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Cryo-EM structure of a human pre-40S ribosomal subunit - State UTP14
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7wts
Q-score: 0.429
Cheng J, Lau B, Thoms M, Ameismeier M, Berninghausen O, Hurt E, Beckmann R
Nucleic Acids Res (2022) 50 pp. 11924-11937 [ Pubmed: 36321656 DOI: doi:10.1093/nar/gkac961 ]
- 40s ribosomal protein s13 (17 kDa, Protein from human)
- Yeast pre-40s ribosomal subunit (Complex from Homo sapiens)
- 40s ribosomal protein s6 (28 kDa, Protein from human)
- 40s ribosomal protein s9 (22 kDa, Protein from human)
- Probable dimethyladenosine transferase (35 kDa, Protein from human)
- 40s ribosomal protein s4, x isoform (29 kDa, Protein from human)
- 40s ribosomal protein s11 (18 kDa, Protein from human)
- Probable 18s rrna (guanine-n(7))-methyltransferase (31 kDa, Protein from human)
- Rrp12-like protein (143 kDa, Protein from human)
- 40s ribosomal protein s14 (16 kDa, Protein from human)
- Pre-rrna-processing protein tsr1 homolog (91 kDa, Protein from human)
- 40s ribosomal protein s15a (14 kDa, Protein from human)
- 40s ribosomal protein s23 (15 kDa, Protein from human)
- Ribosome biogenesis protein slx9 homolog (25 kDa, Protein from human)
- 40s ribosomal protein s27 (9 kDa, Protein from human)
- 40s ribosomal protein s7 (22 kDa, Protein from human)
- Multifunctional methyltransferase subunit trm112-like protein (14 kDa, Protein from human)
- U3 small nucleolar rna-associated protein 14 homolog a (88 kDa, Protein from human)
- Rna-binding protein pno1 (27 kDa, Protein from human)
- 40s ribosomal protein s30 (6 kDa, Protein from human)
- 18s rrna (604 kDa, RNA from Homo sapiens)
- 40s ribosomal protein s24 (15 kDa, Protein from human)
- 40s ribosomal protein s8 (24 kDa, Protein from human)
- 40s ribosomal protein s3a (30 kDa, Protein from human)
Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-A1 (with CK1)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7wtt
Q-score: 0.426
Cheng J, Lau B, Thoms M, Ameismeier M, Berninghausen O, Hurt E, Beckmann R
Nucleic Acids Res (2022) 50 pp. 11924-11937 [ Pubmed: 36321656 DOI: doi:10.1093/nar/gkac961 ]
- 40s ribosomal protein s13 (17 kDa, Protein from human)
- Casein kinase i isoform alpha (38 kDa, Protein from human)
- 40s ribosomal protein s5 (22 kDa, Protein from human)
- Yeast pre-40s ribosomal subunit (Complex from Homo sapiens)
- Protein ltv1 homolog (54 kDa, Protein from human)
- 40s ribosomal protein s6 (28 kDa, Protein from human)
- 40s ribosomal protein s9 (22 kDa, Protein from human)
- 18s rrna (604 kDa, RNA from Homo sapiens)
- 40s ribosomal protein s4, x isoform (29 kDa, Protein from human)
- 40s ribosomal protein s11 (18 kDa, Protein from human)
- Bystin (49 kDa, Protein from human)
- 40s ribosomal protein s19 (16 kDa, Protein from human)
- 40s ribosomal protein s14 (16 kDa, Protein from human)
- Probable 18s rrna (guanine-n(7))-methyltransferase (31 kDa, Protein from human)
- Pre-rrna-processing protein tsr1 homolog (91 kDa, Protein from human)
- 40s ribosomal protein s15a (14 kDa, Protein from human)
- Rrp12-like protein (143 kDa, Protein from human)
- Ubiquitin-40s ribosomal protein s27a (18 kDa, Protein from human)
- 40s ribosomal protein s12 (14 kDa, Protein from human)
- 40s ribosomal protein s23 (15 kDa, Protein from human)
- 40s ribosomal protein s15 (17 kDa, Protein from human)
- Ribosome biogenesis protein slx9 homolog (25 kDa, Protein from human)
- 40s ribosomal protein s27 (9 kDa, Protein from human)
