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Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7xz5
Q-score: 0.514
Xu P, Huang S, Guo S, Yun Y, Cheng X, He X, Cai P, Lan Y, Zhou H, Jiang H, Jiang Y, Xie X, Xu HE
Nat Struct Mol Biol (2022) 29 pp. 863-870 [ DOI: doi:10.1038/s41594-022-00816-5 Pubmed: 35970999 ]
- Gpr119-gs (Complex from Homo sapiens)
- (4r,7r,18e)-4,7-dihydroxy-n,n,n-trimethyl-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide (522 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nanobody35 (15 kDa, Protein from Lama glama)
- Nb35 (Complex)
- Soluble cytochrome b562,glucose-dependent insulinotropic receptor (53 kDa, Protein from Homo sapiens)
- Gpr119-gs-nb35-lpc complex (Complex from Homo sapiens)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7xz6
Q-score: 0.552
Xu P, Huang S, Guo S, Yun Y, Cheng X, He X, Cai P, Lan Y, Zhou H, Jiang H, Jiang Y, Xie X, Xu HE
Nat Struct Mol Biol (2022) 29 pp. 863-870 [ DOI: doi:10.1038/s41594-022-00816-5 Pubmed: 35970999 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nanobody35 (15 kDa, Protein from Lama glama)
- Nb35 (Complex)
- Propan-2-yl 4-[1-(2-fluoranyl-4-methylsulfonyl-phenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxypiperidine-1-carboxylate (477 Da, Ligand)
- Soluble cytochrome b562,glucose-dependent insulinotropic receptor (53 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Gpr119-gs (Complex from Lama glama)
- Gpr119-gs-nb35-apd668 complex (Complex from Homo sapiens)
Cryo-EM structure of the neuromedin U-bound neuromedin U receptor 1-Gq protein complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7w53
Q-score: 0.514
You C, Zhang Y, Xu P, Huang S, Yin W, Eric Xu H, Jiang Y
Nat Commun (2022) 13 pp. 2045-2045 [ Pubmed: 35440625 DOI: doi:10.1038/s41467-022-29683-w ]
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Neuromedin-u-25 (3 kDa, Protein from Homo sapiens)
- The neuromedin u-bound neuromedin u receptor 1-gq protein complex (Complex from Homo sapiens)
- Neuromedin-u receptor 1 (83 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
Cryo-EM structure of the neuromedin U-bound neuromedin U receptor 2-Gq protein complex
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7w55
Q-score: 0.489
You C, Zhang Y, Xu P, Huang S, Yin W, Eric Xu H, Jiang Y
Nat Commun (2022) 13 pp. 2045-2045 [ Pubmed: 35440625 DOI: doi:10.1038/s41467-022-29683-w ]
- The neuromedin u-bound neuromedin u receptor 2-gq protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Neuromedin-u receptor 2 (65 kDa, Protein from Homo sapiens)
- Neuromedin-u-25 (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
Cryo-EM structure of the neuromedin S-bound neuromedin U receptor 1-Gq protein complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7w56
Q-score: 0.477
You C, Zhang Y, Xu P, Huang S, Yin W, Eric Xu H, Jiang Y
Nat Commun (2022) 13 pp. 2045-2045 [ Pubmed: 35440625 DOI: doi:10.1038/s41467-022-29683-w ]
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- The neuromedin s-bound neuromedin u receptor 1-gq protein complex (Complex from Homo sapiens)
- Neuromedin u receptor 1 (83 kDa, Protein from Homo sapiens)
- Neuromedin-s (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of the neuromedin S-bound neuromedin U receptor 2-Gq protein complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7w57
Q-score: 0.533
You C, Zhang Y, Xu P, Huang S, Yin W, Eric Xu H, Jiang Y
Nat Commun (2022) 13 pp. 2045-2045 [ Pubmed: 35440625 DOI: doi:10.1038/s41467-022-29683-w ]
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- The neuromedin s-bound neuromedin u receptor 2-gq protein complex (Complex from Homo sapiens)
