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Cryo-EM structure of CDK2-cyclin A in complex with CDC25A
Rowland RJ, Korolchuk S, Salamina M, Ault JR, Hart S, Turkenburg JP, Blaza JN, Noble MEM, Endicott JA
To Be Published
- M-phase inducer phosphatase 1 (22 kDa, Protein from Homo sapiens)
- Trimeric complex of cdk2-cyclin a-cdc25a (86 kDa, Complex from Homo sapiens)
- Cyclin-a2 (30 kDa, Protein from Bos taurus)
- Cyclin-dependent kinase 2 (34 kDa, Protein from Homo sapiens)
Cryo-EM structure of SKP1-SKP2-CKS1-CDK2-CyclinA-p27KIP1 Complex
Resolution: 3.38 Å
EM Method: Single-particle
Fitted PDBs: 8bya
Q-score: 0.445
Rowland RJ, Heath R, Maskell D, Thompson RF, Ranson NA, Blaza JN, Endicott JA, Noble MEM, Salamina M
Sci Rep (2023) 13 pp. 10718-10718 [ DOI: doi:10.1038/s41598-023-37609-9 Pubmed: 37400515 ]
- Cyclin-dependent kinase inhibitor 1b (17 kDa, Protein from Homo sapiens)
- Hexameric complex of skp1-skp2-cks1 with cdk2-cyclina-p27(kip1) (175 kDa, Complex from Homo sapiens)
- Cyclin-dependent kinase 2 (33 kDa, Protein from Homo sapiens)
- Cyclin-dependent kinases regulatory subunit 1 (9 kDa, Protein from Homo sapiens)
- P27 kip1 c-terminus (1 kDa, Protein from Homo sapiens)
- S-phase kinase-associated protein 1 (18 kDa, Protein from Homo sapiens)
- S-phase kinase-associated protein 2 (47 kDa, Protein from Homo sapiens)
- Cyclin-a2 (48 kDa, Protein from Homo sapiens)
Cryo-EM structure of CDK2-CyclinA in complex with p27 from the SCFSKP2 E3 ligase Complex
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8bzo
Q-score: 0.48
Rowland RJ, Heath R, Maskell D, Thompson RF, Ranson NA, Blaza JN, Endicott JA, Noble MEM, Salamina M
Sci Rep (2023) 13 pp. 10718-10718 [ DOI: doi:10.1038/s41598-023-37609-9 Pubmed: 37400515 ]
- Cyclin-dependent kinase inhibitor 1b (17 kDa, Protein from Homo sapiens)
- Complex of cdk2-cyclina-p27(kip1)from the scfskp2 e3 ligase complex (74 kDa, Complex from Homo sapiens)
- Cyclin-dependent kinase 2 (33 kDa, Protein from Homo sapiens)
- Cyclin-a2 (48 kDa, Protein from Homo sapiens)
CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8or0
Q-score: 0.218
Shaaban M, Clapperton JA, Ding S, Kunzelmann S, Maeots ME, Maslen SL, Skehel JM, Enchev RI
Mol Cell (2023) 83 pp. 2332- [ DOI: doi:10.1016/j.molcel.2023.05.034 Pubmed: 37339624 ]
- S-phase kinase-associated protein 2 (48 kDa, Protein from Homo sapiens)
- Cullin-associated nedd8-dissociated protein 1 (137 kDa, Protein from Homo sapiens)
- Cand1-cul1-rbx1-skp1-skp2-cks1-cdk2 (Complex from Homo sapiens)
- Cullin-1 (93 kDa, Protein from Homo sapiens)
- Cyclin-dependent kinases regulatory subunit 1 (8 kDa, Protein from Homo sapiens)
- S-phase kinase-associated protein 1 (18 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
- Cyclin-dependent kinase 2 (33 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8or3
Q-score: 0.415
Shaaban M, Clapperton JA, Ding S, Kunzelmann S, Maeots ME, Maslen SL, Skehel JM, Enchev RI
Mol Cell (2023) 83 pp. 2332- [ DOI: doi:10.1016/j.molcel.2023.05.034 Pubmed: 37339624 ]
- S-phase kinase-associated protein 2 (48 kDa, Protein from Homo sapiens)
- Cullin-associated nedd8-dissociated protein 1 (137 kDa, Protein from Homo sapiens)
