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Structure of hantaan orthohantavirus (HTNV) polymerase - Apo core
Structure of hantaan orthohantavirus (HTNV) polymerase - Apo core endonuclease
Structure of hantaan orthohantavirus (HTNV) polymerase - Apo full length
Structure of hantaan orthohantavirus (HTNV) polymerase bound to 5'vRNA and NTP Mg
Keown JR, Carrique L, Grimes JM
To Be Published
- Rna-directed rna polymerase l (251 kDa, Protein from Hantaan orthohantavirus)
- Rna (5'-r(p*ap*gp*up*ap*g)-3') (5 kDa, RNA from Hantaan orthohantavirus)
- Magnesium ion (24 Da, Ligand)
- Rna-dependent rna polymerase of hantaan orthohantavirus (htnv). (247 kDa, Complex from Hantaan orthohantavirus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
Structure of hantaan orthohantavirus (HTNV) polymerase bound to 5'vRNA
Keown JR, Carrique L, Grimes JM
To Be Published
- Rna (5'-r(p*ap*gp*up*ap*g)-3') (5 kDa, RNA from Hantaan orthohantavirus)
- Rna-directed rna polymerase l (251 kDa, Protein from Hantaan orthohantavirus)
- Rna-dependent rna polymerase of hantaan orthohantavirus (htnv). (247 kDa, Complex from Hantaan orthohantavirus)
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8r6u
Q-score: 0.565
Williams HM, Thorkelsson SR, Vogel D, Busch C, Milewski M, Cusack S, Grunewald K, Quemin ERJ, Rosenthal M
Nucleic Acids Res (2024) [ DOI: doi:10.1093/nar/gkae330 Pubmed: 38709882 ]
- Rna primer tail-end (5 kDa, RNA from SFTS virus AH12)
- Rna-directed rna polymerase l (235 kDa, Protein from SFTS virus AH12)
- Sftsv l protein in complex with 5' and 3' rna, as well as rna acting as a primer. (240 kDa, Complex from SFTS virus AH12)
- Magnesium ion (24 Da, Ligand)
- Rna (5'-r(p*cp*up*gp*gp*gp*cp*gp*gp*up*cp*up*up*up*gp*up*gp*u)-3') (8 kDa, RNA from SFTS virus AH12)
- Rna primer (6 kDa, RNA from SFTS virus AH12)
Resolution: 3.35 Å
EM Method: Single-particle
Fitted PDBs: 8r6w
Q-score: 0.44
Williams HM, Thorkelsson SR, Vogel D, Busch C, Milewski M, Cusack S, Grunewald K, Quemin ERJ, Rosenthal M
Nucleic Acids Res (2024) [ DOI: doi:10.1093/nar/gkae330 Pubmed: 38709882 ]
- Rna (5'-r(*ap*cp*ap*cp*ap*gp*ap*gp*ap*cp*gp*cp*cp*cp*ap*g)-3') (6 kDa, RNA from SFTS virus AH12)
- Sftsv l protein in complex with 5' and 3' rna, as well as rna acting as a primer. (240 kDa, Complex from SFTS virus AH12)
- Rna (5'-r(p*cp*up*gp*gp*gp*cp*gp*gp*up*cp*up*up*up*gp*up*gp*u)-3') (8 kDa, RNA from SFTS virus AH12)
- Rna (5'-r(*ap*cp*ap*c)-3') (5 kDa, RNA from SFTS virus AH12)
- Rna (5'-r(*(m7g)*ap*ap*a)-3') (5 kDa, RNA from SFTS virus AH12)
- Rna-directed rna polymerase l (235 kDa, Protein from SFTS virus AH12)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8r6y
Q-score: 0.456
Williams HM, Thorkelsson SR, Vogel D, Busch C, Milewski M, Cusack S, Grunewald K, Quemin ERJ, Rosenthal M
Nucleic Acids Res (2024) [ DOI: doi:10.1093/nar/gkae330 Pubmed: 38709882 ]
- Rna (5'-r(*ap*cp*ap*cp*ap*gp*ap*gp*ap*cp*gp*cp*cp*cp*ap*g)-3') (6 kDa, RNA from SFTS virus AH12)
- Sftsv l protein in complex with 5' and 3' rna, as well as rna acting as a primer. (240 kDa, Complex from SFTS virus AH12)
- 5'-o-[(s)-hydroxy{[(s)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine (483 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Rna (5'-r(p*cp*up*gp*gp*gp*cp*gp*gp*up*ap*ap*ap*up*gp*u)-3') (6 kDa, RNA from SFTS virus AH12)
- Rna (5'-r(p*ap*cp*a)-3') (918 Da, RNA from SFTS virus AH12)
- Rna (5'-r(*(m7g)*ap*ap*a)-3') (5 kDa, RNA from SFTS virus AH12)
- Rna-directed rna polymerase l (235 kDa, Protein from SFTS virus AH12)
Cryo-EM structure of the human parainfluenza virus hPIV3 L-P polymerase in dimeric form
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8kdb
Q-score: 0.577
Xie J, Ouizougun-Oubari M, Wang L, Zhai G, Wu D, Lin Z, Wang M, Ludeke B, Yan X, Nilsson T, Gao L, Huang X, Fearns R, Chen S
Nat Commun (2024) 15 pp. 3163-3163 [ DOI: doi:10.1038/s41467-024-47470-7 Pubmed: 38605025 ]
- Human parainfluenza virus hpiv3 l-p polymerase in dimeric form (Complex from Human respirovirus 3)
- Rna-directed rna polymerase l (260 kDa, Protein from Human respirovirus 3)
- Magnesium ion (24 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Phosphoprotein (68 kDa, Protein from Human respirovirus 3)
Cryo-EM structure of the human parainfluenza virus hPIV3 L-P polymerase in monomeric form
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8kdc
Q-score: 0.506
Xie J, Ouizougun-Oubari M, Wang L, Zhai G, Wu D, Lin Z, Wang M, Ludeke B, Yan X, Nilsson T, Gao L, Huang X, Fearns R, Chen S
Nat Commun (2024) 15 pp. 3163-3163 [ DOI: doi:10.1038/s41467-024-47470-7 Pubmed: 38605025 ]
- Rna-directed rna polymerase l (260 kDa, Protein from Human respirovirus 3)
- Magnesium ion (24 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Phosphoprotein (68 kDa, Protein from Human respirovirus 3)
- Human parainfluenza virus hpiv3 l-p polymerase in monomeric form (Complex from Human respirovirus 3)