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Structure of TRPC3 at 2.7 angstrom in high calcium state
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7dxb
Q-score: 0.56
Guo W, Tang Q, Wei M, Kang Y, Wu JX, Chen L
Neuron (2022) 110 pp. 1023-1035.e5 [ Pubmed: 35051376 DOI: doi:10.1016/j.neuron.2021.12.023 ]
- Short transient receptor potential channel 3 (96 kDa, Protein from Homo sapiens)
- [(2s)-2-[(e)-octadec-10-enoyl]oxy-3-oxidanyl-propyl] octadec-10-enoate (620 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Human transient receptor potential channel 3 tetramer (Complex from Homo sapiens)
Structure of TRPC3 at 3.06 angstrom in low calcium state
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 7dxc
Q-score: 0.454
Guo W, Tang Q, Wei M, Kang Y, Wu JX, Chen L
Neuron (2022) 110 pp. 1023-1035.e5 [ Pubmed: 35051376 DOI: doi:10.1016/j.neuron.2021.12.023 ]
- Short transient receptor potential channel 3 (96 kDa, Protein from Homo sapiens)
- [(2s)-2-[(e)-octadec-10-enoyl]oxy-3-oxidanyl-propyl] octadec-10-enoate (620 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Human transient receptor potential channel 3 tetramer (Complex from Homo sapiens)
Structure of TRPC3 gain of function mutation R803C at 3.2 angstrom in 1340nM free calcium state
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7dxe
Q-score: 0.51
Guo W, Tang Q, Wei M, Kang Y, Wu JX, Chen L
Neuron (2022) 110 pp. 1023-1035.e5 [ Pubmed: 35051376 DOI: doi:10.1016/j.neuron.2021.12.023 ]
- Short transient receptor potential channel 3 (96 kDa, Protein from Homo sapiens)
- [(2s)-2-[(e)-octadec-10-enoyl]oxy-3-oxidanyl-propyl] octadec-10-enoate (620 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Human transient receptor potential channel 3 tetramer (Complex from Homo sapiens)
Structure of BTDM-bound human TRPC6 nanodisc at 2.9 angstrom in high calcium state
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7dxf
Q-score: 0.515
Guo W, Tang Q, Wei M, Kang Y, Wu JX, Chen L
Neuron (2022) 110 pp. 1023-1035.e5 [ Pubmed: 35051376 DOI: doi:10.1016/j.neuron.2021.12.023 ]
- [(2s)-2-[(e)-octadec-10-enoyl]oxy-3-oxidanyl-propyl] octadec-10-enoate (620 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- [2-(1,3-benzodioxol-5-ylamino)-1,3-thiazol-4-yl]-[(3r,5s)-3,5-dimethylpiperidin-1-yl]methanone (359 Da, Ligand)
- Human transient receptor potential channel 6 tetramer (Complex from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Short transient receptor potential channel 6 (106 kDa, Protein from Homo sapiens)
Structure of SAR7334-bound TRPC6 at 2.9 angstrom
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7dxg
Q-score: 0.551
Guo W, Tang Q, Wei M, Kang Y, Wu JX, Chen L
Neuron (2022) 110 pp. 1023-1035.e5 [ Pubmed: 35051376 DOI: doi:10.1016/j.neuron.2021.12.023 ]
- [(2s)-2-[(e)-octadec-10-enoyl]oxy-3-oxidanyl-propyl] octadec-10-enoate (620 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- 4-[[(1r,2r)-2-[(3r)-3-azanylpiperidin-1-yl]-2,3-dihydro-1h-inden-1-yl]oxy]-3-chloranyl-benzenecarbonitrile (367 Da, Ligand)
- Human transient receptor potential channel 6 tetramer (Complex from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Short transient receptor potential channel 6 (106 kDa, Protein from Homo sapiens)
Structure of TRPC3 at 3.9 angstrom in 1340 nM free calcium state
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7dxd
Q-score: 0.383
Guo W, Tang Q, Wei M, Kang Y, Wu JX, Chen L
Neuron (2022) 110 pp. 1023-1035.e5 [ Pubmed: 35051376 DOI: doi:10.1016/j.neuron.2021.12.023 ]
- Short transient receptor potential channel 3 (96 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Human transient receptor potential channel 3 tetramer (Complex from Homo sapiens)