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CryoEM structure of 20S Trichomonas vaginalis proteasome in complex with proteasome inhibitor CP-17
Silhan J, Fajtova P, O'Donoghue A, Boura E
To Be Published
- Family t1, proteasome alpha subunit, threonine peptidase (25 kDa, Protein from Trichomonas vaginalis G3)
- Proteasome subunit beta (21 kDa, Protein from Trichomonas vaginalis G3)
- Proteasome subunit alpha type (26 kDa, Protein from Trichomonas vaginalis G3)
- Proteasome subunit beta (23 kDa, Protein from Trichomonas vaginalis G3)
- Family t1, proteasome alpha subunit, threonine peptidase (26 kDa, Protein from Trichomonas vaginalis G3)
- N-[(2s)-1-[[(2s)-1-[[(1s)-1-[(2s,3r,5s,6r)-3-(hydroxymethyl)-5-methanoyl-2,3,6-trimethyl-morpholin-2-yl]-2-phenyl-ethyl]amino]-3-(1h-indol-3-yl)-1-oxidanylidene-propan-2-yl]amino]-3-(1h-indol-3-yl)-1-oxidanylidene-propan-2-yl]hexanamide (776 Da, Ligand)
- Proteasome subunit alpha type (27 kDa, Protein from Trichomonas vaginalis G3)
- Family t1, proteasome alpha subunit, threonine peptidase (25 kDa, Protein from Trichomonas vaginalis G3)
- Proteasome subunit alpha type (27 kDa, Protein from Trichomonas vaginalis G3)
- Ternary complex of 20s proteasome from trichomonas vaginalis (704 kDa, Complex from Trichomonas vaginalis G3)
- Proteasome subunit beta (21 kDa, Protein from Trichomonas vaginalis G3)
- Proteasome subunit beta (22 kDa, Protein from Trichomonas vaginalis G3)
- Family t1, proteasome alpha subunit, threonine peptidase (27 kDa, Protein from Trichomonas vaginalis G3)
- Proteasome subunit beta (25 kDa, Protein from Trichomonas vaginalis G3)
- Proteasome endopeptidase complex (26 kDa, Protein from Trichomonas vaginalis G3)
- Family t1, proteasome beta subunit, threonine peptidase (26 kDa, Protein from Trichomonas vaginalis G3)
60S ribosome biogenesis intermediate (Dbp10 pre-catalytic structure - Overall map)
Resolution: 2.53 Å
EM Method: Single-particle
Fitted PDBs: 8v83
Q-score: 0.53
Cruz VE, Weirich CS, Peddada N, Erzberger JP
Nat Commun (2024) 15 pp. 3296-3296 [ DOI: doi:10.1038/s41467-024-47616-7 Pubmed: 38632236 ]
- 60s ribosomal protein l17-a (20 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Large ribosomal subunit protein ul13a (22 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Large ribosomal subunit protein el15a (24 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Saccharomyces cerevisiae s288c 25s ribosomal rna (1 MDa, RNA from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l26-a (14 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosome subunit biogenesis protein nip7 (20 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosome biogenesis intermediate (Complex from Saccharomyces cerevisiae BY4741)
- Pescadillo homolog (69 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l32 (14 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Zinc ion (65 Da, Ligand)
- Saccharomyces cerevisiae its-2 (74 kDa, RNA from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l37-a (9 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Ribosome production factor 1 (35 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l36-a (11 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Ribosome biogenesis protein nsa1 (51 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l4-a (39 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Proteasome-interacting protein cic1 (42 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Ribosome biogenesis protein rlp24 (24 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l33-a (12 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Large ribosomal subunit protein el8a (28 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Ribosome biogenesis protein ssf1 (51 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Eukaryotic translation initiation factor 6 (26 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l6-a (20 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Ribosome biogenesis protein 15 (25 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l13-a (22 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Nucleolar protein 16 (26 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l14-a (15 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l23-a (14 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Atp-dependent rna helicase has1 (56 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l18-a (20 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Saccharomyces cerevisiae s288c 5.8s ribosomal rna (50 kDa, RNA from Saccharomyces cerevisiae BY4741)
- Protein mak16 (35 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Large ribosomal subunit protein ul1a (24 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Nucleolar gtp-binding protein 1 (74 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Ribosome biogenesis protein rlp7 (36 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Ribosomal rna-processing protein 1 (33 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Ribosomal rna-processing protein 15 (28 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l35-a (13 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal subunit assembly/export protein loc1 (23 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Ribosome assembly factor mrt4 (27 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l3 (43 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Rrna-processing protein ebp2 (49 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l7-a (27 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Ribosome biogenesis protein nsa2 (29 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Large ribosomal subunit protein ul6a (21 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Ribosomal rna-processing protein 14 (50 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Large ribosomal subunit protein el20a (20 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Ribosome biogenesis protein erb1 (91 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Ribosome biogenesis protein brx1 (33 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 25s rrna (cytosine(2870)-c(5))-methyltransferase (69 kDa, Protein from Saccharomyces cerevisiae BY4741)
