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DNA initiation complex (configuration 1) of Xenopus laevis DNA polymerase alpha-primase
Resolution: 11.16 Å
EM Method: Single-particle
Fitted PDBs: 8v6g
Q-score: 0.051
Mullins EA, Salay LE, Durie CL, Bradley NP, Jackman JE, Ohi MD, Chazin WJ, Eichman BF
Nat Struct Mol Biol (2024) [ Pubmed: 38491139 DOI: doi:10.1038/s41594-024-01227-4 ]
- Dna primase (49 kDa, Protein from Xenopus laevis)
- Dna template (15 kDa, DNA from synthetic construct)
- Dna polymerase alpha catalytic subunit (129 kDa, Protein from Xenopus laevis)
- Dna primase large subunit (59 kDa, Protein from Xenopus laevis)
- Dna polymerase alpha subunit b (67 kDa, Protein from Xenopus laevis)
- Primase (Complex from Xenopus laevis)
- Rna primer (2 kDa, RNA from synthetic construct)
- Polymerase alpha-primase with a dna initiation substrate (110 kDa, Complex)
- Polymerase alpha (Complex from Xenopus laevis)
- Magnesium ion (24 Da, Ligand)
- Dna initiation substrate (20 kDa, Complex from synthetic construct)
- 2'-deoxyguanosine-5'-triphosphate (507 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Iron/sulfur cluster (351 Da, Ligand)
DNA initiation complex (configuration 2) of Xenopus laevis DNA polymerase alpha-primase
Resolution: 11.11 Å
EM Method: Single-particle
Fitted PDBs: 8v6h
Q-score: 0.02
Mullins EA, Salay LE, Durie CL, Bradley NP, Jackman JE, Ohi MD, Chazin WJ, Eichman BF
Nat Struct Mol Biol (2024) [ Pubmed: 38491139 DOI: doi:10.1038/s41594-024-01227-4 ]
- Dna primase (49 kDa, Protein from Xenopus laevis)
- Dna template (15 kDa, DNA from synthetic construct)
- Dna polymerase alpha catalytic subunit (129 kDa, Protein from Xenopus laevis)
- Dna primase large subunit (59 kDa, Protein from Xenopus laevis)
- Dna polymerase alpha subunit b (67 kDa, Protein from Xenopus laevis)
- Primase (Complex from Xenopus laevis)
- Rna primer (2 kDa, RNA from synthetic construct)
- Polymerase alpha-primase with a dna initiation substrate (110 kDa, Complex)
- Polymerase alpha (Complex from Xenopus laevis)
- Magnesium ion (24 Da, Ligand)
- Dna initiation substrate (20 kDa, Complex from synthetic construct)
- 2'-deoxyguanosine-5'-triphosphate (507 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Iron/sulfur cluster (351 Da, Ligand)
DNA elongation complex (configuration 1) of Xenopus laevis DNA polymerase alpha-primase
Resolution: 14.06 Å
EM Method: Single-particle
Fitted PDBs: 8v6i
Q-score: 0.027
Mullins EA, Salay LE, Durie CL, Bradley NP, Jackman JE, Ohi MD, Chazin WJ, Eichman BF
Nat Struct Mol Biol (2024) [ Pubmed: 38491139 DOI: doi:10.1038/s41594-024-01227-4 ]
- Dna primase (49 kDa, Protein from Xenopus laevis)
- Dna template (15 kDa, DNA from synthetic construct)
- Dna polymerase alpha catalytic subunit (129 kDa, Protein from Xenopus laevis)
- Dna primase large subunit (59 kDa, Protein from Xenopus laevis)
- Dna polymerase alpha subunit b (67 kDa, Protein from Xenopus laevis)
- Iron/sulfur cluster (351 Da, Ligand)
- Primase (Complex from Xenopus laevis)
- Rna-dna primer (6 kDa, Macromolecule from synthetic construct)
- Polymerase alpha (Complex from Xenopus laevis)
- Dna elongation substrate (20 kDa, Complex from synthetic construct)
- Magnesium ion (24 Da, Ligand)
- 2'-deoxyguanosine-5'-triphosphate (507 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Polymerase alpha-primase with a dna elongation substrate (110 kDa, Complex)
DNA elongation complex (configuration 2) of Xenopus laevis DNA polymerase alpha-primase
Resolution: 11.11 Å
EM Method: Single-particle
Fitted PDBs: 8v6j
Q-score: 0.029
Mullins EA, Salay LE, Durie CL, Bradley NP, Jackman JE, Ohi MD, Chazin WJ, Eichman BF
Nat Struct Mol Biol (2024) [ Pubmed: 38491139 DOI: doi:10.1038/s41594-024-01227-4 ]
- Dna primase (49 kDa, Protein from Xenopus laevis)
- Dna template (15 kDa, DNA from synthetic construct)
- Dna polymerase alpha catalytic subunit (129 kDa, Protein from Xenopus laevis)
- Dna primase large subunit (59 kDa, Protein from Xenopus laevis)
- Dna polymerase alpha subunit b (67 kDa, Protein from Xenopus laevis)
- Iron/sulfur cluster (351 Da, Ligand)
- Primase (Complex from Xenopus laevis)
- Rna-dna primer (6 kDa, Macromolecule from synthetic construct)
- Polymerase alpha (Complex from Xenopus laevis)
- Dna elongation substrate (20 kDa, Complex from synthetic construct)
- Magnesium ion (24 Da, Ligand)
