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Structure of the human ATP synthase bound to bedaquiline (composite)
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 8ki3
Q-score: 0.547
Zhang Y, Lai Y, Liu F, Rao Z, Gong H
To Be Published
- Atp synthase subunit a (24 kDa, Protein from Homo sapiens)
- Atp synthase protein 8 (8 kDa, Protein from Homo sapiens)
- Atp synthase subunit o, mitochondrial (20 kDa, Protein from Homo sapiens)
- Atpase inhibitor, mitochondrial (9 kDa, Protein from Homo sapiens)
- Atp synthase-coupling factor 6, mitochondrial (12 kDa, Protein from Homo sapiens)
- Atp synthase subunit gamma, mitochondrial (30 kDa, Protein from Homo sapiens)
- Atp synthase subunit g, mitochondrial (11 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Atp synthase subunit d, mitochondrial (18 kDa, Protein from Homo sapiens)
- Atp synthase subunit atp5mj, mitochondrial (6 kDa, Protein from Homo sapiens)
- Atp synthase f(0) complex subunit b1, mitochondrial (24 kDa, Protein from Homo sapiens)
- Atp synthase subunit f, mitochondrial (10 kDa, Protein from Homo sapiens)
- Atp synthase subunit beta, mitochondrial (51 kDa, Protein from Homo sapiens)
- Atp synthase subunit alpha, mitochondrial (55 kDa, Protein from Homo sapiens)
- Atp synthase subunit epsilon, mitochondrial (5 kDa, Protein from Homo sapiens)
- Bedaquiline (555 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Atp synthase subunit e, mitochondrial (7 kDa, Protein from Homo sapiens)
- Atp synthase subunit delta, mitochondrial (15 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Atp synthase f(0) complex subunit c1, mitochondrial (7 kDa, Protein from Homo sapiens)
- Human atp synthase (Complex from Homo sapiens)
Yeast ATP synthase map in conformation-1 at pH 6
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8f29
Q-score: 0.301
Sharma S, Luo M, Patel H, Mueller DM, Liao M
Nat Struct Mol Biol (2024) 31 pp. 657-666 [ DOI: doi:10.1038/s41594-024-01219-4 Pubmed: 38316880 ]
- Atp synthase subunit beta, mitochondrial (50 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit a (25 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit 5, mitochondrial (20 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit j, mitochondrial (4 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit h, mitochondrial (10 kDa, Protein from Saccharomyces cerevisiae)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Atp synthase subunit d, mitochondrial (19 kDa, Protein from Saccharomyces cerevisiae)
- Phosphate ion (94 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Atp synthase subunit f, mitochondrial (9 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit 9, mitochondrial (7 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit epsilon, mitochondrial (6 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit 4, mitochondrial (17 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit delta, mitochondrial (14 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase protein 8 (5 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase (Complex from Saccharomyces cerevisiae)
- Atp synthase subunit gamma, mitochondrial (28 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit alpha, mitochondrial (54 kDa, Protein from Saccharomyces cerevisiae)
Yeast ATP synthase map in conformation-2, at pH 6
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8f39
Q-score: 0.301
Sharma S, Luo M, Patel H, Mueller DM, Liao M
Nat Struct Mol Biol (2024) 31 pp. 657-666 [ DOI: doi:10.1038/s41594-024-01219-4 Pubmed: 38316880 ]
- Atp synthase subunit beta, mitochondrial (50 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit delta, mitochondrial (14 kDa, Protein from Saccharomyces cerevisiae)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Atp synthase subunit j, mitochondrial (4 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit h, mitochondrial (10 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit gamma, mitochondrial (29 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit 4, mitochondrial (17 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit d, mitochondrial (19 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit 5, mitochondrial (17 kDa, Protein from Saccharomyces cerevisiae)
- Magnesium ion (24 Da, Ligand)
