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Cryo-EM structure of GPR156 of GPR156-miniGo-scFv16 complex (local refine)
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 8ieb
Q-score: 0.435
Shin J, Park J, Jeong J, Lam JH, Qiu X, Wu D, Kim K, Lee JY, Robinson CV, Hyun J, Katritch V, Kim KP, Cho Y
Nat Struct Mol Biol (2024) 31 pp. 678-687 [ Pubmed: 38332368 DOI: doi:10.1038/s41594-024-01224-7 ]
- [(2r)-3-[(e)-hexadec-9-enoyl]oxy-2-octadecanoyloxy-propyl] 2-(trimethylazaniumyl)ethyl phosphate (760 Da, Ligand)
- Gpr156 (131 MDa, Complex from Homo sapiens)
- Probable g-protein coupled receptor 156 (65 kDa, Protein from Homo sapiens)
Cryo-EM structure of miniGo-scFv16 of GPR156-miniGo-scFv16 complex (local refine)
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 8iec
Q-score: 0.412
Shin J, Park J, Jeong J, Lam JH, Qiu X, Wu D, Kim K, Lee JY, Robinson CV, Hyun J, Katritch V, Kim KP, Cho Y
Nat Struct Mol Biol (2024) 31 pp. 678-687 [ Pubmed: 38332368 DOI: doi:10.1038/s41594-024-01224-7 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (25 kDa, Protein from Homo sapiens)
- Minigo heterotrimeric complex (Complex from Homo sapiens)
- Single-chain variable fragment scfv16 (27 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Minigo-scfv16 (27 MDa, Complex from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
Cryo-EM structure of GPR156-miniGo-scFv16 complex
Resolution: 3.33 Å
EM Method: Single-particle
Fitted PDBs: 8ied
Q-score: 0.402
Shin J, Park J, Jeong J, Lam JH, Qiu X, Wu D, Kim K, Lee JY, Robinson CV, Hyun J, Katritch V, Kim KP, Cho Y
Nat Struct Mol Biol (2024) 31 pp. 678-687 [ Pubmed: 38332368 DOI: doi:10.1038/s41594-024-01224-7 ]
- Gpr156-minigo-scfv16 complex (27 MDa, Complex from Homo sapiens)
- Gpr156 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Minigo heterotrimeric complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (25 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Probable g-protein coupled receptor 156 (65 kDa, Protein from Homo sapiens)
- [(2r)-3-[(e)-hexadec-9-enoyl]oxy-2-octadecanoyloxy-propyl] 2-(trimethylazaniumyl)ethyl phosphate (760 Da, Ligand)
- Scfv16 (Complex from Mus musculus)
- Single-chain variable fragment scfv16 (27 kDa, Protein from Mus musculus)
Cryo-EM structure of GPR156A/B of G-protein free GPR156 (local refine)
Resolution: 2.62 Å
EM Method: Single-particle
Fitted PDBs: 8iei
Q-score: 0.507
Shin J, Park J, Jeong J, Lam JH, Qiu X, Wu D, Kim K, Lee JY, Robinson CV, Hyun J, Katritch V, Kim KP, Cho Y
Nat Struct Mol Biol (2024) 31 pp. 678-687 [ Pubmed: 38332368 DOI: doi:10.1038/s41594-024-01224-7 ]
- [(2r)-3-[(e)-hexadec-9-enoyl]oxy-2-octadecanoyloxy-propyl] 2-(trimethylazaniumyl)ethyl phosphate (760 Da, Ligand)
- Gpr156a/b (131 MDa, Complex from Homo sapiens)
- Probable g-protein coupled receptor 156 (65 kDa, Protein from Homo sapiens)
Cryo-EM structure of GPR156C/D of G-protein free GPR156 (local refine)
Resolution: 2.61 Å
EM Method: Single-particle
Fitted PDBs: 8iep
Q-score: 0.511
Shin J, Park J, Jeong J, Lam JH, Qiu X, Wu D, Kim K, Lee JY, Robinson CV, Hyun J, Katritch V, Kim KP, Cho Y
Nat Struct Mol Biol (2024) 31 pp. 678-687 [ Pubmed: 38332368 DOI: doi:10.1038/s41594-024-01224-7 ]
- [(2r)-3-[(e)-hexadec-9-enoyl]oxy-2-octadecanoyloxy-propyl] 2-(trimethylazaniumyl)ethyl phosphate (760 Da, Ligand)
- Gpr156c/d (131 MDa, Complex from Homo sapiens)
- Probable g-protein coupled receptor 156 (65 kDa, Protein from Homo sapiens)
Cryo-EM structure of G-protein free GPR156
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8ieq
