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CryoEM structure of DDB1-VprBP complex in ARM-up conformation
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7v7b
Q-score: 0.262
To Be Published
- Cryoem structure of ddb1-vprbp complex in "arm-up" conformation (Complex from Homo sapiens)
- Dna damage-binding protein 1 (127 kDa, Protein from Homo sapiens)
- Ddb1- and cul4-associated factor 1 (169 kDa, Protein from Homo sapiens)
CryoEM structure of DDB1-VprBP-Vpr-UNG2(94-313) complex
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7v7c
Q-score: 0.283
To Be Published
- Ddb1- and cul4-associated factor 1 (169 kDa, Protein from Homo sapiens)
- Protein vpr (11 kDa, Protein from Human immunodeficiency virus 1)
- Uracil-dna glycosylase (25 kDa, Protein from Homo sapiens)
- Ddb1-vprbp-vpr-ung2(94-313) complex (660 kDa, Complex from Homo sapiens)
- Dna damage-binding protein 1 (127 kDa, Protein from Homo sapiens)
Structure of yeast Ubr1 in complex with Ubc2 and monoubiquitinated N-degron
Resolution: 3.67 Å
EM Method: Single-particle
Fitted PDBs: 7mey
Q-score: 0.407
Pan M, Zheng Q, Wang T, Liang L, Mao J, Zuo C, Ding R, Ai H, Xie Y, Si D, Yu Y, Liu L, Zhao M
Nature (2021) 600 pp. 334-338 [ Pubmed: 34789879 DOI: doi:10.1038/s41586-021-04097-8 ]
- Ubiquitin (8 kDa, Protein from Homo sapiens)
- 2-(ethylamino)ethane-1-thiol (105 Da, Ligand)
- Ubiquitin-conjugating enzyme e2 2 (19 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Zinc ion (65 Da, Ligand)
- E3 ubiquitin-protein ligase ubr1 (225 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Yeast ubr1 in complex with ubc2 and monoubiquitinated n-degron (Complex from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Ubiquitin (8 kDa, Protein from Homo sapiens)
- Monoubiquitinated n-degron (4 kDa, Protein from Saccharomyces cerevisiae S288C)
Akirin2 bound human proteasome
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7nht
Q-score: 0.547
de Almeida M, Hinterndorfer M, Brunner H, Grishkovskaya I, Singh K, Schleiffer A, Jude J, Deswal S, Kalis R, Vunjak M, Lendl T, Imre R, Roitinger E, Neumann T, Kandolf S, Schutzbier M, Mechtler K, Versteeg GA, Haselbach D, Zuber J
Nature (2021) 599 pp. 491-496 [ Pubmed: 34711951 DOI: doi:10.1038/s41586-021-04035-8 ]
- Akirin2 (Complex from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Human)
- Proteasome subunit beta type-3 (22 kDa, Protein from Human)
- Akirin-2 (22 kDa, Protein from Homo sapiens)
- 20s proteasome (Complex from Homo sapiens)
- Proteasome subunit beta type-1 (26 kDa, Protein from Human)
- Potassium ion (39 Da, Ligand)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Human)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Human)
- Proteasome subunit beta type-4 (29 kDa, Protein from Human)
- Proteasome subunit beta type-2 (22 kDa, Protein from Human)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Human)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Human)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Human)
- Akirin2 bound to 20s proteasome (780 kDa, Complex)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Human)
- Proteasome subunit beta type-6 (25 kDa, Protein from Human)
- Proteasome subunit beta type-7 (30 kDa, Protein from Human)
- Proteasome subunit beta type-5 (28 kDa, Protein from Human)
Cryo-EM structure of alpha 7 homo-tetradecamer
Resolution: 5.9 Å
EM Method: Single-particle
Fitted PDBs: 7e55
Q-score: 0.159
Song C, Satoh T, Sekiguchi T, Kato K, Murata K
Int J Mol Sci (2021) 22 [ Pubmed: 33926037 DOI: doi:10.3390/ijms22094519 ]
- Proteasome subunit alpha type-7 (Complex from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
Yeast 26S proteasome bound to ubiquitinated substrate (4D motor state)
Resolution: 4.17 Å
EM Method: Single-particle
Fitted PDBs: 6ef3
Q-score: 0.46
