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Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 8bzy
Q-score: 0.522
Lehmann EF, Liziczai M, Drozdzyk K, Altermatt P, Langini C, Manolova V, Sundstrom H, Durrenberger F, Dutzler R, Manatschal C
eLife (2023) 12 [ Pubmed: 36943194 DOI: doi:10.7554/eLife.83053 ]
- Complex of ferroportin with synthetic nanobody and inhibitor (Complex from Homo sapiens)
- Solute carrier family 40 member 1 (63 kDa, Protein from Homo sapiens)
- Diundecyl phosphatidyl choline (622 Da, Ligand)
- Sybody 3 (16 kDa, Protein from synthetic construct)
- 2-[2-[2-(1~{h}-benzimidazol-2-yl)ethylamino]ethyl]-~{n}-[(3-fluoranylpyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide (408 Da, Ligand)
Structure of SLC40/ferroportin in complex with synthetic nanobody Sy3 in occluded conformation
Resolution: 4.09 Å
EM Method: Single-particle
Fitted PDBs: 8c02
Q-score: 0.349
Lehmann EF, Liziczai M, Drozdzyk K, Altermatt P, Langini C, Manolova V, Sundstrom H, Durrenberger F, Dutzler R, Manatschal C
eLife (2023) 12 [ Pubmed: 36943194 DOI: doi:10.7554/eLife.83053 ]
- Sybody3 (16 kDa, Protein from synthetic construct)
- Complex of ferroportin with synthetic nanobody (Complex from Homo sapiens)
- Solute carrier family 40 member 1 (63 kDa, Protein from Homo sapiens)
Resolution: 3.89 Å
EM Method: Single-particle
Fitted PDBs: 8c03
Q-score: 0.399
Lehmann EF, Liziczai M, Drozdzyk K, Altermatt P, Langini C, Manolova V, Sundstrom H, Durrenberger F, Dutzler R, Manatschal C
eLife (2023) 12 [ Pubmed: 36943194 DOI: doi:10.7554/eLife.83053 ]
Cryo-EM structure of human ferroportin/slc40 bound to Ca2+ in nanodisc
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8dl6
Q-score: 0.468
Shen J, Wilbon AS, Zhou M, Pan Y
eLife (2023) 12 [ DOI: doi:10.7554/eLife.82947 Pubmed: 36648329 ]
- Solute carrier family 40 member 1 (63 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Water (18 Da, Ligand)
- Cryo-em structure of human ferroportin/slc40 bound to ca2+ in nanodisc (Complex from Homo sapiens)
- 11f9 heavy-chain (25 kDa, Protein from mouse)
- 11f9 light-chain (23 kDa, Protein from mouse)
Cryo-EM structure of human ferroportin/slc40 bound to minihepcidin PR73 in nanodisc
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8dl7
Q-score: 0.514
Wilbon AS, Shen J, Ruchala P, Zhou M, Pan Y
PLoS Biol (2023) 21 pp. e3001936-e3001936 [ DOI: doi:10.1371/journal.pbio.3001936 Pubmed: 36649314 ]
- Cryo-em structure of human ferroportin/slc40 bound to minihepcidin pr73 in nanodisc (Complex from Homo sapiens)
- Solute carrier family 40 member 1 (63 kDa, Protein from Homo sapiens)
- 11f9 heavy-chain (25 kDa, Protein from Mus musculus)
- 11f9 light-chain (23 kDa, Protein from Mus musculus)
- Water (18 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Minihepcidin pr73 (1 kDa, Protein from synthetic construct)
Cryo-EM structure of human ferroportin/slc40 bound to Co2+ in nanodisc
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8dl8
Q-score: 0.48
Wilbon AS, Shen J, Ruchala P, Zhou M, Pan Y
PLoS Biol (2023) 21 pp. e3001936-e3001936 [ DOI: doi:10.1371/journal.pbio.3001936 Pubmed: 36649314 ]
- Solute carrier family 40 member 1 (63 kDa, Protein from Homo sapiens)
- Cryo-em structure of human ferroportin/slc40 bound to co2+ in nanodisc (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- 11f9 heavy-chain (25 kDa, Protein from mouse)
- 11f9 light-chain (23 kDa, Protein from mouse)
- Cobalt (ii) ion (58 Da, Ligand)
Structure of apo human ferroportin in lipid nanodisc
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6w4s
Q-score: 0.525
Billesbolle CB, Azumaya CM, Kretsch RC, Powers AS, Gonen S, Schneider S, Arvedson T, Dror RO, Cheng Y, Manglik A
Nature (2020) 586 pp. 807-811 [ DOI: doi:10.1038/s41586-020-2668-z Pubmed: 32814342 ]
- Fab45d8 light chain (24 kDa, Protein from Mus musculus)
- Solute carrier family 40 member 1 (66 kDa, Protein from Homo sapiens)
- Fab45d8 (Complex from Mus musculus)
- Ferroportin (Complex from Homo sapiens)
- Fab45d8 heavy chain (23 kDa, Protein from Mus musculus)
- Ferroportin-fab45d8 complex (Complex)
Structure of human ferroportin bound to hepcidin and cobalt in lipid nanodisc
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 6wbv
Q-score: 0.597
Billesbolle CB, Azumaya CM, Kretsch RC, Powers AS, Gonen S, Schneider S, Arvedson T, Dror RO, Cheng Y, Manglik A
Nature (2020) 586 pp. 807-811 [ DOI: doi:10.1038/s41586-020-2668-z Pubmed: 32814342 ]
- Fab45d8 light chain (24 kDa, Protein from Mus musculus)
- Solute carrier family 40 member 1 (66 kDa, Protein from Homo sapiens)
- Fab45d8 (Complex from Mus musculus)
- Hepcidin (2 kDa, Protein from Homo sapiens)
- Ferroportin-hepcidin complex (Complex from Homo sapiens)
- Fab45d8 heavy chain (23 kDa, Protein from Mus musculus)
- Water (18 Da, Ligand)
- Ferroportin-fab45d8 complex (Complex)
- Cobalt (ii) ion (58 Da, Ligand)
- (1s)-2-{[{[(2s)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(pentanoyloxy)methyl]ethyl octanoate (455 Da, Ligand)