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26S proteasome from the cell with TDP-25 inclusion
Riemenschneider H, Guo Q, Bader J, Frottin F, Farny D, Kleinberger G, Haass C, Mann M, Hartl FU, Baumeister W, Hipp MS, Meissner F, Fernandez-Busnadiego R, Edbauer D
EMBO Rep (2022) 23 pp. e53890-e53890 [ DOI: doi:10.15252/embr.202153890 Pubmed: 35438230 ]
tomogram of a rat primary neuron harboring TDP-25 inclusion
Riemenschneider H, Guo Q, Bader J, Frottin F, Farny D, Kleinberger G, Haass C, Mann M, Hartl FU, Baumeister W, Hipp MS, Meissner F, Fernandez-Busnadiego R, Edbauer D
EMBO Rep (2022) 23 pp. e53890-e53890 [ DOI: doi:10.15252/embr.202153890 Pubmed: 35438230 ]
Guo Q, Lehmer C, Martinez-Sanchez A, Rudack T, Beck F, Hartmann H, Perez-Berlanga M, Frottin F, Hipp MS, Hartl FU, Edbauer D, Baumeister W, Fernandez-Busnadiego R
Cell (2018) 172 pp. 696-705.e12 [ DOI: doi:10.1016/j.cell.2017.12.030 Pubmed: 29398115 ]
Ground state 26S proteasome (GS2)
Resolution: 12.3 Å
EM Method: Subtomogram averaging
Fitted PDBs: 6epc
Q-score: 0.052
Guo Q, Lehmer C, Martinez-Sanchez A, Rudack T, Beck F, Hartmann H, Perez-Berlanga M, Frottin F, Hipp MS, Hartl FU, Edbauer D, Baumeister W, Fernandez-Busnadiego R
Cell (2018) 172 pp. 696-705.e12 [ DOI: doi:10.1016/j.cell.2017.12.030 Pubmed: 29398115 ]
- Proteasome subunit alpha type-5 (26 kDa, Protein from Rattus norvegicus)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Rattus norvegicus)
- 26s proteasome regulatory subunit 8 (45 kDa, Protein from Rattus norvegicus)
- Proteasome subunit beta type-3 (22 kDa, Protein from Rattus norvegicus)
- 26s proteasome regulatory subunit 4 (49 kDa, Protein from Rattus norvegicus)
- Rcg28037 (8 kDa, Protein from Rattus norvegicus)
- 26s proteasome non-atpase regulatory subunit 2 (100 kDa, Protein from Rattus norvegicus)
- Proteasome (prosome, macropain) 26s subunit, non-atpase, 14 (34 kDa, Protein from Rattus norvegicus)
- 26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from Rattus norvegicus)
- Proteasome subunit alpha type-7 (28 kDa, Protein from Rattus norvegicus)
- 26s proteasome regulatory subunit 7 (48 kDa, Protein from Rattus norvegicus)
- Proteasome 26s subunit, atpase 6 (45 kDa, Protein from Rattus norvegicus)
- Proteasome (prosome, macropain) 26s subunit, non-atpase, 7 (predicted) (36 kDa, Protein from Rattus norvegicus)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Rattus norvegicus)
- Ground state 26s proteasome (gs2) (Complex from Rattus norvegicus)
- Proteasome subunit beta type-1 (26 kDa, Protein from Rattus norvegicus)
- Proteasome subunit beta type-4 (29 kDa, Protein from Rattus norvegicus)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Rattus norvegicus)
- Proteasome subunit beta type-6 (25 kDa, Protein from Rattus norvegicus)
- Proteasome subunit beta type-2 (22 kDa, Protein from Rattus norvegicus)
- Proteasome (prosome, macropain) 26s subunit, non-atpase, 3 (60 kDa, Protein from Rattus norvegicus)
- Proteasome (prosome, macropain) 26s subunit, non-atpase, 12 (53 kDa, Protein from Rattus norvegicus)
- 26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from Rattus norvegicus)
- 26s proteasome regulatory subunit 6a (49 kDa, Protein from Rattus norvegicus)
- 26s proteasome subunit s5a (40 kDa, Protein from Rattus norvegicus)