60S ribosome biogenesis intermediate (Dbp10 catalytic structure - Overall map)
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8v84
Q-score: 0.461
Cruz VE, Weirich CS, Peddada N, Erzberger JP
Nat Commun (2024) 15 pp. 3296-3296 [ DOI: doi:10.1038/s41467-024-47616-7 Pubmed: 38632236 ]
- 60s ribosomal protein l17-a (20 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Large ribosomal subunit protein ul13a (22 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Large ribosomal subunit protein el15a (24 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l26-a (14 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosome subunit biogenesis protein nip7 (20 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosome biogenesis intermediate (Complex from Saccharomyces cerevisiae BY4741)
- Pescadillo homolog (69 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l32 (14 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Atp-dependent rna helicase dbp10 (113 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Zinc ion (65 Da, Ligand)
- 60s ribosomal protein l37-a (9 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Ribosome production factor 1 (35 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l36-a (11 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Ribosome biogenesis protein nsa1 (51 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l4-a (39 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Proteasome-interacting protein cic1 (42 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Ribosome biogenesis protein rlp24 (24 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l33-a (12 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Large ribosomal subunit protein el8a (28 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Ribosome biogenesis protein ssf1 (51 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Eukaryotic translation initiation factor 6 (26 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l6-a (20 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Large ribosomal subunit protein ul3 (43 kDa, Protein from Saccharomyces cerevisiae BY4741-AV16)
- 60s ribosomal protein l13-a (22 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Ribosome biogenesis protein 15 (25 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Nucleolar protein 16 (26 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l14-a (15 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l23-a (14 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Atp-dependent rna helicase has1 (56 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l18-a (20 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Protein mak16 (35 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Saccharomyces cerevisiae 25s ribosomal rna (1 MDa, RNA from Saccharomyces cerevisiae BY4741)
- Large ribosomal subunit protein ul1a (24 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Nucleolar gtp-binding protein 1 (74 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Ribosome biogenesis protein rlp7 (36 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Ribosomal rna-processing protein 1 (33 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Ribosomal rna-processing protein 15 (28 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l35-a (13 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Its2 rna (74 kDa, RNA from Saccharomyces cerevisiae BY4741)
- 60s ribosomal subunit assembly/export protein loc1 (23 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Ribosome assembly factor mrt4 (27 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Rrna-processing protein ebp2 (49 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l7-a (27 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Saccharomyces cerevisiae 5.8s ribosomal rna (50 kDa, RNA from Saccharomyces cerevisiae BY4741)
- Magnesium ion (24 Da, Ligand)
- Ribosome biogenesis protein nsa2 (29 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Large ribosomal subunit protein ul6a (21 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Ribosomal rna-processing protein 14 (50 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Large ribosomal subunit protein el20a (20 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Ribosome biogenesis protein erb1 (91 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Ribosome biogenesis protein brx1 (33 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 25s rrna (cytosine(2870)-c(5))-methyltransferase (69 kDa, Protein from Saccharomyces cerevisiae BY4741)
60S ribosome biogenesis intermediate (Dbp10 post-catalytic structure - Overall map)
Resolution: 2.66 Å
EM Method: Single-particle
Fitted PDBs: 8v87
Q-score: 0.519
Cruz VE, Weirich CS, Peddada N, Erzberger JP
Nat Commun (2024) 15 pp. 3296-3296 [ DOI: doi:10.1038/s41467-024-47616-7 Pubmed: 38632236 ]
