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Structural biology

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Structural biology

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Hinxton

EMBL-EBI: European Bioinformatics Institute

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Epigenetics and neurobiology

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sample_name:"Neutral amino acid transporter B(0)" AND author_name:"Paulino C"

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EMDB [5]

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EMD-12142

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ASCT2 in the presence of the inhibitor Lc-BPE in the outward-open conformation.

Release date: Sept. 22, 2021
Resolution: 3.43 Å
EM Method: Single-particle
Fitted PDBs: 7bcq
Q-score: 0.427

Garibsingh RA, Ndaru E, Garaeva AA, Shi Y, Zielewicz L, Zakrepine P, Bonomi M, Slotboom DJ, Paulino C, Grewer C, Schlessinger A

PNAS (2021) 118 [ Pubmed: 34507995 DOI: doi:10.1073/pnas.2104093118 ]

Sample:

4-(4-phenylphenyl)carbonyloxypyrrolidine-2-carboxylic acid (311 Da, Ligand)
Neutral amino acid transporter b(0) (56 kDa, Protein from Homo sapiens)
Asct2 in the presence of the inhibitor lc-bpe in the outward-open conformation. (Complex from Homo sapiens)

EMD-12143

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ASCT2 in the presence of the inhibitor ERA-21 in the outward-open conformation.

Release date: Sept. 22, 2021
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 7bct
Q-score: 0.382

Garibsingh RA, Ndaru E, Garaeva AA, Shi Y, Zielewicz L, Zakrepine P, Bonomi M, Slotboom DJ, Paulino C, Grewer C, Schlessinger A

PNAS (2021) 118 [ Pubmed: 34507995 DOI: doi:10.1073/pnas.2104093118 ]

Sample:

Neutral amino acid transporter b(0) (56 kDa, Protein from Homo sapiens)
Asct2 in the presence of the inhibitor era-21 in the outward-open conformation. (Complex from Homo sapiens)

EMD-10016

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Inward-open structure of the ASCT2 (SLC1A5) mutant C467R in presence of TBOA

Release date: Aug. 7, 2019
Resolution: 3.61 Å
EM Method: Single-particle
Fitted PDBs: 6rvx
Q-score: 0.488

Garaeva AA, Guskov A, Slotboom DJ, Paulino C

Nat Commun (2019) 10 pp. 3427-3427 [ DOI: doi:10.1038/s41467-019-11363-x Pubmed: 31366933 ]

Sample:

C467r mutant of asct2 (alanine serine cysteine transporter 2, slc1a) (172 kDa, Complex from Homo sapiens)
Neutral amino acid transporter b(0) (57 kDa, Protein from Homo sapiens)

EMD-10018

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Inward-open structure of the ASCT2 (SLC1A5) mutant C467R in absence of substrate

Release date: Aug. 7, 2019
Resolution: 4.13 Å
EM Method: Single-particle
Fitted PDBs: 6rvy
Q-score: 0.369

Garaeva AA, Guskov A, Slotboom DJ, Paulino C

Nat Commun (2019) 10 pp. 3427-3427 [ DOI: doi:10.1038/s41467-019-11363-x Pubmed: 31366933 ]

Sample:

C467r mutant of asct2 (alanine serine cysteine transporter 2, slc1a) (172 kDa, Complex from Homo sapiens)
Neutral amino acid transporter b(0) (57 kDa, Protein from Homo sapiens)

EMD-4386

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cryo-EM structure of the human neutral amino acid transporter ASCT2

Release date: June 13, 2018
Resolution: 3.85 Å
EM Method: Single-particle
Fitted PDBs: 6gct
Q-score: 0.424

Garaeva AA, Oostergetel GT, Gati C, Guskov A, Paulino C, Slotboom DJ

Nat Struct Mol Biol (2018) 25 pp. 515-521 [ DOI: doi:10.1038/s41594-018-0076-y Pubmed: 29872227 ]

Sample:

Glutamine (146 Da, Ligand)
Neutral amino acid transporter b(0) (56 kDa, Protein from Homo sapiens)
Human asct2 slc1a5 (172 kDa, Complex from Homo sapiens)

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Showing 1 - 5 of 5. Page 1 of 1

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EMDB [5]

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