- Atp synthase subunit f, mitochondrial (9 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit 9, mitochondrial (7 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit epsilon, mitochondrial (6 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit a (25 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase protein 8 (5 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase (Complex from Saccharomyces cerevisiae)
- Atp synthase subunit alpha, mitochondrial (54 kDa, Protein from Saccharomyces cerevisiae)
Human ATP synthase F1 domain, state 1
Resolution: 2.53 Å
EM Method: Single-particle
Fitted PDBs: 8h9e
Q-score: 0.622
Lai Y, Zhang Y, Zhou S, Xu J, Du Z, Feng Z, Yu L, Zhao Z, Wang W, Tang Y, Yang X, Guddat LW, Liu F, Gao Y, Rao Z, Gong H
Mol Cell (2023) 83 pp. 2137- [ DOI: doi:10.1016/j.molcel.2023.04.029 Pubmed: 37244256 ]
- Atp synthase subunit gamma, mitochondrial (30 kDa, Protein from human)
- Human atp synthase (600 kDa, Complex from Homo sapiens)
- Atpase inhibitor, mitochondrial (9 kDa, Protein from human)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Atp synthase subunit beta, mitochondrial (51 kDa, Protein from human)
- Magnesium ion (24 Da, Ligand)
- Atp synthase subunit o, mitochondrial (20 kDa, Protein from human)
- Atp synthase subunit alpha, mitochondrial (55 kDa, Protein from human)
- Adenosine-5'-triphosphate (507 Da, Ligand)
Human ATP synthase F1 domain, state2
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8h9i
Q-score: 0.564
Lai Y, Zhang Y, Zhou S, Xu J, Du Z, Feng Z, Yu L, Zhao Z, Wang W, Tang Y, Yang X, Guddat LW, Liu F, Gao Y, Rao Z, Gong H
Mol Cell (2023) 83 pp. 2137- [ DOI: doi:10.1016/j.molcel.2023.04.029 Pubmed: 37244256 ]
- Atp synthase subunit gamma, mitochondrial (30 kDa, Protein from human)
- Human atp synthase (600 kDa, Complex from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Atp synthase subunit beta, mitochondrial (51 kDa, Protein from human)
- Magnesium ion (24 Da, Ligand)
- Atp synthase subunit o, mitochondrial (20 kDa, Protein from human)
- Atp synthase subunit alpha, mitochondrial (55 kDa, Protein from human)
- Adenosine-5'-triphosphate (507 Da, Ligand)
Human ATP synthase F1 domain, state 3a
Resolution: 2.61 Å
EM Method: Single-particle
Fitted PDBs: 8h9l
Q-score: 0.615
Lai Y, Zhang Y, Zhou S, Xu J, Du Z, Feng Z, Yu L, Zhao Z, Wang W, Tang Y, Yang X, Guddat LW, Liu F, Gao Y, Rao Z, Gong H
Mol Cell (2023) 83 pp. 2137- [ DOI: doi:10.1016/j.molcel.2023.04.029 Pubmed: 37244256 ]
- Atp synthase subunit gamma, mitochondrial (30 kDa, Protein from human)
- Human atp synthase (600 kDa, Complex from Homo sapiens)
- Atpase inhibitor, mitochondrial (9 kDa, Protein from human)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Atp synthase subunit beta, mitochondrial (51 kDa, Protein from human)
- Magnesium ion (24 Da, Ligand)
- Atp synthase subunit o, mitochondrial (20 kDa, Protein from human)
- Atp synthase subunit alpha, mitochondrial (55 kDa, Protein from human)
- Adenosine-5'-triphosphate (507 Da, Ligand)
Human ATP synthase F1 domain, state 3b
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 8h9p
Q-score: 0.535
Lai Y, Zhang Y, Zhou S, Xu J, Du Z, Feng Z, Yu L, Zhao Z, Wang W, Tang Y, Yang X, Guddat LW, Liu F, Gao Y, Rao Z, Gong H
Mol Cell (2023) 83 pp. 2137- [ DOI: doi:10.1016/j.molcel.2023.04.029 Pubmed: 37244256 ]
- Atp synthase subunit gamma, mitochondrial (30 kDa, Protein from human)
- Human atp synthase (600 kDa, Complex from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Atp synthase subunit beta, mitochondrial (51 kDa, Protein from human)
- Magnesium ion (24 Da, Ligand)
- Atp synthase subunit o, mitochondrial (20 kDa, Protein from human)
- Atp synthase subunit alpha, mitochondrial (55 kDa, Protein from human)
- Adenosine-5'-triphosphate (507 Da, Ligand)
Human ATP synthase state 1 (combined)
Resolution: 2.53 Å
EM Method: Single-particle
Fitted PDBs: 8h9s
Q-score: 0.601
Lai Y, Zhang Y, Zhou S, Xu J, Du Z, Feng Z, Yu L, Zhao Z, Wang W, Tang Y, Yang X, Guddat LW, Liu F, Gao Y, Rao Z, Gong H
Mol Cell (2023) 83 pp. 2137- [ DOI: doi:10.1016/j.molcel.2023.04.029 Pubmed: 37244256 ]
- Human atp synthase (600 kDa, Complex from Homo sapiens)
- Atp synthase subunit f, mitochondrial (10 kDa, Protein from human)
- Atp synthase subunit d, mitochondrial (18 kDa, Protein from human)
- Atp synthase subunit e, mitochondrial (7 kDa, Protein from human)
- Atp synthase subunit atp5mj, mitochondrial (6 kDa, Protein from human)
- Atp synthase f(0) complex subunit c1, mitochondrial (7 kDa, Protein from human)
