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Human spliceosomal PM5 C* complex
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8c6j
Q-score: 0.353
Dybkov O, Preussner M, El Ayoubi L, Feng VY, Harnisch C, Merz K, Leupold P, Yudichev P, Agafonov DE, Will CL, Girard C, Dienemann C, Urlaub H, Kastner B, Heyd F, Luehrmann R
Sci Adv (2023) 9 pp. eadf1785- [ Pubmed: 36867703 DOI: doi:10.1126/sciadv.adf1785 ]
- Peptidyl-prolyl cis-trans isomerase-like 3 (18 kDa, Protein from human)
- Probable atp-dependent rna helicase ddx41 (69 kDa, Protein from human)
- U6 snrna (34 kDa, RNA from human)
- U2 snrna (60 kDa, RNA from human)
- Protein fam50a (40 kDa, Protein from human)
- Protein bud31 homolog (17 kDa, Protein from human)
- Eukaryotic initiation factor 4a-iii (46 kDa, Protein from human)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from human)
- Pm5 5' exon (78 kDa, RNA from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase-like 1 (18 kDa, Protein from human)
- Zinc ion (65 Da, Ligand)
- Splicing factor ess-2 homolog (52 kDa, Protein from human)
- Sting er exit protein (25 kDa, Protein from human)
- U5 snrna (36 kDa, RNA from human)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from human)
- Splicing regulator sde2 (49 kDa, Protein from human)
- Pre-mrna-splicing factor syf1 (100 kDa, Protein from human)
- Pre-mrna-splicing factor syf2 (28 kDa, Protein from human)
- Atp-dependent rna helicase dhx8 (139 kDa, Protein from human)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from human)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from human)
- Protein fam32a (13 kDa, Protein from human)
- U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from human)
- Pre-mrna-processing factor 17 (65 kDa, Protein from human)
- Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from human)
- Pre-mrna-processing factor 19 (55 kDa, Protein from human)
- U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from human)
- Pre-mrna-splicing factor cwc22 homolog (57 kDa, Protein from human)
- Potassium ion (39 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Nf-kappa-b-activating protein (47 kDa, Protein from human)
- Snw domain-containing protein 1 (61 kDa, Protein from human)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from human)
- Pm5 intron (74 kDa, RNA from Homo sapiens)
- Intron-binding protein aquarius (171 kDa, Protein from human)
- Rna-binding protein 8a (19 kDa, Protein from human)
- Protein mago nashi homolog (17 kDa, Protein from human)
- Splicing factor c9orf78 (33 kDa, Protein from human)
- Peptidyl-prolyl cis-trans isomerase e (33 kDa, Protein from human)
- Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from human)
- U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from human)
- Inositol hexakisphosphate (660 Da, Ligand)
- Cell division cycle 5-like protein (92 kDa, Protein from human)
- Pre-mrna-splicing factor isy1 homolog (33 kDa, Protein from human)
- Pre-mrna-splicing factor slu7 (68 kDa, Protein from human)
- Splicing factor cactin (88 kDa, Protein from human)
- Pre-mrna-splicing factor rbm22 (46 kDa, Protein from human)
- Pre-mrna-splicing factor spf27 (26 kDa, Protein from human)
- Pleiotropic regulator 1 (57 kDa, Protein from human)
- U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from human)
- Prkr-interacting protein 1 (21 kDa, Protein from human)
- Magnesium ion (24 Da, Ligand)
- 116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from human)
- Crooked neck-like protein 1 (83 kDa, Protein from human)
- Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from human)
- Serine/arginine repetitive matrix protein 2 (300 kDa, Protein from human)
- Human spliceosomal c* complex assembled on pm5 pre-mrna (Complex from Homo sapiens)
- Nitric oxide synthase-interacting protein (33 kDa, Protein from human)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from human)
