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SARS-CoV-2 Omicron Variant S Trimer complexed with two JMB2002 Fab
Resolution: 2.69 Å
EM Method: Single-particle
Fitted PDBs: 7wpe
Q-score: 0.338
Yin W, Xu Y, Xu P, Cao X, Wu C, Gu C, He X, Wang X, Huang S, Yuan Q, Wu K, Hu W, Huang Z, Liu J, Wang Z, Jia F, Xia K, Liu P, Wang X, Song B, Zheng J, Jiang H, Cheng X, Jiang Y, Deng SJ, Xu HE
Science (2022) 375 pp. 1048-1053 [ Pubmed: 35133176 DOI: doi:10.1126/science.abn8863 ]
- Sars-cov-2 omicron variant s (Complex from Mus musculus)
- Jmb2002 fab heavy chain (25 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Anti-fab nanobody (Complex)
- Sars-cov-2 omicron variant s trimer complexed with jmb2002 fab (Complex from Severe acute respiratory syndrome coronavirus)
- Anti-fab nanobody (14 kDa, Protein from Lama glama)
- Jmb2002 fab (Complex from Lama glama)
- Jmb2002 fab light chian (23 kDa, Protein from Mus musculus)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
The interface of JMB2002 Fab binds to SARS-CoV-2 Omicron Variant S
Resolution: 2.47 Å
EM Method: Single-particle
Fitted PDBs: 7wrv
Q-score: 0.507
Yin W, Xu Y, Xu P, Cao X, Wu C, Gu C, He X, Wang X, Huang S, Yuan Q, Wu K, Hu W, Huang Z, Liu J, Wang Z, Jia F, Xia K, Liu P, Wang X, Song B, Zheng J, Jiang H, Cheng X, Jiang Y, Deng SJ, Xu HE
Science (2022) 375 pp. 1048-1053 [ Pubmed: 35133176 DOI: doi:10.1126/science.abn8863 ]
- Sars-cov-2 omicron variant s (Complex from Mus musculus)
- Jmb2002 fab heavy chain (25 kDa, Protein from Mus musculus)
- Jmb2002 fab (Complex)
- Sars-cov-2 omicron variant s trimer complexed with jmb2002 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- Jmb2002 fab light chain (23 kDa, Protein from Mus musculus)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 Omicron Variant S Trimer complexed with one JMB2002 Fab
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 7wpd
Q-score: 0.265
Yin W, Xu Y, Xu P, Cao X, Wu C, Gu C, He X, Wang X, Huang S, Yuan Q, Wu K, Hu W, Huang Z, Liu J, Wang Z, Jia F, Xia K, Liu P, Wang X, Song B, Zheng J, Jiang H, Cheng X, Jiang Y, Deng SJ, Xu HE
Science (2022) 375 pp. 1048-1053 [ Pubmed: 35133176 DOI: doi:10.1126/science.abn8863 ]
- Anti fab nanobody (Complex)
- Jmb2002 fab heavy chain (25 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 omicron variant s trimer (Complex from Mus musculus)
- Sars-cov-2 omicron variant s trimer complexed with jmb2002 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- Anti-fab nanobody (14 kDa, Protein from Lama glama)
- Jmb2002 fab (Complex from Lama glama)
- Jmb2002 fab light chian (23 kDa, Protein from Mus musculus)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 Omicron Variant S Trimer complexed with three JMB2002 Fab
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 7wpf
Q-score: 0.226
Yin W, Xu Y, Xu P, Cao X, Wu C, Gu C, He X, Wang X, Huang S, Yuan Q, Wu K, Hu W, Huang Z, Liu J, Wang Z, Jia F, Xia K, Liu P, Wang X, Song B, Zheng J, Jiang H, Cheng X, Jiang Y, Deng SJ, Xu HE
Science (2022) 375 pp. 1048-1053 [ Pubmed: 35133176 DOI: doi:10.1126/science.abn8863 ]
- Sars-cov-2 omicron variant s (Complex from Mus musculus)
- Jmb2002 fab heavy chain (25 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 omicron variant s trimer complexed with jmb2002 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- Jmb2002 fab light chain (23 kDa, Protein from Mus musculus)
- Anti-fab nanobody (14 kDa, Protein from Lama glama)
- Jmb2002 fab (Complex from Lama glama)
- Anti fab nanobody (Complex)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 Omicron Variant SPIKE trimer, all RBDs down
Resolution: 2.56 Å
EM Method: Single-particle
Fitted PDBs: 7wp9
Q-score: 0.377
SARS-CoV-2 Omicron Variant SPIKE trimer complexed with ACE2
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 7wpa
Q-score: 0.371