Q-score: 0.551
Shin J, Park J, Jeong J, Lam JH, Qiu X, Wu D, Kim K, Lee JY, Robinson CV, Hyun J, Katritch V, Kim KP, Cho Y
Nat Struct Mol Biol (2024) 31 pp. 678-687 [ Pubmed: 38332368 DOI: doi:10.1038/s41594-024-01224-7 ]
Cryo-EM structure of Human respiratory syncytial virus F variant (construct pXCS847A)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7uja
Q-score: 0.492
Che Y, Gribenko AV, Song X, Handke LD, Efferen KS, Tompkins K, Kodali S, Nunez L, Prasad AK, Phelan LM, Ammirati M, Yu X, Lees JA, Chen W, Martinez L, Roopchand V, Han S, Qiu X, DeVincenzo JP, Jansen KU, Dormitzer PR, Swanson KA
Sci Transl Med (2023) 15 pp. eade6422-eade6422 [ Pubmed: 37023209 DOI: doi:10.1126/scitranslmed.ade6422 ]
- Am14 fab light chain (23 kDa, Protein from Mus musculus)
- Rsv variant (construct pxcs847a) f2 (12 kDa, Protein from Respiratory syncytial virus)
- Am22 fab heavy chain (25 kDa, Protein from Mus musculus)
- Rsv variant (construct pxcs847a) f1 (45 kDa, Protein from Respiratory syncytial virus)
- Am14 fab heavy chain (26 kDa, Protein from Mus musculus)
- Am22 fab light chain (23 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human respiratory syncytial virus f variant (construct pxcs847a) with fabs am14 and am22 (Complex from Respiratory syncytial virus)
Cryo-EM structure of human GPR158
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7she
Q-score: 0.352
Patil DN, Singh S, Laboute T, Strutzenberg TS, Qiu X, Wu D, Novick SJ, Robinson CV, Griffin PR, Hunt JF, Izard T, Singh AK, Martemyanov KA
Science (2022) 375 pp. 86-91 [ Pubmed: 34793198 DOI: doi:10.1126/science.abl4732 ]
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- G-protein coupled receptor 158 (88 kDa, Protein from Homo sapiens)
- Receptor (170 kDa, Complex from Homo sapiens)
- (2s)-1-{[(s)-hydroxy{[(1s,2r,3r,4r,5s,6s)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl (5e,8e,11e,14e)-icosa-5,8,11,14-tetraenoate (887 Da, Ligand)
Cryo-EM structure of GPR158 coupled to the RGS7-Gbeta5 complex
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7shf
Q-score: 0.478
Patil DN, Singh S, Laboute T, Strutzenberg TS, Qiu X, Wu D, Novick SJ, Robinson CV, Griffin PR, Hunt JF, Izard T, Singh AK, Martemyanov KA
Science (2022) 375 pp. 86-91 [ Pubmed: 34793198 DOI: doi:10.1126/science.abl4732 ]
- Guanine nucleotide-binding protein subunit beta-5 (38 kDa, Protein from Mus musculus)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- G-protein coupled receptor 158 (88 kDa, Protein from Homo sapiens)
- (2s)-1-{[(s)-hydroxy{[(1s,2r,3r,4r,5s,6s)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl (5e,8e,11e,14e)-icosa-5,8,11,14-tetraenoate (887 Da, Ligand)
- Gpcr complex (270 kDa, Complex from Homo sapiens)
- Isoform 2 of regulator of g-protein signaling 7 (54 kDa, Protein from Homo sapiens)
Structure of Wild-Type Human Potassium Chloride Transporter KCC3 in NaCl (LMNG/CHS)
Resolution: 3.64 Å
EM Method: Single-particle
Fitted PDBs: 7ngb
Q-score: 0.395
Chi G, Ebenhoch R, Man H, Tang H, Tremblay LE, Reggiano G, Qiu X, Bohstedt T, Liko I, Almeida FG, Garneau AP, Wang D, McKinley G, Moreau CP, Bountra KD, Abrusci P, Mukhopadhyay SMM, Fernandez-Cid A, Slimani S, Lavoie JL, Burgess-Brown NA, Tehan B, DiMaio F, Jazayeri A, Isenring P, Robinson CV, Durr KL
EMBO J (2021) 40 pp. e107294-e107294 [ Pubmed: 34031912 DOI: doi:10.15252/embj.2020107294 ]
- Homodimeric membrane protein complex (240 kDa, Complex from Homo sapiens)
- Isoform 2 of solute carrier family 12 member 6 (122 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)