Structural organization of a late activated human spliceosome (Baqr, core region)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7qtt
Q-score: 0.384
Schmitzova J, Cretu C, Dienemann C, Urlaub H, Pena V
Nature (2023) 617 pp. 842-850 [ Pubmed: 37165190 DOI: doi:10.1038/s41586-023-06049-w ]
- Putative pre-mrna-splicing factor atp-dependent rna helicase dhx16 (119 kDa, Protein from human)
- Crooked neck-like protein 1 (100 kDa, Protein from human)
- Splicing factor 3b subunit 1 (146 kDa, Protein from human)
- Protein bud31 homolog (17 kDa, Protein from human)
- U2snrna (60 kDa, RNA from human)
- Bud13 homolog (70 kDa, Protein from human)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from human)
- G-patch domain and kow motifs-containing protein (52 kDa, Protein from human)
- Peptidyl-prolyl cis-trans isomerase-like 1 (18 kDa, Protein from human)
- Ring finger protein 113a (38 kDa, Protein from human)
- Zinc ion (65 Da, Ligand)
- U6snrna (34 kDa, RNA from Homo sapiens)
- Ring-type e3 ubiquitin-protein ligase ppil2 (58 kDa, Protein from human)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from human)
- Splicing factor 3b subunit 3 (135 kDa, Protein from human)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from human)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Minx (102 kDa, RNA from unidentified adenovirus)
- Splicing factor 3b subunit 5 (10 kDa, Protein from human)
- Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from human)
- Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from human)
- Splicing factor 3a subunit 3 (58 kDa, Protein from human)
- U5 snrna (37 kDa, RNA from human)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from human)
- Pre-mrna-splicing factor cwc22 homolog (105 kDa, Protein from human)
- Splicing factor 3b subunit 4 (44 kDa, Protein from human)
- Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from human)
- Peptidyl-prolyl cis-trans isomerase-like 4 (57 kDa, Protein from human)
- Late human activated spliceosome arrested with a dominant-negative mutant of the splicing helicase aquarius (aquarius k829a) (Complex from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Cell division cycle 5-like protein (92 kDa, Protein from human)
- Snw domain-containing protein 1 (61 kDa, Protein from human)
- Splicing factor 3a subunit 2 (49 kDa, Protein from human)
- Pre-mrna-splicing factor rbm22 (46 kDa, Protein from human)
- Pleiotropic regulator 1 (57 kDa, Protein from human)
- Magnesium ion (24 Da, Ligand)
- Splicing factor 3b subunit 2 (100 kDa, Protein from human)
- 116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from human)
- Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from human)
- Serine/arginine repetitive matrix protein 2 (300 kDa, Protein from human)
- Phd finger-like domain-containing protein 5a (12 kDa, Protein from human)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from human)
Resolution: 5.9 Å
EM Method: Single-particle
Fitted PDBs: 8ch6
Q-score: 0.154
Schmitzova J, Cretu C, Dienemann C, Urlaub H, Pena V
Nature (2023) 617 pp. 842-850 [ Pubmed: 37165190 DOI: doi:10.1038/s41586-023-06049-w ]
- Putative pre-mrna-splicing factor atp-dependent rna helicase dhx16 (119 kDa, Protein from human)
- Crooked neck-like protein 1 (100 kDa, Protein from human)
- Splicing factor 3b subunit 1 (146 kDa, Protein from human)
- Protein bud31 homolog (17 kDa, Protein from human)
- Bud13 homolog (70 kDa, Protein from human)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from human)
- G-patch domain and kow motifs-containing protein (52 kDa, Protein from human)
- Peptidyl-prolyl cis-trans isomerase-like 1 (18 kDa, Protein from human)
- Ring finger protein 113a (38 kDa, Protein from human)
- Zinc ion (65 Da, Ligand)
- Ring-type e3 ubiquitin-protein ligase ppil2 (58 kDa, Protein from human)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from human)
- Pre-mrna-splicing factor syf1 (100 kDa, Protein from human)