- Atp synthase subunit alpha, mitochondrial (55 kDa, Protein from human)
- Atp synthase subunit a (24 kDa, Protein from human)
- Cardiolipin (1 kDa, Ligand)
- Atpase inhibitor, mitochondrial (9 kDa, Protein from human)
- Atp synthase subunit g, mitochondrial (11 kDa, Protein from human)
- Atp synthase subunit epsilon, mitochondrial (5 kDa, Protein from human)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Atp synthase subunit gamma, mitochondrial (30 kDa, Protein from human)
- Atp synthase protein 8 (8 kDa, Protein from human)
- Atp synthase subunit delta, mitochondrial (15 kDa, Protein from human)
- Atp synthase f(0) complex subunit b1, mitochondrial (24 kDa, Protein from human)
- Atp synthase-coupling factor 6, mitochondrial (12 kDa, Protein from human)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Atp synthase subunit beta, mitochondrial (51 kDa, Protein from human)
- Magnesium ion (24 Da, Ligand)
- 1,2-diacyl-glycerol-3-sn-phosphate (704 Da, Ligand)
- Atp synthase subunit o, mitochondrial (20 kDa, Protein from human)
Human ATP synthase state 2 (combined)
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8h9t
Q-score: 0.515
Lai Y, Zhang Y, Zhou S, Xu J, Du Z, Feng Z, Yu L, Zhao Z, Wang W, Tang Y, Yang X, Guddat LW, Liu F, Gao Y, Rao Z, Gong H
Mol Cell (2023) 83 pp. 2137- [ DOI: doi:10.1016/j.molcel.2023.04.029 Pubmed: 37244256 ]
- Human atp synthase (600 kDa, Complex from Homo sapiens)
- Atp synthase subunit f, mitochondrial (10 kDa, Protein from human)
- Atp synthase subunit d, mitochondrial (18 kDa, Protein from human)
- Atp synthase subunit e, mitochondrial (7 kDa, Protein from human)
- Atp synthase subunit atp5mj, mitochondrial (6 kDa, Protein from human)
- Atp synthase f(0) complex subunit c1, mitochondrial (7 kDa, Protein from human)
- Atp synthase subunit a (24 kDa, Protein from human)
- Atp synthase subunit alpha, mitochondrial (55 kDa, Protein from human)
- Atp synthase subunit g, mitochondrial (11 kDa, Protein from human)
- Atp synthase subunit epsilon, mitochondrial (5 kDa, Protein from human)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Atp synthase subunit gamma, mitochondrial (30 kDa, Protein from human)
- Atp synthase protein 8 (8 kDa, Protein from human)
- Atp synthase subunit delta, mitochondrial (15 kDa, Protein from human)
- Atp synthase f(0) complex subunit b1, mitochondrial (24 kDa, Protein from human)
- Atp synthase-coupling factor 6, mitochondrial (12 kDa, Protein from human)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Atp synthase subunit beta, mitochondrial (51 kDa, Protein from human)
- Magnesium ion (24 Da, Ligand)
- Atp synthase subunit o, mitochondrial (20 kDa, Protein from human)
Human ATP synthase state 3a (combined)
Resolution: 2.61 Å
EM Method: Single-particle
Fitted PDBs: 8h9u
Q-score: 0.553
Lai Y, Zhang Y, Zhou S, Xu J, Du Z, Feng Z, Yu L, Zhao Z, Wang W, Tang Y, Yang X, Guddat LW, Liu F, Gao Y, Rao Z, Gong H
Mol Cell (2023) 83 pp. 2137- [ DOI: doi:10.1016/j.molcel.2023.04.029 Pubmed: 37244256 ]
- Human atp synthase (600 kDa, Complex from Homo sapiens)
- Atp synthase subunit f, mitochondrial (10 kDa, Protein from human)
- Atp synthase subunit d, mitochondrial (18 kDa, Protein from human)
- Atp synthase subunit e, mitochondrial (7 kDa, Protein from human)
- Atp synthase subunit atp5mj, mitochondrial (6 kDa, Protein from human)
- Atp synthase f(0) complex subunit c1, mitochondrial (7 kDa, Protein from human)
- Atp synthase subunit alpha, mitochondrial (55 kDa, Protein from human)
- Atp synthase subunit a (24 kDa, Protein from human)
- Atpase inhibitor, mitochondrial (9 kDa, Protein from human)
- Atp synthase subunit g, mitochondrial (11 kDa, Protein from human)
- Atp synthase subunit epsilon, mitochondrial (5 kDa, Protein from human)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Atp synthase subunit gamma, mitochondrial (30 kDa, Protein from human)
- Atp synthase protein 8 (8 kDa, Protein from human)
- Atp synthase subunit delta, mitochondrial (15 kDa, Protein from human)
- Atp synthase f(0) complex subunit b1, mitochondrial (24 kDa, Protein from human)
- Atp synthase-coupling factor 6, mitochondrial (12 kDa, Protein from human)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Atp synthase subunit beta, mitochondrial (51 kDa, Protein from human)
- Magnesium ion (24 Da, Ligand)
- Atp synthase subunit o, mitochondrial (20 kDa, Protein from human)