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Structure of cGAS in complex with SPSB3-ELOBC
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 8okx
Q-score: 0.282
Xu P, Liu Y, Liu C, Guey B, Li L, Melenec P, Ricci J, Ablasser A
Nature (2024) 627 pp. 873-879 [ DOI: doi:10.1038/s41586-024-07112-w Pubmed: 38418882 ]
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Spry domain-containing socs box protein 3 (27 kDa, Protein from Homo sapiens)
- Cyclic gmp-amp synthase (42 kDa, Protein from Homo sapiens)
- Cgas-spsb3-elobc complex (Complex from Homo sapiens)
- Elongin-c (12 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
cGAS-Nucleosome in complex with SPSB3-ELOBC (composite structure)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8ol1
Q-score: 0.4
Xu P, Liu Y, Liu C, Guey B, Li L, Melenec P, Ricci J, Ablasser A
Nature (2024) 627 pp. 873-879 [ DOI: doi:10.1038/s41586-024-07112-w Pubmed: 38418882 ]
- Dna (145-mer) (44 kDa, DNA from Homo sapiens)
- Cyclic gmp-amp synthase (42 kDa, Protein from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Histone h2b type 1-h (10 kDa, Protein from Homo sapiens)
- Histone h2a type 1-h (11 kDa, Protein from Homo sapiens)
- Spry domain-containing socs box protein 3 (27 kDa, Protein from Homo sapiens)
- Dna (145-mer) (44 kDa, DNA from Homo sapiens)
- Histone h4 (9 kDa, Protein from Homo sapiens)
- Cgas-spsb3-elobc complex (Complex from Homo sapiens)
- Histone h2b type 1-n (10 kDa, Protein from Homo sapiens)
- Histone h2a type 1-j (11 kDa, Protein from Homo sapiens)
- Elongin-c (12 kDa, Protein from Homo sapiens)
- Histone h3.2 (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
Consensus refinement of cGAS/spsb3/EloBC/Nucleosome
Xu P, Liu Y, Liu C, Guey B, Li L, Melenec P, Ricci J, Ablasser A
Nature (2024) 627 pp. 873-879 [ DOI: doi:10.1038/s41586-024-07112-w Pubmed: 38418882 ]
human cGAS/spsb3/EloBC in complex with nucleosome (2:2)
Xu P, Liu Y, Liu C, Guey B, Li L, Melenec P, Ricci J, Ablasser A
Nature (2024) 627 pp. 873-879 [ DOI: doi:10.1038/s41586-024-07112-w Pubmed: 38418882 ]
phospho-STING binding to adaptor protein complex-1
Resolution: 2.34 Å
EM Method: Single-particle
Fitted PDBs: 7r4h
Q-score: 0.551
Liu Y, Xu P, Rivara S, Liu C, Ricci J, Ren X, Hurley JH, Ablasser A
Nature (2022) 610 pp. 761-767 [ DOI: doi:10.1038/s41586-022-05354-0 Pubmed: 36261523 ]
- Phospho-sting binding to adaptor protein complex-1 (Complex from Homo sapiens)
- Ap-1 complex subunit sigma-3 (18 kDa, Protein from Homo sapiens)
- Adp-ribosylation factor 1 (18 kDa, Protein from Homo sapiens)
- Stimulator of interferon genes protein (1 kDa, Protein from Homo sapiens)
- Ap-1 complex subunit mu-1 (48 kDa, Protein from Mus musculus)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Ap-1 complex subunit gamma-1 (67 kDa, Protein from Mus musculus)
- Ap-1 complex subunit beta-1 (66 kDa, Protein from Homo sapiens)
The mouse cGAS catalytic domain binding to human assembled nucleosome
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 6x59
Q-score: 0.54
Zhao B, Xu P, Rowlett CM, Jing T, Shinde O, Lei Y, West AP, Liu WR, Li P
Nature (2020) 587 pp. 673-677 [ DOI: doi:10.1038/s41586-020-2749-z Pubmed: 32911481 ]
- Cgas-nucleosome complex (Complex from Homo sapiens)
- Histone h2a type 1 (13 kDa, Protein from Homo sapiens)
- Histone h3.2 (15 kDa, Protein from Homo sapiens)
- Histone h4 (11 kDa, Protein from Homo sapiens)
- Dna (45 kDa, DNA from Homo sapiens)
- Dna (45 kDa, DNA from Homo sapiens)
- Histone h2b type 1-c/e/f/g/i (13 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cyclic gmp-amp synthase (43 kDa, Protein from Mus musculus)
The mouse cGAS catalytic domain binding to human nucleosome that purified from HEK293T cells
Resolution: 4.36 Å
EM Method: Single-particle
Fitted PDBs: 6x5a
Q-score: 0.265
Zhao B, Xu P, Rowlett CM, Jing T, Shinde O, Lei Y, West AP, Liu WR, Li P
Nature (2020) 587 pp. 673-677 [ DOI: doi:10.1038/s41586-020-2749-z Pubmed: 32911481 ]
- Cgas-nucleosome complex (Complex from Homo sapiens)
- Histone h2b type 1-c/e/f/g/i (13 kDa, Protein from Homo sapiens)
- Dna (natural) (45 kDa, DNA from Homo sapiens)
- Histone h3.2 (15 kDa, Protein from Homo sapiens)
- Histone h4 (11 kDa, Protein from Homo sapiens)
- Dna (natural) (45 kDa, DNA from Homo sapiens)
- Histone h2a type 1 (13 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cyclic gmp-amp synthase (43 kDa, Protein from Mus musculus)
Two mouse cGAS catalytic domain binding to human assembled nucleosome
Resolution: 6.8 Å
EM Method: Single-particle
Fitted PDBs: 6xjd
Q-score: 0.196
Zhao B, Xu P, Rowlett CM, Jing T, Shinde O, Lei Y, West AP, Liu WR, Li P
Nature (2020) 587 pp. 673-677 [ DOI: doi:10.1038/s41586-020-2749-z Pubmed: 32911481 ]
- Cyclic gmp-amp synthase (Complex from Mus musculus)
- Histone h2b type 1-c/e/f/g/i (13 kDa, Protein from Homo sapiens)
- Histone h2a type 1 (13 kDa, Protein from Homo sapiens)
- Histone h3.2 (15 kDa, Protein from Homo sapiens)
- Histone h4 (11 kDa, Protein from Homo sapiens)
- Dna (145-mer) (45 kDa, DNA from Homo sapiens)
- Dna (145-mer) (45 kDa, DNA from Homo sapiens)
- Histone (Complex from Homo sapiens)
- Dna (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cyclic gmp-amp synthase (43 kDa, Protein from Mus musculus)
- Cgas-nucleosome complex (Complex)