- Splicing factor 3b subunit 3 (135 kDa, Protein from human)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from human)
- Rnu5a-1 (37 kDa, RNA from human)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Splicing factor 3b subunit 5 (10 kDa, Protein from human)
- Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from human)
- U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from human)
- Pre-mrna-processing factor 19 (55 kDa, Protein from human)
- Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from human)
- Pre-mrna-processing factor 17 (65 kDa, Protein from human)
- Splicing factor 3a subunit 3 (58 kDa, Protein from human)
- U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from human)
- Rnu6-1 (34 kDa, RNA from Homo sapiens)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from human)
- Pre-mrna-splicing factor cwc22 homolog (105 kDa, Protein from human)
- Intron-binding protein aquarius (171 kDa, Protein from human)
- Rnu2-1 (60 kDa, RNA from human)
- Splicing factor 3b subunit 4 (44 kDa, Protein from human)
- Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from human)
- Peptidyl-prolyl cis-trans isomerase e (33 kDa, Protein from human)
- Peptidyl-prolyl cis-trans isomerase-like 4 (57 kDa, Protein from human)
- Late human activated spliceosome arrested with a dominant-negative mutant of the splicing helicase aquarius (aquarius k829a) (Complex from Homo sapiens)
- U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from human)
- Inositol hexakisphosphate (660 Da, Ligand)
- Cell division cycle 5-like protein (92 kDa, Protein from human)
- Splicing factor 3a subunit 1 (88 kDa, Protein from human)
- Snw domain-containing protein 1 (61 kDa, Protein from human)
- Pre-mrna-splicing factor isy1 homolog (33 kDa, Protein from human)
- Splicing factor 3a subunit 2 (49 kDa, Protein from human)
- Pre-mrna-splicing factor spf27 (26 kDa, Protein from human)
- Pre-mrna-splicing factor rbm22 (46 kDa, Protein from human)
- Pleiotropic regulator 1 (57 kDa, Protein from human)
- U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from human)
- Magnesium ion (24 Da, Ligand)
- Splicing factor 3b subunit 2 (100 kDa, Protein from human)
- Minx-m3 (102 kDa, RNA from unidentified adenovirus)
- 116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from human)
- Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from human)
- Serine/arginine repetitive matrix protein 2 (300 kDa, Protein from human)
- Phd finger-like domain-containing protein 5a (12 kDa, Protein from human)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from human)
The cryo-EM structure of human pre-C*-I complex
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7w59
Q-score: 0.268
Zhan X, Lu Y, Zhang X, Yan C, Shi Y
Mol Cell (2022) 82 pp. 2769-2778.e4 [ DOI: doi:10.1016/j.molcel.2022.05.021 Pubmed: 35705093 ]
- U6 snrna (34 kDa, RNA from Human)
- Psme3-interacting protein (28 kDa, Protein from human)
- Crooked neck-like protein 1 (100 kDa, Protein from human)
- U2 snrna (60 kDa, RNA from human)
- Protein bud31 homolog (17 kDa, Protein from human)
- Eukaryotic initiation factor 4a-iii (46 kDa, Protein from human)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from human)
- Peptidyl-prolyl cis-trans isomerase-like 1 (18 kDa, Protein from human)
- Zinc ion (65 Da, Ligand)
- Rna helicase aquarius (171 kDa, Protein from human)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from human)
- Pre-mrna-splicing factor syf1 (100 kDa, Protein from human)
- Pre-mrna-splicing factor syf2 (28 kDa, Protein from human)
- Atp-dependent rna helicase dhx8 (139 kDa, Protein from human)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from human)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from human)
- U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from human)
- Pre-mrna-processing factor 17 (65 kDa, Protein from human)
- Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from human)
- Pre-mrna-processing factor 19 (55 kDa, Protein from human)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- U5 snrna (37 kDa, RNA from human)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from human)
- Snw domain-containing protein 1 (61 kDa, Protein from human)
- Pre-mrna-splicing factor cwc22 homolog (105 kDa, Protein from human)
- Rna-binding protein 8a (19 kDa, Protein from human)
- Protein mago nashi homolog (17 kDa, Protein from human)
- Human pre-c*-i complex (Complex from Homo sapiens)
- Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from human)
- Peptidyl-prolyl cis-trans isomerase e (33 kDa, Protein from human)
- U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from human)
- Inositol hexakisphosphate (660 Da, Ligand)
- Cell division cycle 5-like protein (92 kDa, Protein from human)
- Pre-mrna (55 kDa, RNA from unidentified adenovirus)
- Pre-mrna-splicing factor rbm22 (46 kDa, Protein from human)
- Protein casc3 (76 kDa, Protein from human)
- Pre-mrna-splicing factor spf27 (26 kDa, Protein from human)
- Pleiotropic regulator 1 (57 kDa, Protein from human)
- U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from human)
- Magnesium ion (24 Da, Ligand)
- 116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from human)
- Pre-mrna (14 kDa, RNA from unidentified adenovirus)
- Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from human)
- Serine/arginine repetitive matrix protein 2 (300 kDa, Protein from human)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from human)
The cryo-EM structure of human pre-C*-II complex
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7w5a
Q-score: 0.269
Zhan X, Lu Y, Zhang X, Yan C, Shi Y
Mol Cell (2022) 82 pp. 2769-2778.e4 [ DOI: doi:10.1016/j.molcel.2022.05.021 Pubmed: 35705093 ]
- Psme3-interacting protein (28 kDa, Protein from human)
- Crooked neck-like protein 1 (100 kDa, Protein from human)
- Cactin (88 kDa, Protein from human)
- U2 snrna (60 kDa, RNA from human)
- Protein bud31 homolog (17 kDa, Protein from human)
- Eukaryotic initiation factor 4a-iii (46 kDa, Protein from human)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from human)
- Peptidyl-prolyl cis-trans isomerase-like 1 (18 kDa, Protein from human)
- Pre-mrna (55 kDa, RNA from unidentified adenovirus)
- Zinc ion (65 Da, Ligand)
- Rna helicase aquarius (171 kDa, Protein from human)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from human)
- Pre-mrna-splicing factor syf1 (100 kDa, Protein from human)
- Pre-mrna-splicing factor syf2 (28 kDa, Protein from human)
- Atp-dependent rna helicase dhx8 (139 kDa, Protein from human)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from human)
- Human pre-c*-ii complex (Complex from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from human)
- Protein fam32a (13 kDa, Protein from human)
- U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from human)
- Pre-mrna-processing factor 17 (65 kDa, Protein from human)
- Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from human)
- Pre-mrna-processing factor 19 (55 kDa, Protein from human)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- U5 snrna (37 kDa, RNA from human)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from human)
- Snw domain-containing protein 1 (61 kDa, Protein from human)
- Pre-mrna-splicing factor cwc22 homolog (105 kDa, Protein from human)
- Rna-binding protein 8a (19 kDa, Protein from human)
- Protein mago nashi homolog (17 kDa, Protein from human)
- Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from human)
- Peptidyl-prolyl cis-trans isomerase e (33 kDa, Protein from human)
- U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from human)
- Inositol hexakisphosphate (660 Da, Ligand)
- Cell division cycle 5-like protein (92 kDa, Protein from human)
- Pre-mrna-splicing factor slu7 (68 kDa, Protein from human)
