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Structure of TFIIH/Rad4-Rad23-Rad33/DNA in DNA opening
Resolution: 9.25 Å
EM Method: Single-particle
Fitted PDBs: 7k04
Q-score: 0.122
van Eeuwen T, Shim Y, Kim HJ, Zhao T, Basu S, Garcia BA, Kaplan CD, Min JH, Murakami K
Nat Commun (2021) 12 pp. 3338-3338 [ DOI: doi:10.1038/s41467-021-23684-x Pubmed: 34099686 ]
- General transcription and dna repair factor iih subunit tfb2 (58 kDa, Protein from Baker's yeast)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Dna repair protein rad33 (20 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Undamaged dna strand (8 kDa, DNA from synthetic construct)
- General transcription and dna repair factor iih subunit tfb1 (72 kDa, Protein from Baker's yeast)
- Dna repair protein rad4 (87 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Rna polymerase ii transcription factor b subunit 5 (8 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 10 component complex of rad4-23, rad33 and tfiih on damaged dna (Complex)
- General transcription and dna repair factor iih subunit tfb4 (37 kDa, Protein from Baker's yeast)
- General transcription and dna repair factor iih subunit ssl1 (52 kDa, Protein from Baker's yeast)
- Dna repair helicase rad25 (95 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Iron/sulfur cluster (351 Da, Ligand)
- Damaged dna strand (8 kDa, DNA from synthetic construct)
- Dna repair helicase rad3 (89 kDa, Protein from Baker's yeast)
Cryo-EM structure of the BRCA1-UbcH5c/BARD1 E3-E2 module bound to a nucleosome
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7jzv
Q-score: 0.313
Witus SR, Burrell AL, Farrell DP, Kang J, Wang M, Hansen JM, Pravat A, Tuttle LM, Stewart MD, Brzovic PS, Chatterjee C, Zhao W, DiMaio F, Kollman JM, Klevit RE
Nat Struct Mol Biol (2021) 28 pp. 268-277 [ DOI: doi:10.1038/s41594-020-00556-4 Pubmed: 33589814 ]
- Brca1-ubch5c/bard1 e3-e2 module (Complex from Homo sapiens)
- Histone h2a type 2-a (14 kDa, Protein from Homo sapiens)
- Brca1-associated ring domain protein 1 (12 kDa, Protein from Homo sapiens)
- Nucleosome core particle (Complex from Homo sapiens)
- Widom 601 153-bp (46 kDa, DNA from synthetic construct)
- Histone h3.2 (15 kDa, Protein from Homo sapiens)
- Histone h4 (11 kDa, Protein from Homo sapiens)
- Brca1-ubch5c/bard1 e3-e2 module bound to nucleosome core particle (200 kDa, Complex from Homo sapiens)
- Brca1,ubiquitin-conjugating enzyme e2 d3 (28 kDa, Protein from Homo sapiens)
- Widom 601 153-bp (47 kDa, DNA from synthetic construct)
- Histone h2b type 1-k (13 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
A complex structure of arrestin-2 bound to neurotensin receptor 1
Resolution: 4.9 Å
EM Method: Single-particle
Fitted PDBs: 6pwc
Q-score: 0.23
Yin W, Li Z, Jin M, Yin YL, de Waal PW, Pal K, Yin Y, Gao X, He Y, Gao J, Wang X, Zhang Y, Zhou H, Melcher K, Jiang Y, Cong Y, Edward Zhou X, Yu X, Eric Xu H
Cell Res (2019) 29 pp. 971-983 [ DOI: doi:10.1038/s41422-019-0256-2 Pubmed: 31776446 ]
- Fusion complex of bril-ntsr1-beta-arrestin1-fab30 (Complex from Homo sapiens)
- Fab30 light chain (23 kDa, Protein from synthetic construct)
- Beta-arrestin-1 (44 kDa, Protein from Homo sapiens)
- Fab30 heavy chain (25 kDa, Protein from synthetic construct)
- Neurotensin peptide (819 Da, Protein from synthetic construct)
- Neurotensin receptor type 1 (41 kDa, Protein from Homo sapiens)
Human 26S proteasome in complex with Oprozomib
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 5m32
Q-score: 0.404
Haselbach D, Schrader J, Lambrecht F, Henneberg F, Chari A, Stark H
Nat Commun (2017) 8 pp. 15578-15578 [ DOI: doi:10.1038/ncomms15578 Pubmed: 28541292 ]
- Proteasome subunit alpha type-1 (26 kDa, Protein from Human)
- Proteasome subunit beta type-3 (22 kDa, Protein from Human)
- Proteasome subunit beta type-4 (29 kDa, Protein from Human)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Human)
- 26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from Human)
- 26s protease regulatory subunit 8 (39 kDa, Protein from Human)
- 26s proteasome non-atpase regulatory subunit 14 (34 kDa, Protein from Human)
- Proteasome subunit beta type-1 (26 kDa, Protein from Human)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Human)
- 26s protease regulatory subunit 6a (49 kDa, Protein from Human)
- 26s proteasome complex subunit sem1 (8 kDa, Protein from Human)
- 26s proteasome non-atpase regulatory subunit 3 (61 kDa, Protein from Human)
- Human 26s proteasome in complex with oprozomib (1 MDa, Complex)
- Proteasome subunit beta type-2 (22 kDa, Protein from Human)
- 26s protease regulatory subunit 7 (48 kDa, Protein from Human)
- 26s protease regulatory subunit 6b (47 kDa, Protein from Human)
- 26s protease regulatory subunit 10b (43 kDa, Protein from Human)
- Proteasome subunit beta type-6 (25 kDa, Protein from Human)
- Proteasome subunit beta type-7 (30 kDa, Protein from Human)
- Proteasome subunit alpha type-7 (26 kDa, Protein from Human)
- 26s protease regulatory subunit 4 (47 kDa, Protein from Human)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Human)
- Proteasome subunit alpha type-1 (26 kDa, Protein from Human)
- 26s proteasome non-atpase regulatory subunit 7 (37 kDa, Protein from Human)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Human)
- 26s proteasome non-atpase regulatory subunit 6 (45 kDa, Protein from Human)
- 26s proteasome non-atpase regulatory subunit 4 (40 kDa, Protein from Human)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- 26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from Human)
- 26s proteasome non-atpase regulatory subunit 8 (39 kDa, Protein from Human)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Human)
- Human 26s proteasome (Complex from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from Human)
- Bound oprozomib (536 Da, Protein from Synthetic construct)
- Bound oprozomib (Complex from Synthetic construct)
- Proteasome subunit beta type-5 (22 kDa, Protein from Human)
- Proteasome subunit alpha type-7 (26 kDa, Protein from Human)
- 26s proteasome non-atpase regulatory subunit 12 (52 kDa, Protein from Human)
Structure and function based design of Plasmodium-selective proteasome inhibitors
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 5fmg
Q-score: 0.47
Li H, O' Donoghue AJ, van der Linden WA, Xie SC, Yoo E, Foe IT, Tilley L, Craik CS, da Fonseca PCA, Bogyo M
Nature (2016) 530 pp. 233-236 [ Pubmed: 26863983 DOI: doi:10.1038/nature16936 ]