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Resolution: 3.87 Å
EM Method: Single-particle
Fitted PDBs: 7txd
Q-score: 0.352
Glogl M, Friedrich N, Cerutti G, Lemmin T, Kwon YD, Gorman J, Maliqi L, Mittl PRE, Hesselman MC, Schmidt D, Weber J, Foulkes C, Dingens AS, Bylund T, Olia AS, Verardi R, Reinberg T, Baumann NS, Rusert P, Dreier B, Shapiro L, Kwong PD, Pluckthun A, Trkola A
Nat Struct Mol Biol (2023) 30 pp. 1323-1336 [ DOI: doi:10.1038/s41594-023-01062-z Pubmed: 37605043 ]
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- T-cell surface glycoprotein cd4 (20 kDa, Protein from Homo sapiens)
- Bg505 sosip hiv-1 env trimer in complex with cd4 receptor (d1d2) and broadly neutralizing darpin bnd.9 (Complex from Human immunodeficiency virus 1)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Broadly neutralizing darpin bnd.9 (21 kDa, Protein from synthetic construct)
Structure of Bispecific CAP256V2LS-J3 Fab in complex with BG505 DS-SOSIP.664
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 8fis
Q-score: 0.453
Zhang B, Gorman J, Kwon YD, Pegu A, Chao CW, Liu T, Asokan M, Bender MF, Bylund T, Damron L, Gollapudi D, Lei P, Li Y, Liu C, Louder MK, McKee K, Olia AS, Rawi R, Schon A, Wang S, Yang ES, Yang Y, Carlton K, Doria-Rose NA, Shapiro L, Seaman MS, Mascola JR, Kwong PD
MABs (2023) 15 pp. 2165390-2165390 [ DOI: doi:10.1080/19420862.2023.2165390 Pubmed: 36729903 ]
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- J3-vrc26.25 light (37 kDa, Protein from Lama glama)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cap256v2ls-j3-3 fab in complex with bg505 ds-sosip.664 (Complex from Human immunodeficiency virus 1)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Vrc26.25 heavy (26 kDa, Protein from Homo sapiens)
Cryo-EM structure of SARS-CoV-2 spike in complex with FSR22, an anti-SARS-CoV-2 DARPin
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 7tyz
Q-score: 0.391
Chonira V, Kwon YD, Gorman J, Case JB, Ku Z, Simeon R, Casner RG, Harris DR, Olia AS, Stephens T, Shapiro L, Bender MF, Boyd H, Teng IT, Tsybovsky Y, Krammer F, Zhang N, Diamond MS, Kwong PD, An Z, Chen Z
Nat Chem Biol (2023) 19 pp. 284-291 [ DOI: doi:10.1038/s41589-022-01193-2 Pubmed: 36411391 ]
- Spike glycoprotein (138 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Darpin fsr22 (23 kDa, Protein from Escherichia phage EcSzw-2Escherichia coli)
- Darpin fsr22 in complex with sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 4.17 Å
EM Method: Single-particle
Fitted PDBs: 7tz0
Q-score: 0.228
Resolution: 4.11 Å
EM Method: Single-particle
Fitted PDBs: 8dw2
Q-score: 0.351
Chonira V, Kwon YD, Gorman J, Case JB, Ku Z, Simeon R, Casner RG, Harris DR, Olia AS, Stephens T, Shapiro L, Bender MF, Boyd H, Teng IT, Tsybovsky Y, Krammer F, Zhang N, Diamond MS, Kwong PD, An Z, Chen Z
Nat Chem Biol (2023) 19 pp. 284-291 [ DOI: doi:10.1038/s41589-022-01193-2 Pubmed: 36411391 ]
- Darpin sr22 in complex with sars-cov-2 rbd and antibody fabs, s309 and cr3022 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Antibody cr3022 light chain (24 kDa, Protein from Homo sapiens)
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Antibody cr3022 heavy chain (23 kDa, Protein from Homo sapiens)
- Antibody s309 heavy chain (24 kDa, Protein from Homo sapiens)
- Antibody s309 light chain (23 kDa, Protein from Homo sapiens)