- Pre-mrna-splicing factor spf27 (26 kDa, Protein from human)
- Pre-mrna-splicing factor rbm22 (46 kDa, Protein from human)
- Protein casc3 (76 kDa, Protein from human)
- Pleiotropic regulator 1 (57 kDa, Protein from human)
- U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from human)
- Prkr-interacting protein 1 (21 kDa, Protein from human)
- U6 snrna (34 kDa, RNA from human)
- Magnesium ion (24 Da, Ligand)
- Pre-mrna (14 kDa, RNA from unidentified adenovirus)
- 116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from human)
- Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from human)
- Serine/arginine repetitive matrix protein 2 (300 kDa, Protein from human)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from human)
The cryo-EM structure of human C* complex
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 7w5b
Q-score: 0.192
Zhan X, Lu Y, Zhang X, Yan C, Shi Y
Mol Cell (2022) 82 pp. 2769-2778.e4 [ DOI: doi:10.1016/j.molcel.2022.05.021 Pubmed: 35705093 ]
- Crooked neck-like protein 1 (100 kDa, Protein from human)
- Cactin (88 kDa, Protein from human)
- U2 snrna (60 kDa, RNA from human)
- Protein bud31 homolog (17 kDa, Protein from human)
- Eukaryotic initiation factor 4a-iii (46 kDa, Protein from human)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from human)
- Peptidyl-prolyl cis-trans isomerase-like 1 (18 kDa, Protein from human)
- Pre-mrna (55 kDa, RNA from unidentified adenovirus)
- Zinc ion (65 Da, Ligand)
- Rna helicase aquarius (171 kDa, Protein from human)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from human)
- Pre-mrna-splicing factor syf1 (100 kDa, Protein from human)
- Pre-mrna-splicing factor syf2 (28 kDa, Protein from human)
- Atp-dependent rna helicase dhx8 (139 kDa, Protein from human)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from human)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from human)
- Protein fam32a (13 kDa, Protein from human)
- U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from human)
- Pre-mrna-processing factor 17 (65 kDa, Protein from human)
- Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from human)
- Pre-mrna-processing factor 19 (55 kDa, Protein from human)
- U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from human)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- U5 snrna (37 kDa, RNA from human)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from human)
- Snw domain-containing protein 1 (61 kDa, Protein from human)
- Nf-kappa-b-activating protein (47 kDa, Protein from human)
- Pre-mrna-splicing factor cwc22 homolog (105 kDa, Protein from human)
- Rna-binding protein 8a (19 kDa, Protein from human)
- Protein mago nashi homolog (17 kDa, Protein from human)
- Human pre-c*-i complex (Complex from Homo sapiens)
- Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from human)
- Peptidyl-prolyl cis-trans isomerase e (33 kDa, Protein from human)
- U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from human)
- Inositol hexakisphosphate (660 Da, Ligand)
- Cell division cycle 5-like protein (92 kDa, Protein from human)
- Pre-mrna-splicing factor slu7 (68 kDa, Protein from human)
- Pre-mrna-splicing factor spf27 (26 kDa, Protein from human)
- Pre-mrna-splicing factor rbm22 (46 kDa, Protein from human)
- Protein casc3 (76 kDa, Protein from human)
- Pleiotropic regulator 1 (57 kDa, Protein from human)
- U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from human)
- Prkr-interacting protein 1 (21 kDa, Protein from human)
- U6 snrna (34 kDa, RNA from human)
- Magnesium ion (24 Da, Ligand)
- Pre-mrna (14 kDa, RNA from unidentified adenovirus)
- 116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from human)
- Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from human)
- Serine/arginine repetitive matrix protein 2 (300 kDa, Protein from human)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from human)
