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Cryo-EM reconstruction of the APC/C-MCC-Cdk2-cyclinA2-Cks2 complex in the open conformation
Nat Commun (2019) 10 pp. 3863-3863 [ Pubmed: 31455778 DOI: doi:10.1038/s41467-019-11833-2 ]
- Apc1 (Protein)
- Bub3 (Protein)
- Apc13 (Protein)
- Apc16 (Protein)
- Cryo-em reconstruction of the apc/c-mcc-cdk2-cyclina2-cks2 complex in the open conformation (1 MDa, Complex from Homo sapiens)
- Apc5 (Protein)
- Cdk2 (Protein)
- Mad2 (Protein)
- Apc6 (Protein)
- Apc10 (Protein)
- Apc7 (Protein)
- Apc8 (Protein)
- Apc3 (Protein)
- Apc4 (Protein)
- Apc12 (Protein)
- Cyclin a2 (Protein)
- Apc11 (Protein)
- Cks2 (Protein)
- Apc15 (Protein)
- Apc2 (Protein)
- Cdc20 (Protein)
- Bubr1 (Protein)
Cryo-EM reconstruction of the APC/C-MCC-Cdk2-cyclinA2-Cks2 complex in the closed conformation
Nat Commun (2019) 10 pp. 3863-3863 [ Pubmed: 31455778 DOI: doi:10.1038/s41467-019-11833-2 ]
- Apc1 (Protein)
- Bub3 (Protein)
- Apc13 (Protein)
- Apc16 (Protein)
- Apc5 (Protein)
- Cdk2 (Protein)
- Mad2 (Protein)
- Apc6 (Protein)
- Apc10 (Protein)
- Apc7 (Protein)
- Apc8 (Protein)
- Apc3 (Protein)
- Apc4 (Protein)
- Apc12 (Protein)
- Cyclin a2 (Protein)
- Apc11 (Protein)
- Cks2 (Protein)
- Apc15 (Protein)
- Apc2 (Protein)
- Cdc20 (Protein)
- Cryo-em reconstruction of the apc/c-mcc-cdk2-cyclina2-cks2 complex in the closed conformation (1 MDa, Complex from Homo sapiens)
- Bubr1 (Protein)
Cryo-EM structure of human apo unphosphorylated APC/C
Zhang S, Chang L, Alfieri C, Zhang Z, Yang J, Maslen S, Skehel M, Barford D
Nature (2016) 533 pp. 260-264 [ DOI: doi:10.1038/nature17973 Pubmed: 27120157 ]
- Anaphase-promoting complex subunit 11 (9 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 8 (68 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 16 (11 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 6 (71 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 2 (93 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 7 (66 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 13 (8 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 4 (92 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 3 (91 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 5 (85 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 15 (14 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 1 (216 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 10 (21 kDa, Protein from Homo sapiens)
- Recombinant human apo unphosphorylated apc/c (1 MDa, Sample)
- Anaphase-promoting complex subunit 12 (9 kDa, Protein from Homo sapiens)
Cryo-EM structure of combined apo phosphorylated APC/C
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 5g05
Q-score: 0.375
Zhang S, Chang L, Alfieri C, Zhang Z, Yang J, Maslen S, Skehel M, Barford D
Nature (2016) 533 pp. 260-264 [ DOI: doi:10.1038/nature17973 Pubmed: 27120157 ]
- Anaphase-promoting complex subunit 11 (9 kDa, Protein from Homo sapiens)
- Recombinant human apo apc/c phosphorylated in vitro (1 MDa, Sample)
- Anaphase-promoting complex subunit 8 (68 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 16 (11 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 6 (71 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 2 (93 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 7 (66 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 13 (8 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 4 (92 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 5 (85 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 15 (14 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 1 (216 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 10 (21 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 3 (91 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 12 (9 kDa, Protein from Homo sapiens)
Cryo-EM structure of a human APC/C mutant with Apc1 300s loop deleted
Zhang S, Chang L, Alfieri C, Zhang Z, Yang J, Maslen S, Skehel M, Barford D
Nature (2016) 533 pp. 260-264 [ DOI: doi:10.1038/nature17973 Pubmed: 27120157 ]
- Anaphase-promoting complex subunit 11 (9 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 8 (68 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 16 (11 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 6 (71 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 2 (93 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 7 (66 kDa, Protein from Homo sapiens)
- Human apc/c mutant with apc1 300s loop deleted (1 MDa, Sample)
- Anaphase-promoting complex subunit 13 (8 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 4 (92 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 5 (85 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 15 (14 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 1 (216 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 10 (21 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 3 (91 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 12 (9 kDa, Protein from Homo sapiens)
Cryo-EM structure of a human APC/C mutant with Apc1 300s loop deleted in complex with TAME
Zhang S, Chang L, Alfieri C, Zhang Z, Yang J, Maslen S, Skehel M, Barford D
Nature (2016) 533 pp. 260-264 [ DOI: doi:10.1038/nature17973 Pubmed: 27120157 ]
