Electron Microscopy Data Bank

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proteasome* AND author_name:"Zhu Y" AND film_detector_model:"GATAN K2 SUMMIT (4K X 4K)" AND author_orcid:"0000-0001-8085-8928"

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EMD-7010

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Cryo-EM structure of human immunoproteasome with a novel noncompetitive inhibitor that selectively inhibits activated lymphocytes

Release date: Dec. 6, 2017
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6avo
Q-score: 0.431

Santos RLA, Bai L, Singh PK, Murakami N, Fan H, Zhan W, Zhu Y, Jiang X, Zhang K, Assker JP, Nathan CF, Li H, Azzi J, Lin G

Nat Commun (2017) 8 pp. 1692-1692 [ Pubmed: 29167449 DOI: doi:10.1038/s41467-017-01760-5 ]

Sample:

N~1~-{2-[([1,1'-biphenyl]-3-carbonyl)amino]ethyl}-n~4~-tert-butyl-n~2~-(3-phenylpropanoyl)-l-aspartamide (542 Da, Ligand)
Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
Proteasome subunit beta type-4 (24 kDa, Protein from Homo sapiens)
Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
Proteasome subunit beta type-10 (24 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
Proteasome subunit beta type-8 (22 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
Proteasome subunit beta type-9 (21 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
Human immunoproteasome with a novel noncompetitive inhibitor that selectively inhibits activated lymphocytes (Complex from Homo sapiens)
Proteasome subunit beta type-1 (23 kDa, Protein from Homo sapiens)

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