosis-specific nuclear structural protein 1 (60 kDa, Protein from human)
- Cilia- and flagella-associated protein 43 (192 kDa, Protein from human)
- Dynein regulatory complex protein 8 (29 kDa, Protein from human)
- Cilia- and flagella-associated protein 58 (103 kDa, Protein from human)
- Sperm surface protein sp17 (17 kDa, Protein from human)
- Magnesium ion (24 Da, Ligand)
- Cilia- and flagella-associated protein 91 (90 kDa, Protein from human)
- Protein flattop (19 kDa, Protein from human)
- Dynein light chain tctex-type protein 2b (16 kDa, Protein from human)
- Centrin-2 (19 kDa, Protein from human)
Composite cryo-EM density map of the 8-nm repeat of the human sperm tip singlet microtubule
Resolution: 6.0 Å
EM Method: Single-particle
Fitted PDBs: 7un1
Q-score: 0.254
Gui M, Croft JT, Zabeo D, Acharya V, Kollman JM, Burgoyne T, Hoog JL, Brown A
PNAS (2022) 119 pp. e2207605119-e2207605119 [ Pubmed: 36191189 DOI: doi:10.1073/pnas.2207605119 ]
- Tubulin beta-4b chain (49 kDa, Protein from human)
- Magnesium ion (24 Da, Ligand)
- Tubulin alpha-1a chain (50 kDa, Protein from human)
- Sperm acrosome-associated protein 9 (25 kDa, Protein from human)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Singlet microtubule and associated spaca9 (Complex from Homo sapiens)
Composite cryo-EM density map of the 48-nm repeat of the human respiratory doublet microtubule
Gui M, Croft JT, Zabeo D, Acharya V, Kollman JM, Burgoyne T, Hoog JL, Brown A
PNAS (2022) 119 pp. e2207605119-e2207605119 [ Pubmed: 36191189 DOI: doi:10.1073/pnas.2207605119 ]
- Protein fam183a (16 kDa, Protein from human)
- Upf0691 protein c9orf116 (15 kDa, Protein from human)
- Cilia- and flagella-associated protein 161 (34 kDa, Protein from human)
- Tubulin alpha-1a chain (50 kDa, Protein from human)
- Uncharacterized protein c15orf65 (13 kDa, Protein from human)
- Ef-hand domain-containing protein 1 (74 kDa, Protein from human)
- Sperm-associated antigen 8 (51 kDa, Protein from human)
- Isoform 2 of cilia- and flagella-associated protein 77 (33 kDa, Protein from human)
- Rib43a-like with coiled-coils protein 2 (45 kDa, Protein from human)
- Parkin coregulated gene protein (29 kDa, Protein from human)
- Protein fam166c (23 kDa, Protein from human)
- Cilia- and flagella-associated protein 20 (22 kDa, Protein from human)
- Cilia- and flagella-associated protein 53 (61 kDa, Protein from human)
- Sperm acrosome-associated protein 9 (25 kDa, Protein from human)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Uncharacterized protein c5orf49 (17 kDa, Protein from human)
- Doublet microtubule and associated proteins (Complex from Homo sapiens)
- Protein cfap95 (26 kDa, Protein from human)
- Cilia- and flagella-associated protein 52 (68 kDa, Protein from human)
- Protein fam166b (30 kDa, Protein from human)
- Tektin-1 (48 kDa, Protein from human)
- Cilia- and flagella-associated protein 45 (65 kDa, Protein from human)
- Tektin-4 (50 kDa, Protein from human)
- Protein cfap141 (12 kDa, Protein from human)
- Meiosis-specific nuclear structural protein 1 (60 kDa, Protein from human)
- Protein cfap107 (23 kDa, Protein from human)
- Upf0686 protein c11orf1 (17 kDa, Protein from human)
- Protein cfap210 (66 kDa, Protein from human)
- Ef-hand domain-containing family member b (93 kDa, Protein from human)
- Tubulin beta-4b chain (49 kDa, Protein from human)
- Nucleoside diphosphate kinase 7 (42 kDa, Protein from human)
- Tektin-2 (49 kDa, Protein from human)
- Magnesium ion (24 Da, Ligand)
- Tektin-3 (56 kDa, Protein from human)
- Protein flattop (19 kDa, Protein from human)
- Enkurin (29 kDa, Protein from human)
- Protein cfap276 (19 kDa, Protein from human)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Ef-hand domain-containing family member c2 (87 kDa, Protein from human)