- 40s ribosomal protein s7 (22 kDa, Protein from human)
- Multifunctional methyltransferase subunit trm112-like protein (14 kDa, Protein from human)
- Zinc ion (65 Da, Ligand)
- 40s ribosomal protein s18 (17 kDa, Protein from human)
- 40s ribosomal protein s17 (15 kDa, Protein from human)
- 40s ribosomal protein s28 (7 kDa, Protein from human)
- Rna-binding protein pno1 (27 kDa, Protein from human)
- 40s ribosomal protein s30 (6 kDa, Protein from human)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- 40s ribosomal protein s24 (15 kDa, Protein from human)
- 40s ribosomal protein s8 (24 kDa, Protein from human)
- 40s ribosomal protein s25 (13 kDa, Protein from human)
- 40s ribosomal protein s3a (30 kDa, Protein from human)
- 40s ribosomal protein s16 (16 kDa, Protein from human)
Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-A1 (without CK1)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7wtu
Q-score: 0.43
Cheng J, Lau B, Thoms M, Ameismeier M, Berninghausen O, Hurt E, Beckmann R
Nucleic Acids Res (2022) 50 pp. 11924-11937 [ Pubmed: 36321656 DOI: doi:10.1093/nar/gkac961 ]
- 40s ribosomal protein s13 (17 kDa, Protein from human)
- 40s ribosomal protein s5 (22 kDa, Protein from human)
- Yeast pre-40s ribosomal subunit (Complex from Homo sapiens)
- Protein ltv1 homolog (54 kDa, Protein from human)
- 40s ribosomal protein s6 (28 kDa, Protein from human)
- 40s ribosomal protein s9 (22 kDa, Protein from human)
- 18s rrna (604 kDa, RNA from Homo sapiens)
- 40s ribosomal protein s4, x isoform (29 kDa, Protein from human)
- 40s ribosomal protein s11 (18 kDa, Protein from human)
- Bystin (49 kDa, Protein from human)
- 40s ribosomal protein s19 (16 kDa, Protein from human)
- 40s ribosomal protein s14 (16 kDa, Protein from human)
- Probable 18s rrna (guanine-n(7))-methyltransferase (31 kDa, Protein from human)
- Pre-rrna-processing protein tsr1 homolog (91 kDa, Protein from human)
- 40s ribosomal protein s15a (14 kDa, Protein from human)
- Rrp12-like protein (143 kDa, Protein from human)
- Ubiquitin-40s ribosomal protein s27a (18 kDa, Protein from human)
- 40s ribosomal protein s12 (14 kDa, Protein from human)
- 40s ribosomal protein s23 (15 kDa, Protein from human)
- 40s ribosomal protein s15 (17 kDa, Protein from human)
- Ribosome biogenesis protein slx9 homolog (25 kDa, Protein from human)
- 40s ribosomal protein s27 (9 kDa, Protein from human)
- 40s ribosomal protein s7 (22 kDa, Protein from human)
- Multifunctional methyltransferase subunit trm112-like protein (14 kDa, Protein from human)
- Zinc ion (65 Da, Ligand)
- 40s ribosomal protein s18 (17 kDa, Protein from human)
- 40s ribosomal protein s17 (15 kDa, Protein from human)
- 40s ribosomal protein s28 (7 kDa, Protein from human)
- Rna-binding protein pno1 (27 kDa, Protein from human)
- 40s ribosomal protein s30 (6 kDa, Protein from human)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- 40s ribosomal protein s24 (15 kDa, Protein from human)
- 40s ribosomal protein s8 (24 kDa, Protein from human)
- 40s ribosomal protein s25 (13 kDa, Protein from human)
- 40s ribosomal protein s3a (30 kDa, Protein from human)
- 40s ribosomal protein s16 (16 kDa, Protein from human)
Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-A2
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7wtv
Q-score: 0.378
Cheng J, Lau B, Thoms M, Ameismeier M, Berninghausen O, Hurt E, Beckmann R
Nucleic Acids Res (2022) 50 pp. 11924-11937 [ Pubmed: 36321656 DOI: doi:10.1093/nar/gkac961 ]
