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Structure of C5a-pep bound mouse C5aR1 in complex with Go
Resolution: 3.39 Å
EM Method: Single-particle
Fitted PDBs: 8hpt
Q-score: 0.491
Saha S, Maharana J, Yadav MK, Sarma P, Chami M, Banerjee R, Shukla AK
Cell (2023) [ DOI: doi:https://doi.org/10.1016/j.cell.2023.09.020 ]
- Synthetic peptide (Complex)
- Antibody fragment (Complex from Mus musculus)
- Antibody fragment scfv16 (27 kDa, Protein from Mus musculus)
- C5a anaphylatoxin chemotactic receptor 1 (Complex from Mus musculus)
- C5a anaphylatoxin chemotactic receptor 1 (44 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (27 kDa, Protein from Homo sapiens)
- Mea-lys-pro-zal-alc-dar (869 Da, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Gpcr-g protein in complex with a synthetic peptide agonist (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
Structure of a GPCR-G protein in complex with a natural peptide agonist
Resolution: 3.89 Å
EM Method: Single-particle
Fitted PDBs: 8hqc
Q-score: 0.443
Saha S, Maharana J, Yadav MK, Sarma P, Chami M, Banerjee R, Shukla AK
Cell (2023) [ DOI: doi:https://doi.org/10.1016/j.cell.2023.09.020 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Antibody fragment (27 kDa, Protein from Mus musculus)
- C5a anaphylatoxin (Complex from Homo sapiens)
- C5a anaphylatoxin chemotactic receptor 1 (Complex from Mus musculus)
- C5a anaphylatoxin chemotactic receptor 1 (44 kDa, Protein from Mus musculus)
- C5a anaphylatoxin (8 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (27 kDa, Protein from Homo sapiens)
- Gpcr-g protein in complex with a natural peptide agonist (Complex)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Antibody fragment (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Structure of C5a bound human C5aR1 in complex with Go (Composite map)
Resolution: 3.21 Å
EM Method: Single-particle
Fitted PDBs: 8ia2
Q-score: 0.441
Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C
Cell (2023) 186 pp. 4956-4973.e21 [ Pubmed: 37852260 DOI: doi:10.1016/j.cell.2023.09.020 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (28 kDa, Protein from Homo sapiens)
- C5a anaphylatoxin (Complex from Homo sapiens)
- C5a anaphylatoxin (8 kDa, Protein from Homo sapiens)
- C5a anaphylatoxin chemotactic receptor 1 (45 kDa, Protein from Homo sapiens)
- C5a bound human c5ar1 in complex with go (Complex)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
- C5a anaphylatoxin chemotactic receptor 1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Antibody fragment - scfv16 (Complex from Mus musculus)
- Antibody fragment - scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Structure of human C5a-desArg bound human C5aR1 in complex with Go
Resolution: 3.31 Å
EM Method: Single-particle
Fitted PDBs: 8jzz
Q-score: 0.434
Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C
Cell (2023) 186 pp. 4956-4973.e21 [ Pubmed: 37852260 DOI: doi:10.1016/j.cell.2023.09.020 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Human c5a-desarg bound human c5ar1 in complex with go (Complex)
- C5a anaphylatoxin (8 kDa, Protein from Homo sapiens)
- C5a anaphylatoxin chemotactic receptor 1 (45 kDa, Protein from Homo sapiens)
- Human c5a-desarg bound human c5ar1 in complex with go (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (27 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (26 kDa, Protein from Mus musculus)
- Antibody (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Resolution: 3.41 Å
EM Method: Single-particle
Fitted PDBs: 8go8
Q-score: 0.457
Maharana J, Sarma P, Yadav MK, Banerjee R, Shukla AK
Mol Cell (2023) [ DOI: doi:https://doi.org/10.1016/j.molcel.2023.04.025 ]
- Peptide bound beta-arrestin1 in complex with fab30 (190 kDa, Complex)
- Fab30 (Complex from Mus musculus)
