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Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor
Dissociated S1 domain of SARS-CoV-2 Spike bound to ACE2 (Unmasked Refinement)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7a92
Q-score: 0.293
Benton DJ, Wrobel AG, Xu P, Roustan C, Martin SR, Rosenthal PB, Skehel JJ, Gamblin SJ
Nature (2020) 588 pp. 327-330 [ DOI: doi:10.1038/s41586-020-2772-0 Pubmed: 32942285 ]
- Angiotensin-converting enzyme 2 (75 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Angiotensin-converting enzyme 2 (Complex from Homo sapiens)
- Dissociated s1 domain of sars-cov-2 spike bound to ace2 (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (79 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
The mouse cGAS catalytic domain binding to human nucleosome that purified from HEK293T cells
Resolution: 4.36 Å
EM Method: Single-particle
Fitted PDBs: 6x5a
Q-score: 0.265
Zhao B, Xu P, Rowlett CM, Jing T, Shinde O, Lei Y, West AP, Liu WR, Li P
Nature (2020) 587 pp. 673-677 [ Pubmed: 32911481 DOI: doi:10.1038/s41586-020-2749-z ]
- Histone h2b type 1-c/e/f/g/i (13 kDa, Protein from Homo sapiens)
- Histone h3.2 (15 kDa, Protein from Homo sapiens)
- Dna (natural) (45 kDa, DNA from Homo sapiens)
- Histone h4 (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Dna (natural) (45 kDa, DNA from Homo sapiens)
- Cgas-nucleosome complex (Complex from Homo sapiens)
- Cyclic gmp-amp synthase (43 kDa, Protein from Mus musculus)
- Histone h2a type 1 (13 kDa, Protein from Homo sapiens)
Two mouse cGAS catalytic domain binding to human assembled nucleosome
Resolution: 6.8 Å
EM Method: Single-particle
Fitted PDBs: 6xjd
Q-score: 0.196
Zhao B, Xu P, Rowlett CM, Jing T, Shinde O, Lei Y, West AP, Liu WR, Li P
Nature (2020) 587 pp. 673-677 [ Pubmed: 32911481 DOI: doi:10.1038/s41586-020-2749-z ]
- Dna (145-mer) (45 kDa, DNA from Homo sapiens)
- Cyclic gmp-amp synthase (Complex from Mus musculus)
- Histone (Complex from Homo sapiens)
- Histone h3.2 (15 kDa, Protein from Homo sapiens)
- Dna (145-mer) (45 kDa, DNA from Homo sapiens)
- Histone h2b type 1-c/e/f/g/i (13 kDa, Protein from Homo sapiens)
- Histone h4 (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cgas-nucleosome complex (Complex)
- Cyclic gmp-amp synthase (43 kDa, Protein from Mus musculus)
- Dna (Complex from Homo sapiens)
- Histone h2a type 1 (13 kDa, Protein from Homo sapiens)
Furin Cleaved Spike Protein of SARS-CoV-2 in Intermediate Conformation
Resolution: 6.8 Å
EM Method: Single-particle
Fitted PDBs: 6zgh
Q-score: 0.151
Wrobel AG, Benton DJ, Xu P, Roustan C, Martin SR, Rosenthal PB, Skehel JJ, Gamblin SJ
Nat Struct Mol Biol (2020) 27 pp. 763-767 [ DOI: doi:10.1038/s41594-020-0468-7 Pubmed: 32647346 ]