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Full composite cryo-EM map of p97/VCP in ADP.Pi state
Resolution: 2.61 Å
EM Method: Single-particle
Fitted PDBs: 8ooi
Q-score: 0.522
Shein M, Hitzenberger M, Cheng TC, Rout SR, Leitl KD, Sato Y, Zacharias M, Sakata E, Schutz AK
Nat Chem (2024) 16 pp. 363-372 [ Pubmed: 38326645 DOI: doi:10.1038/s41557-024-01440-0 ]
- Phosphate ion (94 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Water (18 Da, Ligand)
- Transitional endoplasmic reticulum atpase (89 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- P97/vcp (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
26S proteasome WT-Ubp6-UbVS complex in the si state (ATPases, Rpn1, Ubp6, and UbVS)
Resolution: 7.0 Å
EM Method: Single-particle
Fitted PDBs: 7qo4
Q-score: 0.112
Hung KYS, Klumpe S, Eisele MR, Elsasser S, Tian G, Sun S, Moroco JA, Cheng TC, Joshi T, Seibel T, Van Dalen D, Feng XH, Lu Y, Ovaa H, Engen JR, Lee BH, Rudack T, Sakata E, Finley D
Nat Commun (2022) 13 pp. 838- [ DOI: doi:10.1038/s41467-022-28186-y ]
- Rpt2 isoform 1 (48 kDa, Protein from baker's yeast)
- Rpt3 isoform 1 (47 kDa, Protein from baker's yeast)
- 26s proteasome wt-ubp6-ubvs complex in the si state (2 MDa, Complex)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Polyubiquitin-b (8 kDa, Protein from Homo sapiens)
- Yeast wt 26s proteasome body2 (atpase, rpn1) (Complex from Saccharomyces cerevisiae)
- Rpt5 isoform 1 (48 kDa, Protein from baker's yeast)
- Rpt1 isoform 1 (52 kDa, Protein from baker's yeast)
- Ubp6-ubvs (Complex from Saccharomyces cerevisiae)
- Magnesium ion (24 Da, Ligand)
- Rpt6 isoform 1 (45 kDa, Protein from baker's yeast)
- Rpt4 isoform 1 (49 kDa, Protein from baker's yeast)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- 26s proteasome regulatory subunit rpn1 (109 kDa, Protein from baker's yeast)
- Ubiquitin carboxyl-terminal hydrolase (57 kDa, Protein from Saccharomyces cerevisiae)
Structure of the 26S proteasome-Ubp6 complex in the si state (Core Particle and Lid)
Resolution: 6.1 Å
EM Method: Single-particle
Fitted PDBs: 7qo3
Q-score: 0.133
Hung KYS, Klumpe S, Eisele MR, Elsasser S, Tian G, Sun S, Moroco JA, Cheng TC, Joshi T, Seibel T, Van Dalen D, Feng XH, Lu Y, Ovaa H, Engen JR, Lee BH, Rudack T, Sakata E, Finley D
Nat Commun (2022) 13 pp. 838-838 [ DOI: doi:10.1038/s41467-022-28186-y Pubmed: 35149681 ]
- Probable proteasome subunit alpha type-7 (31 kDa, Protein from baker's yeast)
- Proteasome subunit beta type-3 (22 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit rpn5 (51 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit rpn3 (60 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit rpn7 (49 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit rpn9 (45 kDa, Protein from baker's yeast)
- Proteasome subunit alpha type-3 (28 kDa, Protein from baker's yeast)
- Proteasome subunit alpha type-2 (27 kDa, Protein from baker's yeast)
- Proteasome subunit alpha type-6 (25 kDa, Protein from baker's yeast)
- Ubiquitin carboxyl-terminal hydrolase rpn11 (34 kDa, Protein from baker's yeast)
- Proteasome subunit alpha type-5 (28 kDa, Protein from baker's yeast)
- 26s proteasome complex subunit sem1 (10 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit rpn2 (104 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit rpn8 (38 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit rpn1 (109 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit rpn13 (17 kDa, Protein from baker's yeast)
- Proteasome subunit alpha type-4 (28 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit rpn6 (49 kDa, Protein from baker's yeast)
- Proteasome subunit beta type-6 (26 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit rpn10 (29 kDa, Protein from baker's yeast)
- Proteasome subunit beta type-1 (23 kDa, Protein from baker's yeast)
- Proteasome subunit beta type-2 (28 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit rpn12 (31 kDa, Protein from baker's yeast)
- 26s proteasome-ubp6 complex (si state) (Complex from Saccharomyces cerevisiae)
- Proteasome subunit beta type-4 (22 kDa, Protein from baker's yeast)
- Proteasome subunit beta type-5 (31 kDa, Protein from baker's yeast)
- Proteasome subunit beta type-7 (29 kDa, Protein from baker's yeast)
- Proteasome subunit alpha type-1 (28 kDa, Protein from baker's yeast)
26S proteasome Rpt1-RK -Ubp6-UbVS complex in the si state
Resolution: 6.0 Å
EM Method: Single-particle
Fitted PDBs: 7qo5
Q-score: 0.133
Hung KYS, Klumpe S, Eisele MR, Elsasser S, Tian G, Sun S, Moroco JA, Cheng TC, Joshi T, Seibel T, Van Dalen D, Feng XH, Lu Y, Ovaa H, Engen JR, Lee BH, Rudack T, Sakata E, Finley D
Nat Commun (2022) 13 pp. 838-838 [ DOI: doi:10.1038/s41467-022-28186-y Pubmed: 35149681 ]
- Probable proteasome subunit alpha type-7 (31 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit 4 homolog (48 kDa, Protein from baker's yeast)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Proteasome subunit beta type-3 (22 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit rpn5 (51 kDa, Protein from baker's yeast)
- 26s proteasome rpt1-rk -ubp6-ubvs complex in the si state (Complex)
- 26s proteasome regulatory subunit rpn3 (60 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit rpn7 (49 kDa, Protein from baker's yeast)
- Yeast rpt1-rk 26s proteasome in si state (Complex from Saccharomyces cerevisiae)
- 26s proteasome regulatory subunit rpn9 (45 kDa, Protein from baker's yeast)
- Ubiquitin carboxyl-terminal hydrolase 6 (57 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit alpha type-3 (28 kDa, Protein from baker's yeast)
- 26s proteasome subunit rpt4 (49 kDa, Protein from baker's yeast)
- Proteasome subunit alpha type-2 (27 kDa, Protein from baker's yeast)
- Proteasome subunit alpha type-6 (25 kDa, Protein from baker's yeast)