- Cullin-1 (93 kDa, Protein from Homo sapiens)
- Cand1-cul1-rbx1-skp1-skp2-cks1-cdk2-cycline-dcnl1 (Complex from Homo sapiens)
- Dcn1-like protein 1 (30 kDa, Protein from Homo sapiens)
- S-phase kinase-associated protein 1 (18 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
Partially dissociated CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8or4
Q-score: 0.285
Shaaban M, Clapperton JA, Ding S, Kunzelmann S, Maeots ME, Maslen SL, Skehel JM, Enchev RI
Mol Cell (2023) 83 pp. 2332- [ DOI: doi:10.1016/j.molcel.2023.05.034 Pubmed: 37339624 ]
- S-phase kinase-associated protein 2 (48 kDa, Protein from Homo sapiens)
- Cullin-associated nedd8-dissociated protein 1 (137 kDa, Protein from Homo sapiens)
- Partially dissociated cand1-cul1-rbx1-skp1-skp2-cks1-cdk2 (Complex from Homo sapiens)
- Cullin-1 (93 kDa, Protein from Homo sapiens)
- Cyclin-dependent kinases regulatory subunit 1 (8 kDa, Protein from Homo sapiens)
- S-phase kinase-associated protein 1 (18 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
- Cyclin-dependent kinase 2 (33 kDa, Protein from Homo sapiens)
CAND1-SCF-SKP2 with substrate p27-CKSHS1-CyclinA-CDK2, CAND1 engaged SCF rocked
Baek K, Scott DC, Henneberg LT, King MT, Mann M, Schulman BA
Cell (2023) 186 pp. 1895-1911.e21 [ DOI: doi:10.1016/j.cell.2023.02.035 Pubmed: 37028429 ]
CAND1-SCF-SKP2 with substrate p27-CKSHS1-CyclinA-CDK2, CAND1 rolling SCF engaged
Baek K, Scott DC, Henneberg LT, King MT, Mann M, Schulman BA
Cell (2023) 186 pp. 1895-1911.e21 [ DOI: doi:10.1016/j.cell.2023.02.035 Pubmed: 37028429 ]
CAND1-SCF-SKP2 with substrate p27-CKSHS1-CyclinA-CDK2, no CAND1 SCF engaged
Baek K, Scott DC, Henneberg LT, King MT, Mann M, Schulman BA
Cell (2023) 186 pp. 1895-1911.e21 [ DOI: doi:10.1016/j.cell.2023.02.035 Pubmed: 37028429 ]
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7b5l
Q-score: 0.427
Horn-Ghetko D, Krist DT, Prabu JR, Baek K, Mulder MPC, Klugel M, Scott DC, Ovaa H, Kleiger G, Schulman BA
Nature (2021) 590 pp. 671-676 [ DOI: doi:10.1038/s41586-021-03197-9 Pubmed: 33536622 ]
- Nedd8-cul1-rbx1-skp1-skp2-ckshs1-cyclin a-cdk2-p27-ube2l3~ub~arih1. transition state 1 composite map. (300 kDa, Complex)
- Polyubiquitin-c (8 kDa, Protein from Homo sapiens)
- Nedd8-skp1-skp2-ckshs1-cyclin a-cdk2-p27-ube2l3~ub~arih1. transition state 1 composite map. (Complex from Homo sapiens)
- E3 ubiquitin-protein ligase arih1 (64 kDa, Protein from Homo sapiens)
- Cyclin-a2 (48 kDa, Protein from Homo sapiens)
- Cyclin-dependent kinase inhibitor 1b (22 kDa, Protein from Homo sapiens)
- Cullin-1 (89 kDa, Protein from Homo sapiens)
- Cyclin-dependent kinases regulatory subunit 1 (8 kDa, Protein from Homo sapiens)
- S-phase kinase-associated protein 1 (18 kDa, Protein from Homo sapiens)
- S-phase kinase-associated protein 2 (47 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
- Ubiquitin-conjugating enzyme e2 l3 (17 kDa, Protein from Homo sapiens)
- Cyclin-dependent kinase 2 (34 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 5-azanylpentan-2-one (101 Da, Ligand)
- Cullin-1, e3 ubiquitin-protein ligase rbx1 (Complex from Homo sapiens)
- Nedd8 (8 kDa, Protein from Homo sapiens)