- 40s ribosomal protein s13 (17 kDa, Protein from human)
- 40s ribosomal protein s5 (22 kDa, Protein from human)
- Yeast pre-40s ribosomal subunit (Complex from Homo sapiens)
- 40s ribosomal protein s6 (28 kDa, Protein from human)
- 40s ribosomal protein s9 (22 kDa, Protein from human)
- 40s ribosomal protein sa (32 kDa, Protein from human)
- 40s ribosomal protein s21 (9 kDa, Protein from human)
- 18s rrna (604 kDa, RNA from Homo sapiens)
- 40s ribosomal protein s4, x isoform (29 kDa, Protein from human)
- 40s ribosomal protein s11 (18 kDa, Protein from human)
- Bystin (49 kDa, Protein from human)
- 40s ribosomal protein s19 (16 kDa, Protein from human)
- 40s ribosomal protein s14 (16 kDa, Protein from human)
- Probable 18s rrna (guanine-n(7))-methyltransferase (31 kDa, Protein from human)
- Pre-rrna-processing protein tsr1 homolog (91 kDa, Protein from human)
- 40s ribosomal protein s15a (14 kDa, Protein from human)
- Rrp12-like protein (143 kDa, Protein from human)
- Ubiquitin-40s ribosomal protein s27a (18 kDa, Protein from human)
- 40s ribosomal protein s12 (14 kDa, Protein from human)
- 40s ribosomal protein s23 (15 kDa, Protein from human)
- 40s ribosomal protein s15 (17 kDa, Protein from human)
- Ribosome biogenesis protein slx9 homolog (25 kDa, Protein from human)
- 40s ribosomal protein s27 (9 kDa, Protein from human)
- 40s ribosomal protein s7 (22 kDa, Protein from human)
- Multifunctional methyltransferase subunit trm112-like protein (14 kDa, Protein from human)
- Zinc ion (65 Da, Ligand)
- 40s ribosomal protein s18 (17 kDa, Protein from human)
- 40s ribosomal protein s17 (15 kDa, Protein from human)
- 40s ribosomal protein s28 (7 kDa, Protein from human)
- Rna-binding protein pno1 (27 kDa, Protein from human)
- 40s ribosomal protein s2 (31 kDa, Protein from human)
- 40s ribosomal protein s30 (6 kDa, Protein from human)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- 40s ribosomal protein s24 (15 kDa, Protein from human)
- 40s ribosomal protein s8 (24 kDa, Protein from human)
- 40s ribosomal protein s25 (13 kDa, Protein from human)
- 40s ribosomal protein s3a (30 kDa, Protein from human)
- 40s ribosomal protein s16 (16 kDa, Protein from human)
Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-A3
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7wtw
Q-score: 0.401
Cheng J, Lau B, Thoms M, Ameismeier M, Berninghausen O, Hurt E, Beckmann R
Nucleic Acids Res (2022) 50 pp. 11924-11937 [ Pubmed: 36321656 DOI: doi:10.1093/nar/gkac961 ]
- 40s ribosomal protein s13 (17 kDa, Protein from human)
- 40s ribosomal protein s5 (22 kDa, Protein from human)
- Yeast pre-40s ribosomal subunit (Complex from Homo sapiens)
- Protein ltv1 homolog (54 kDa, Protein from human)
- 40s ribosomal protein s6 (28 kDa, Protein from human)
- 40s ribosomal protein s9 (22 kDa, Protein from human)
- 40s ribosomal protein sa (32 kDa, Protein from human)
- 40s ribosomal protein s21 (9 kDa, Protein from human)
- 18s rrna (604 kDa, RNA from Homo sapiens)
- 40s ribosomal protein s4, x isoform (29 kDa, Protein from human)
- 40s ribosomal protein s11 (18 kDa, Protein from human)
- Bystin (49 kDa, Protein from human)
- 40s ribosomal protein s19 (16 kDa, Protein from human)
- 40s ribosomal protein s14 (16 kDa, Protein from human)
- Rrp12-like protein (143 kDa, Protein from human)
- Pre-rrna-processing protein tsr1 homolog (91 kDa, Protein from human)
- 40s ribosomal protein s15a (14 kDa, Protein from human)
- Ubiquitin-40s ribosomal protein s27a (18 kDa, Protein from human)