de la Pena AH, Goodall EA, Gates SN, Lander GC, Martin A
Science (2018) 362 [ Pubmed: 30309908 DOI: doi:10.1126/science.aav0725 ]
- Proteasome subunit beta type-7 (29 kDa, Protein from Saccharomyces cerevisiae S288c)
- Substrate (Complex from Homo sapiens)
- Proteasome subunit alpha type-1 (28 kDa, Protein from Saccharomyces cerevisiae S288c)
- Proteasome subunit alpha type-2 (27 kDa, Protein from Saccharomyces cerevisiae S288c)
- Substrate-engaged 26s proteasome in the 4d state (Complex)
- Ubiquitin carboxyl-terminal hydrolase rpn11 (34 kDa, Protein from Saccharomyces cerevisiae S288c)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Proteasome subunit beta type-4 (22 kDa, Protein from Saccharomyces cerevisiae S288c)
- Proteasome subunit beta type-5 (31 kDa, Protein from Saccharomyces cerevisiae S288c)
- 26s proteasome regulatory subunit 4 homolog (48 kDa, Protein from Saccharomyces cerevisiae S288c)
- Ubiquitin-60s ribosomal protein l40 (14 kDa, Protein from Saccharomyces cerevisiae S288c)
- Probable proteasome subunit alpha type-7 (31 kDa, Protein from Saccharomyces cerevisiae S288c)
- Proteasome subunit beta type-7 (1 kDa, Protein from Saccharomyces cerevisiae S288c)
- Proteasome subunit alpha type-4 (28 kDa, Protein from Saccharomyces cerevisiae S288c)
- Proteasome subunit beta type-1 (23 kDa, Protein from Saccharomyces cerevisiae S288c)
- Proteasome subunit alpha type-6 (25 kDa, Protein from Saccharomyces cerevisiae S288c)
- Proteasome subunit beta type-2 (28 kDa, Protein from Saccharomyces cerevisiae S288c)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Saccharomyces cerevisiae S288c)
- Model substrate polypeptide (4 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-3 (22 kDa, Protein from Saccharomyces cerevisiae S288c)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Proteasome subunit alpha type-5 (28 kDa, Protein from Saccharomyces cerevisiae S288c)
- 26s proteasome regulatory subunit 6b homolog (47 kDa, Protein from Saccharomyces cerevisiae S288c)
- Proteasome subunit beta type-6 (26 kDa, Protein from Saccharomyces cerevisiae S288c)
- 26s proteasome subunit rpt4 (49 kDa, Protein from Saccharomyces cerevisiae S288c)
- 26s proteasome regulatory subunit 8 homolog (45 kDa, Protein from Saccharomyces cerevisiae S288c)
- 26s proteasome regulatory subunit 7 homolog (52 kDa, Protein from Saccharomyces cerevisiae S288c)
- 26s proteasome regulatory subunit 6a (48 kDa, Protein from Saccharomyces cerevisiae S288c)
- Proteasome (Complex from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Cryo-EM map of the human 26S proteasome at 3.5A resolution with C2 symmetry
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 5gjr
Q-score: 0.358
Nat Struct Mol Biol (2016) 23 pp. 778-785 [ DOI: doi:10.1038/nsmb.3273 Pubmed: 27428775 ]
- 26s proteasome non-atpase regulatory subunit 7 (37 kDa, Protein from Human)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Human)
- 26s protease regulatory subunit 6b (47 kDa, Protein from Human)
- Proteasome subunit beta type-5 (28 kDa, Protein from Human)
- 26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from Human)
- Proteasome subunit beta type-3 (22 kDa, Protein from Human)
- Proteasome subunit beta type-6 (25 kDa, Protein from Human)
- 26s proteasome non-atpase regulatory subunit 3 (60 kDa, Protein from Human)
- 26s protease regulatory subunit 4 (49 kDa, Protein from Human)
- Proteasome subunit beta type-1 (26 kDa, Protein from Human)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Human)
- 26s proteasome non-atpase regulatory subunit 14 (34 kDa, Protein from Human)
- 26s protease regulatory subunit 10b (44 kDa, Protein from Human)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Human)
- 26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from Human)
