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phospho-STING binding to adaptor protein complex-1
Resolution: 2.34 Å
EM Method: Single-particle
Fitted PDBs: 7r4h
Q-score: 0.551
Liu Y, Xu P, Rivara S, Liu C, Ricci J, Ren X, Hurley JH, Ablasser A
Nature (2022) 610 pp. 761-767 [ DOI: doi:10.1038/s41586-022-05354-0 Pubmed: 36261523 ]
- Ap-1 complex subunit gamma-1 (67 kDa, Protein from Mus musculus)
- Adp-ribosylation factor 1 (18 kDa, Protein from Homo sapiens)
- Stimulator of interferon genes protein (1 kDa, Protein from Homo sapiens)
- Ap-1 complex subunit mu-1 (48 kDa, Protein from Mus musculus)
- Ap-1 complex subunit sigma-3 (18 kDa, Protein from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Ap-1 complex subunit beta-1 (66 kDa, Protein from Homo sapiens)
- Phospho-sting binding to adaptor protein complex-1 (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
Serotonin 5A (5-HT5A) receptor-Gi protein complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7x5h
Q-score: 0.497
Tan Y, Xu P, Huang S, Yang G, Zhou F, He X, Ma H, Xu HE, Jiang Y
Cell Discov (2022) 8 pp. 50-50 [ Pubmed: 35610220 DOI: doi:10.1038/s41421-022-00412-3 ]
- 5-ht5a-gi-scfv16 complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from Mus musculus)
- 5-ht5a-gi (Complex from Mus musculus)
- 3-(2-azanylethyl)-1h-indole-5-carboxamide (203 Da, Ligand)
- Scfv16 (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 5a,hydroxytryptamine receptor 5a (77 kDa, Protein from Homo sapiens)
Cryo-EM structure of the apo CCR3-Gi complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7x9y
Q-score: 0.375
Shao Z, Tan Y, Shen Q, Hou L, Yao B, Qin J, Xu P, Mao C, Chen LN, Zhang H, Shen DD, Zhang C, Li W, Du X, Li F, Chen ZH, Jiang Y, Xu HE, Ying S, Ma H, Zhang Y, Shen H
Cell Discov (2022) 8 pp. 44-44 [ Pubmed: 35570218 DOI: doi:10.1038/s41421-022-00403-4 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cryo-em structure of the apo ccr3-gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- C-c chemokine receptor type 3 (41 kDa, Protein from Homo sapiens)
Cryo-EM structure of the CCL2 bound CCR2-Gi complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7xa3
Q-score: 0.454
Shao Z, Tan Y, Shen Q, Hou L, Yao B, Qin J, Xu P, Mao C, Chen LN, Zhang H, Shen DD, Zhang C, Li W, Du X, Li F, Chen ZH, Jiang Y, Xu HE, Ying S, Ma H, Zhang Y, Shen H
Cell Discov (2022) 8 pp. 44-44 [ Pubmed: 35570218 DOI: doi:10.1038/s41421-022-00403-4 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Isoform b of c-c chemokine receptor type 2 (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- C-c motif chemokine 2 (7 kDa, Protein from Homo sapiens)
- Cryo-em structure of the apo ccr3-gi complex (Complex from Homo sapiens)
- Scfv16 (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
TSHR-thyroid stimulating hormone-Gs-ML109 complex
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 7xw5
Q-score: 0.482
Duan J, Xu P, Luan X, Ji Y, He X, Song N, Yuan Q, Jin Y, Cheng X, Jiang H, Zheng J, Zhang S, Jiang Y, Xu HE
Nature (2022) 609 pp. 854-859 [ Pubmed: 35940204 DOI: doi:10.1038/s41586-022-05173-3 ]
- Thyrotropin subunit beta (13 kDa, Protein from Homo sapiens)
- ~{n}-[4-[[2-methoxy-5-[(2~{s})-5-oxidanyl-4-oxidanylidene-3-(phenylmethyl)-1,2-dihydroquinazolin-2-yl]phenyl]methoxy]phenyl]ethanamide (523 Da, Ligand)
- Nanobody35 (14 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Glycoprotein hormones alpha chain (10 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Thyrotropin receptor (79 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (29 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- Tshr-thyroid stimulating hormone-gs-ml109 complex (Complex from Homo)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7xz5
