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Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6utf
Q-score: 0.389
Yu Z, Yu Y, Wang F, Myasnikov AG, Coffino P, Cheng Y
Nat Commun (2020) 11 pp. 4580-4580 [ DOI: doi:10.1038/s41467-020-18415-7 Pubmed: 32917864 ]
- Proteasome subunit beta (23 kDa, Protein from Thermoplasma acidophilum)
- Proteasome subunit alpha (25 kDa, Protein from Thermoplasma acidophilum)
- Proteasome singly capped with a pan complex together with gfpssra as a substrate (Complex from Thermoplasma acidophilum)
- Proteasome subunit alpha (25 kDa, Protein from Thermoplasma acidophilum)
Allosteric coupling between alpha-rings of the 20S proteasome, 20S singly capped with a PA26/V230F
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6utg
Q-score: 0.431
Yu Z, Yu Y, Wang F, Myasnikov AG, Coffino P, Cheng Y
Nat Commun (2020) 11 pp. 4580-4580 [ DOI: doi:10.1038/s41467-020-18415-7 Pubmed: 32917864 ]
- Proteasome subunit alpha (25 kDa, Protein from Thermoplasma acidophilum)
- Proteasome subunit beta (22 kDa, Protein from Thermoplasma acidophilum)
- The complex of archaea 20s singly capped by one pa26/v230f (Complex from Thermoplasma acidophilum)
- Proteasome activator protein pa26 (24 kDa, Protein from Trypanosoma brucei)
- Proteasome subunit alpha (24 kDa, Protein from Thermoplasma acidophilum)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6uth
Q-score: 0.459
Yu Z, Yu Y, Wang F, Myasnikov AG, Coffino P, Cheng Y
Nat Commun (2020) 11 pp. 4580-4580 [ DOI: doi:10.1038/s41467-020-18415-7 Pubmed: 32917864 ]
- Proteasome subunit alpha (25 kDa, Protein from Thermoplasma acidophilum)
- Proteasome subunit alpha (25 kDa, Protein from Thermoplasma acidophilum)
- Proteasome subunit beta (22 kDa, Protein from Thermoplasma acidophilum)
- Proteasome activator protein pa26 (25 kDa, Protein from Trypanosoma brucei brucei)
- Singly capped t20s proteasome by pa26panc, lfp (Complex from Thermoplasma acidophilum)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6uti
Q-score: 0.481
Yu Z, Yu Y, Wang F, Myasnikov AG, Coffino P, Cheng Y
Nat Commun (2020) 11 pp. 4580-4580 [ DOI: doi:10.1038/s41467-020-18415-7 Pubmed: 32917864 ]
- Proteasome subunit alpha (25 kDa, Protein from Thermoplasma acidophilum)
- Complex of 20s proteasome with singly capped pan (Complex from Thermoplasma acidophilum)
- Proteasome subunit alpha (25 kDa, Protein from Thermoplasma acidophilum)
- Proteasome subunit beta (22 kDa, Protein from Thermoplasma acidophilum)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 6utj
Q-score: 0.492
Yu Z, Yu Y, Wang F, Myasnikov AG, Coffino P, Cheng Y
Nat Commun (2020) 11 pp. 4580-4580 [ DOI: doi:10.1038/s41467-020-18415-7 Pubmed: 32917864 ]
- Proteasome subunit alpha (25 kDa, Protein from Thermoplasma acidophilum)
- Proteasome subunit beta (22 kDa, Protein from Thermoplasma acidophilum)
- Proteasome activator protein pa26 (25 kDa, Protein from Trypanosoma brucei brucei)
- Proteasome subunit alpha (24 kDa, Protein from Thermoplasma acidophilum)
- Allosteric coupling between alpha rings of the 20s proteasome (Complex from Thermoplasma acidophilum)
Leishmania tarentolae proteasome 20S subunit complexed with LXE408
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6tcz
Q-score: 0.514
Nagle A, Biggart A, Be C, Srinivas H, Hein A, Caridha D, Sciotti RJ, Pybus B, Kreishman-Deitrick M, Bursulaya B, Lai YH, Gao MY, Liang F, Mathison CJN, Liu X, Yeh V, Smith J, Lerario I, Xie Y, Chianelli D, Gibney M, Berman A, Chen YL, Jiricek J, Davis LC, Liu X, Ballard J, Khare S, Eggimann FK, Luneau A, Groessl T, Shapiro M, Richmond W, Johnson K, Rudewicz PJ, Rao SPS, Thompson C, Tuntland T, Spraggon G, Glynne RJ, Supek F, Wiesmann C, Molteni V
J Med Chem (2020) 63 pp. 10773-10781 [ Pubmed: 32667203 DOI: doi:10.1021/acs.jmedchem.0c00499 ]
- Proteasome subunit beta (22 kDa, Protein from Leishmania donovani)
- Leishmania tarentolae proteasome 20s subunit complex (Complex from Leishmania donovani)
- Proteasome subunit alpha type (38 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (27 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (27 kDa, Protein from Leishmania donovani)
- Proteasome endopeptidase complex (25 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (30 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (25 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (33 kDa, Protein from Leishmania donovani)
- Proteasome subunit family protein (23 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (24 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (47 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (37 kDa, Protein from Leishmania donovani)
- ~{n}-[4-fluoranyl-3-[6-(3-methylpyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]phenyl]-2,4-dimethyl-1,3-oxazole-5-carboxamide (443 Da, Ligand)
- Proteasome subunit alpha type (32 kDa, Protein from Leishmania donovani)
- Proteasome endopeptidase complex (27 kDa, Protein from Leishmania donovani)
Leishmania tarentolae proteasome 20S subunit complexed with LXE408 and bortezomib
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6td5
