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Human SMG1-8-9 kinase complex bound to a SMG1 inhibitor
Resolution: 3.27 Å
EM Method: Single-particle
Fitted PDBs: 7pw4
Q-score: 0.495
Langer LM, Bonneau F, Gat Y, Conti E
eLife (2021) 10 [ Pubmed: 34698635 DOI: doi:10.7554/eLife.72353 ]
- Serine/threonine-protein kinase smg1,serine/threonine-protein kinase smg1,serine/threonine-protein kinase smg1,serine/threonine-protein kinase smg1,serine/threonine-protein kinase smg1,serine/threonine-protein kinase smg1,serine/threonine-protein kinase smg1,serine/threonine-protein kinase smg1 (397 kDa, Protein from Homo sapiens)
- Smg1-smg8-smg9 kinase complex bound to a smg1 inhibitor (597 kDa, Complex from Homo sapiens)
- Protein smg9 (57 kDa, Protein from Homo sapiens)
- Protein smg8 (109 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Inositol hexakisphosphate (660 Da, Ligand)
- 1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea (566 Da, Ligand)
Human SMG1-8-9 kinase complex with AlphaFold predicted SMG8 C-terminus, bound to a SMG1 inhibitor
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7pw5
Q-score: 0.357
Langer LM, Bonneau F, Gat Y, Conti E
eLife (2021) 10 [ Pubmed: 34698635 DOI: doi:10.7554/eLife.72353 ]
- Smg1,serine/threonine-protein kinase smg1,smg1,serine/threonine-protein kinase smg1,smg1,serine/threonine-protein kinase smg1,smg1,serine/threonine-protein kinase smg1 (397 kDa, Protein from Homo sapiens)
- Smg1-smg8-smg9 kinase complex bound to a smg1 inhibitor (597 kDa, Complex from Homo sapiens)
- Protein smg9 (57 kDa, Protein from Homo sapiens)
- Protein smg8 (109 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Inositol hexakisphosphate (660 Da, Ligand)
- 1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea (566 Da, Ligand)
Human SMG1-8-9 kinase complex bound to a SMG1 inhibitor - SMG1 body
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 7pw6
Q-score: 0.539
Langer LM, Bonneau F, Gat Y, Conti E
eLife (2021) 10 [ Pubmed: 34698635 DOI: doi:10.7554/eLife.72353 ]
- Smg1-smg8-smg9 kinase complex bound to a smg1 inhibitor (597 kDa, Complex from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Serine/threonine-protein kinase smg1,serine/threonine-protein kinase smg1,serine/threonine-protein kinase smg1,serine/threonine-protein kinase smg1,serine/threonine-protein kinase smg1,serine/threonine-protein kinase smg1,serine/threonine-protein kinase smg1 (320 kDa, Protein from Homo sapiens)
- 1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea (566 Da, Ligand)
Human SMG1-8-9 kinase complex bound to AMPPNP
Resolution: 2.82 Å
EM Method: Single-particle
Fitted PDBs: 7pw8
Q-score: 0.558
Langer LM, Bonneau F, Gat Y, Conti E
eLife (2021) 10 [ Pubmed: 34698635 DOI: doi:10.7554/eLife.72353 ]
- Smg1-smg8-smg9 kinase complex bound to amppnp (597 kDa, Complex from Homo sapiens)
- Protein smg9 (57 kDa, Protein from Homo sapiens)
- Protein smg8 (109 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Smg1,serine/threonine-protein kinase smg1,smg1,serine/threonine-protein kinase smg1,smg1 (397 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Inositol hexakisphosphate (660 Da, Ligand)
Structure of SMG1-8-9 kinase complex bound to UPF1-LSQ
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 6z3r
