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Human 20S proteasome core particle
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7nan
Q-score: 0.531
Zhao J, Makhija S, Zhou C, Zhang H, Wang Y, Muralidharan M, Huang B, Cheng Y
PNAS (2022) 119 pp. e2207200119-e2207200119 [ DOI: doi:10.1073/pnas.2207200119 Pubmed: 35858375 ]
- Proteasome subunit beta type-1 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-6 (25 kDa, Protein from Homo sapiens)
- 20s proteasome core particle (Complex from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-5 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (30 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
Human PA28-20S proteasome complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7nao
Q-score: 0.512
Zhao J, Makhija S, Zhou C, Zhang H, Wang Y, Muralidharan M, Huang B, Cheng Y
PNAS (2022) 119 pp. e2207200119-e2207200119 [ DOI: doi:10.1073/pnas.2207200119 Pubmed: 35858375 ]
- Proteasome subunit beta type-1 (26 kDa, Protein from Homo sapiens)
- Proteasome activator complex subunit 2 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-6 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (30 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-5 (28 kDa, Protein from Homo sapiens)
- Pa28-20s proteasome complex (Complex from Homo sapiens)
- Proteasome activator complex subunit 1 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
Human PA28-20S-PA28 proteasome complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7nap
Q-score: 0.445
Zhao J, Makhija S, Zhou C, Zhang H, Wang Y, Muralidharan M, Huang B, Cheng Y
PNAS (2022) 119 pp. e2207200119-e2207200119 [ DOI: doi:10.1073/pnas.2207200119 Pubmed: 35858375 ]
- Proteasome subunit beta type-1 (26 kDa, Protein from Homo sapiens)
- Proteasome activator complex subunit 2 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-6 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome activator complex subunit 1 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-5 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (30 kDa, Protein from Homo sapiens)
- Pa28-20s-pa28 proteasome complex (Complex from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
Human PA200-20S proteasome complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7naq
Q-score: 0.483
Zhao J, Makhija S, Zhou C, Zhang H, Wang Y, Muralidharan M, Huang B, Cheng Y
PNAS (2022) 119 pp. e2207200119-e2207200119 [ DOI: doi:10.1073/pnas.2207200119 Pubmed: 35858375 ]
- Proteasome subunit beta type-1 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Proteasome subunit beta type-6 (25 kDa, Protein from Homo sapiens)
- Proteasome activator complex subunit 4 (211 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (29 kDa, Protein from Homo sapiens)
- Pa200-20s proteasome complex (Complex from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-5 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (30 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
Human 20S proteasome with MG-132
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8cvr
Q-score: 0.582
Zhao J, Makhija S, Zhou C, Zhang H, Wang Y, Muralidharan M, Huang B, Cheng Y
PNAS (2022) 119 pp. e2207200119-e2207200119 [ DOI: doi:10.1073/pnas.2207200119 Pubmed: 35858375 ]
- Proteasome subunit beta type-6 (21 kDa, Protein from human)
- N-[(benzyloxy)carbonyl]-l-leucyl-n-[(2s)-4-methyl-1-oxopentan-2-yl]-l-leucinamide (475 Da, Ligand)
- Proteasome subunit beta type-1 (26 kDa, Protein from human)
- Proteasome subunit beta type-2 (22 kDa, Protein from human)
- Proteasome subunit beta type-3 (22 kDa, Protein from human)
- 20s proteasome complex (Complex from Homo sapiens)
- Proteasome subunit beta type-5 (22 kDa, Protein from human)
- Proteasome subunit alpha type-1 (29 kDa, Protein from human)
- Proteasome subunit alpha type-3 (28 kDa, Protein from human)
- Proteasome subunit beta type-4 (29 kDa, Protein from human)
- Proteasome subunit alpha type-7 (27 kDa, Protein from human)
- Proteasome subunit beta type-7 (25 kDa, Protein from human)
- Proteasome subunit alpha type-4 (29 kDa, Protein from human)
- Proteasome subunit alpha type-5 (26 kDa, Protein from human)
- Proteasome subunit alpha type-2 (25 kDa, Protein from human)
- Proteasome subunit alpha type-6 (27 kDa, Protein from human)
Human PA28-20S proteasome with MG-132 (mixed PA28 subunits)
Zhao J, Makhija S, Zhou C, Zhang H, Wang Y, Muralidharan M, Huang B, Cheng Y
PNAS (2022) 119 pp. e2207200119-e2207200119 [ DOI: doi:10.1073/pnas.2207200119 Pubmed: 35858375 ]