- Ubiquitin carboxyl-terminal hydrolase rpn11 (34 kDa, Protein from baker's yeast)
- Proteasome subunit alpha type-5 (28 kDa, Protein from baker's yeast)
- 26s proteasome complex subunit sem1 (10 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit 8 homolog (45 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit rpn2 (104 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit rpn8 (38 kDa, Protein from baker's yeast)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- 26s proteasome regulatory subunit rpn1 (109 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit rpn13 (17 kDa, Protein from baker's yeast)
- Proteasome subunit alpha type-4 (28 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit rpn6 (49 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit 7 homolog (52 kDa, Protein from baker's yeast)
- Proteasome subunit beta type-6 (26 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit rpn10 (29 kDa, Protein from baker's yeast)
- Proteasome subunit beta type-1 (23 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit 6a (48 kDa, Protein from baker's yeast)
- Polyubiquitin-b (8 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-2 (28 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit rpn12 (31 kDa, Protein from baker's yeast)
- Proteasome subunit beta type-4 (22 kDa, Protein from baker's yeast)
- Magnesium ion (24 Da, Ligand)
- Proteasome subunit beta type-5 (31 kDa, Protein from baker's yeast)
- Proteasome subunit beta type-7 (29 kDa, Protein from baker's yeast)
- Ubp6-ubvs complex (Complex from Saccharomyces cerevisiae)
- 26s proteasome regulatory subunit 6b homolog (47 kDa, Protein from baker's yeast)
- Proteasome subunit alpha type-1 (28 kDa, Protein from baker's yeast)
26S proteasome Rpt1-RK -Ubp6-UbVS complex in the s2 state
Resolution: 6.3 Å
EM Method: Single-particle
Fitted PDBs: 7qo6
Q-score: 0.096
Hung KYS, Klumpe S, Eisele MR, Elsasser S, Tian G, Sun S, Moroco JA, Cheng TC, Joshi T, Seibel T, Van Dalen D, Feng XH, Lu Y, Ovaa H, Engen JR, Lee BH, Rudack T, Sakata E, Finley D
Nat Commun (2022) 13 pp. 838-838 [ DOI: doi:10.1038/s41467-022-28186-y Pubmed: 35149681 ]
- Bj4_g0021480.mrna.1.cds.1 (28 kDa, Protein from baker's yeast)
- Proteasome subunit beta (22 kDa, Protein from baker's yeast)
- Probable proteasome subunit alpha type-7 (31 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit 4 homolog (48 kDa, Protein from baker's yeast)
- Hlj1_g0013750.mrna.1.cds.1 (26 kDa, Protein from baker's yeast)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- 26s proteasome regulatory subunit rpn5 (51 kDa, Protein from baker's yeast)
- Em14s01-3b_g0050020.mrna.1.cds.1 (31 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit rpn3 (60 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit rpn7 (49 kDa, Protein from baker's yeast)
- Hlj1_g0048980.mrna.1.cds.1 (28 kDa, Protein from baker's yeast)
- Bj4_g0043800.mrna.1.cds.1 (25 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit rpn9 (45 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit rpn11 (34 kDa, Protein from baker's yeast)
- 26s proteasome subunit rpt4 (49 kDa, Protein from baker's yeast)
- Hlj1_g0039880.mrna.1.cds.1 (27 kDa, Protein from baker's yeast)
- Bj4_g0020160.mrna.1.cds.1 (28 kDa, Protein from baker's yeast)
- Ubiquitin carboxyl-terminal hydrolase (57 kDa, Protein from Saccharomyces cerevisiae)
- 26s proteasome rpt1-rk -ubp6-ubvs complex in the s2 state (2 MDa, Complex from Saccharomyces cerevisiae)
- 26s proteasome complex subunit sem1 (10 kDa, Protein from baker's yeast)
- Em14s01-3b_g0035190.mrna.1.cds.1 (28 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit 8 homolog (45 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit rpn2 (104 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit rpn8 (38 kDa, Protein from baker's yeast)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- 26s proteasome regulatory subunit rpn1 (109 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit rpn6 (49 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit 7 homolog (52 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit rpn10 (29 kDa, Protein from baker's yeast)
- Proteasome endopeptidase complex (22 kDa, Protein from baker's yeast)
- Proteasome subunit beta type-1 (23 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit 6a (48 kDa, Protein from baker's yeast)
- Polyubiquitin-b (8 kDa, Protein from Homo sapiens)
- Proteasome endopeptidase complex (28 kDa, Protein from baker's yeast)
- Hlj1_g0030700.mrna.1.cds.1 (17 kDa, Protein from baker's yeast)
- Magnesium ion (24 Da, Ligand)
- Proteasome subunit beta type-5 (31 kDa, Protein from baker's yeast)
- Proteasome subunit beta type-7 (29 kDa, Protein from baker's yeast)
- 26s proteasome regulatory subunit 6b homolog (47 kDa, Protein from baker's yeast)
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 6fvw
Q-score: 0.204
Eisele MR, Reed RG, Rudack T, Schweitzer A, Beck F, Nagy I, Pfeifer G, Plitzko JM, Baumeister W, Tomko Jr RJ, Sakata E
Cell Rep (2018) 24 pp. 1301-1315.e5 [ DOI: doi:10.1016/j.celrep.2018.07.004 Pubmed: 30067984 ]
- 26s proteasome regulatory subunit rpn6 (49 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Ubiquitin carboxyl-terminal hydrolase rpn11 (32 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit 6a (46 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit 7 homolog (47 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Adenosine-5'-triphosphate (507 Da, Ligand)
