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T. cruzi topoisomerase II alpha bound to dsDNA and the covalent inhibitor CT1
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8gcc
Q-score: 0.574
Rao SPS, Gould MK, Noeske J, Saldivia M, Jumani RS, Ng PS, Rene O, Chen YL, Kaiser M, Ritchie R, Francisco AF, Johnson N, Patra D, Cheung H, Deniston C, Schenk AD, Cortopassi WA, Schmidt RS, Wiedemar N, Thomas B, Palkar R, Ghafar NA, Manoharan V, Luu C, Gable JE, Wan KF, Myburgh E, Mottram JC, Barnes W, Walker J, Wartchow C, Aziz N, Osborne C, Wagner J, Sarko C, Kelly JM, Manjunatha UH, Maeser P, Jiricek J, Lakshminarayana SB, Barrett MP, Diagana TT
Science (2023) 380 pp. 1349-1356 [ Pubmed: 37384702 DOI: doi:10.1126/science.adh0614 ]
- Dsdna (Complex from Escherichia coli)
- Topoisomerase ii alpha bound to dsdna and inhibitor ct1 (Complex from Trypanosoma cruzi)
- 2-{3-[(z)-iminomethyl]-1h-1,2,4-triazol-1-yl}-1-{(3m)-3-[2-(trifluoromethyl)phenyl]-6h-pyrrolo[3,4-b]pyridin-6-yl}ethan-1-one (398 Da, Ligand)
- Topoisomerase ii alpha (Complex from Trypanosoma cruzi)
- Dna topoisomerase 2 (89 kDa, Protein from Trypanosoma cruzi strain CL Brener)
- Dna (28-mer) (8 kDa, DNA from Escherichia coli)
Subtomogram average of the T. kivui 70S ribosome in situ
Dietrich HM, Righetto RD, Kumar A, Wietrzynski W, Trischler R, Schuller SK, Wagner J, Schwarz FM, Engel BD, Mueller V, Schuller JM
Nature (2022) 607 pp. 823-830 [ Pubmed: 35859174 DOI: doi:10.1038/s41586-022-04971-z ]
In situ cryo-electron tomography of T. kivui cells
Dietrich HM, Righetto RD, Kumar A, Wietrzynski W, Trischler R, Schuller SK, Wagner J, Schwarz FM, Engel BD, Müller V, Schuller JM
Nature (2022) 607 pp. 823-830 [ DOI: 10.1038/s41586-022-04971-z Pubmed: 35859174 ]
Image sets:
- Denoised tomograms of T. kivui FIB-milled cells at bin4
- Tilt series of T. kivui FIB-milled cells - session 2020-10-22
- Unaligned raw frames of T. kivui FIB-milled cells tilt series - session 2020-10-22
- Unaligned raw frames of T. kivui FIB-milled cells tilt series - session 2021-02-12
- Subtomograms of T. kivui ribosome particles at bin1
- Subtomograms of HDCR filament particles at bin2
- Tilt series of T. kivui FIB-milled cells - session 2021-02-12
Cryo-EM structure of Hydrogen-dependent CO2 reductase.
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7qv7
Q-score: 0.325
Dietrich HM, Righetto RD, Kumar A, Wietrzynski W, Trischler R, Schuller SK, Wagner J, Schwarz FM, Engel BD, Muller V, Schuller JM
Nature (2022) 607 pp. 823-830 [ Pubmed: 35859174 DOI: doi:10.1038/s41586-022-04971-z ]
- Hydrogen dependent carbon dioxide reductase subunit hyda2 (51 kDa, Protein from Thermoanaerobacter kivui)
- Hydrogen-dependent co2 reductase (hdcr) complex with iron-sulphur clusters and the h-cluster. (Complex from Thermoanaerobacter kivui LKT-1)
- Hydrogen dependent carbon dioxide reductase subunit hycb3 (20 kDa, Protein from Thermoanaerobacter kivui)
- Hydrogen dependent carbon dioxide reductase subunit fdhf (82 kDa, Protein from Thermoanaerobacter kivui)
- Hydrogen dependent carbon dioxide reductase subunit hycb4 (23 kDa, Protein from Thermoanaerobacter kivui)
- Dicarbonyl[bis(cyanide-kappac)]-mu-(iminodimethanethiolatato-1kappas:2kappas)-mu-(oxomethylidene)diiron(2+) (354 Da, Ligand)
- Iron/sulfur cluster (351 Da, Ligand)
In situ structure of HDCR filaments
Dietrich HM, Righetto RD, Kumar A, Wietrzynski W, Trischler R, Schuller SK, Wagner J, Schwarz FM, Engel BD, Muller V, Schuller JM
Nature (2022) 607 pp. 823-830 [ Pubmed: 35859174 DOI: doi:10.1038/s41586-022-04971-z ]
In situ structure of the T. kivui ribosome
Dietrich HM, Righetto RD, Kumar A, Wietrzynski W, Trischler R, Schuller SK, Wagner J, Schwarz FM, Engel BD, Muller V, Schuller JM
Nature (2022) 607 pp. 823-830 [ Pubmed: 35859174 DOI: doi:10.1038/s41586-022-04971-z ]
In situ cryo-electron tomogram of a T. kivui cell 1
Dietrich HM, Righetto RD, Kumar A, Wietrzynski W, Trischler R, Schuller SK, Wagner J, Schwarz FM, Engel BD, Muller V, Schuller JM
Nature (2022) 607 pp. 823-830 [ Pubmed: 35859174 DOI: doi:10.1038/s41586-022-04971-z ]
In situ cryo-electron tomogram of a T. kivui cell 2
Dietrich HM, Righetto RD, Kumar A, Wietrzynski W, Trischler R, Schuller SK, Wagner J, Schwarz FM, Engel BD, Muller V, Schuller JM
Nature (2022) 607 pp. 823-830 [ Pubmed: 35859174 DOI: doi:10.1038/s41586-022-04971-z ]
the neuron ribosome bound to the membrane
Jiang W, Wagner J, Du W, Plitzko J, Baumeister W, Beck F, Guo Q
Nucleic Acids Res (2022) 50 pp. 9001-9011 [ Pubmed: 35811088 DOI: doi:10.1093/nar/gkac547 ]
the tomogram of neuron cortical cell
Jiang W, Wagner J, Du W, Plitzko J, Baumeister W, Beck F, Guo Q
Nucleic Acids Res (2022) 50 pp. 9001-9011 [ Pubmed: 35811088 DOI: doi:10.1093/nar/gkac547 ]