- Sr22 (16 kDa, Protein from Escherichia phage EcSzw-2)
Resolution: 4.26 Å
EM Method: Single-particle
Fitted PDBs: 8dw3
Q-score: 0.337
Chonira V, Kwon YD, Gorman J, Case JB, Ku Z, Simeon R, Casner RG, Harris DR, Olia AS, Stephens T, Shapiro L, Bender MF, Boyd H, Teng IT, Tsybovsky Y, Krammer F, Zhang N, Diamond MS, Kwong PD, An Z, Chen Z
Nat Chem Biol (2023) 19 pp. 284-291 [ DOI: doi:10.1038/s41589-022-01193-2 Pubmed: 36411391 ]
- Anti-sars-cov-2 darpin sr16m (16 kDa, Protein from Homo sapiens)
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Antibody s309 heavy chain (24 kDa, Protein from Homo sapiens)
- Antibody cr3022 heavy chain (23 kDa, Protein from Homo sapiens)
- Antibody s309 light chain (23 kDa, Protein from Homo sapiens)
- Darpin sr16m in complex with sars-cov-2 rbd and antibody fabs, s309 and cr3022 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Antibody cr3022 light chain (24 kDa, Protein from Homo sapiens)
Cryo-EM structure of llama J3 VHH antibody in complex with HIV-1 Env BG505 DS-SOSIP.664
Resolution: 3.61 Å
EM Method: Single-particle
Fitted PDBs: 7lpn
Q-score: 0.465
Zhou T, Chen L, Gorman J, Wang S, Kwon YD, Lin BC, Louder MK, Rawi R, Stancofski ED, Yang Y, Zhang B, Quigley AF, McCoy LE, Rutten L, Verrips T, Weiss RA, Doria-Rose NA, Shapiro L, Kwong PD
Structure (2022) 30 pp. 862-875.e4 [ Pubmed: 35413243 DOI: doi:10.1016/j.str.2022.03.012 ]
- Hiv-1 env with llama j3 vhh (Complex from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope glycoprotein gp160 (53 kDa, Protein from Human immunodeficiency virus 1)
- J3 vhh (14 kDa, Protein from Lama glama)
- Hiv-1 envelope glycoprotein bg505 sosip.664 gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
Cryo-EM structure of VRC01.23 in complex with HIV-1 Env BG505 DS.SOSIP
Resolution: 3.43 Å
EM Method: Single-particle
Fitted PDBs: 6vi0
Q-score: 0.502
Kwon YD, Asokan M, Gorman J, Zhang B, Liu Q, Louder MK, Lin BC, McKee K, Pegu A, Verardi R, Yang ES, Program VP, Carlton K, Doria-Rose NA, Lusso P, Mascola JR, Kwong PD
MABs () 13 pp. 1946918-1946918 [ DOI: doi:10.1080/19420862.2021.1946918 Pubmed: 34328065 ]
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Bg505 gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Vrc01.23 heavy chain (25 kDa, Protein from Homo sapiens)
- Vrc01.23 light chain (22 kDa, Protein from Homo sapiens)
- Bg505 ds.sosip with antibody vrc01.23 fab (Complex from Human immunodeficiency virus 1)
- Hiv-1 env bg505 ds-sosip and antibodies vrc01.23 (Complex)
Full-length HIV-1 Envelope glycoprotein clone PC64 in DOPC-CHS bicelle
Rantalainen K, Berndsen ZT, Antanasijevic A, Schiffner T, Zhang X, Lee WH, Torres JL, Zhang L, Irimia A, Copps J, Zhou KH, Kwon YD, Law WH, Schramm CA, Verardi R, Krebs SJ, Kwong PD, Doria-Rose NA, Wilson IA, Zwick MB, Schief WR, Ward AB
Cell Rep (2020) 31 pp. 107583-107583 [ DOI: doi:10.1016/j.celrep.2020.107583 Pubmed: 32348769 ]
Full-length HIV-1 Envelope glycoprotein clone PC64 in complex with PGT151 Fab and VRC42.01 Fab
Rantalainen K, Berndsen ZT, Antanasijevic A, Schiffner T, Zhang X, Lee WH, Torres JL, Zhang L, Irimia A, Copps J, Zhou KH, Kwon YD, Law WH, Schramm CA, Verardi R, Krebs SJ, Kwong PD, Doria-Rose NA, Wilson IA, Zwick MB, Schief WR, Ward AB
Cell Rep (2020) 31 pp. 107583-107583 [ DOI: doi:10.1016/j.celrep.2020.107583 Pubmed: 32348769 ]