- Anaphase-promoting complex subunit 11 (9 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 8 (68 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 16 (11 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 6 (71 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 2 (93 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 7 (66 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 13 (8 kDa, Protein from Homo sapiens)
- Recombinant human apc/c mutant with apc1 300s loop deleted in complex with tame (1 MDa, Sample)
- Anaphase-promoting complex subunit 4 (92 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 5 (85 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 15 (14 kDa, Protein from Homo sapiens)
- Tosyl-l-arginine methyl ester (Ligand from unidentified)
- Anaphase-promoting complex subunit 1 (216 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 10 (21 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 3 (91 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 12 (9 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human APC/C-Cdc20-Hsl1 complex
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 5g04
Q-score: 0.299
Zhang S, Chang L, Alfieri C, Zhang Z, Yang J, Maslen S, Skehel M, Barford D
Nature (2016) 533 pp. 260-264 [ DOI: doi:10.1038/nature17973 Pubmed: 27120157 ]
- Anaphase-promoting complex subunit 11 (9 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 8 (68 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 16 (11 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 6 (71 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 2 (93 kDa, Protein from Homo sapiens)
- Hsl1 (24 kDa, Protein from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit 7 (66 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 13 (8 kDa, Protein from Homo sapiens)
- Cell division cycle protein 20 homolog (54 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 4 (92 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 5 (85 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 15 (14 kDa, Protein from Homo sapiens)
- Recombinant human apc/c-cdc20-hsl1 complex (1 MDa, Sample)
- Anaphase-promoting complex subunit 1 (216 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 10 (21 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 3 (91 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 12 (9 kDa, Protein from Homo sapiens)
Cryo-EM structure of human apo phosphorylated APC/C
Zhang S, Chang L, Alfieri C, Zhang Z, Yang J, Maslen S, Skehel M, Barford D
Nature (2016) 533 pp. 260-264 [ DOI: doi:10.1038/nature17973 Pubmed: 27120157 ]
- Anaphase-promoting complex subunit 11 (9 kDa, Protein from Homo sapiens)
- Recombinant human apo apc/c phosphorylated in vitro (1 MDa, Sample)
- Anaphase-promoting complex subunit 8 (68 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 16 (11 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 6 (71 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 2 (93 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 7 (66 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 13 (8 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 4 (92 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 5 (85 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 15 (14 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 1 (216 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 10 (21 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 3 (91 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 12 (9 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human APC/C-Cdh1-Emi1 ternary complex at 3.6 angstrom resolution.
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 4ui9
Q-score: 0.378
Chang L, Zhang Z, Yang J, McLaughlin SH, Barford D
Nature (2015) 522 pp. 450-454 [ DOI: doi:10.1038/nature14471 Pubmed: 26083744 ]
- Apc4 (Protein from Homo sapiens)
- Apc3 (Protein from Homo sapiens)
- Apc7 (Protein from Homo sapiens)
- Apc16 (Protein from Homo sapiens)
- Apc2 (Protein from Homo sapiens)
- Apc5 (Protein from Homo sapiens)
- Apc15 (Protein from Homo sapiens)
- Apc8 (Protein from Homo sapiens)
- Emi1 (Protein from Homo sapiens)
- Apc1 (Protein from Homo sapiens)
- Apc10 (Protein from Homo sapiens)
- Apc11 (Protein from Homo sapiens)
- Apc6 (Protein from Homo sapiens)
- Apc12 (Protein from Homo sapiens)
- Cdh1 (Protein from Homo sapiens)
- Apc13 (Protein from Homo sapiens)
- Recombinant human apc/c-cdh1-emi1 ternary complex (1 MDa, Sample)
Cryo-EM structure of the human APC/C-Cdh1-Hsl1-UbcH10-Ub complex.
Resolution: 5.7 Å
EM Method: Single-particle
Fitted PDBs: 5a31
Q-score: 0.007
Chang L, Zhang Z, Yang J, McLaughlin SH, Barford D
Nature (2015) 522 pp. 450-454 [ DOI: doi:10.1038/nature14471 Pubmed: 26083744 ]
- Apc16 (Protein from Homo sapiens)
- Apc2 (Protein from Homo sapiens)
- Apc12 (Protein from Homo sapiens)
- Apc7 (Protein from Homo sapiens)
- Apc5 (Protein from Homo sapiens)
- Apc8 (Protein from Homo sapiens)
- Apc11 (Protein from Homo sapiens)
- Cdh1 (Protein from Homo sapiens)
- Apc4 (Protein from Homo sapiens)
- Apc3 (Protein from Homo sapiens)
- Hsl1 (Protein from Homo sapiens)
- Apc6 (Protein from Homo sapiens)
- Ubch10-ubiquitin (Protein from Homo sapiens)
- Apc15 (Protein from Homo sapiens)
- E2-ubiquitin conjugate (Protein from Homo sapiens)
- Recombinant human apc/c-cdh1-hsl1-ubch10lr-ub complex (1 MDa, Sample)
- Apc1 (Protein from Homo sapiens)
- Apc10 (Protein from Homo sapiens)
- Apc13 (Protein from Homo sapiens)