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Structure of an intact ESX-5 inner membrane complex, C1 symmetry
Resolution: 4.03 Å
EM Method: Single-particle
Fitted PDBs: 7np7
Q-score: 0.383
Bunduc CM, Fahrenkamp D, Wald J, Ummels R, Bitter W, Houben ENG, Marlovits TC
Nature (2021) 593 pp. 445-448 [ Pubmed: 33981042 DOI: doi:10.1038/s41586-021-03517-z ]
- Esx-5 secretion system protein eccd5 (53 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Esx-5 secretion system protein eccc5 (152 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Esx-5 secretion system atpase eccb5 (53 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Intact esx-5 inner membrane complex (2 MDa, Complex from Mycobacterium tuberculosis H37Rv)
- Mycosin-5 (60 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
Structure of an intact ESX-5 inner membrane complex, C3 symmetry
Resolution: 3.82 Å
EM Method: Single-particle
Fitted PDBs: 7npr
Q-score: 0.407
Bunduc CM, Fahrenkamp D, Wald J, Ummels R, Bitter W, Houben ENG, Marlovits TC
Nature (2021) 593 pp. 445-448 [ Pubmed: 33981042 DOI: doi:10.1038/s41586-021-03517-z ]
- Esx-5 secretion system protein eccd5 (53 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Esx-5 secretion system protein eccc5 (152 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Esx-5 secretion system atpase eccb5 (53 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Mycosin-5 (60 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Intact esx-5 inner membrane complex, c3 symmetry (2 MDa, Complex from Mycobacterium tuberculosis H37Rv)
MycP5-free ESX-5 inner membrane complex, state I
Resolution: 4.48 Å
EM Method: Single-particle
Fitted PDBs: 7npu
Q-score: 0.268
Bunduc CM, Fahrenkamp D, Wald J, Ummels R, Bitter W, Houben ENG, Marlovits TC
Nature (2021) 593 pp. 445-448 [ Pubmed: 33981042 DOI: doi:10.1038/s41586-021-03517-z ]
- Esx-5 secretion system protein eccc5 (152 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Esx-5 secretion system protein eccd5 (53 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Esx-5 secretion system atpase eccb5 (53 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Mycp5-free esx-5 inner membrane complex, state i (Complex from Mycobacterium tuberculosis H37Rv)
MycP5-free ESX-5 inner membrane complex, State II
Resolution: 6.66 Å
EM Method: Single-particle
Fitted PDBs: 7npv
Q-score: 0.216
Bunduc CM, Fahrenkamp D, Wald J, Ummels R, Bitter W, Houben ENG, Marlovits TC
Nature (2021) 593 pp. 445-448 [ Pubmed: 33981042 DOI: doi:10.1038/s41586-021-03517-z ]
- Esx-5 secretion system protein eccc5 (152 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Intact esx-5 inner membrane complex (Complex from Mycobacterium tuberculosis H37Rv)
- Esx-5 secretion system protein eccd5 (53 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Esx-5 secretion system atpase eccb5 (53 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
Structure of the periplasmic assembly from the ESX-5 inner membrane complex, C1 symmetry
Resolution: 3.81 Å
EM Method: Single-particle
Fitted PDBs: 7nps
Q-score: 0.476
Bunduc CM, Fahrenkamp D, Wald J, Ummels R, Bitter W, Houben ENG, Marlovits TC
Nature (2021) 593 pp. 445-448 [ Pubmed: 33981042 DOI: doi:10.1038/s41586-021-03517-z ]
- Mycosin-5 (60 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Periplasmic assembly of the esx-5 inner membrane complex (Complex from Mycobacterium tuberculosis H37Rv)
- Esx-5 secretion system atpase eccb5 (53 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
Periplasmic assembly of the intact ESX-5 inner membrane complex, C3 symmetry
Bunduc CM, Fahrenkamp D, Wald J, Ummels R, Bitter W, Houben ENG, Marlovits TC
Nature (2021) 593 pp. 445-448 [ Pubmed: 33981042 DOI: doi:10.1038/s41586-021-03517-z ]
Cytosolic bridge of an intact ESX-5 inner membrane complex
Resolution: 3.27 Å
EM Method: Single-particle
Fitted PDBs: 7npt
Q-score: 0.483
Bunduc CM, Fahrenkamp D, Wald J, Ummels R, Bitter W, Houben ENG, Marlovits TC
Nature (2021) 593 pp. 445-448 [ Pubmed: 33981042 DOI: doi:10.1038/s41586-021-03517-z ]
- Esx-5 secretion system protein eccc5 (152 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Esx-5 secretion system protein eccd5 (53 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Cytosolic bridge of an intact esx-5 inner membrane complex (Complex from Mycobacterium tuberculosis H37Rv)
Structure of an intact ESX-5 inner membrane complex, EccC5 extended
Bunduc CM, Fahrenkamp D, Wald J, Ummels R, Bitter W, Houben ENG, Marlovits TC
Nature (2021) 593 pp. 445-448 [ Pubmed: 33981042 DOI: doi:10.1038/s41586-021-03517-z ]
Structure of an intact ESX-5 inner membrane complex, EccC contracted
Bunduc CM, Fahrenkamp D, Wald J, Ummels R, Bitter W, Houben ENG, Marlovits TC
Nature (2021) 593 pp. 445-448 [ Pubmed: 33981042 DOI: doi:10.1038/s41586-021-03517-z ]
The structure of the ESX-5 mycobacterial type VII secretion system membrane complex
Beckham KS, Ciccarelli L, Bunduc CM, Mertens HD, Ummels R, Lugmayr W, Mayr J, Rettel M, Savitski MM, Svergun DI, Bitter W, Wilmanns M, Marlovits TC, Parret AH, Houben EN
Nat Microbiol (2017) 2 pp. 17047-17047 [ DOI: doi:10.1038/nmicrobiol.2017.47 Pubmed: 28394313 ]