- 26s proteasome regulatory subunit 6b homolog (43 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn10 (21 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-5 (23 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-7 (25 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn8 (34 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-6 (25 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit 4 homolog (43 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn2 (101 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome subunit rpt4 (43 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn7 (46 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-6 (24 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-1 (27 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-2 (24 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn13 (14 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn3 (55 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit 8 homolog (45 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn9 (45 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-2 (26 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Probable proteasome subunit alpha type-7 (27 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-3 (26 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-3 (22 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-5 (26 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn1 (106 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome complex subunit sem1 (10 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Adenosine-5'-diphosphate (427 Da, Ligand)
- 26s proteasome regulatory subunit rpn5 (51 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn12 (31 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome (Complex from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-4 (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Water (18 Da, Ligand)
- Proteasome subunit beta type-1 (21 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-4 (22 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Magnesium ion (24 Da, Ligand)
Resolution: 5.4 Å
EM Method: Single-particle
Fitted PDBs: 6fvv
Q-score: 0.149
Eisele MR, Reed RG, Rudack T, Schweitzer A, Beck F, Nagy I, Pfeifer G, Plitzko JM, Baumeister W, Tomko Jr RJ, Sakata E
Cell Rep (2018) 24 pp. 1301-1315.e5 [ DOI: doi:10.1016/j.celrep.2018.07.004 Pubmed: 30067984 ]
- 26s proteasome regulatory subunit rpn6 (49 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-1 (27 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Ubiquitin carboxyl-terminal hydrolase rpn11 (32 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Probable proteasome subunit alpha type-7 (26 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit 6a (46 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Proteasome subunit alpha type-4 (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-5 (26 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn10 (21 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-5 (23 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-7 (25 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn8 (34 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit 4 homolog (43 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn2 (101 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome subunit rpt4 (43 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn7 (46 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-6 (24 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-2 (24 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn13 (14 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-3 (27 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn3 (55 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn9 (45 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit 6b homolog (44 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit 8 homolog (45 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn1 (106 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-3 (22 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Adenosine-5'-diphosphate (427 Da, Ligand)
- 26s proteasome complex subunit sem1 (10 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit 7 homolog (46 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn5 (51 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-6 (25 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn12 (31 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome (Complex from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-2 (27 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-1 (21 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-4 (22 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Magnesium ion (24 Da, Ligand)
Resolution: 4.9 Å
EM Method: Single-particle
Fitted PDBs: 6fvx
Q-score: 0.187
Eisele MR, Reed RG, Rudack T, Schweitzer A, Beck F, Nagy I, Pfeifer G, Plitzko JM, Baumeister W, Tomko Jr RJ, Sakata E
Cell Rep (2018) 24 pp. 1301-1315.e5 [ DOI: doi:10.1016/j.celrep.2018.07.004 Pubmed: 30067984 ]
- 26s proteasome regulatory subunit rpn6 (49 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Ubiquitin carboxyl-terminal hydrolase rpn11 (32 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit 6a (46 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit 7 homolog (47 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Probable proteasome subunit alpha type-7 (26 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn10 (21 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-5 (23 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-7 (25 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn8 (34 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-6 (25 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit 4 homolog (43 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn2 (101 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome subunit rpt4 (43 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn7 (46 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-6 (24 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-2 (24 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn13 (14 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn3 (55 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn9 (45 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit 6b homolog (44 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit 8 homolog (45 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-3 (26 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn1 (106 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-3 (22 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Adenosine-5'-diphosphate (427 Da, Ligand)