- Neuromedin-u receptor 2 (65 kDa, Protein from Homo sapiens)
- Neuromedin-s (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
SARS-CoV-2 Omicron Variant S Trimer complexed with two JMB2002 Fab
Resolution: 2.69 Å
EM Method: Single-particle
Fitted PDBs: 7wpe
Q-score: 0.338
Yin W, Xu Y, Xu P, Cao X, Wu C, Gu C, He X, Wang X, Huang S, Yuan Q, Wu K, Hu W, Huang Z, Liu J, Wang Z, Jia F, Xia K, Liu P, Wang X, Song B, Zheng J, Jiang H, Cheng X, Jiang Y, Deng SJ, Xu HE
Science (2022) 375 pp. 1048-1053 [ Pubmed: 35133176 DOI: doi:10.1126/science.abn8863 ]
- Sars-cov-2 omicron variant s (Complex from Mus musculus)
- Jmb2002 fab heavy chain (25 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Anti-fab nanobody (Complex)
- Sars-cov-2 omicron variant s trimer complexed with jmb2002 fab (Complex from Severe acute respiratory syndrome coronavirus)
- Anti-fab nanobody (14 kDa, Protein from Lama glama)
- Jmb2002 fab (Complex from Lama glama)
- Jmb2002 fab light chian (23 kDa, Protein from Mus musculus)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
The interface of JMB2002 Fab binds to SARS-CoV-2 Omicron Variant S
Resolution: 2.47 Å
EM Method: Single-particle
Fitted PDBs: 7wrv
Q-score: 0.507
Yin W, Xu Y, Xu P, Cao X, Wu C, Gu C, He X, Wang X, Huang S, Yuan Q, Wu K, Hu W, Huang Z, Liu J, Wang Z, Jia F, Xia K, Liu P, Wang X, Song B, Zheng J, Jiang H, Cheng X, Jiang Y, Deng SJ, Xu HE
Science (2022) 375 pp. 1048-1053 [ Pubmed: 35133176 DOI: doi:10.1126/science.abn8863 ]
- Sars-cov-2 omicron variant s (Complex from Mus musculus)
- Jmb2002 fab heavy chain (25 kDa, Protein from Mus musculus)
- Jmb2002 fab (Complex)
- Sars-cov-2 omicron variant s trimer complexed with jmb2002 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- Jmb2002 fab light chain (23 kDa, Protein from Mus musculus)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 Omicron Variant S Trimer complexed with one JMB2002 Fab
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 7wpd
Q-score: 0.265
Yin W, Xu Y, Xu P, Cao X, Wu C, Gu C, He X, Wang X, Huang S, Yuan Q, Wu K, Hu W, Huang Z, Liu J, Wang Z, Jia F, Xia K, Liu P, Wang X, Song B, Zheng J, Jiang H, Cheng X, Jiang Y, Deng SJ, Xu HE
Science (2022) 375 pp. 1048-1053 [ Pubmed: 35133176 DOI: doi:10.1126/science.abn8863 ]
- Anti fab nanobody (Complex)
- Jmb2002 fab heavy chain (25 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 omicron variant s trimer (Complex from Mus musculus)
- Sars-cov-2 omicron variant s trimer complexed with jmb2002 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- Anti-fab nanobody (14 kDa, Protein from Lama glama)
- Jmb2002 fab (Complex from Lama glama)
- Jmb2002 fab light chian (23 kDa, Protein from Mus musculus)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 Omicron Variant S Trimer complexed with three JMB2002 Fab
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 7wpf
Q-score: 0.226
Yin W, Xu Y, Xu P, Cao X, Wu C, Gu C, He X, Wang X, Huang S, Yuan Q, Wu K, Hu W, Huang Z, Liu J, Wang Z, Jia F, Xia K, Liu P, Wang X, Song B, Zheng J, Jiang H, Cheng X, Jiang Y, Deng SJ, Xu HE
Science (2022) 375 pp. 1048-1053 [ Pubmed: 35133176 DOI: doi:10.1126/science.abn8863 ]
- Sars-cov-2 omicron variant s (Complex from Mus musculus)
- Jmb2002 fab heavy chain (25 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 omicron variant s trimer complexed with jmb2002 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- Jmb2002 fab light chain (23 kDa, Protein from Mus musculus)
- Anti-fab nanobody (14 kDa, Protein from Lama glama)
- Jmb2002 fab (Complex from Lama glama)
- Anti fab nanobody (Complex)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)