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Cryo-EM structure of the wild-type alpha-synuclein fibril.
Resolution: 3.1 Å
EM Method: Helical reconstruction
Fitted PDBs: 8oqi
Q-score: 0.562
Pesch V, Flores-Fernandez JM, Reithofer S, Ma L, Ozduzenciler P, Busch Y, Sriraman A, Wang Y, Amidian S, Kroepel CVM, Muller L, Lien Y, Rudtke O, Frieg B, Schroder GF, Wille H, Tamguney G
Brain (2024) 147 pp. 1644-1652 [ Pubmed: 38428032 DOI: doi:10.1093/brain/awae061 ]
- Human wild-type alpha-synuclein fibril (Complex from Homo sapiens)
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
Cryo-EM structure of PfAgo-guide DNA-target DNA complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8jpx
Q-score: 0.575
Wang L, Chen W, Zhang C, Xie X, Huang F, Chen M, Mao W, Yu N, Wei Q, Ma L, Li Z
Mol Cell (2024) 84 pp. 675-686.e4 [ DOI: doi:10.1016/j.molcel.2024.01.004 Pubmed: 38295801 ]
- Excess dna (1 kDa, DNA from Pyrococcus furiosus DSM 3638)
- Magnesium ion (24 Da, Ligand)
- Guide dna (5 kDa, DNA from Pyrococcus furiosus DSM 3638)
- Target dna (5 kDa, DNA from Pyrococcus furiosus DSM 3638)
- Protein argonaute (90 kDa, Protein from Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1))
- Cryo-em structure of a pfago-guide dna-target dna complex (Complex from Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1))
Cryo-EM structure of TtdAgo-guide DNA-target DNA complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8wd8
Q-score: 0.593
Wang L, Chen W, Zhang C, Xie X, Huang F, Chen M, Mao W, Yu N, Wei Q, Ma L, Li Z
Mol Cell (2024) 84 pp. 675-686.e4 [ DOI: doi:10.1016/j.molcel.2024.01.004 Pubmed: 38295801 ]
- Magnesium ion (24 Da, Ligand)
- Argonaute family protein (87 kDa, Protein from Thermococcus thioreducens)
- Dna binding protein (Complex)
- Guide dna (5 kDa, DNA from Thermus thermophilus)
- Target dna (5 kDa, DNA from Thermus thermophilus)
- Dna (Complex)
- Zinc ion (65 Da, Ligand)
- Cryo-em structure of ttdago-guide dna-target dna complex (Complex from Thermus thermophilus)
Structure of monkeypox virus polymerase complex F8-A22-E4-H5 (tag-free A22) with exogenous DNA
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8wpe
Q-score: 0.47
Mol Cell (2023) 83 pp. 4398- [ Pubmed: 37995690 DOI: doi:10.1016/j.molcel.2023.10.038 ]
- H5r late gene transcription factor (23 kDa, Protein from Monkeypox virus)
- Magnesium ion (24 Da, Ligand)
- Template dna (14 kDa, DNA from synthetic construct)
- Dna polymerase (117 kDa, Protein from Monkeypox virus)
- F8-a22-e4-h5 (Complex)
- F8-a22-e4-h5 (tag-free a22) with exogenous dna (Complex from Monkeypox virus)
- Dna (Complex)
- 2',3'-dideoxy-thymidine-5'-triphosphate (466 Da, Ligand)
- Primer dna (10 kDa, DNA from synthetic construct)
- A22r dna polymerase processivity factor (49 kDa, Protein from Monkeypox virus)
- E4r uracil-dna glycosylase, dna polymerase processivity factor (25 kDa, Protein from Monkeypox virus)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8wpf
Q-score: 0.448
Mol Cell (2023) 83 pp. 4398- [ Pubmed: 37995690 DOI: doi:10.1016/j.molcel.2023.10.038 ]
- F8-a22-e4-h5 with exogenous dna bearing one abasic site (Complex from Monkeypox virus)
- Template dna (14 kDa, DNA from synthetic construct)
- H5r late gene transcription factor (23 kDa, Protein from Monkeypox virus)
- A22r dna polymerase processivity factor (50 kDa, Protein from Monkeypox virus)
- Magnesium ion (24 Da, Ligand)
- F8-a22-e4-h5 (Complex)
- 2',3'-dideoxy-thymidine-5'-triphosphate (466 Da, Ligand)
- Dna (Complex)
- Primer dna (10 kDa, DNA from synthetic construct)
