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Cryo-EM structure of human NCX1 in complex with SEA0400
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8sgi
Q-score: 0.553
To Be Published
- Sodium ion (22 Da, Ligand)
- Human ncx1-sea0400 in complex with antibody fab fragment (Complex)
- Fab heavy chain (26 kDa, Protein from Mus musculus)
- Calcium ion (40 Da, Ligand)
- 2-{4-[(2,5-difluorophenyl)methoxy]phenoxy}-5-ethoxyaniline (371 Da, Ligand)
- Fab light chain (21 kDa, Protein from Mus musculus)
- Water (18 Da, Ligand)
- Antibody fab fragment (Complex from Mus musculus)
- Sodium/calcium exchanger 1 (109 kDa, Protein from Homo sapiens)
- Human cardiac sodium calcium exchanger ncx1 in complex with sea0400 (Complex from Homo sapiens)
Cryo-EM structure of human NCX1 in apo inactivated state
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8sgj
Q-score: 0.499
Xue J, Zeng W, Han Y, John S, Ottolia M, Jiang Y
Nat Commun (2023) 14 pp. 6181-6181 [ DOI: doi:10.1038/s41467-023-41885-4 Pubmed: 37794011 ]
- Sodium ion (22 Da, Ligand)
- Fab heavy chain (26 kDa, Protein from Mus musculus)
- Calcium ion (40 Da, Ligand)
- Human cardiac ncx1 in apo inactivated state (Complex from Homo sapiens)
- Human cardiac ncx1 in complex with antibody fab fragment (Complex)
- Fab light chain (21 kDa, Protein from Mus musculus)
- Water (18 Da, Ligand)
- Antibody fab fragment (Complex from Mus musculus)
- Sodium/calcium exchanger 1 (109 kDa, Protein from Homo sapiens)
Xue J, Zeng W, Han Y, John S, Ottolia M, Jiang Y
Nat Commun (2023) 14 pp. 6181-6181 [ DOI: doi:10.1038/s41467-023-41885-4 Pubmed: 37794011 ]
- Human cardiac sodium calcium exchanger ncx1 in apo, inactivated state ( group i in the presence of 0.5mm ca2+) and bound fab fragment (Complex)
- Antibody fab fragment (Complex from Mus musculus)
- Human cardiac sodium calcium exchanger ncx1 (Protein from Homo sapiens)
- Human cardiac sodium calcium exchanger ncx1 in apo, inactivated state ( group i in the presence of 0.5mm ca2+) (Complex from Homo sapiens)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8sgt
Q-score: 0.239
Xue J, Zeng W, Han Y, John S, Ottolia M, Jiang Y
Nat Commun (2023) 14 pp. 6181-6181 [ DOI: doi:10.1038/s41467-023-41885-4 Pubmed: 37794011 ]
- Fab heavy chain (26 kDa, Protein from Mus musculus)
- Calcium ion (40 Da, Ligand)
- Human ncx1 in ca bound, activated state (Complex from Homo sapiens)
- Fab light chain (21 kDa, Protein from Mus musculus)
- Human ncx1 in complex with antibody fab fragment (Complex)
- Antibody fab fragment (Complex from Mus musculus)
- Sodium/calcium exchanger 1 (109 kDa, Protein from Homo sapiens)
Outward_facing SLC15A4 monomer
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 8jzr
Q-score: 0.477
Chen X, Xie M, Zhang S, Monguio-Tortajada M, Yin J, Liu C, Zhang Y, Delacretaz M, Song M, Wang Y, Dong L, Ding Q, Zhou B, Tian X, Deng H, Xu L, Liu X, Yang Z, Chang Q, Na J, Zeng W, Superti-Furga G, Rebsamen M, Yang M
Nat Commun (2023) 14 pp. 6627-6627 [ Pubmed: 37863913 DOI: doi:10.1038/s41467-023-42210-9 ]
- Endolysosomal transporter (Cellular component from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Lysosomal transporter,alfa tag (62 kDa, Protein from Homo sapiens)
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 8jzs
Q-score: 0.521
Chen X, Xie M, Zhang S, Monguio-Tortajada M, Yin J, Liu C, Zhang Y, Delacretaz M, Song M, Wang Y, Dong L, Ding Q, Zhou B, Tian X, Deng H, Xu L, Liu X, Yang Z, Chang Q, Na J, Zeng W, Superti-Furga G, Rebsamen M, Yang M
Nat Commun (2023) 14 pp. 6627-6627 [ Pubmed: 37863913 DOI: doi:10.1038/s41467-023-42210-9 ]
- Endolysosomal transporter (Cellular component from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Lysosomal transporter (66 kDa, Protein from Homo sapiens)
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 8jzu
Q-score: 0.443
Chen X, Xie M, Zhang S, Monguio-Tortajada M, Yin J, Liu C, Zhang Y, Delacretaz M, Song M, Wang Y, Dong L, Ding Q, Zhou B, Tian X, Deng H, Xu L, Liu X, Yang Z, Chang Q, Na J, Zeng W, Superti-Furga G, Rebsamen M, Yang M
Nat Commun (2023) 14 pp. 6627-6627 [ Pubmed: 37863913 DOI: doi:10.1038/s41467-023-42210-9 ]
- Endolysosomal transporter (Cellular component from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Lysosomal transporter (62 kDa, Protein from Homo sapiens)
- Tlr adapter interacting with slc15a4 on the lysosome (33 kDa, Protein from Homo sapiens)
Cryo-EM structure of a riboendonclease
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8ewg
Q-score: 0.518
Cryo-EM structure of a riboendonuclease
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8h4u
Q-score: 0.439
Human TMEM175-LAMP1 full-length complex
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8fy5
Q-score: 0.505
Zhang J, Zeng W, Han Y, Lee WR, Liou J, Jiang Y
Mol Cell (2023) 83 pp. 2524-2539.e7 [ DOI: doi:10.1016/j.molcel.2023.06.004 Pubmed: 37390818 ]
- Lysosome-associated membrane glycoprotein 1 (44 kDa, Protein from Homo sapiens)
- Tmem175-lamp1 full-length (Complex from Homo sapiens)
- Endosomal/lysosomal potassium channel tmem175 (55 kDa, Protein from Homo sapiens)