Cryo-EM Structure of the Activated Human Minor Spliceosome (minor Bact Complex)
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 7dvq
Q-score: 0.432
Bai R, Wan R, Wang L, Xu K, Zhang Q, Lei J, Shi Y
Science (2021) 371 [ DOI: doi:10.1126/science.abg0879 Pubmed: 33509932 ]
- Phd finger-like domain-containing protein 5a (12 kDa, Protein from Human)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Human)
- Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from Human)
- Peptidyl-prolyl cis-trans isomerase cwc27 homolog (53 kDa, Protein from Human)
- G-patch domain and kow motifs-containing protein (52 kDa, Protein from Human)
- Pleiotropic regulator 1 (57 kDa, Protein from Human)
- Pre-mrna-splicing factor atp-dependent rna helicase dhx16 (119 kDa, Protein from Human)
- Splicing factor 3b subunit 2 (100 kDa, Protein from Human)
- Zinc ion (65 Da, Ligand)
- Ring finger protein 113a (38 kDa, Protein from Human)
- U12 snrna (48 kDa, RNA from Homo sapiens)
- Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Human)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Human)
- The activated human minor spliceosome (human minor bact complex) (Complex from Homo sapiens)
- Splicing factor 3b subunit 6 (14 kDa, Protein from Human)
- Rna-binding protein 48 (41 kDa, Protein from Human)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Serine/arginine repetitive matrix protein 1 (102 kDa, Protein from Human)
- Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Human)
- U5 snrna (37 kDa, RNA from Homo sapiens)
- Water (18 Da, Ligand)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Human)
- Potassium ion (39 Da, Ligand)
- U6atac snrna (39 kDa, RNA from Homo sapiens)
- Rna-binding motif protein, x-linked 2 (37 kDa, Protein from Human)
- U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from Human)
- 116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Human)
- 5'-o-[(s)-hydroxy{[(r)-hydroxy{[(s)-hydroxy(methoxy)phosphoryl]oxy}phosphoryl]oxy}phosphoryl]guanosine (537 Da, Ligand)
- Sodium channel modifier 1 (25 kDa, Protein from Human)
- Bud13 homolog (70 kDa, Protein from Human)
- Splicing factor 3b subunit 4 (44 kDa, Protein from Human)
- Splicing factor 3b subunit 3 (135 kDa, Protein from Human)
- Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Human)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Human)
- Cell division cycle 5-like protein (92 kDa, Protein from Human)
- Serine/arginine repetitive matrix protein 2 (300 kDa, Protein from Human)
- Inositol hexakisphosphate (660 Da, Ligand)
- Crooked neck-like protein 1 (100 kDa, Protein from Human)
- Splicing factor 3b subunit 1 (146 kDa, Protein from Human)
- U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from Human)
- Magnesium ion (24 Da, Ligand)
- Cysteine-rich pdz-binding protein (11 kDa, Protein from Human)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Human)
- Pre-mrna-splicing factor cwc22 homolog (105 kDa, Protein from Human)
- Snw domain-containing protein 1 (61 kDa, Protein from Human)
- Armadillo repeat-containing protein 7 (21 kDa, Protein from Human)
- Ring-type e3 ubiquitin-protein ligase ppil2 (58 kDa, Protein from Human)
- Splicing factor 3b subunit 5 (10 kDa, Protein from Human)
- Pre-mrna (44 kDa, RNA from Homo sapiens)
- Smad nuclear-interacting protein 1 (45 kDa, Protein from Human)
Resolution: 8.0 Å
EM Method: Single-particle
Fitted PDBs: 7abi
Q-score: 0.152
Townsend C, Leelaram MN, Agafonov DE, Dybkov O, Will CL, Bertram K, Urlaub H, Kastner B, Stark H, Luhrmann R
Science (2020) 370 [ Pubmed: 33243851 DOI: doi:10.1126/science.abc3753 ]
- Pre-mrna-processing factor 17 (65 kDa, Protein from Human)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Human)
- Inositol hexakisphosphate (660 Da, Ligand)
- Minx m3 pre-mrna (Complex from synthetic construct)
- Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from Human)
- Intron-binding protein aquarius (171 kDa, Protein from Human)