- Dna polymerase (117 kDa, Protein from Monkeypox virus)
- E4r uracil-dna glycosylase, dna polymerase processivity factor (25 kDa, Protein from Monkeypox virus)
Structure of monkeypox virus polymerase complex F8-A22-E4-H5 with exgenous DNA
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8wpk
Q-score: 0.512
Mol Cell (2023) 83 pp. 4398- [ Pubmed: 37995690 DOI: doi:10.1016/j.molcel.2023.10.038 ]
- Dna polymerase processivity factor (50 kDa, Protein from Monkeypox virus)
- H5r late gene transcription factor (23 kDa, Protein from Monkeypox virus)
- Magnesium ion (24 Da, Ligand)
- F8-a22-e4-h5 (Complex from Monkeypox virus)
- Template dna (14 kDa, DNA from synthetic construct)
- 2',3'-dideoxy-thymidine-5'-triphosphate (466 Da, Ligand)
- Primer dna (10 kDa, DNA from synthetic construct)
- Dna (Complex from Homo sapiens)
- F8-a22-e4-h5 with exogenous dna (Complex)
- Dna polymerase (117 kDa, Protein from Monkeypox virus)
- E4r uracil-dna glycosylase, dna polymerase processivity factor (25 kDa, Protein from Monkeypox virus)
Structure of monkeypox virus polymerase complex F8-A22-E4-H5 with endogenous DNA
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8wpp
Q-score: 0.41
Mol Cell (2023) 83 pp. 4398- [ Pubmed: 37995690 DOI: doi:10.1016/j.molcel.2023.10.038 ]
- H5r late gene transcription factor (23 kDa, Protein from Monkeypox virus)
- Primer dna (10 kDa, DNA from Homo sapiens)
- A22r dna polymerase processivity factor (50 kDa, Protein from Monkeypox virus)
- Template dna (14 kDa, DNA from Homo sapiens)
- F8-a22-e4-h5 (Complex from Monkeypox virus)
- F8-a22-e4-h5 with endogenous dna (Complex)
- Dna (Complex from Homo sapiens)
- Dna polymerase (117 kDa, Protein from Monkeypox virus)
- E4r uracil-dna glycosylase, dna polymerase processivity factor (25 kDa, Protein from Monkeypox virus)
Mol Cell (2023) 83 pp. 4398-4412.e4 [ Pubmed: 37995690 DOI: doi:10.1016/j.molcel.2023.10.038 ]
Cryo-EM structure of compound 9n bound ketone body receptor HCAR2-Gi signaling complex
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 8jhy
Q-score: 0.538
Zhao C, Wang H, Liu Y, Cheng L, Wang B, Tian X, Fu H, Wu C, Li Z, Shen C, Yu J, Yang S, Hu H, Fu P, Ma L, Wang C, Yan W, Shao Z
Mol Cell (2023) 83 pp. 3171- [ Pubmed: 37597514 DOI: doi:10.1016/j.molcel.2023.07.030 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Hca2 in complex with gi heterotrimer (Complex)
- Hydroxycarboxylic acid receptor 2 (46 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- 7-methyl-n-[(2r)-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide (428 Da, Ligand)
- Nicotinic acid receptor in complex with gi heterotrimer (Complex from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
Cryo-EM structure of compound 9n and niacin bound ketone body receptor HCAR2-Gi signaling complex
Resolution: 3.17 Å
EM Method: Single-particle
Fitted PDBs: 8jii
Q-score: 0.521
Zhao C, Wang H, Liu Y, Cheng L, Wang B, Tian X, Fu H, Wu C, Li Z, Shen C, Yu J, Yang S, Hu H, Fu P, Ma L, Wang C, Yan W, Shao Z
Mol Cell (2023) 83 pp. 3171- [ Pubmed: 37597514 DOI: doi:10.1016/j.molcel.2023.07.030 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nicotinic acid (123 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Hca2 in complex with gi heterotrimer (Complex)
- Hydroxycarboxylic acid receptor 2 (46 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- 7-methyl-n-[(2r)-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide (428 Da, Ligand)
- Water (18 Da, Ligand)
- Nicotinic acid receptor in complex with gi heterotrimer (Complex from Homo sapiens)
- Scfv16 (Complex from Mus musculus)