- 26s proteasome complex subunit sem1 (10 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn5 (51 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-2 (26 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn12 (31 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome (Complex from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-4 (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-1 (27 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-1 (21 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-4 (22 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Magnesium ion (24 Da, Ligand)
Resolution: 6.1 Å
EM Method: Single-particle
Fitted PDBs: 6fvy
Q-score: 0.136
Eisele MR, Reed RG, Rudack T, Schweitzer A, Beck F, Nagy I, Pfeifer G, Plitzko JM, Baumeister W, Tomko Jr RJ, Sakata E
Cell Rep (2018) 24 pp. 1301-1315.e5 [ DOI: doi:10.1016/j.celrep.2018.07.004 Pubmed: 30067984 ]
- 26s proteasome regulatory subunit rpn6 (49 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Ubiquitin carboxyl-terminal hydrolase rpn11 (32 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit 6a (46 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit 7 homolog (47 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Adenosine-5'-triphosphate (507 Da, Ligand)
- 26s proteasome regulatory subunit rpn10 (21 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-5 (23 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-7 (25 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn8 (34 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-6 (25 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit 4 homolog (43 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn2 (101 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-2 (26 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome subunit rpt4 (43 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn7 (46 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-6 (24 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-1 (27 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-2 (24 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn13 (14 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn3 (55 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn9 (45 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit 6b homolog (44 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit 8 homolog (45 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Probable proteasome subunit alpha type-7 (27 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-3 (26 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-3 (22 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-5 (26 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn1 (106 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome complex subunit sem1 (10 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Adenosine-5'-diphosphate (427 Da, Ligand)
- 26s proteasome regulatory subunit rpn5 (51 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn12 (31 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome (Complex from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-4 (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-1 (21 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-4 (22 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Magnesium ion (24 Da, Ligand)
The human 26S Proteasome at 6.8 Ang.
Resolution: 6.8 Å
EM Method: Single-particle
Fitted PDBs: 5ln3
Q-score: 0.141
Wang X, Cimermancic P, Yu C, Schweitzer A, Chopra N, Engel JL, Greenberg C, Huszagh AS, Beck F, Sakata E, Yang Y, Novitsky EJ, Leitner A, Nanni P, Kahraman A, Guo X, Dixon JE, Rychnovsky SD, Aebersold R, Baumeister W, Sali A, Huang L
Mol Cell Proteomics (2017) 16 pp. 840-854 [ Pubmed: 28292943 DOI: doi:10.1074/mcp.M116.065326 ]
- Proteasome subunit beta type-5 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 14 (34 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (29 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 7 (37 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 4 (40 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 4 (49 kDa, Protein from Homo sapiens)
- Human 26s proteasome (2 MDa, Complex from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 6 (45 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 6a (49 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 12 (52 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-6 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 8 (45 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 10b (44 kDa, Protein from Homo sapiens)
- 26s proteasome complex subunit dss1 (8 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (30 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 7 (48 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 6b (47 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 2 (100 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 3 (61 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 8 (39 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-1 (26 kDa, Protein from Homo sapiens)