- Beta-arrestin1 (Complex from Rattus norvegicus)
- Beta-arrestin-1 (47 kDa, Protein from Rattus norvegicus)
- Fab30 light chain (23 kDa, Protein from Mus musculus)
- C5a anaphylatoxin chemotactic receptor 1 (Complex from Homo sapiens)
- Fab30 heavy chain (25 kDa, Protein from Mus musculus)
- C5a anaphylatoxin chemotactic receptor 1 (2 kDa, Protein from Homo sapiens)
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 8goo
Q-score: 0.289
Maharana J, Sarma P, Yadav MK, Banerjee R, Shukla AK
Mol Cell (2023) [ DOI: doi:https://doi.org/10.1016/j.molcel.2023.04.025 ]
- Beta-arrestin-2 (47 kDa, Protein from Bos taurus)
- Fab30 light chain (23 kDa, Protein from Mus musculus)
- Fab30 (Complex from Mus musculus)
- Beta-arrestin 2 (Complex from Bos taurus)
- C5a anaphylatoxin chemotactic receptor 1 (Complex from Homo sapiens)
- Fab30 heavy chain (25 kDa, Protein from Mus musculus)
- C5a anaphylatoxin chemotactic receptor 1 (2 kDa, Protein from Homo sapiens)
- Peptide4 bound beta-arrestin2 in complex with fab30 (280 kDa, Complex)
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 8i0n
Q-score: 0.513
Maharana J, Sarma P, Yadav MK, Banerjee R, Shukla AK
Mol Cell (2023) [ DOI: doi:https://doi.org/10.1016/j.molcel.2023.04.025 ]
- Fab30 (Complex from Mus musculus)
- Beta-arrestin1 (Complex from Rattus norvegicus)
- Beta-arrestin-1 (47 kDa, Protein from Rattus norvegicus)
- Fab30 light chain (23 kDa, Protein from Mus musculus)
- C5a anaphylatoxin chemotactic receptor 1 (Complex from Homo sapiens)
- Peptide 1 bound beta-arrestin1 in complex with fab30 - local refine (190 kDa, Complex)
- Fab30 heavy chain (25 kDa, Protein from Mus musculus)
- C5a anaphylatoxin chemotactic receptor 1 (2 kDa, Protein from Homo sapiens)
Resolution: 4.33 Å
EM Method: Single-particle
Fitted PDBs: 8i0z
Q-score: 0.355
Maharana J, Sarma P, Yadav MK, Banerjee R, Shukla AK
Mol Cell (2023) [ DOI: doi:https://doi.org/10.1016/j.molcel.2023.04.025 ]
- Beta-arrestin-2 (47 kDa, Protein from Bos taurus)
- Fab30 light chain (23 kDa, Protein from Mus musculus)
- Fab30 (Complex from Mus musculus)
- C5a anaphylatoxin chemotactic receptor 1 phosphopeptide (Complex from Homo sapiens)
- Beta-arrestin 2 (Complex from Bos taurus)
- Fab30 heavy chain (25 kDa, Protein from Mus musculus)
- C5a anaphylatoxin chemotactic receptor 1 (2 kDa, Protein from Homo sapiens)
- Peptide4 bound beta-arrestin2 in complex with fab30 (280 kDa, Complex)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8hk5
Q-score: 0.456
Wang Y, Liu W, Xu Y, He X, Yuan Q, Luo P, Fan W, Zhu J, Zhang X, Cheng X, Jiang Y, Xu HE, Zhuang Y
Nat Chem Biol (2023) 19 pp. 1351-1360 [ Pubmed: 37169960 DOI: doi:10.1038/s41589-023-01339-w ]
- Complement c5 (8 kDa, Protein from Homo sapiens)
- C5a anaphylatoxin chemotactic receptor 1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- C5ar1-gi-c5a protein complex (160 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Palmitic acid (256 Da, Ligand)
- Guanine nucleotide-binding protein subunit gamma (7 kDa, Protein from Bos taurus)
Cryo-EM structure of C5a-bound C5aR1 in complex with Gi protein
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7y64
Q-score: 0.498
Feng Y, Zhao C, Deng Y, Wang H, Ma L, Liu S, Tian X, Wang B, Bin Y, Chen P, Yan W, Fu P, Shao Z
Cell Res (2023) 33 pp. 312-324 [ DOI: doi:10.1038/s41422-023-00779-2 Pubmed: 36806352 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- C5a anaphylatoxin chemotactic receptor 1 (38 kDa, Protein from Homo sapiens)
- C5a-bound c5ar1 (Complex from Homo sapiens)
- C5a anaphylatoxin (8 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- C5a-bound c5ar1 in complex with gi heterotrimer (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Scfv16 (Complex from Mus musculus)
- Gi heterotrimer (Complex from Homo sapiens)