Yin W, Xu Y, Xu P, Cao X, Wu C, Gu C, He X, Wang X, Huang S, Yuan Q, Wu K, Hu W, Huang Z, Liu J, Wang Z, Jia F, Xia K, Liu P, Wang X, Song B, Zheng J, Jiang H, Cheng X, Jiang Y, Deng SJ, Xu HE
Science (2022) 375 pp. 1048-1053 [ Pubmed: 35133176 DOI: doi:10.1126/science.abn8863 ]
- Ace2 (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Chloride ion (35 Da, Ligand)
- Sars-cov-2 omicron variant spike (Complex from Homo sapiens)
- Sars-cov-2 omicron variant spike trimer complexed with ace2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Zinc ion (65 Da, Ligand)
- Angiotensin-converting enzyme 2 (92 kDa, Protein from Homo sapiens)
SARS-CoV-2 Omicron Variant RBD complexed with ACE2
Resolution: 2.79 Å
EM Method: Single-particle
Fitted PDBs: 7wpb
Q-score: 0.599
Yin W, Xu Y, Xu P, Cao X, Wu C, Gu C, He X, Wang X, Huang S, Yuan Q, Wu K, Hu W, Huang Z, Liu J, Wang Z, Jia F, Xia K, Liu P, Wang X, Song B, Zheng J, Jiang H, Cheng X, Jiang Y, Deng SJ, Xu HE
Science (2022) 375 pp. 1048-1053 [ Pubmed: 35133176 DOI: doi:10.1126/science.abn8863 ]
- Ace2 (Complex)
- Sars-cov-2 omicron variant rbd (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 omicron variant rbd complexed with ace2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Chloride ion (35 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Angiotensin-converting enzyme 2 (92 kDa, Protein from Homo sapiens)
The second RBD of SARS-CoV-2 Omicron Variant in complexed with RBD-ACE2
Resolution: 2.57 Å
EM Method: Single-particle
Fitted PDBs: 7wpc
Q-score: 0.405
Yin W, Xu Y, Xu P, Cao X, Wu C, Gu C, He X, Wang X, Huang S, Yuan Q, Wu K, Hu W, Huang Z, Liu J, Wang Z, Jia F, Xia K, Liu P, Wang X, Song B, Zheng J, Jiang H, Cheng X, Jiang Y, Deng SJ, Xu HE
Science (2022) 375 pp. 1048-1053 [ Pubmed: 35133176 DOI: doi:10.1126/science.abn8863 ]
- Ace2 (Complex)
- Sars-cov-2 omicron variant rbd (Complex from Homo sapiens)
- The second rbd of sars-cov-2 omicron variant in complexed with rbd-ace2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Chloride ion (35 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Angiotensin-converting enzyme 2 (92 kDa, Protein from Homo sapiens)
Cryo-EM structure of the compound 2-bound human GLP-1 receptor-Gs complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7dur
Q-score: 0.273
Cong Z, Chen LN, Ma H, Zhou Q, Zou X, Ye C, Dai A, Liu Q, Huang W, Sun X, Wang X, Xu P, Zhao L, Xia T, Zhong W, Yang D, Eric Xu H, Zhang Y, Wang MW
Nat Commun (2021) 12 pp. 3763-3763 [ DOI: doi:10.1038/s41467-021-24058-z Pubmed: 34145245 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Cholesterol (386 Da, Ligand)
- N-tert-butyl-6,7-bis(chloranyl)quinoxalin-2-amine (270 Da, Ligand)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
- Nanobody-35 (Complex from synthetic construct)
- Glucagon-like peptide 1 receptor (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Cryo-em structure of the compound 2-bound human glp-1 receptor-gs complex (Complex)
- Guanine nucleotide-binding protein (Complex from Homo sapiens)
Cryo-EM structure of the compound 2-bound human GLP-1 receptor-Gs complex
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7evm
Q-score: 0.481
Cong Z, Chen LN, Ma H, Zhou Q, Zou X, Ye C, Dai A, Liu Q, Huang W, Sun X, Wang X, Xu P, Zhao L, Xia T, Zhong W, Yang D, Eric Xu H, Zhang Y, Wang MW
Nat Commun (2021) 12 pp. 3763-3763 [ DOI: doi:10.1038/s41467-021-24058-z Pubmed: 34145245 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Cholesterol (386 Da, Ligand)
- N-tert-butyl-6,7-bis(chloranyl)quinoxalin-2-amine (270 Da, Ligand)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
- Glp-1 receptor (Complex from Homo sapiens)
- Guanine nucleotide-binding (Complex from Homo sapiens)
- Nanobody-35 (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Cryo-em structure of the compound 2-bound human glp-1 receptor-gs complex (Complex)