- Proteasome subunit beta type-5 (28 kDa, Protein from Rattus norvegicus)
- Proteasome 26s subunit, non-atpase 8 (39 kDa, Protein from Rattus norvegicus)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Rattus norvegicus)
- Proteasome subunit beta type-7 (29 kDa, Protein from Rattus norvegicus)
- Proteasome (prosome, macropain) 26s subunit, non-atpase, 6 (45 kDa, Protein from Rattus norvegicus)
- 26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from Rattus norvegicus)
- 26s proteasome regulatory subunit 6b (47 kDa, Protein from Rattus norvegicus)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Rattus norvegicus)
Substrate processing state 26S proteasome (SPS1)
Resolution: 15.4 Å
EM Method: Subtomogram averaging
Fitted PDBs: 6epd
Q-score: 0.05
Guo Q, Lehmer C, Martinez-Sanchez A, Rudack T, Beck F, Hartmann H, Perez-Berlanga M, Frottin F, Hipp MS, Hartl FU, Edbauer D, Baumeister W, Fernandez-Busnadiego R
Cell (2018) 172 pp. 696-705.e12 [ DOI: doi:10.1016/j.cell.2017.12.030 Pubmed: 29398115 ]
- Proteasome subunit alpha type-5 (26 kDa, Protein from Rattus norvegicus)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Rattus norvegicus)
- 26s proteasome regulatory subunit 8 (45 kDa, Protein from Rattus norvegicus)
- Proteasome subunit beta type-3 (22 kDa, Protein from Rattus norvegicus)
- 26s proteasome regulatory subunit 4 (49 kDa, Protein from Rattus norvegicus)
- Rcg28037 (8 kDa, Protein from Rattus norvegicus)
- 26s proteasome non-atpase regulatory subunit 2 (100 kDa, Protein from Rattus norvegicus)
- Substrate processing state 26s proteasome (sps1) (Complex from Rattus norvegicus)
- Proteasome (prosome, macropain) 26s subunit, non-atpase, 14 (34 kDa, Protein from Rattus norvegicus)
- 26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from Rattus norvegicus)
- Proteasome subunit alpha type-7 (28 kDa, Protein from Rattus norvegicus)
- 26s proteasome regulatory subunit 7 (48 kDa, Protein from Rattus norvegicus)
- Proteasome 26s subunit, atpase 6 (45 kDa, Protein from Rattus norvegicus)
- Proteasome (prosome, macropain) 26s subunit, non-atpase, 7 (predicted) (36 kDa, Protein from Rattus norvegicus)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Rattus norvegicus)
- Proteasome subunit beta type-1 (26 kDa, Protein from Rattus norvegicus)
- Proteasome subunit beta type-4 (29 kDa, Protein from Rattus norvegicus)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Rattus norvegicus)
- Proteasome subunit beta type-6 (25 kDa, Protein from Rattus norvegicus)
- Proteasome subunit beta type-2 (22 kDa, Protein from Rattus norvegicus)
- Proteasome (prosome, macropain) 26s subunit, non-atpase, 3 (60 kDa, Protein from Rattus norvegicus)
- Proteasome (prosome, macropain) 26s subunit, non-atpase, 12 (53 kDa, Protein from Rattus norvegicus)
- 26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from Rattus norvegicus)
- 26s proteasome regulatory subunit 6a (49 kDa, Protein from Rattus norvegicus)
- 26s proteasome subunit s5a (40 kDa, Protein from Rattus norvegicus)
- Proteasome subunit beta type-5 (28 kDa, Protein from Rattus norvegicus)
- Proteasome 26s subunit, non-atpase 8 (39 kDa, Protein from Rattus norvegicus)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Rattus norvegicus)
- Proteasome subunit beta type-7 (29 kDa, Protein from Rattus norvegicus)