- 2'-deoxyguanosine-5'-triphosphate (507 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Polymerase alpha-primase with a dna elongation substrate (110 kDa, Complex)
RNA priming complex of Human polymerase alpha-primase (Conformation 2)
Cordoba JJ, Mullins EA, Salay LE, Eichman BF, Chazin WJ
J Mol Biol (2023) 435 pp. 168330-168330 [ DOI: doi:10.1016/j.jmb.2023.168330 Pubmed: 37884206 ]
- Dna primase large subunit (Protein from Homo sapiens)
- Rna priming substrate - template (DNA from Homo sapiens)
- Dna primase small subunit (Protein from Homo sapiens)
- Dna polymerase alpha subunit b (Protein from Homo sapiens)
- Ternary complex of polymerase alpha-primase bound to an rna primed-template substrate. (200 kDa, Complex from Homo sapiens)
- Dna polymerase alpha catalytic subunit (Protein from Homo sapiens)
- Rna priming substrate - primer (RNA from Homo sapiens)
Human Polymerase alpha-Primase, polymerase alpha catalytic domain deletion mutant (Conformation 1)
Cordoba JJ, Mullins EA, Salay LE, Eichman BF, Chazin WJ
J Mol Biol (2023) 435 pp. 168330-168330 [ DOI: doi:10.1016/j.jmb.2023.168330 Pubmed: 37884206 ]
- Dna primase large subunit (Protein from Homo sapiens)
- Polymerase alpha-primase, pol alpha catalytic domain deletion mutant (180 kDa, Complex from Homo sapiens)
- Dna primase small subunit (Protein from Homo sapiens)
- Dna polymerase alpha subunit b (Protein from Homo sapiens)
- Dna polymerase alpha catalytic subunit (Protein from Homo sapiens)
Human Polymerase alpha-Primase, polymerase alpha catalytic domain deletion mutant (Conformation 2)
Cordoba JJ, Mullins EA, Salay LE, Eichman BF, Chazin WJ
J Mol Biol (2023) 435 pp. 168330-168330 [ DOI: doi:10.1016/j.jmb.2023.168330 Pubmed: 37884206 ]
- Dna primase large subunit (Protein from Homo sapiens)
- Polymerase alpha-primase, pol alpha catalytic domain deletion mutant (180 kDa, Complex from Homo sapiens)
- Dna primase small subunit (Protein from Homo sapiens)
- Dna polymerase alpha subunit b (Protein from Homo sapiens)
- Dna polymerase alpha catalytic subunit (Protein from Homo sapiens)
RNA priming complex of Human Polymerase-Alpha-Primase (Conformation 1)
Cordoba JJ, Mullins EA, Salay LE, Eichman BF, Chazin WJ
J Mol Biol (2023) 435 pp. 168330-168330 [ DOI: doi:10.1016/j.jmb.2023.168330 Pubmed: 37884206 ]
- Dna primase large subunit (Protein from Homo sapiens)
- Rna priming substrate - template (DNA from Homo sapiens)
- Dna primase small subunit (Protein from Homo sapiens)
- Dna polymerase alpha subunit b (Protein from Homo sapiens)
- Ternary complex of polymerase alpha-primase bound to an rna primed-template substrate. (200 kDa, Complex from Homo sapiens)
- Dna polymerase alpha catalytic subunit (Protein from Homo sapiens)
- Rna priming substrate - primer (RNA from Homo sapiens)
RNA priming complex of Human Polymerase alpha-primase (Conformation 3)
Cordoba JJ, Mullins EA, Salay LE, Eichman BF, Chazin WJ
J Mol Biol (2023) 435 pp. 168330-168330 [ DOI: doi:10.1016/j.jmb.2023.168330 Pubmed: 37884206 ]
- Dna primase large subunit (Protein from Homo sapiens)
- Rna priming substrate - template (DNA from Homo sapiens)
- Dna primase small subunit (Protein from Homo sapiens)
- Dna polymerase alpha subunit b (Protein from Homo sapiens)
- Ternary complex of polymerase alpha-primase bound to an rna primed-template substrate. (200 kDa, Complex from Homo sapiens)
- Dna polymerase alpha catalytic subunit (Protein from Homo sapiens)
- Rna priming substrate - primer (RNA from Homo sapiens)
Partial DNA termination subcomplex of Xenopus laevis DNA polymerase alpha-primase
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8ucu
Q-score: 0.52
Mullins EA, Salay LE, Durie CL, Bradley NP, Jackman JE, Ohi MD, Chazin WJ, Eichman BF
Nat Struct Mol Biol (2024) [ Pubmed: 38491139 DOI: doi:10.1038/s41594-024-01227-4 ]
- Dna polymerase alpha catalytic subunit (129 kDa, Protein from Xenopus laevis)
- Dna template (18 kDa, DNA from synthetic construct)
- Polymerase alpha-primase with a dna termination substrate (330 kDa, Complex)
- Polymerase alpha (200 kDa, Complex from Xenopus laevis)
- Primase (110 kDa, Complex from Xenopus laevis)
- Rna-dna primer (9 kDa, DNA from synthetic construct)
- Magnesium ion (24 Da, Ligand)
- Dna termination substrate (30 kDa, Complex from synthetic construct)
- 2'-deoxyguanosine-5'-triphosphate (507 Da, Ligand)