Q-score: 0.512
Nagle A, Biggart A, Be C, Srinivas H, Hein A, Caridha D, Sciotti RJ, Pybus B, Kreishman-Deitrick M, Bursulaya B, Lai YH, Gao MY, Liang F, Mathison CJN, Liu X, Yeh V, Smith J, Lerario I, Xie Y, Chianelli D, Gibney M, Berman A, Chen YL, Jiricek J, Davis LC, Liu X, Ballard J, Khare S, Eggimann FK, Luneau A, Groessl T, Shapiro M, Richmond W, Johnson K, Rudewicz PJ, Rao SPS, Thompson C, Tuntland T, Spraggon G, Glynne RJ, Supek F, Wiesmann C, Molteni V
J Med Chem (2020) 63 pp. 10773-10781 [ Pubmed: 32667203 DOI: doi:10.1021/acs.jmedchem.0c00499 ]
- Proteasome subunit beta (22 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (38 kDa, Protein from Leishmania donovani)
- Proteasome endopeptidase complex (27 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (27 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (24 kDa, Protein from Leishmania donovani)
- ~{n}-[4-fluoranyl-3-[6-(3-methylpyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]phenyl]-2,4-dimethyl-1,3-oxazole-5-carboxamide (443 Da, Ligand)
- Proteasome endopeptidase complex (25 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (24 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (22 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (25 kDa, Protein from Leishmania donovani)
- Proteasome subunit family protein (23 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (47 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (37 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (32 kDa, Protein from Leishmania donovani)
- N-[(1r)-1-(dihydroxyboryl)-3-methylbutyl]-n-(pyrazin-2-ylcarbonyl)-l-phenylalaninamide (384 Da, Ligand)
- Proteasome subunit beta (24 kDa, Protein from Leishmania donovani)
- Leishmania tarentolae proteasome 20s subunit complexed with lxe408 and bortezomib (Complex from Leishmania donovani)
Human 20S proteasome bound to an engineered 11S (PA26) activator
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6xmj
Q-score: 0.584
Opoku-Nsiah KA, de la Pena AH, Williams SK, Chopra N, Sali A, Lander GC, Gestwicki JE
Nat Commun (2022) 13 pp. 1226-1226 [ Pubmed: 35264557 DOI: doi:10.1038/s41467-022-28864-x ]
- Proteasome (Complex from Homo sapiens)
- Proteasome subunit beta type-5 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-1 (23 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-6 (21 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-4 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (23 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Proteasome activator protein pa26 (24 kDa, Protein from Trypanosoma brucei)
- Pa26-bound proteasome (Complex)
- Proteasome subunit alpha type-3 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (24 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- Mutant pa26 (Complex from Trypanosoma brucei)
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 6tu3
Q-score: 0.586
Vimer S, Ben-Nissan G, Morgenstern D, Kumar-Deshmukh F, Polkinghorn C, Quintyn RS, Vasil'ev YV, Beckman JS, Elad N, Wysocki VH, Sharon M
ACS Cent Sci (2020) 6 pp. 573-588 [ DOI: doi:10.1021/acscentsci.0c00080 Pubmed: 32342007 ]
- Proteasome subunit alpha type-5 (26 kDa, Protein from Rattus norvegicus)
- Proteasome subunit beta type-4 (29 kDa, Protein from Rattus norvegicus)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Rattus norvegicus)
- Rat liver 20s proteasome (Complex from Rattus norvegicus)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Rattus norvegicus)
- Proteasome subunit beta type-6 (25 kDa, Protein from Rattus norvegicus)
- Proteasome subunit beta type-5 (28 kDa, Protein from Rattus norvegicus)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Rattus norvegicus)
- Proteasome subunit beta type-7 (29 kDa, Protein from Rattus norvegicus)
- Proteasome subunit beta type-2 (22 kDa, Protein from Rattus norvegicus)
- Proteasome subunit beta type-3 (22 kDa, Protein from Rattus norvegicus)
- Proteasome subunit alpha type-7 (28 kDa, Protein from Rattus norvegicus)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Rattus norvegicus)
- Proteasome subunit beta type-1 (26 kDa, Protein from Rattus norvegicus)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Rattus norvegicus)
Resolution: 2.72 Å
EM Method: Single-particle
Fitted PDBs: 6kwy
Q-score: 0.576
Guan H, Wang Y, Yu T, Huang Y, Li M, Saeed AFUH, Perculija V, Li D, Xiao J, Wang D, Zhu P, Ouyang S
PLoS Biol (2020) 18 pp. e3000654-e3000654 [ DOI: doi:10.1371/journal.pbio.3000654 Pubmed: 32134919 ]
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (30 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-5 (28 kDa, Protein from Homo sapiens)
- [(1~{s},2~{r},3~{r},4~{s},5~{s},6~{r})-2-[oxidanyl(phosphonooxy)phosphoryl]oxy-3,4,5,6-tetraphosphonooxy-cyclohexyl] phosphono hydrogen phosphate (819 Da, Ligand)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- Proteasome activator complex subunit 4 (215 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-1 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-6 (25 kDa, Protein from Homo sapiens)
- Complex of human pa200-20s (Cell from Homo sapiens)