- Proteasome (prosome, macropain) 26s subunit, non-atpase, 6 (45 kDa, Protein from Rattus norvegicus)
- 26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from Rattus norvegicus)
- 26s proteasome regulatory subunit 6b (47 kDa, Protein from Rattus norvegicus)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Rattus norvegicus)
Substrate processing state 26S proteasome (SPS2)
Resolution: 12.8 Å
EM Method: Subtomogram averaging
Fitted PDBs: 6epe
Q-score: 0.053
Guo Q, Lehmer C, Martinez-Sanchez A, Rudack T, Beck F, Hartmann H, Perez-Berlanga M, Frottin F, Hipp MS, Hartl FU, Edbauer D, Baumeister W, Fernandez-Busnadiego R
Cell (2018) 172 pp. 696-705.e12 [ DOI: doi:10.1016/j.cell.2017.12.030 Pubmed: 29398115 ]
- Proteasome subunit alpha type-5 (26 kDa, Protein from Rattus norvegicus)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Rattus norvegicus)
- 26s proteasome regulatory subunit 8 (45 kDa, Protein from Rattus norvegicus)
- Proteasome subunit beta type-3 (22 kDa, Protein from Rattus norvegicus)
- 26s proteasome regulatory subunit 4 (49 kDa, Protein from Rattus norvegicus)
- Rcg28037 (8 kDa, Protein from Rattus norvegicus)
- Substrate processing state 26s proteasome (sps2) (Complex from Rattus norvegicus)
- 26s proteasome non-atpase regulatory subunit 2 (100 kDa, Protein from Rattus norvegicus)
- Proteasome (prosome, macropain) 26s subunit, non-atpase, 14 (34 kDa, Protein from Rattus norvegicus)
- 26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from Rattus norvegicus)
- Proteasome subunit alpha type-7 (28 kDa, Protein from Rattus norvegicus)
- 26s proteasome regulatory subunit 7 (48 kDa, Protein from Rattus norvegicus)
- Proteasome 26s subunit, atpase 6 (45 kDa, Protein from Rattus norvegicus)
- Proteasome (prosome, macropain) 26s subunit, non-atpase, 7 (predicted) (36 kDa, Protein from Rattus norvegicus)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Rattus norvegicus)
- Proteasome subunit beta type-1 (26 kDa, Protein from Rattus norvegicus)
- Proteasome subunit beta type-4 (29 kDa, Protein from Rattus norvegicus)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Rattus norvegicus)
- Proteasome subunit beta type-6 (25 kDa, Protein from Rattus norvegicus)
- Proteasome subunit beta type-2 (22 kDa, Protein from Rattus norvegicus)
- Proteasome (prosome, macropain) 26s subunit, non-atpase, 3 (60 kDa, Protein from Rattus norvegicus)
- Proteasome (prosome, macropain) 26s subunit, non-atpase, 12 (53 kDa, Protein from Rattus norvegicus)
- 26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from Rattus norvegicus)
- 26s proteasome regulatory subunit 6a (49 kDa, Protein from Rattus norvegicus)
- 26s proteasome subunit s5a (40 kDa, Protein from Rattus norvegicus)
- Proteasome subunit beta type-5 (28 kDa, Protein from Rattus norvegicus)
- Proteasome 26s subunit, non-atpase 8 (39 kDa, Protein from Rattus norvegicus)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Rattus norvegicus)
- Proteasome subunit beta type-7 (29 kDa, Protein from Rattus norvegicus)
- Proteasome (prosome, macropain) 26s subunit, non-atpase, 6 (45 kDa, Protein from Rattus norvegicus)
- 26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from Rattus norvegicus)
- 26s proteasome regulatory subunit 6b (47 kDa, Protein from Rattus norvegicus)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Rattus norvegicus)
