Do data resources managed by EMBL-EBI and our collaborators make a difference to your work? Please take 10 minutes to fill in our annual user survey, and help us make the case for why sustaining open data resources is critical for life sciences research. We appreciate your responses prior to closing of the survey on Monday 17th June.
Structure of the Plasmodium falciparum 20S proteasome complexed with inhibitor TDI-8304
Resolution: 2.18 Å
EM Method: Single-particle
Fitted PDBs: 8g6e
Q-score: 0.715
Hsu HC, Li D, Zhan W, Ye J, Liu YJ, Leung A, Qin J, Crespo B, Gamo FJ, Zhang H, Cui L, Roth A, Kirkman LA, Li H, Lin G
Nat Commun (2023) 14 pp. 8302-8302 [ Pubmed: 38097652 DOI: doi:10.1038/s41467-023-44077-2 ]
- Proteasome subunit beta (22 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit beta (27 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit beta (30 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit alpha type-6 (29 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit alpha type-3 (29 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit alpha type-2 (26 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit alpha type (28 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit beta (24 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit beta (23 kDa, Protein from Plasmodium falciparum NF54)
- Water (18 Da, Ligand)
- Proteasome subunit alpha type (27 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit alpha type-1 (28 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit alpha type (27 kDa, Protein from Plasmodium falciparum NF54)
- Proteasome subunit beta (25 kDa, Protein from Plasmodium falciparum NF54)
- Plasmodium falciparum 20s proteasome complexed with inhibitor tdi-8304 (700 kDa, Complex from Plasmodium falciparum NF54)
- Proteasome subunit beta type-6 (29 kDa, Protein from Plasmodium falciparum NF54)
- (7s,10s,13s)-n-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide (597 Da, Ligand)
Resolution: 2.58 Å
EM Method: Single-particle
Fitted PDBs: 8g6f
Q-score: 0.645
Hsu HC, Li D, Zhan W, Ye J, Liu YJ, Leung A, Qin J, Crespo B, Gamo FJ, Zhang H, Cui L, Roth A, Kirkman LA, Li H, Lin G
Nat Commun (2023) 14 pp. 8302-8302 [ Pubmed: 38097652 DOI: doi:10.1038/s41467-023-44077-2 ]
- Proteasome subunit alpha type-6 (29 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit alpha type-1 (28 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit beta-4 (22 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit beta-7 (30 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit alpha type-5 (28 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit beta-2 (25 kDa, Protein from Plasmodium falciparum Dd2)
- The plasmodium falciparum 20s proteasome beta-6 a117d mutant complexed with inhibitor wlw-vs (700 kDa, Complex from Plasmodium falciparum Dd2)
- Proteasome subunit alpha type-3 (29 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit alpha type-2 (26 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit beta-3 (24 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit beta-6 (27 kDa, Protein from Plasmodium falciparum Dd2)
- (2s)-n-[(e,2s)-1-(1h-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2s)-3-(1h-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide (690 Da, Ligand)
- Water (18 Da, Ligand)
- Proteasome subunit alpha type-4 (27 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit alpha type-3 (27 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome subunit beta-5 (23 kDa, Protein from Plasmodium falciparum Dd2)
- Proteasome endopeptidase complex (29 kDa, Protein from Plasmodium falciparum Dd2)
Structure of human constitutive 20S proteasome complexed with the inhibitor TDI-8304
Resolution: 2.04 Å
