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Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7xz5
Q-score: 0.514
Xu P, Huang S, Guo S, Yun Y, Cheng X, He X, Cai P, Lan Y, Zhou H, Jiang H, Jiang Y, Xie X, Xu HE
Nat Struct Mol Biol (2022) 29 pp. 863-870 [ DOI: doi:10.1038/s41594-022-00816-5 Pubmed: 35970999 ]
- Gpr119-gs (Complex from Homo sapiens)
- (4r,7r,18e)-4,7-dihydroxy-n,n,n-trimethyl-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide (522 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nanobody35 (15 kDa, Protein from Lama glama)
- Nb35 (Complex)
- Soluble cytochrome b562,glucose-dependent insulinotropic receptor (53 kDa, Protein from Homo sapiens)
- Gpr119-gs-nb35-lpc complex (Complex from Homo sapiens)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7xz6
Q-score: 0.552
Xu P, Huang S, Guo S, Yun Y, Cheng X, He X, Cai P, Lan Y, Zhou H, Jiang H, Jiang Y, Xie X, Xu HE
Nat Struct Mol Biol (2022) 29 pp. 863-870 [ DOI: doi:10.1038/s41594-022-00816-5 Pubmed: 35970999 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nanobody35 (15 kDa, Protein from Lama glama)
- Nb35 (Complex)
- Propan-2-yl 4-[1-(2-fluoranyl-4-methylsulfonyl-phenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxypiperidine-1-carboxylate (477 Da, Ligand)
- Soluble cytochrome b562,glucose-dependent insulinotropic receptor (53 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Gpr119-gs (Complex from Lama glama)
- Gpr119-gs-nb35-apd668 complex (Complex from Homo sapiens)
ghrelin-bound ghrelin receptor in complex with Gq
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7f9y
Q-score: 0.469
Wang Y, Guo S, Zhuang Y, Yun Y, Xu P, He X, Guo J, Yin W, Xu HE, Xie X, Jiang Y
Nat Commun (2021) 12 pp. 5064-5064 [ DOI: doi:10.1038/s41467-021-25364-2 Pubmed: 34417468 ]
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Nb35 (15 kDa, Protein from Lama glama)
- Ghrelin-28 (3 kDa, Protein from Homo sapiens)
- Octanoic acid (caprylic acid) (144 Da, Ligand)
- Engineered g-alpha-q subunit (41 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562 (74 kDa, Protein from Homo sapiens)
- Ghrelin-bound ghrelin receptor in complex with gq (Complex from Homo sapiens)
GHRP-6-bound ghrelin receptor in complex with Gq
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7f9z
Q-score: 0.363
Wang Y, Guo S, Zhuang Y, Yun Y, Xu P, He X, Guo J, Yin W, Xu HE, Xie X, Jiang Y
Nat Commun (2021) 12 pp. 5064-5064 [ DOI: doi:10.1038/s41467-021-25364-2 Pubmed: 34417468 ]
- Human ghrelin receptor (74 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (32 kDa, Protein from Mus musculus)
- Nb35 (15 kDa, Protein from Lama glama)
- Engineered g-alpha-q (41 kDa, Protein from Homo sapiens)
- Ghrp-6-bound ghrelin receptor in complex with gq (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- 3-pyridin-4-yl-2,4-dihydro-indeno[1,2-.c.]pyrazole (873 Da, Protein from synthetic construct)