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Cryo-EM structure of SV2A in complex with BoNT/A2 Hc and levetiracetam
Resolution: 2.88 Å
EM Method: Single-particle
Fitted PDBs: 8jlc
Q-score: 0.454
Yamagata A, Ito K, Suzuki T, Dohmae N, Terada T, Shirouzu M
Nat Commun (2024) 15 pp. 3027-3027 [ DOI: doi:10.1038/s41467-024-47322-4 Pubmed: 38637505 ]
- Botulinum neurotoxin (49 kDa, Protein from Clostridium botulinum)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sv2a in complex with bont/a2 hc domain and anti-epileptic drug, levetiracetam (Complex from Homo sapiens)
- Synaptic vesicle glycoprotein 2a (83 kDa, Protein from Homo sapiens)
- (2s)-2-(2-oxidanylidenepyrrolidin-1-yl)butanamide (170 Da, Ligand)
Resolution: 2.82 Å
EM Method: Single-particle
Fitted PDBs: 8jle
Q-score: 0.517
Yamagata A, Ito K, Suzuki T, Dohmae N, Terada T, Shirouzu M
Nat Commun (2024) 15 pp. 3027-3027 [ DOI: doi:10.1038/s41467-024-47322-4 Pubmed: 38637505 ]
- Sv2a in complex with bont/a2 hc domain and anti-epileptic drug, levetiracetam (Complex from Homo sapiens)
- Botulinum neurotoxin (49 kDa, Protein from Clostridium botulinum)
- Synaptic vesicle glycoprotein 2a (12 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of SV2A in complex with BoNT/A2 Hc
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8jlf
Q-score: 0.48
Yamagata A, Ito K, Suzuki T, Dohmae N, Terada T, Shirouzu M
Nat Commun (2024) 15 pp. 3027-3027 [ DOI: doi:10.1038/s41467-024-47322-4 Pubmed: 38637505 ]
- Synaptic vesicle glycoprotein 2a (83 kDa, Protein from Homo sapiens)
- Sv2a in complex with bont/a2 hc domain (Complex from Homo sapiens)
- Botulinum neurotoxin (49 kDa, Protein from Clostridium botulinum)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of SV2A in complex with BoNT/A2 Hc and levetiracetam
Resolution: 2.88 Å
EM Method: Single-particle
Fitted PDBs: 8js8
Q-score: 0.54
Yamagata A, Ito K, Suzuki T, Dohmae N, Terada T, Shirouzu M
Nat Commun (2024) 15 pp. 3027-3027 [ DOI: doi:10.1038/s41467-024-47322-4 Pubmed: 38637505 ]
- Botulinum neurotoxin (49 kDa, Protein from Clostridium botulinum)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sv2a in complex with bont/a2 hc domain and anti-epileptic drug, levetiracetam (Complex from Homo sapiens)
- Synaptic vesicle glycoprotein 2a (83 kDa, Protein from Homo sapiens)
- (2s)-2-(2-oxidanylidenepyrrolidin-1-yl)butanamide (170 Da, Ligand)
Cryo-EM structure of SV2A in complex with BoNT/A2 Hc
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8js9
Q-score: 0.54
Yamagata A, Ito K, Suzuki T, Dohmae N, Terada T, Shirouzu M
Nat Commun (2024) 15 pp. 3027-3027 [ DOI: doi:10.1038/s41467-024-47322-4 Pubmed: 38637505 ]
- Synaptic vesicle glycoprotein 2a (83 kDa, Protein from Homo sapiens)
- Sv2a in complex with bont/a2 hc (Complex from Homo sapiens)
- Botulinum neurotoxin (49 kDa, Protein from Clostridium botulinum)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)