- 60s ribosomal protein l17-a (20 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Nucleolar complex-associated protein 3 (75 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Large ribosomal subunit protein ul13a (22 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Large ribosomal subunit protein el15a (24 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 5.8s ribosomal rna (50 kDa, RNA from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l26-a (14 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosome subunit biogenesis protein nip7 (20 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosome biogenesis intermediate (Complex from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l38 (8 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Pescadillo homolog (69 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l32 (14 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Atp-dependent rna helicase dbp10 (113 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Zinc ion (65 Da, Ligand)
- 60s ribosomal protein l27-a (15 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l37-a (9 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Upf0642 protein ybl028c (12 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l25 (15 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l36-a (11 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Ytm1 isoform 1 (51 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l4-a (39 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Proteasome-interacting protein cic1 (42 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Ribosome biogenesis protein rlp24 (24 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l30 (11 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l33-a (12 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Large ribosomal subunit protein el8a (28 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Eukaryotic translation initiation factor 6 (26 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l6-a (20 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Ribosome biogenesis protein 15 (25 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l13-a (22 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Nucleolar protein 16 (26 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l19-a (21 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l14-a (15 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l23-a (14 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Atp-dependent rna helicase has1 (56 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l18-a (20 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Nucleolar gtp-binding protein 1 (74 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Potassium ion (39 Da, Ligand)
- Large ribosomal subunit protein ul1a (24 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Ribosome biogenesis protein rlp7 (36 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 27s pre-rrna (guanosine(2922)-2'-o)-methyltransferase (96 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l35-a (13 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Its2 rna (74 kDa, RNA from Saccharomyces cerevisiae BY4741)
- 60s ribosomal subunit assembly/export protein loc1 (23 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Ribosome assembly factor mrt4 (27 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l3 (43 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Nuclear gtp-binding protein nug1 (57 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Rrna-processing protein ebp2 (49 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l7-a (27 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l34-a (13 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 25s ribosomal rna (1 MDa, RNA from Saccharomyces cerevisiae BY4741)
- Nucleolar complex protein 2 (81 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- 60s ribosomal protein l31-a (12 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Ribosome biogenesis protein nsa2 (29 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Large ribosomal subunit protein ul6a (21 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 60s ribosomal protein l22-a (13 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Large ribosomal subunit protein el20a (20 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Ribosome biogenesis protein erb1 (91 kDa, Protein from Saccharomyces cerevisiae BY4741)
- Ribosome biogenesis protein brx1 (33 kDa, Protein from Saccharomyces cerevisiae BY4741)
- 25s rrna (cytosine(2870)-c(5))-methyltransferase (69 kDa, Protein from Saccharomyces cerevisiae BY4741)
Preholo-Proteasome from Beta 3 D205 deletion
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8u6y
Q-score: 0.513
Velez B, Walsh Jr RM, Rawson S, Razi A, Adams L, Perez EF, Jiao F, Blickling M, Rajakumar T, Fung D, Huang L, Hanna J
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01262-1 Pubmed: 38600323 ]
- Proteasome subunit beta type-1 (23 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-5 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-4 (22 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-3 (22 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-5 (31 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-6 (26 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-4 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-2 (27 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-7 (29 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-1 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Preholo-proteasome from beta 3 d205 deletion mutant (750 kDa, Complex from Saccharomyces cerevisiae S288C)