- 26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from Human)
- 26s proteasome complex subunit dss1 (8 kDa, Protein from Human)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Human)
- Proteasome subunit beta type-4 (29 kDa, Protein from Human)
- Proteasome subunit beta type-2 (22 kDa, Protein from Human)
- 26s protease regulatory subunit 7 (48 kDa, Protein from Human)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Human)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Human)
- Human 26s proteasome (2 MDa, Complex from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- 26s proteasome non-atpase regulatory subunit 12 (52 kDa, Protein from Human)
- 26s proteasome non-atpase regulatory subunit 4 (40 kDa, Protein from Human)
- 26s proteasome non-atpase regulatory subunit 8 (39 kDa, Protein from Human)
- 26s protease regulatory subunit 8 (45 kDa, Protein from Human)
- 26s protease regulatory subunit 6a (49 kDa, Protein from Human)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Human)
- Proteasome subunit beta type-7 (30 kDa, Protein from Human)
- 26s proteasome non-atpase regulatory subunit 2 (100 kDa, Protein from Human)
- 26s proteasome non-atpase regulatory subunit 6 (45 kDa, Protein from Human)
Cryo-EM map of the human 26S proteasome bound to USP14_UbAl
Resolution: 4.35 Å
EM Method: Single-particle
Fitted PDBs: 5gjq
Q-score: 0.274
Nat Struct Mol Biol (2016) 23 pp. 778-785 [ DOI: doi:10.1038/nsmb.3273 Pubmed: 27428775 ]
- 26s proteasome non-atpase regulatory subunit 2 (100 kDa, Protein from Human)
- 26s proteasome non-atpase regulatory subunit 7 (37 kDa, Protein from Human)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Human)
- 26s protease regulatory subunit 6b (47 kDa, Protein from Human)
- 26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from Human)
- Proteasome subunit beta type-3 (22 kDa, Protein from Human)
- Proteasome subunit beta type-6 (25 kDa, Protein from Human)
- 26s protease regulatory subunit 4 (49 kDa, Protein from Human)
- Proteasome subunit beta type-1 (26 kDa, Protein from Human)
- Human 26s proteasome bound to usp14-ubal (2 MDa, Complex from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Human)
- 26s proteasome non-atpase regulatory subunit 14 (34 kDa, Protein from Human)
- 26s protease regulatory subunit 10b (44 kDa, Protein from Human)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Human)
- Ubiquitin carboxyl-terminal hydrolase 14 (56 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from Human)
- 26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from Human)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Human)
- 26s proteasome complex subunit dss1 (8 kDa, Protein from Human)
- Proteasome subunit beta type-4 (29 kDa, Protein from Human)
- 26s proteasome non-atpase regulatory subunit 3 (61 kDa, Protein from Human)
- Proteasome subunit beta type-2 (22 kDa, Protein from Human)
- 26s protease regulatory subunit 7 (48 kDa, Protein from Human)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Human)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Human)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- 26s proteasome non-atpase regulatory subunit 12 (52 kDa, Protein from Human)
- 26s proteasome non-atpase regulatory subunit 4 (40 kDa, Protein from Human)
- 26s proteasome non-atpase regulatory subunit 8 (39 kDa, Protein from Human)
- 26s protease regulatory subunit 8 (45 kDa, Protein from Human)
- 26s protease regulatory subunit 6a (49 kDa, Protein from Human)
- Polyubiquitin-b (8 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Human)
- Proteasome subunit beta type-7 (30 kDa, Protein from Human)
- Proteasome subunit beta type-5 (28 kDa, Protein from Human)
- 26s proteasome non-atpase regulatory subunit 6 (45 kDa, Protein from Human)