Ground state 26S proteasome (GS1)
Resolution: 11.8 Å
EM Method: Subtomogram averaging
Fitted PDBs: 6epf
Q-score: 0.057
Guo Q, Lehmer C, Martinez-Sanchez A, Rudack T, Beck F, Hartmann H, Perez-Berlanga M, Frottin F, Hipp MS, Hartl FU, Edbauer D, Baumeister W, Fernandez-Busnadiego R
Cell (2018) 172 pp. 696-705.e12 [ DOI: doi:10.1016/j.cell.2017.12.030 Pubmed: 29398115 ]
- Proteasome subunit alpha type-5 (26 kDa, Protein from Rattus norvegicus)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Rattus norvegicus)
- 26s proteasome regulatory subunit 8 (45 kDa, Protein from Rattus norvegicus)
- Proteasome subunit beta type-3 (22 kDa, Protein from Rattus norvegicus)
- 26s proteasome regulatory subunit 4 (49 kDa, Protein from Rattus norvegicus)
- Rcg28037 (8 kDa, Protein from Rattus norvegicus)
- 26s proteasome non-atpase regulatory subunit 2 (100 kDa, Protein from Rattus norvegicus)
- Proteasome (prosome, macropain) 26s subunit, non-atpase, 14 (34 kDa, Protein from Rattus norvegicus)
- 26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from Rattus norvegicus)
- Proteasome subunit alpha type-7 (28 kDa, Protein from Rattus norvegicus)
- 26s proteasome regulatory subunit 7 (48 kDa, Protein from Rattus norvegicus)
- Proteasome 26s subunit, atpase 6 (45 kDa, Protein from Rattus norvegicus)
- Proteasome (prosome, macropain) 26s subunit, non-atpase, 7 (predicted) (36 kDa, Protein from Rattus norvegicus)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Rattus norvegicus)
- Proteasome subunit beta type-1 (26 kDa, Protein from Rattus norvegicus)
- Proteasome subunit beta type-4 (29 kDa, Protein from Rattus norvegicus)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Rattus norvegicus)
- Proteasome subunit beta type-6 (25 kDa, Protein from Rattus norvegicus)
- Proteasome subunit beta type-2 (22 kDa, Protein from Rattus norvegicus)
- Proteasome (prosome, macropain) 26s subunit, non-atpase, 3 (60 kDa, Protein from Rattus norvegicus)
- Proteasome (prosome, macropain) 26s subunit, non-atpase, 12 (53 kDa, Protein from Rattus norvegicus)
- 26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from Rattus norvegicus)
- 26s proteasome regulatory subunit 6a (49 kDa, Protein from Rattus norvegicus)
- 26s proteasome subunit s5a (40 kDa, Protein from Rattus norvegicus)
- Ground state 26s proteasome (gs1) (Complex from Rattus norvegicus)
- Proteasome subunit beta type-5 (28 kDa, Protein from Rattus norvegicus)
- Proteasome 26s subunit, non-atpase 8 (39 kDa, Protein from Rattus norvegicus)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Rattus norvegicus)
- Proteasome subunit beta type-7 (29 kDa, Protein from Rattus norvegicus)
- Proteasome (prosome, macropain) 26s subunit, non-atpase, 6 (45 kDa, Protein from Rattus norvegicus)
- 26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from Rattus norvegicus)
- 26s proteasome regulatory subunit 6b (47 kDa, Protein from Rattus norvegicus)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Rattus norvegicus)
In situ cryo-electron tomogram from Rat neuron with C9ORF72 Poly-GA aggregates
Guo Q, Lehmer C, Martinez-Sanchez A, Rudack T, Beck F, Hartmann H, Perez-Berlanga M, Frottin F, Hipp MS, Hartl FU, Edbauer D, Baumeister W, Fernandez-Busnadiego R
Cell (2018) 172 pp. 696-705.e12 [ DOI: doi:10.1016/j.cell.2017.12.030 Pubmed: 29398115 ]