- Splicing factor 3a subunit 2 (49 kDa, Protein from Human)
- Dna/rna-binding protein kin17 (45 kDa, Protein from Human)
- Pleiotropic regulator 1 (57 kDa, Protein from Human)
- Splicing factor 3a subunit 3 (58 kDa, Protein from Human)
- Protein bud31 homolog (17 kDa, Protein from Human)
- Splicing factor 3b subunit 2 (100 kDa, Protein from Human)
- U5 snrna (36 kDa, RNA from Human)
- Splicing factor 3b subunit 3 (135 kDa, Protein from Human)
- Pre-mrna-splicing factor syf1 (100 kDa, Protein from Human)
- Peptidyl-prolyl cis-trans isomerase e (33 kDa, Protein from Human)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Human)
- Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Human)
- Pre-mrna-splicing factor rbm22 (46 kDa, Protein from Human)
- U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from Human)
- U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from Human)
- Microfibrillar-associated protein 1 (52 kDa, Protein from Human)
- Splicing factor 3b subunit 1 (146 kDa, Protein from Human)
- Human pre-bact-2 spliceosome (Complex)
- Serine/arginine repetitive matrix protein 1 (102 kDa, Protein from Human)
- Rna-binding motif protein, x-linked 2 (37 kDa, Protein from Human)
- Minx m3 pre-mrna (103 kDa, RNA from synthetic construct)
- Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Human)
- Human pre-bact-2 spliceosome (Complex from Homo sapiens)
- U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from Human)
- U6 snrna (34 kDa, RNA from Human)
- Splicing factor 3b subunit 6 (14 kDa, Protein from Human)
- Phd finger-like domain-containing protein 5a (12 kDa, Protein from Human)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Human)
- Splicing factor 3b subunit 4 (44 kDa, Protein from Human)
- Beta-catenin-like protein 1 (65 kDa, Protein from Human)
- 116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Human)
- U2 snrna (60 kDa, RNA from Human)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Human)
- Cell division cycle 5-like protein (92 kDa, Protein from Human)
- Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Human)
- U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from Human)
- Crooked neck-like protein 1 (100 kDa, Protein from Human)
- Pre-mrna-splicing factor 38a (37 kDa, Protein from Human)
- Ubiquitin-like protein 5 (8 kDa, Protein from Human)
- Snw domain-containing protein 1 (61 kDa, Protein from Human)
- Zinc finger matrin-type protein 2 (23 kDa, Protein from Human)
- Splicing factor 3a subunit 1 (88 kDa, Protein from Human)
- Magnesium ion (24 Da, Ligand)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Human)
- Ring-type e3 ubiquitin-protein ligase ppil2 (58 kDa, Protein from Human)
- Splicing factor 3b subunit 5 (10 kDa, Protein from Human)
- Bud13 homolog (70 kDa, Protein from Human)
- Smad nuclear-interacting protein 1 (45 kDa, Protein from Human)
Resolution: 7.8 Å
EM Method: Single-particle
Fitted PDBs: 7abg
Q-score: 0.147
Townsend C, Leelaram MN, Agafonov DE, Dybkov O, Will CL, Bertram K, Urlaub H, Kastner B, Stark H, Luhrmann R
Science (2020) 370 [ Pubmed: 33243851 DOI: doi:10.1126/science.abc3753 ]
- Splicing factor 3a subunit 1 (88 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 3 (135 kDa, Protein from Homo sapiens)
- U6 snrna-associated sm-like protein lsm7 (11 kDa, Protein from Homo sapiens)
- Serine/arginine-rich splicing factor 1 (27 kDa, Protein from Homo sapiens)
- Serine/arginine repetitive matrix protein 1 (102 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Homo sapiens)
- U2 snrna (60 kDa, RNA from Homo sapiens)
- Minx m3 pre-mrna (73 kDa, RNA from synthetic construct)
- U6 snrna-associated sm-like protein lsm2 (10 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 6 (14 kDa, Protein from Homo sapiens)
- Splicing factor 3a subunit 3 (58 kDa, Protein from Homo sapiens)
- Pleiotropic regulator 1 (57 kDa, Protein from Homo sapiens)
