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Inner channel lipids regulated gating mechanism of human pannexins
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8gyo
Q-score: 0.353
To Be Published
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Pannexin-1 (48 kDa, Protein from Homo sapiens)
- Digitonin (1 kDa, Ligand)
- Pannexin-1 (350 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
CryoEM structure of human Pannexin1 with R217H congenital mutation.
Resolution: 3.87 Å
EM Method: Single-particle
Fitted PDBs: 8gts
Q-score: 0.38
Hussain N, Apotikar A, Pidathala S, Mukherjee S, Burada AP, Sikdar SK, Vinothkumar KR, Penmatsa A
To Be Published
- Pannexin 1 (r217h) (48 MDa, Cellular component from Homo sapiens)
- Pannexin-1 (48 kDa, Protein from Homo sapiens)
Cryo-EM structure of human Pannexin1 resembling Pannexin2 pore with W74R/R75Dmutations
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8gtt
Q-score: 0.462
Hussain N, Apotikar A, Pidathala S, Mukherjee S, Burada AP, Sikdar SK, Vinothkumar KR, Penmatsa A
To Be Published
- Pannexin-1 (49 kDa, Protein from Homo sapiens)
- Pannexin 1 (w74r/r75d) (48 MDa, Complex from Homo sapiens)
Hussain N, Apotikar A, Pidathala S, Mukherjee S, Burada AP, Sikdar SK, Vinothkumar KR, Penmatsa A
To Be Published
- Pannexin 1 (48 MDa, Cellular component from Homo sapiens)
- Human pannexin1 (Protein from Homo sapiens)
Cryo-EM structure of mouse Pannexin 1 purified in Salipro nanoparticles
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8a3b
Q-score: 0.453
Drulyte I, Gutgsell AR, Lloris-Garcera P, Liss M, Geschwindner S, Radjainia M, Frauenfeld J, Loving R
Sci Rep (2023) 13 pp. 1420-1420 [ Pubmed: 36697499 DOI: doi:10.1038/s41598-023-28455-w ]
- Salipro-mpanx1 (353 kDa, Cellular component from Mus musculus)
- Pannexin-1 (50 kDa, Protein from Mus musculus)
Cryo-EM structure of the N-terminal deletion mutant of human pannexin-1 in a nanodisc
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 7wsv
Q-score: 0.325
Kuzuya M, Hirano H, Hayashida K, Watanabe M, Kobayashi K, Terada T, Mahmood MI, Tama F, Tani K, Fujiyoshi Y, Oshima A
Sci Signal (2022) 15 pp. eabg6941-eabg6941 [ DOI: doi:10.1126/scisignal.abg6941 Pubmed: 35133866 ]
Cryo-EM structure of human pannexin-1 in a nanodisc
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7f8j
Q-score: 0.48
Kuzuya M, Hirano H, Hayashida K, Watanabe M, Kobayashi K, Terada T, Mahmood MI, Tama F, Tani K, Fujiyoshi Y, Oshima A
Sci Signal (2022) 15 pp. eabg6941-eabg6941 [ DOI: doi:10.1126/scisignal.abg6941 Pubmed: 35133866 ]
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Pannexin-1 (48 kDa, Protein from Homo sapiens)
- Heptamar of human pannexin-1 channel in a nanodisc (Complex from Homo sapiens)
Human pannexin-1 showing a conformational change in the N-terminal domain and blocked pore
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7f8n
Q-score: 0.488
Kuzuya M, Hirano H, Hayashida K, Watanabe M, Kobayashi K, Terada T, Mahmood MI, Tama F, Tani K, Fujiyoshi Y, Oshima A
Sci Signal (2022) 15 pp. eabg6941-eabg6941 [ DOI: doi:10.1126/scisignal.abg6941 Pubmed: 35133866 ]
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Human pannexin-1 (Complex from Homo sapiens)
- Pannexin-1 (48 kDa, Protein from Homo sapiens)
Cryo-EM structure of the C-terminal deletion mutant of human PANX1 in a nanodisc
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7f8o
Q-score: 0.444
Kuzuya M, Hirano H, Hayashida K, Watanabe M, Kobayashi K, Terada T, Mahmood MI, Tama F, Tani K, Fujiyoshi Y, Oshima A
Sci Signal (2022) 15 pp. eabg6941-eabg6941 [ DOI: doi:10.1126/scisignal.abg6941 Pubmed: 35133866 ]
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Pannexin-1 (48 kDa, Protein from Homo sapiens)
- Heptamar of human pannexin-1 channel in a nanodisc (Complex from Homo sapiens)
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 7dwb
Q-score: 0.338
Zhang S, Yuan B, Lam JH, Zhou J, Zhou X, Ramos-Mandujano G, Tian X, Liu Y, Han R, Li Y, Gao X, Li M, Yang M
Cell Discov (2021) 7 pp. 30-30 [ DOI: doi:10.1038/s41421-021-00259-0 Pubmed: 33947837 ]
- Plasma membaren channel (Cellular component from Homo sapiens)
- Pannexin-1 (49 kDa, Protein from Homo sapiens)