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Cryo-EM structure of human p97-R155H mutant bound to ADP.
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7rl6
Q-score: 0.303
Caffrey B, Zhu X, Berezuk A, Tuttle K, Chittori S, Subramaniam S
J Biol Chem (2021) 297 pp. 101187-101187 [ Pubmed: 34520757 DOI: doi:10.1016/j.jbc.2021.101187 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Transitional endoplasmic reticulum atpase (91 kDa, Protein from Homo sapiens)
- Full-length hexameric p97-r155h mutant (540 kDa, Complex from Homo sapiens)
Cryo-EM structure of human p97-R155H mutant bound to ATPgS.
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7rl7
Q-score: 0.419
Caffrey B, Zhu X, Berezuk A, Tuttle K, Chittori S, Subramaniam S
J Biol Chem (2021) 297 pp. 101187-101187 [ Pubmed: 34520757 DOI: doi:10.1016/j.jbc.2021.101187 ]
- Magnesium ion (24 Da, Ligand)
- Transitional endoplasmic reticulum atpase (91 kDa, Protein from Homo sapiens)
- Full-length hexameric p97-r155h mutant. (540 kDa, Complex from Homo sapiens)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
Cryo-EM structure of human p97-R191Q mutant bound to ADP.
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7rl9
Q-score: 0.351
Caffrey B, Zhu X, Berezuk A, Tuttle K, Chittori S, Subramaniam S
J Biol Chem (2021) 297 pp. 101187-101187 [ Pubmed: 34520757 DOI: doi:10.1016/j.jbc.2021.101187 ]
- Full-length hexameric p97-r191q mutant. (540 kDa, Complex from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Transitional endoplasmic reticulum atpase (91 kDa, Protein from Homo sapiens)
Cryo-EM structure of human p97-R191Q mutant bound to ATPgS.
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7rla
Q-score: 0.333
Caffrey B, Zhu X, Berezuk A, Tuttle K, Chittori S, Subramaniam S
J Biol Chem (2021) 297 pp. 101187-101187 [ Pubmed: 34520757 DOI: doi:10.1016/j.jbc.2021.101187 ]
- Full-length hexameric p97-r191q mutant. (540 kDa, Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Transitional endoplasmic reticulum atpase (91 kDa, Protein from Homo sapiens)
Cryo-EM structure of human p97-A232E mutant bound to ADP
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7rlb
Q-score: 0.277
Caffrey B, Zhu X, Berezuk A, Tuttle K, Chittori S, Subramaniam S
J Biol Chem (2021) 297 pp. 101187-101187 [ Pubmed: 34520757 DOI: doi:10.1016/j.jbc.2021.101187 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Full-length hexameric p97-a232e mutant. (540 kDa, Complex from Homo sapiens)
- Transitional endoplasmic reticulum atpase (91 kDa, Protein from Homo sapiens)
Cryo-EM structure of human p97-A232E mutant bound to ATPgS.
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7rlc
Q-score: 0.374
Caffrey B, Zhu X, Berezuk A, Tuttle K, Chittori S, Subramaniam S
J Biol Chem (2021) 297 pp. 101187-101187 [ Pubmed: 34520757 DOI: doi:10.1016/j.jbc.2021.101187 ]
- Magnesium ion (24 Da, Ligand)
- Full-length hexameric p97-a232e mutant. (540 kDa, Complex from Homo sapiens)
- Transitional endoplasmic reticulum atpase (91 kDa, Protein from Homo sapiens)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
Cryo-EM structure of human p97-E470D mutant bound to ADP.
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7rld
Q-score: 0.376
Caffrey B, Zhu X, Berezuk A, Tuttle K, Chittori S, Subramaniam S
J Biol Chem (2021) 297 pp. 101187-101187 [ Pubmed: 34520757 DOI: doi:10.1016/j.jbc.2021.101187 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Transitional endoplasmic reticulum atpase (91 kDa, Protein from Homo sapiens)
- Full-length hexameric p97-e470d mutant. (540 kDa, Complex from Homo sapiens)
Cryo-EM structure of human p97-E470D mutant bound to ATPgS.
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7rlf
Q-score: 0.48
Caffrey B, Zhu X, Berezuk A, Tuttle K, Chittori S, Subramaniam S
J Biol Chem (2021) 297 pp. 101187-101187 [ Pubmed: 34520757 DOI: doi:10.1016/j.jbc.2021.101187 ]
- Magnesium ion (24 Da, Ligand)
- Full-length hexameric p97-e470d mutant. (540 kDa, Complex from Homo sapiens)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Transitional endoplasmic reticulum atpase (89 kDa, Protein from Homo sapiens)
Cryo-EM structure of human p97-D592N mutant bound to ADP.
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7rlg
Q-score: 0.395
Caffrey B, Zhu X, Berezuk A, Tuttle K, Chittori S, Subramaniam S
J Biol Chem (2021) 297 pp. 101187-101187 [ Pubmed: 34520757 DOI: doi:10.1016/j.jbc.2021.101187 ]
- Full-length hexameric p97-d592n mutant. (540 kDa, Complex from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Transitional endoplasmic reticulum atpase (91 kDa, Protein from Homo sapiens)
Cryo-EM structure of human p97-D592N mutant bound to ATPgS.
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7rlh
Q-score: 0.48
Caffrey B, Zhu X, Berezuk A, Tuttle K, Chittori S, Subramaniam S
J Biol Chem (2021) 297 pp. 101187-101187 [ Pubmed: 34520757 DOI: doi:10.1016/j.jbc.2021.101187 ]
- Full-length hexameric p97-d592n mutant. (540 kDa, Complex from Homo sapiens)
- Transitional endoplasmic reticulum atpase (89 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)