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Cryo-EM structure of succinate receptor bound to cis-epoxysuccinic acid coupling to Gi
Wang T, Tang W, Zhu X, Lv Z, Chen J, Li Y, Sun X, Lv H, Gu Q, Li F, Wang J
Cell Res (2024) [ Pubmed: 38744983 DOI: doi:10.1038/s41422-024-00968-7 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,succinate receptor 1,oplophorus-luciferin 2-monooxygenase catalytic subunit (75 kDa, Protein from Oplophorus gracilirostris)
- Gpcr complex of succinate receptor (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from Homo sapiens)
- (2r,3s)-oxirane-2,3-dicarboxylic acid (132 Da, Ligand)
Cryo-EM structure of succinate receptor bound to succinate acid coupling MiniGsq
Wang T, Tang W, Zhu X, Lv Z, Chen J, Li Y, Sun X, Lv H, Gu Q, Li F, Wang J
Cell Res (2024) [ Pubmed: 38744983 DOI: doi:10.1038/s41422-024-00968-7 ]
- Succinic acid (118 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (29 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,succinate receptor 1,oplophorus-luciferin 2-monooxygenase catalytic subunit (74 kDa, Protein from Oplophorus gracilirostris)
- Gpcr complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
Cryo-EM of human cannabinoid receptor 1 bound to Fenofibrate with MiniGsq and Nb35 complex
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 8x90
Q-score: 0.439
Li Z, Cong Y, Wu T, Wang T, Lou X, Yang X, Yan N
Cell Res (2024) [ Pubmed: 38443561 DOI: doi:10.1038/s41422-024-00940-5 ]
- Cholesterol (386 Da, Ligand)
- [(2r)-1-octadecanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8z)-icosa-5,8,11,14-tetraenoate (1 kDa, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Voltage-dependent p/q-type calcium channel subunit alpha-1a (287 kDa, Protein from Homo sapiens)
- Voltage-dependent l-type calcium channel subunit beta-3 (56 kDa, Protein from Homo sapiens)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Voltage-gated p/q type calcium channel (Complex from Homo sapiens)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (126 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- 1,2-didecanoyl-sn-glycero-3-[phospho-l-serine] (566 Da, Ligand)
- Calcium ion (40 Da, Ligand)
P/Q type calcium channel in complex with omega-conotoxin MVIIC
Resolution: 3.11 Å
EM Method: Single-particle
Fitted PDBs: 8x91
Q-score: 0.417
Li Z, Cong Y, Wu T, Wang T, Lou X, Yang X, Yan N
Cell Res (2024) [ Pubmed: 38443561 DOI: doi:10.1038/s41422-024-00940-5 ]
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- [(2r)-1-octadecanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8z)-icosa-5,8,11,14-tetraenoate (1 kDa, Ligand)
- Voltage-dependent p/q-type calcium channel subunit alpha-1a (287 kDa, Protein from Homo sapiens)
- Voltage-dependent l-type calcium channel subunit beta-3 (56 kDa, Protein from Homo sapiens)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Voltage-gated p/q type calcium channel (Complex from Homo sapiens)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (126 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Omega-conotoxin mviic (2 kDa, Protein from Conus magus)
- Calcium ion (40 Da, Ligand)
P/Q type calcium channel in complex with omega-Agatoxin IVA
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 8x93
Q-score: 0.463
Li Z, Cong Y, Wu T, Wang T, Lou X, Yang X, Yan N
Cell Res (2024) [ Pubmed: 38443561 DOI: doi:10.1038/s41422-024-00940-5 ]
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- [(2r)-1-octadecanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8z)-icosa-5,8,11,14-tetraenoate (1 kDa, Ligand)
- Voltage-dependent p/q-type calcium channel subunit alpha-1a (287 kDa, Protein from Homo sapiens)
- Voltage-gated p/q type calcium channel in complex with omega-agatoxin iva (Complex from Homo sapiens)
- Voltage-dependent l-type calcium channel subunit beta-3 (56 kDa, Protein from Homo sapiens)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (126 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Calcium ion (40 Da, Ligand)
Cry-EM structure of cannabinoid receptor-arrestin 2 complex
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8wrz
Q-score: 0.24
Wang Y, Wu L, Wang T, Liu J, Li F, Jiang L, Fan Z, Yu Y, Chen N, Sun Q, Tan Q, Hua T, Liu ZJ
Protein Cell (2024) 15 pp. 230-234 [ Pubmed: 38102480 DOI: doi:10.1093/procel/pwad055 ]
- Beta-arrestin-1 (44 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,cannabinoid receptor 1 (53 kDa, Protein from Homo sapiens)
- Scfv30 light chain, scfv30 heavy chain (28 kDa, Protein from Phage display vector pTDisp)
- Vasopressin v2 receptor (2 kDa, Protein from Homo sapiens)
- (6~{a}~{r},9~{r},10~{a}~{r})-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyl-octan-2-yl)-6,6-dimethyl-6~{a},7,8,9,10,10~{a}-hexahydrobenzo[c]chromen-1-ol (445 Da, Ligand)
- Cry-em structure of cannabinoid receptor-arrestin 2 complex (Complex from Homo sapiens)
Cannabinoid Receptor 1 bound to Fenofibrate coupling MiniGsq and Nb35 Complex
Resolution: 2.88 Å
EM Method: Single-particle
Fitted PDBs: 8k8j
Q-score: 0.534
Wang T, Tang W, Zhao Z, Zhao R, Lv Z, Guo X, Gu Q, Liu B, Lv H, Chen J, Zhang K, Li F, Wang J
Adv Sci (2024) 11 pp. e2306311-e2306311 [ Pubmed: 38298116 DOI: doi:10.1002/advs.202306311 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (30 kDa, Protein from Homo sapiens)
- Propan-2-yl 2-[4-(4-chlorophenyl)carbonylphenoxy]-2-methyl-propanoate (360 Da, Ligand)
- Soluble cytochrome b562,cannabinoid receptor 1 (59 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Homo sapiens)
- Cannabinoid receptor 1-g protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (10 kDa, Protein from Homo sapiens)