Q-score: 0.514
Xu P, Huang S, Guo S, Yun Y, Cheng X, He X, Cai P, Lan Y, Zhou H, Jiang H, Jiang Y, Xie X, Xu HE
Nat Struct Mol Biol (2022) 29 pp. 863-870 [ DOI: doi:10.1038/s41594-022-00816-5 Pubmed: 35970999 ]
- Gpr119-gs (Complex from Homo sapiens)
- (4r,7r,18e)-4,7-dihydroxy-n,n,n-trimethyl-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide (522 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nanobody35 (15 kDa, Protein from Lama glama)
- Nb35 (Complex)
- Soluble cytochrome b562,glucose-dependent insulinotropic receptor (53 kDa, Protein from Homo sapiens)
- Gpr119-gs-nb35-lpc complex (Complex from Homo sapiens)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7xz6
Q-score: 0.552
Xu P, Huang S, Guo S, Yun Y, Cheng X, He X, Cai P, Lan Y, Zhou H, Jiang H, Jiang Y, Xie X, Xu HE
Nat Struct Mol Biol (2022) 29 pp. 863-870 [ DOI: doi:10.1038/s41594-022-00816-5 Pubmed: 35970999 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nanobody35 (15 kDa, Protein from Lama glama)
- Nb35 (Complex)
- Propan-2-yl 4-[1-(2-fluoranyl-4-methylsulfonyl-phenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxypiperidine-1-carboxylate (477 Da, Ligand)
- Soluble cytochrome b562,glucose-dependent insulinotropic receptor (53 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Gpr119-gs (Complex from Lama glama)
- Gpr119-gs-nb35-apd668 complex (Complex from Homo sapiens)
TSHR-Gs-M22 antibody-ML109 complex
Resolution: 2.78 Å
EM Method: Single-particle
Fitted PDBs: 7xw6
Q-score: 0.441
Duan J, Xu P, Luan X, Ji Y, He X, Song N, Yuan Q, Jin Y, Cheng X, Jiang H, Zheng J, Zhang S, Jiang Y, Xu HE
Nature (2022) 609 pp. 854-859 [ Pubmed: 35940204 DOI: doi:10.1038/s41586-022-05173-3 ]
- Cholesterol (386 Da, Ligand)
- ~{n}-[4-[[2-methoxy-5-[(2~{s})-5-oxidanyl-4-oxidanylidene-3-(phenylmethyl)-1,2-dihydroquinazolin-2-yl]phenyl]methoxy]phenyl]ethanamide (523 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- The complex was assembled by co-expression. (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Thyrotropin receptor (79 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Nanobody35 (14 kDa, Protein from Homo sapiens)
- M22 antibody heavy chain (13 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (29 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- M22 antibody light chain (11 kDa, Protein from Mus musculus)
Resolution: 5.5 Å
EM Method: Single-particle
Fitted PDBs: 7xw7
Q-score: 0.04
Duan J, Xu P, Luan X, Ji Y, He X, Song N, Yuan Q, Jin Y, Cheng X, Jiang H, Zheng J, Zhang S, Jiang Y, Xu HE
Nature (2022) 609 pp. 854-859 [ Pubmed: 35940204 DOI: doi:10.1038/s41586-022-05173-3 ]
- Thyrotropin receptor (79 kDa, Protein from Homo sapiens)
- K1-70 scfv (24 kDa, Protein from Homo sapiens)
- Tshr-thyroid stimulating hormone-gs-ml109 complex (Complex from Homo)
Serotonin 4 (5-HT4) receptor-Gs-Nb35 complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7xt8
Q-score: 0.533
Huang S, Xu P, Shen DD, Simon IA, Mao C, Tan Y, Zhang H, Harpsoe K, Li H, Zhang Y, You C, Yu X, Jiang Y, Zhang Y, Gloriam DE, Xu HE
Mol Cell (2022) 82 pp. 2681-2695.e6 [ DOI: doi:10.1016/j.molcel.2022.05.031 Pubmed: 35714614 ]
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 4 (59 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nanobody35 (15 kDa, Protein from Lama glama)
- Serotonin 4 (5-ht4) receptor-gs-nb35 complex (Complex from Homo sapiens)
- Serotonin (176 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)