- Proteasome chaperone 1 (30 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-2 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome maturation factor ump1 (16 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-3 (27 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-6 (25 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-7 (31 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome assembly chaperone 2 (30 kDa, Protein from Saccharomyces cerevisiae S288C)
Proteasome 20S Core Particle from Beta 3 D205 deletion
Resolution: 2.16 Å
EM Method: Single-particle
Fitted PDBs: 8u7u
Q-score: 0.688
Velez B, Walsh Jr RM, Rawson S, Razi A, Adams L, Perez EF, Jiao F, Blickling M, Rajakumar T, Fung D, Huang L, Hanna J
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01262-1 Pubmed: 38600323 ]
- Proteasome subunit beta type-1 (23 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-5 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-6 (25 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-4 (22 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-5 (31 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-6 (26 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-3 (22 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-4 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-2 (27 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-7 (29 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-1 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-2 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome 20s core particle from beta 3 d205 deletion mutant (700 kDa, Complex from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-7 (31 kDa, Protein from Saccharomyces cerevisiae S288C)
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 8oix
Q-score: 0.581
Silhan J, Fajtova P, O'Donoghue A, Boura E
To Be Published
- Family t1, proteasome alpha subunit, threonine peptidase (25 kDa, Protein from Trichomonas vaginalis G3)
- (3ar,6r,6as)-6-((s)-((s)-cyclohex-2-enyl)(hydroxy)methyl)-6a-methyl-4-oxo-hexahydro-2h-furo[3,2-c]pyrrole-6-carbaldehyde (279 Da, Ligand)
- Proteasome subunit beta (21 kDa, Protein from Trichomonas vaginalis G3)
- Proteasome subunit alpha type (26 kDa, Protein from Trichomonas vaginalis G3)
- Proteasome subunit beta (23 kDa, Protein from Trichomonas vaginalis G3)
- Family t1, proteasome alpha subunit, threonine peptidase (26 kDa, Protein from Trichomonas vaginalis G3)
- Proteasome subunit alpha type (27 kDa, Protein from Trichomonas vaginalis G3)
- Family t1, proteasome alpha subunit, threonine peptidase (25 kDa, Protein from Trichomonas vaginalis G3)
- Proteasome subunit alpha type (27 kDa, Protein from Trichomonas vaginalis G3)
- Ternary complex of 20s proteasome from trichomonas vaginalis (704 kDa, Complex from Trichomonas vaginalis G3)
- Proteasome endopeptidase complex (26 kDa, Protein from Trichomonas vaginalis G3)
- Proteasome subunit beta (21 kDa, Protein from Trichomonas vaginalis G3)
- Family t1, proteasome alpha subunit, threonine peptidase (27 kDa, Protein from Trichomonas vaginalis G3)
- Proteasome subunit beta (22 kDa, Protein from Trichomonas vaginalis G3)
- Proteasome subunit beta (25 kDa, Protein from Trichomonas vaginalis G3)
- Family t1, proteasome beta subunit, threonine peptidase (26 kDa, Protein from Trichomonas vaginalis G3)
Cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CCDC89 (conformation 1)
Resolution: 3.39 Å
EM Method: Single-particle
Fitted PDBs: 8wqa
Q-score: 0.362
Chen X, Raiff A, Li S, Guo Q, Zhang J, Zhou H, Timms RT, Yao X, Elledge SJ, Koren I, Zhang K, Xu C
Nat Commun (2024) 15 pp. 3558-3558 [ DOI: doi:10.1038/s41467-024-47890-5 Pubmed: 38670995 ]
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Elongin-c (10 kDa, Protein from Homo sapiens)
- Coiled-coil domain-containing protein 89 (3 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Cryo-em structure of cul2-rbx1-elob-eloc-fem1b bound with the c-degron of ccdc89 (conformation 1) (Complex from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1, n-terminally processed (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Protein fem-1 homolog b (70 kDa, Protein from Homo sapiens)
Cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CCDC89 (conformation 2)
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 8wqb
Q-score: 0.39
Chen X, Raiff A, Li S, Guo Q, Zhang J, Zhou H, Timms RT, Yao X, Elledge SJ, Koren I, Zhang K, Xu C
Nat Commun (2024) 15 pp. 3558-3558 [ DOI: doi:10.1038/s41467-024-47890-5 Pubmed: 38670995 ]
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Elongin-c (10 kDa, Protein from Homo sapiens)
- Coiled-coil domain-containing protein 89 (3 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Cryo-em structure of cul2-rbx1-elob-eloc-fem1b bound with the c-degron of ccdc89 (conformation 2) (Complex from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1, n-terminally processed (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Protein fem-1 homolog b (70 kDa, Protein from Homo sapiens)
cryo-EM structure of neddylated CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CDK5R1
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 8wqc
Q-score: 0.352
Chen X, Raiff A, Li S, Guo Q, Zhang J, Zhou H, Timms RT, Yao X, Elledge SJ, Koren I, Zhang K, Xu C
Nat Commun (2024) 15 pp. 3558-3558 [ DOI: doi:10.1038/s41467-024-47890-5 Pubmed: 38670995 ]
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Elongin-c (10 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Cryo-em structure of neddylated cul2-rbx1-elob-eloc-fem1b bound with the c-degron of cdk5r1 (Complex from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1, n-terminally processed (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Protein fem-1 homolog b (70 kDa, Protein from Homo sapiens)
- Nedd8 (8 kDa, Protein from Homo sapiens)