Q-score: 0.545
Langer LM, Gat Y, Bonneau F, Conti E
eLife (2020) 9 [ Pubmed: 32469312 DOI: doi:10.7554/eLife.57127 ]
- Smg1-8-9 (Complex from Homo sapiens)
- Regulator of nonsense transcripts 1 (1 kDa, Protein from Homo sapiens)
- Serine/threonine-protein kinase smg1,serine/threonine-protein kinase smg1,smg1,serine/threonine-protein kinase smg1,serine/threonine-protein kinase smg1,serine/threonine-protein kinase smg1 (379 kDa, Protein from Homo sapiens)
- Smg1-8-9 bound to amppnp and upf1-lsq (577 kDa, Complex)
- Protein smg9 (57 kDa, Protein from Homo sapiens)
- Upf1-lsq (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Inositol hexakisphosphate (660 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Protein smg8 (109 kDa, Protein from Homo sapiens)
Resolution: 3.43 Å
EM Method: Single-particle
Fitted PDBs: 6l54
Q-score: 0.384
Cell Res (2019) 29 pp. 1027-1034 [ Pubmed: 31729466 DOI: doi:10.1038/s41422-019-0255-3 ]
- Protein smg9 (57 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Smg189 complex (Cellular component from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Serine/threonine-protein kinase smg1 (410 kDa, Protein from Homo sapiens)
- Protein smg8 (109 kDa, Protein from Homo sapiens)
CryoEM structure of the SMG1-SMG8-SMG9 complex
Gat Y, Schuller JM, Lingaraju M, Weyher E, Bonneau F, Strauss M, Murray PJ, Conti E
Nat Struct Mol Biol (2019) 26 pp. 1089-1093 [ DOI: doi:10.1038/s41594-019-0342-7 Pubmed: 31792449 ]
Structure of the SMG1-SMG8-SMG9 complex
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 6syt
Q-score: 0.492
Gat Y, Schuller JM, Lingaraju M, Weyher E, Bonneau F, Strauss M, Murray PJ, Conti E
Nat Struct Mol Biol (2019) 26 pp. 1089-1093 [ DOI: doi:10.1038/s41594-019-0342-7 Pubmed: 31792449 ]
- Protein smg9 (57 kDa, Protein from Homo sapiens)
- Protein smg8 (109 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Smg1-smg8-smg9 pikk kinase complex (Complex from Homo sapiens)
- Smg1,serine/threonine-protein kinase smg1,smg1,serine/threonine-protein kinase smg1,smg1,serine/threonine-protein kinase smg1,smg1,serine/threonine-protein kinase smg1,smg1,serine/threonine-protein kinase smg1 (401 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Inositol hexakisphosphate (660 Da, Ligand)
Electron microscopy of the SMG1C-DHX34 complex
Melero R, Hug N, Lopez-Perrote A, Yamashita A, Caceres J, Llorca O
Nat Commun (2016) 7 pp. 10585-10585 [ Pubmed: 26841701 DOI: doi:10.1038/ncomms10585 ]
- Smg9 (60 kDa, Protein from Homo sapiens)
- Dhx34 (128 kDa, Protein from Homo sapiens)
- Serine/threonine-protein kinase smg1 (410 kDa, Protein from Homo sapiens)
- Smg1c complex, comprising smg1 kinase, smg8 and smg9, bound to the dhx34 helicase (770 kDa, Sample)
- Smg8 (109 kDa, Protein from Homo sapiens)
Deniaud A, Karuppasamy M, Bock T, Masiulis S, Huard K, Garzoni F, Kerschgens K, Hentze MW, Kulozik AE, Beck M, Neu-Yilik G, Schaffitzel C
Nucleic Acids Res (2015) 43 pp. 7600-7611 [ Pubmed: 26130714 DOI: doi:10.1093/nar/gkv668 ]
- Smg-9 (60 kDa, Protein from Homo sapiens)
- Complex of four proteins: smg1, smg8, smg9 and upf1 (720 kDa, Sample)
- Smg-1 (420 kDa, Protein from Homo sapiens)
- Upf1 (130 kDa, Protein from Homo sapiens)
- Smg-8 (110 kDa, Protein from Homo sapiens)