- 40s ribosomal protein s12 (14 kDa, Protein from human)
- 40s ribosomal protein s23 (15 kDa, Protein from human)
- 40s ribosomal protein s15 (17 kDa, Protein from human)
- Ribosome biogenesis protein slx9 homolog (25 kDa, Protein from human)
- 40s ribosomal protein s27 (9 kDa, Protein from human)
- 40s ribosomal protein s7 (22 kDa, Protein from human)
- Probable 18s rrna (guanine-n(7))-methyltransferase (22 kDa, Protein from human)
- Multifunctional methyltransferase subunit trm112-like protein (14 kDa, Protein from human)
- Zinc ion (65 Da, Ligand)
- 40s ribosomal protein s18 (17 kDa, Protein from human)
- 40s ribosomal protein s17 (15 kDa, Protein from human)
- 40s ribosomal protein s28 (7 kDa, Protein from human)
- Rna-binding protein pno1 (27 kDa, Protein from human)
- 40s ribosomal protein s2 (31 kDa, Protein from human)
- 40s ribosomal protein s30 (6 kDa, Protein from human)
- Rna-binding protein nob1 (46 kDa, Protein from human)
- 40s ribosomal protein s24 (15 kDa, Protein from human)
- 40s ribosomal protein s8 (24 kDa, Protein from human)
- 40s ribosomal protein s25 (13 kDa, Protein from human)
- 40s ribosomal protein s3a (30 kDa, Protein from human)
- 40s ribosomal protein s16 (16 kDa, Protein from human)
Cryo-EM structure of a late human pre-40S ribosomal subunit - State A
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 6g4w
Q-score: 0.274
Ameismeier M, Cheng J, Berninghausen O, Beckmann R
Nature (2018) 558 pp. 249-253 [ Pubmed: 29875412 DOI: doi:10.1038/s41586-018-0193-0 ]
- 40s ribosomal protein s6 (28 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s25 (13 kDa, Protein from Homo sapiens)
- Unknown (2 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s28 (7 kDa, Protein from Homo sapiens)
- Pre-rrna-processing protein tsr1 homolog (91 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s14 (16 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s7 (22 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s16 (16 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s15a (14 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s23 (15 kDa, Protein from Homo sapiens)
- Multifunctional methyltransferase subunit trm112-like protein (14 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s3a (30 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s9 (22 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s27 (9 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s11 (18 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s15 (17 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s4, x isoform (29 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s18 (17 kDa, Protein from Homo sapiens)
- Cryo-em structure of a late human pre-40s ribosomal subunit - state a (Complex from Homo sapiens)
- Rrp12 (68 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s5 (22 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s24 (15 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s13 (17 kDa, Protein from Homo sapiens)
- Probable 18s rrna (guanine-n(7))-methyltransferase (31 kDa, Protein from Homo sapiens)
- Bystin (49 kDa, Protein from Homo sapiens)
- Unknown helix (1 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s30 (6 kDa, Protein from Homo sapiens)
- Rna-binding protein pno1 (27 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s8 (24 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s17 (15 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s19 (16 kDa, Protein from Homo sapiens)
- 18s ribosomal rna (607 kDa, RNA from Homo sapiens)