Do data resources managed by EMBL-EBI and our collaborators make a difference to your work? Please take 10 minutes to fill in our annual user survey, and help us make the case for why sustaining open data resources is critical for life sciences research.
Preholo-Proteasome from Beta 3 D205 deletion
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8u6y
Q-score: 0.513
Velez B, Walsh Jr RM, Rawson S, Razi A, Adams L, Perez EF, Jiao F, Blickling M, Rajakumar T, Fung D, Huang L, Hanna J
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01262-1 Pubmed: 38600323 ]
- Proteasome subunit beta type-1 (23 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-5 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-4 (22 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-3 (22 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-5 (31 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-6 (26 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-4 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-2 (27 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-7 (29 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-1 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Preholo-proteasome from beta 3 d205 deletion mutant (750 kDa, Complex from Saccharomyces cerevisiae S288C)
- Proteasome chaperone 1 (30 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-2 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome maturation factor ump1 (16 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-3 (27 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-6 (25 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-7 (31 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome assembly chaperone 2 (30 kDa, Protein from Saccharomyces cerevisiae S288C)
Proteasome 20S Core Particle from Beta 3 D205 deletion
Resolution: 2.16 Å
EM Method: Single-particle
Fitted PDBs: 8u7u
Q-score: 0.688
Velez B, Walsh Jr RM, Rawson S, Razi A, Adams L, Perez EF, Jiao F, Blickling M, Rajakumar T, Fung D, Huang L, Hanna J
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01262-1 Pubmed: 38600323 ]
- Proteasome subunit beta type-1 (23 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-5 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-6 (25 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-4 (22 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-5 (31 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-6 (26 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-3 (22 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-4 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-2 (27 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-7 (29 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-1 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-2 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome 20s core particle from beta 3 d205 deletion mutant (700 kDa, Complex from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-7 (31 kDa, Protein from Saccharomyces cerevisiae S288C)
Bovine 20S proteasome, untreated
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8azk
Q-score: 0.518
Szenkier N, Arie M, Matzov D, Sertchook R, Carmeli R, Cascio P, Stanhill A, Shalev Benami M, Navon A
To Be Published
- Proteasome subunit alpha type-3 (28 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-4 (24 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-7 (25 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-3 (22 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-6 (21 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-1 (23 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-2 (22 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-5 (22 kDa, Protein from Bos taurus)
- Untreated 20s proteasome (700 kDa, Complex from Bos taurus)
Human 20S proteasome assembly intermediate structure 5
Resolution: 2.88 Å
EM Method: Single-particle
Fitted PDBs: 8qyn
Q-score: 0.571
Adolf F, Du J, Goodall EA, Walsh Jr RM, Rawson S, von Gronau S, Harper JW, Hanna J, Schulman BA
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01268-9 Pubmed: 38600324 ]
- Proteasome maturation protein (15 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (35 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-6 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Human 20s proteasome assembly intermediate map 5 (Complex from Homo sapiens)
- Proteasome subunit beta type-1 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome assembly chaperone 2 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-5 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome assembly chaperone 1 (32 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
Human proteasome 20S core particle
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 8qyo
Q-score: 0.596
Adolf F, Du J, Goodall EA, Walsh Jr RM, Rawson S, von Gronau S, Harper JW, Hanna J, Schulman BA
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01268-9 Pubmed: 38600324 ]
- Human proteasome 20s core particle (Complex from Homo sapiens)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-6 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-1 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-5 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (30 kDa, Protein from Homo sapiens)
Human preholo proteasome 20S core particle
Resolution: 3.89 Å
EM Method: Single-particle
Fitted PDBs: 8qys
Q-score: 0.456
Adolf F, Du J, Goodall EA, Walsh Jr RM, Rawson S, von Gronau S, Harper JW, Hanna J, Schulman BA
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01268-9 Pubmed: 38600324 ]
- Proteasome subunit beta type-4 (23 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-1 (23 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-6 (21 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-4 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (26 kDa, Protein from Homo sapiens)
- Proteasome assembly chaperone 2 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-5 (22 kDa, Protein from Homo sapiens)
- Proteasome maturation protein (15 kDa, Protein from Homo sapiens)
- Proteasome assembly chaperone 1 (32 kDa, Protein from Homo sapiens)
- Human preholo proteasome 20s core particle (Complex from Homo sapiens)
Human 20S proteasome assembly intermediate structure 4
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 8qz9
Q-score: 0.555
Adolf F, Du J, Goodall EA, Walsh Jr RM, Rawson S, von Gronau S, Harper JW, Hanna J, Schulman BA
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01268-9 Pubmed: 38600324 ]
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (35 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- Human 20s proteasome assembly intermediate map 4 (Complex from Homo sapiens)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-1 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome assembly chaperone 2 (29 kDa, Protein from Homo sapiens)
- Proteasome maturation protein (15 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-5 (28 kDa, Protein from Homo sapiens)
- Proteasome assembly chaperone 1 (32 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
Structure of human constitutive 20S proteasome complexed with the inhibitor TDI-8304
Resolution: 2.04 Å
EM Method: Single-particle
Fitted PDBs: 8ud9
Q-score: 0.732
Hsu HC, Li D, Zhan W, Ye J, Liu YJ, Leung A, Qin J, Crespo B, Gamo FJ, Zhang H, Cui L, Roth A, Kirkman LA, Li H, Lin G
Nat Commun (2023) 14 pp. 8302-8302 [ Pubmed: 38097652 DOI: doi:10.1038/s41467-023-44077-2 ]
- Proteasome subunit beta type-6 (21 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (24 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (25 kDa, Protein from Homo sapiens)
- Human 20s constitutive proteasome complexed with inhibitor tdi-8304 (700 kDa, Complex from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-5 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- (7s,10s,13s)-n-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide (597 Da, Ligand)
- Proteasome subunit beta type-1 (23 kDa, Protein from Homo sapiens)
Preholo-Proteasome from Pre1-1 Pre4-1 Double Mutant
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8t08
Q-score: 0.504
Walsh Jr RM, Rawson S, Schnell HM, Velez B, Rajakumar T, Hanna J
Nat Struct Mol Biol (2023) 30 pp. 1516-1524 [ Pubmed: 37653242 DOI: doi:10.1038/s41594-023-01081-w ]
- Proteasome subunit beta type-1 (23 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-5 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-5 (31 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-6 (26 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome assembly chaperone 2 (30 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-4 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-4 (22 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-2 (27 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-7 (27 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-1 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Preholo-proteasome from pre1-1 pre4-1 double mutant (918 kDa, Complex from Saccharomyces cerevisiae)
- Proteasome chaperone 1 (30 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-2 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome maturation factor ump1 (16 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-6 (25 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-7 (31 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-3 (22 kDa, Protein from Saccharomyces cerevisiae S288C)
Proteasome 20S core particle from Pre1-1 Pre4-1 Double mutant
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 8t0m
Q-score: 0.66
Walsh Jr RM, Rawson S, Schnell HM, Velez B, Rajakumar T, Hanna J
Nat Struct Mol Biol (2023) 30 pp. 1516-1524 [ Pubmed: 37653242 DOI: doi:10.1038/s41594-023-01081-w ]
- Proteasome subunit beta type-1 (23 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-5 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-5 (31 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-6 (26 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-4 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-4 (22 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-2 (27 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome 20s core particle from pre1-1 pre4-1 double mutant (750 kDa, Complex from Saccharomyces cerevisiae)
- Proteasome subunit beta type-7 (27 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-1 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-2 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-6 (25 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-7 (31 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-3 (22 kDa, Protein from Saccharomyces cerevisiae S288C)