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Zuo H, Park J, Frangaj A, Ye J, Lu G, Manning JJ, Asher WB, Lu Z, Hu GB, Wang L, Mendez J, Eng E, Zhang Z, Lin X, Grassucci R, Hendrickson WA, Clarke OB, Javitch JA, Conigrave AD, Fan QR
Nature (2024) [ DOI: 10.1038/s41586-024-07331-1 Pubmed: 38632411 ]
Image sets:
Structure of human calcium-sensing receptor in complex with miniGi1 protein in detergent
Zuo H, Park J, Frangaj A, Ye J, Lu G, Manning JJ, Asher WB, Lu Z, Hu GB, Wang L, Mendez J, Eng E, Zhang Z, Lin X, Grassucci R, Hendrickson WA, Clarke OB, Javitch JA, Conigrave AD, Fan QR
Nature (2024) 629 pp. 481-488 [ DOI: 10.1038/s41586-024-07331-1 Pubmed: 38632411 ]
Image sets:
Structure of human calcium-sensing receptor in complex with Gi3 protein in nanodiscs
Zuo H, Park J, Frangaj A, Ye J, Lu G, Manning JJ, Asher WB, Lu Z, Hu GB, Wang L, Mendez J, Eng E, Zhang Z, Lin X, Grassucci R, Hendrickson WA, Clarke OB, Javitch JA, Conigrave AD, Fan QR
Nature (2024) [ DOI: 10.1038/s41586-024-07331-1 Pubmed: 38632411 ]
Image sets:
Zuo H, Park J, Frangaj A, Ye J, Lu G, Manning JJ, Asher WB, Lu Z, Hu GB, Wang L, Mendez J, Eng E, Zhang Z, Lin X, Grassucci R, Hendrickson WA, Clarke OB, Javitch JA, Conigrave AD, Fan QR
Nature (2024) [ DOI: 10.1038/s41586-024-07331-1 Pubmed: 38632411 ]
Image sets:
Zuo H, Park J, Frangaj A, Ye J, Lu G, Manning JJ, Asher WB, Lu Z, Hu G, Wang L, Mendez J, Eng E, Zhang Z, Lin X, Grasucci R, Hendrickson WA, Clarke OB, Javitch JA, Conigrave AD, Fan QR
To Be Published
Image sets:
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 9asb
Q-score: 0.524
Zuo H, Park J, Frangaj A, Ye J, Lu G, Manning JJ, Asher WB, Lu Z, Hu GB, Wang L, Mendez J, Eng E, Zhang Z, Lin X, Grassucci R, Hendrickson WA, Clarke OB, Javitch JA, Conigrave AD, Fan QR
Nature (2024) 629 pp. 481-488 [ Pubmed: 38632411 DOI: doi:10.1038/s41586-024-07331-1 ]
- Isoform 1 of extracellular calcium-sensing receptor (102 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Phosphate ion (94 Da, Ligand)
- (19r,22s,25r)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9z)-octadec-9-enoate (749 Da, Ligand)
- 3-(2-chlorophenyl)-n-[(1r)-1-(3-methoxyphenyl)ethyl]propan-1-amine (303 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Human casr in complex with chimeric gq (minigisq) protein (276 kDa, Complex from Homo sapiens)
- Chimeric mini guanine nucleotide-binding protein g(i)(s)(q) subunit alpha (28 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Chimeric mini guanine nucleotide-binding protein g(i)(s)(q) subunit alpha (7 kDa, Protein from Homo sapiens)
- Cyclomethyltryptophan (216 Da, Ligand)
- Calcium ion (40 Da, Ligand)
Consensus map of human CaSR-miniGisq complex in nanodiscs
Zuo H, Park J, Frangaj A, Ye J, Lu G, Manning JJ, Asher WB, Lu Z, Hu GB, Wang L, Mendez J, Eng E, Zhang Z, Lin X, Grassucci R, Hendrickson WA, Clarke OB, Javitch JA, Conigrave AD, Fan QR
Nature (2024) 629 pp. 481-488 [ Pubmed: 38632411 DOI: doi:10.1038/s41586-024-07331-1 ]
Zuo H, Park J, Frangaj A, Ye J, Lu G, Manning JJ, Asher WB, Lu Z, Hu GB, Wang L, Mendez J, Eng E, Zhang Z, Lin X, Grassucci R, Hendrickson WA, Clarke OB, Javitch JA, Conigrave AD, Fan QR
Nature (2024) 629 pp. 481-488 [ Pubmed: 38632411 DOI: doi:10.1038/s41586-024-07331-1 ]
Zuo H, Park J, Frangaj A, Ye J, Lu G, Manning JJ, Asher WB, Lu Z, Hu GB, Wang L, Mendez J, Eng E, Zhang Z, Lin X, Grassucci R, Hendrickson WA, Clarke OB, Javitch JA, Conigrave AD, Fan QR
Nature (2024) 629 pp. 481-488 [ Pubmed: 38632411 DOI: doi:10.1038/s41586-024-07331-1 ]