- Protein bud31 homolog (17 kDa, Protein from Homo sapiens)
- U6 snrna-associated sm-like protein lsm6 (9 kDa, Protein from Homo sapiens)
- U6 snrna-associated sm-like protein lsm8 (10 kDa, Protein from Homo sapiens)
- Nuclear cap-binding protein subunit 1 (91 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Homo sapiens)
- Pre-bact-1 spliceosomal complex (Complex from Homo sapiens)
- 7-methyl-guanosine-5'-triphosphate-5'-guanosine (803 Da, Ligand)
- Splicing factor 3b subunit 2 (100 kDa, Protein from Homo sapiens)
- Splicing factor 3a subunit 2 (49 kDa, Protein from Homo sapiens)
- Snw domain-containing protein 1 (61 kDa, Protein from Homo sapiens)
- U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from Homo sapiens)
- U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 1 (146 kDa, Protein from Homo sapiens)
- Zinc finger matrin-type protein 2 (23 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Homo sapiens)
- Ubiquitin-like protein 5 (8 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Homo sapiens)
- Ww domain-binding protein 11 (70 kDa, Protein from Homo sapiens)
- U5 snrna (36 kDa, RNA from Homo sapiens)
- U6 snrna-associated sm-like protein lsm4 (15 kDa, Protein from Homo sapiens)
- Smad nuclear-interacting protein 1 (45 kDa, Protein from Homo sapiens)
- 116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Homo sapiens)
- U6 snrna (34 kDa, RNA from Homo sapiens)
- U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 4 (44 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 5 (10 kDa, Protein from Homo sapiens)
- Transcription elongation regulator 1 (124 kDa, Protein from Homo sapiens)
- Pre-bact-1 spliceosomal complex (Complex)
- Microfibrillar-associated protein 1 (52 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor rbm22 (46 kDa, Protein from Homo sapiens)
- Nuclear cap-binding protein subunit 2 (18 kDa, Protein from Homo sapiens)
- U6 snrna-associated sm-like protein lsm5 (9 kDa, Protein from Homo sapiens)
- Phd finger-like domain-containing protein 5a (12 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Pre-mrna-splicing factor 38a (37 kDa, Protein from Homo sapiens)
- U6 snrna-associated sm-like protein lsm3 (11 kDa, Protein from Homo sapiens)
- Cell division cycle 5-like protein (92 kDa, Protein from Homo sapiens)
- Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Homo sapiens)
Human pre-Bact-2 spliceosome core structure
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7aav
Q-score: 0.393
Townsend C, Leelaram MN, Agafonov DE, Dybkov O, Will CL, Bertram K, Urlaub H, Kastner B, Stark H, Luhrmann R
Science (2020) 370 [ Pubmed: 33243851 DOI: doi:10.1126/science.abc3753 ]
- Pre-mrna-processing factor 17 (65 kDa, Protein from Human)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Minx m3 pre-mrna (Complex from synthetic construct)
- Pleiotropic regulator 1 (57 kDa, Protein from Human)
- Minx m3 pre-mrna (73 kDa, RNA from synthetic construct)
- Protein bud31 homolog (17 kDa, Protein from Human)
- U5 snrna (36 kDa, RNA from Human)
- Pre-mrna-splicing factor rbm22 (46 kDa, Protein from Human)
- Microfibrillar-associated protein 1 (52 kDa, Protein from Human)
- Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Human)
- D-chiro inositol hexakisphosphate (660 Da, Ligand)
- U6 snrna (34 kDa, RNA from Human)
- 116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Human)
- Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Human)
- U2 snrna (60 kDa, RNA from Human)
- Cell division cycle 5-like protein (92 kDa, Protein from Human)
- Pre-mrna-splicing factor 38a (37 kDa, Protein from Human)
- Snw domain-containing protein 1 (61 kDa, Protein from Human)
- Ubiquitin-like protein 5 (8 kDa, Protein from Human)
- Zinc finger matrin-type protein 2 (23 kDa, Protein from Human)
- Magnesium ion (24 Da, Ligand)
- Pre-bact-2 spliceosomal core structure (Complex from Homo sapiens)
- Pre-bact-2 spliceosomal core structure (Complex)