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Cryo-EM structure of human gamma-secretase in complex with Abeta49
Guo X, Li H, Yan C, Lei J, Zhou R, Shi Y
Science (2024) [ ]
- Presenilin-1 (52 kDa, Protein from Homo sapiens)
- Human gamma-secretase in complex with abeta49 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Nicastrin (78 kDa, Protein from Homo sapiens)
- Amyloid-beta precursor protein (13 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
Cryo-EM structure of human gamma-secretase in complex with Abeta46
Guo X, Li H, Yan C, Lei J, Zhou R, Shi Y
Science (2024) [ ]
- Amyloid-beta precursor protein (4 kDa, Protein from Homo sapiens)
- Nicastrin (78 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gamma-secretase subunit pen-2 (16 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Presenilin-1 (52 kDa, Protein from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Human gamma-secretase in complex with abeta46 (Complex from Homo sapiens)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
Cryo-EM structure of human gamma-secretase in complex with APP-C99
Guo X, Li H, Yan C, Lei J, Zhou R, Shi Y
Science (2024) [ ]
- Human gamma-secretase in complex with app-c99 (Complex from Homo sapiens)
- Presenilin-1 (52 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Nicastrin (78 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Amyloid-beta precursor protein (13 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8oqy
Q-score: 0.473
To Be Published
- Gamma-secretase subunit aph-1b (28 kDa, Protein from Homo sapiens)
- Nicastrin (79 kDa, Protein from Homo sapiens)
- Gamma secretase (172 kDa, Complex from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
- Presenilin-1 ctf12 (52 kDa, Protein from Homo sapiens)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8oqz
Q-score: 0.496
To Be Published
- Presenilin-1 ctf12 (52 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit aph-1b (28 kDa, Protein from Homo sapiens)
- Nicastrin (79 kDa, Protein from Homo sapiens)
- Amyloid-beta peptide 1-46 (5 kDa, Protein from Homo sapiens)
- Gamma secretase (172 kDa, Complex from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
Human gamma-secretase in complex with a substrate mimetic
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8k8e
Q-score: 0.554
Devkota S, Zhou R, Nagarajan V, Maesako M, Do H, Noorani A, Overmeyer C, Bhattarai S, Douglas JT, Saraf A, Miao Y, Ackley BD, Shi Y, Wolfe MS
Cell Rep (2024) 43 pp. 113761-113761 [ DOI: doi:10.1016/j.celrep.2024.113761 Pubmed: 38349793 ]
- Boc-val-gly-aib-val-val-ile-aib-phe-val-aib-gly-gly-gly-val-juu-leu-vlm (1 kDa, Protein from synthetic construct)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- Presenilin-1 (52 kDa, Protein from Homo sapiens)
- Human gamma-secretase (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Nicastrin (78 kDa, Protein from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
Human gamma-secretase treated with ganglioside GM1
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8im7
Q-score: 0.483
Wang X, Zhou R, Sun X, Li J, Wang J, Yue W, Wang L, Liu H, Shi Y, Zhang D
Adv Sci (2023) 10 pp. e2303411-e2303411 [ DOI: doi:10.1002/advs.202303411 Pubmed: 37759382 ]
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- Human gamma-secretase treated with ganglioside gm1 (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Nicastrin (78 kDa, Protein from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
- Presenilin-1 ctf12 (52 kDa, Protein from Homo sapiens)
CryoEM structure of PS1-containing gamma-secretase in complex with MRK-560
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7y5t
Q-score: 0.56
Guo X, Wang Y, Zhou J, Jin C, Wang J, Jia B, Jing D, Yan C, Lei J, Zhou R, Shi Y
Nat Commun (2022) 13 pp. 6299-6299 [ Pubmed: 36272978 DOI: doi:10.1038/s41467-022-33817-5 ]
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- Presenilin-1 (52 kDa, Protein from Homo sapiens)
- ~{n}-[4-[2,5-bis(fluoranyl)phenyl]-4-(4-chlorophenyl)sulfonyl-cyclohexyl]-1,1,1-tris(fluoranyl)methanesulfonamide (517 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Ps1-containing gamma-secretase in complex with mrk-560 (Complex from Homo sapiens)
- Nicastrin (78 kDa, Protein from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
CryoEM structure of PS2-containing gamma-secretase treated with MRK-560
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7y5x
Q-score: 0.532
Guo X, Wang Y, Zhou J, Jin C, Wang J, Jia B, Jing D, Yan C, Lei J, Zhou R, Shi Y
Nat Commun (2022) 13 pp. 6299-6299 [ Pubmed: 36272978 DOI: doi:10.1038/s41467-022-33817-5 ]
- Ps2-containing gamma-secretase complex treated with mrk-560 (Complex from Homo sapiens)
- Presenilin-2 (50 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Nicastrin (78 kDa, Protein from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
CryoEM structure of human PS2-containing gamma-secretase
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7y5z
Q-score: 0.476
Guo X, Wang Y, Zhou J, Jin C, Wang J, Jia B, Jing D, Yan C, Lei J, Zhou R, Shi Y
Nat Commun (2022) 13 pp. 6299-6299 [ Pubmed: 36272978 DOI: doi:10.1038/s41467-022-33817-5 ]
- Presenilin-2 (50 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- Human ps2-containing gamma-secretase (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Nicastrin (78 kDa, Protein from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)