Human PA200-20S proteasome with MG-132
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8cvs
Q-score: 0.559
Zhao J, Makhija S, Zhou C, Zhang H, Wang Y, Muralidharan M, Huang B, Cheng Y
PNAS (2022) 119 pp. e2207200119-e2207200119 [ DOI: doi:10.1073/pnas.2207200119 Pubmed: 35858375 ]
- Proteasome subunit beta type-6 (21 kDa, Protein from human)
- Proteasome activator complex subunit 4 (211 kDa, Protein from human)
- Proteasome subunit beta type-1 (26 kDa, Protein from human)
- Proteasome subunit beta type-2 (22 kDa, Protein from human)
- Proteasome subunit beta type-3 (22 kDa, Protein from human)
- N-[(benzyloxy)carbonyl]-l-leucyl-n-[(2s)-4-methyl-1-oxopentan-2-yl]-l-leucinamide (475 Da, Ligand)
- Inositol hexakisphosphate (660 Da, Ligand)
- Pa200-20s proteasome (Complex from Homo sapiens)
- Proteasome subunit beta type-5 (22 kDa, Protein from human)
- Proteasome subunit alpha type-1 (29 kDa, Protein from human)
- Proteasome subunit alpha type-3 (28 kDa, Protein from human)
- Proteasome subunit beta type-4 (29 kDa, Protein from human)
- Proteasome subunit alpha type-7 (27 kDa, Protein from human)
- Proteasome subunit beta type-7 (25 kDa, Protein from human)
- Proteasome subunit alpha type-4 (29 kDa, Protein from human)
- Proteasome subunit alpha type-5 (26 kDa, Protein from human)
- Proteasome subunit alpha type-2 (25 kDa, Protein from human)
- Proteasome subunit alpha type-6 (27 kDa, Protein from human)
Human 19S-20S proteasome, state SA
Zhao J, Makhija S, Zhou C, Zhang H, Wang Y, Muralidharan M, Huang B, Cheng Y
PNAS (2022) 119 pp. e2207200119-e2207200119 [ DOI: doi:10.1073/pnas.2207200119 Pubmed: 35858375 ]
Human 19S-20S proteasome, state SD1
Zhao J, Makhija S, Zhou C, Zhang H, Wang Y, Muralidharan M, Huang B, Cheng Y
PNAS (2022) 119 pp. e2207200119-e2207200119 [ DOI: doi:10.1073/pnas.2207200119 Pubmed: 35858375 ]
Human 19S-20S proteasome, state SD2
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8cvt
Q-score: 0.376
Zhao J, Makhija S, Zhou C, Zhang H, Wang Y, Muralidharan M, Huang B, Cheng Y
PNAS (2022) 119 pp. e2207200119-e2207200119 [ DOI: doi:10.1073/pnas.2207200119 Pubmed: 35858375 ]
- Proteasome subunit beta type-7 (30 kDa, Protein from human)
- Proteasome subunit beta type-1 (26 kDa, Protein from human)
- Human 19s-20s proteasome (Complex from Homo sapiens)
- 26s proteasome regulatory subunit 6a (49 kDa, Protein from human)
- 26s proteasome regulatory subunit 6b (47 kDa, Protein from human)
- Proteasome subunit beta type-4 (29 kDa, Protein from human)
- 26s proteasome non-atpase regulatory subunit 14 (34 kDa, Protein from human)
- 26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from human)
- 26s proteasome non-atpase regulatory subunit 8 (39 kDa, Protein from human)
- Proteasome subunit alpha type-2 (25 kDa, Protein from human)
- 26s proteasome regulatory subunit 4 (49 kDa, Protein from human)
- Proteasome subunit alpha type-6 (27 kDa, Protein from human)
- N-[(benzyloxy)carbonyl]-l-leucyl-n-[(2s)-4-methyl-1-oxopentan-2-yl]-l-leucinamide (475 Da, Ligand)
- 26s proteasome non-atpase regulatory subunit 3 (61 kDa, Protein from human)
- 26s proteasome non-atpase regulatory subunit 2 (100 kDa, Protein from human)
- Proteasome subunit alpha type-4 (29 kDa, Protein from human)
- 26s protease regulatory subunit 10b (44 kDa, Protein from human)
- 26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from human)
- Proteasome subunit beta type-2 (22 kDa, Protein from human)
- Proteasome subunit alpha type-1 (29 kDa, Protein from human)
- 26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from human)
- 26s proteasome complex subunit sem1 (8 kDa, Protein from human)
- Proteasome subunit beta type-5 (28 kDa, Protein from human)
- Zinc ion (65 Da, Ligand)
- 26s proteasome regulatory subunit 7 (48 kDa, Protein from human)
- Proteasome subunit beta type-3 (22 kDa, Protein from human)
- Proteasome subunit alpha type-3 (28 kDa, Protein from human)
- Proteasome subunit beta type-6 (25 kDa, Protein from human)
- 26s protease regulatory subunit 8 (45 kDa, Protein from human)
- Proteasome subunit alpha type-7 (27 kDa, Protein from human)
- 26s proteasome non-atpase regulatory subunit 7 (37 kDa, Protein from human)
- 26s proteasome non-atpase regulatory subunit 6 (45 kDa, Protein from human)
- 26s proteasome non-atpase regulatory subunit 4 (40 kDa, Protein from human)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Proteasome subunit alpha type-5 (26 kDa, Protein from human)
- 26s proteasome non-atpase regulatory subunit 12 (52 kDa, Protein from human)