EM Method: Single-particle
Fitted PDBs: 8ud9
Q-score: 0.732
Hsu HC, Li D, Zhan W, Ye J, Liu YJ, Leung A, Qin J, Crespo B, Gamo FJ, Zhang H, Cui L, Roth A, Kirkman LA, Li H, Lin G
Nat Commun (2023) 14 pp. 8302-8302 [ Pubmed: 38097652 DOI: doi:10.1038/s41467-023-44077-2 ]
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (24 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- Human 20s constitutive proteasome complexed with inhibitor tdi-8304 (700 kDa, Complex from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-1 (23 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-6 (21 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- (7s,10s,13s)-n-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide (597 Da, Ligand)
- Proteasome subunit beta type-5 (22 kDa, Protein from Homo sapiens)
KCTD5/Cullin3/Gbeta1gamma2 Complex: Local Refinement of KCTD5(CTD)/Gbeta1gamma2
Nguyen DM, Rath DH, Devost D, Petrin D, Rizk R, Ji AX, Narayanan N, Yong D, Zhai A, Kuntz DA, Mian MUQ, Pomroy NC, Keszei AFA, Benlekbir S, Mazhab-Jafari MT, Rubinstein JL, Hebert TE, Prive GG
PNAS (2024) 121 pp. e2315018121-e2315018121 [ DOI: doi:10.1073/pnas.2315018121 Pubmed: 38625940 ]
- Gbb1_human (Protein from Homo sapiens)
- Kctd5_human (Protein from Homo sapiens)
- Complex of substrate adaptor kctd5 with cullin-3 and substrate gbeta-gamma (Complex from Homo sapiens)
- Gbg2_human (Protein from Homo sapiens)
KCTD5/Cullin3/Gbeta1gamma2 Complex: Local Refinement of KCTD5(BTB)/Cullin3(NTD)
Nguyen DM, Rath DH, Devost D, Petrin D, Rizk R, Ji AX, Narayanan N, Yong D, Zhai A, Kuntz DA, Mian MUQ, Pomroy NC, Keszei AFA, Benlekbir S, Mazhab-Jafari MT, Rubinstein JL, Hebert TE, Prive GG
PNAS (2024) 121 pp. e2315018121-e2315018121 [ DOI: doi:10.1073/pnas.2315018121 Pubmed: 38625940 ]
KCTD5/Cullin3/Gbeta1gamma2 Complex State A: Composite Map from RELION Multi-body Refinement
Resolution: 3.82 Å
EM Method: Single-particle
Fitted PDBs: 8u81
Q-score: 0.228
Nguyen DM, Rath DH, Devost D, Petrin D, Rizk R, Ji AX, Narayanan N, Yong D, Zhai A, Kuntz DA, Mian MUQ, Pomroy NC, Keszei AFA, Benlekbir S, Mazhab-Jafari MT, Rubinstein JL, Hebert TE, Prive GG
PNAS (2024) 121 pp. e2315018121-e2315018121 [ DOI: doi:10.1073/pnas.2315018121 Pubmed: 38625940 ]
- Cullin3 1-381 (Protein from Homo sapiens)
- Kctd5_human (Protein from Homo sapiens)
- Gbb1_human (Protein from Homo sapiens)
- Complex of substrate adaptor kctd5 with cullin-3 and substrate gbeta-gamma (Complex from Homo sapiens)
- Gbg2_human (Protein from Homo sapiens)
KCTD5/Cullin3/Gbeta1gamma2 Complex State A: Reference Map for Composite Map EMD-41996
Nguyen DM, Rath DH, Devost D, Petrin D, Rizk R, Ji AX, Narayanan N, Yong D, Zhai A, Kuntz DA, Mian MUQ, Pomroy NC, Keszei AFA, Benlekbir S, Mazhab-Jafari MT, Rubinstein JL, Hebert TE, Prive GG
PNAS (2024) 121 pp. e2315018121-e2315018121 [ DOI: doi:10.1073/pnas.2315018121 Pubmed: 38625940 ]
- Kctd5 (Protein from Homo sapiens)
- Cullin3 1-381 (Protein from Homo sapiens)
- Gbb1_human (Protein from Homo sapiens)
- Complex of substrate adaptor kctd5 with cullin-3 and substrate gbeta-gamma (Complex from Homo sapiens)
- Gbg2_human (Protein from Homo sapiens)
Nguyen DM, Rath DH, Devost D, Petrin D, Rizk R, Ji AX, Narayanan N, Yong D, Zhai A, Kuntz DA, Mian MUQ, Pomroy NC, Keszei AFA, Benlekbir S, Mazhab-Jafari MT, Rubinstein JL, Hebert TE, Prive GG
PNAS (2024) 121 pp. e2315018121-e2315018121 [ DOI: doi:10.1073/pnas.2315018121 Pubmed: 38625940 ]
Nguyen DM, Rath DH, Devost D, Petrin D, Rizk R, Ji AX, Narayanan N, Yong D, Zhai A, Kuntz DA, Mian MUQ, Pomroy NC, Keszei AFA, Benlekbir S, Mazhab-Jafari MT, Rubinstein JL, Hebert TE, Prive GG
PNAS (2024) 121 pp. e2315018121-e2315018121 [ DOI: doi:10.1073/pnas.2315018121 Pubmed: 38625940 ]