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48S late-stage initiation complex with m6A mRNA
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 8p03
Q-score: 0.509
Guca E, Alarcon R, Palo MZ, Santos L, Alonso-Gil S, Davyt M, de Lima LHF, Boissier F, Das S, Zagrovic B, Puglisi JD, Hashem Y, Ignatova Z
Mol Cell (2024) 84 pp. 584-595.e6 [ DOI: doi:10.1016/j.molcel.2023.12.028 Pubmed: 38244546 ]
- 40s ribosomal protein us13 (17 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l41 (3 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s4 (29 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein es19 (15 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein us15 (17 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s6 (27 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s9 (22 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s25 (13 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us9 (15 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein es1 (24 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein s15a (14 kDa, Protein from Oryctolagus cuniculus)
- Magnesium ion (24 Da, Ligand)
- Ribosomal protein es7 (21 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein es10 (11 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s12 (14 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us19 (17 kDa, Protein from Oryctolagus cuniculus)
- Eukaryotic translation initiation factor 4c (12 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein sa (23 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein es17 (15 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s28 (7 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s2 (29 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s29 (6 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein rack1 (34 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein s5 (21 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s24 (15 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s27 (9 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein s3 (25 kDa, Protein from Oryctolagus cuniculus)
- Eukaryotic translation initiation factor 2 subunit 1 (32 kDa, Protein from Oryctolagus cuniculus)
- Atp binding cassette subfamily e member 1 (66 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us10 (13 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s8 (23 kDa, Protein from Oryctolagus cuniculus)
- M6a-methylated mrna (2 kDa, RNA from Oryctolagus cuniculus)
- 40s ribosomal protein s23 (15 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s30 (14 kDa, Protein from Oryctolagus cuniculus)
- 18s ribosomal rna (601 kDa, RNA from Oryctolagus cuniculus)
- 40s ribosomal protein s11 (18 kDa, Protein from Oryctolagus cuniculus)
- 48s late-stage initiation complex with m6a-modified mrna (Complex from Oryctolagus cuniculus)
- Initiator methionylated trna (24 kDa, RNA from Oryctolagus cuniculus)
- 40s ribosomal protein s26 (12 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us11 (16 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s21 (9 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein es31 (8 kDa, Protein from Oryctolagus cuniculus)
48S late-stage initiation complex with non methylated mRNA
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8p09
Q-score: 0.494
Guca E, Alarcon R, Palo MZ, Santos L, Alonso-Gil S, Davyt M, de Lima LHF, Boissier F, Das S, Zagrovic B, Puglisi JD, Hashem Y, Ignatova Z
Mol Cell (2024) 84 pp. 584-595.e6 [ DOI: doi:10.1016/j.molcel.2023.12.028 Pubmed: 38244546 ]
- 40s ribosomal protein us13 (17 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein l41 (3 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s4 (29 kDa, Protein from Oryctolagus cuniculus)
- Mrna (2 kDa, RNA from Oryctolagus cuniculus)
- 40s ribosomal protein es19 (15 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein us15 (17 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s6 (27 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s9 (22 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s25 (13 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us9 (15 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein es1 (24 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein s15a (14 kDa, Protein from Oryctolagus cuniculus)
- 48s late-stage initiation complex with non methylated mrna (Complex from Oryctolagus cuniculus)
- Magnesium ion (24 Da, Ligand)
- Ribosomal protein es7 (21 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein es10 (11 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s12 (14 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us19 (17 kDa, Protein from Oryctolagus cuniculus)
- Eukaryotic translation initiation factor 4c (12 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein sa (23 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein es17 (15 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s28 (7 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s2 (29 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s29 (6 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein rack1 (34 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein s5 (21 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s24 (15 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s27 (9 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein s3 (25 kDa, Protein from Oryctolagus cuniculus)
- Eukaryotic translation initiation factor 2 subunit 1 (32 kDa, Protein from Oryctolagus cuniculus)
- Atp binding cassette subfamily e member 1 (66 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us10 (13 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s8 (23 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s23 (15 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s30 (14 kDa, Protein from Oryctolagus cuniculus)
- 18s ribosomal rna (601 kDa, RNA from Oryctolagus cuniculus)
- 40s ribosomal protein s11 (18 kDa, Protein from Oryctolagus cuniculus)
- Initiator methionylated trna (24 kDa, RNA from Oryctolagus cuniculus)
- 40s ribosomal protein s26 (12 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us11 (16 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s21 (9 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein es31 (8 kDa, Protein from Oryctolagus cuniculus)
Mammalian 48S late-stage initiation complex with beta-globin mRNA
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6yal
Q-score: 0.379
Simonetti A, Guca E, Bochler A, Kuhn L, Hashem Y
Cell Rep (2020) 31 pp. 107497-107497 [ Pubmed: 32268096 DOI: doi:10.1016/j.celrep.2020.03.061 ]
- 40s ribosomal protein es31 (8 kDa, Protein from Rabbit)
- 40s ribosomal protein us14 (6 kDa, Protein from Rabbit)
- Ls48s ic with beta-globin mrna (Complex)
- 40s ribosomal protein us11 (16 kDa, Protein from Rabbit)
- 40s ribosomal protein us4 (21 kDa, Protein from Rabbit)
- 40s ribosomal protein us17 (18 kDa, Protein from Rabbit)
- Atp-binding cassette sub-family e member 1 (abce1) (66 kDa, Protein from Rabbit)
- 40s ribosomal protein us19 (17 kDa, Protein from Rabbit)
- Beta-globin mrna (Complex from Homo sapiens)
- Eukaryotic translation initiation factor 2 subunit alpha (32 kDa, Protein from Rabbit)
- 60s ribosomal protein ul41 (3 kDa, Protein from Rabbit)
- 40s ribosomal protein es27 (9 kDa, Protein from Rabbit)
- 40s ribosomal protein es4 (29 kDa, Protein from Rabbit)
- 40s ribosomal protein es7 (21 kDa, Protein from Rabbit)
- 40s ribosomal protein us10 (13 kDa, Protein from Rabbit)
- Ribosomal protein rack1 (34 kDa, Protein from Rabbit)
- Phosphoaminophosphonic acid-guanylate ester (522 Da, Ligand)
- Iron/sulfur cluster (351 Da, Ligand)
- 18s ribosomal rna (601 kDa, RNA from Rabbit)
- 40s ribosomal protein us13 (17 kDa, Protein from Rabbit)
- Ls48s ic (Complex from Oryctolagus cuniculus)
- 40s ribosomal protein es8 (23 kDa, Protein from Rabbit)
- 40s ribosomal protein es17 (15 kDa, Protein from Rabbit)
- 40s ribosomal protein us5 (24 kDa, Protein from Rabbit)
- 40s ribosomal protein us2 (23 kDa, Protein from Rabbit)
- 40s ribosomal protein es12 (14 kDa, Protein from Rabbit)
- Eukaryotic translation initiation factor 1a (12 kDa, Protein from Rabbit)
- 40s ribosomal protein es24 (15 kDa, Protein from Rabbit)
- 40s ribosomal protein us3 (26 kDa, Protein from Rabbit)
- Initiator methionylated trna (24 kDa, RNA from Rabbit)
- 40s ribosomal protein es1 (29 kDa, Protein from Rabbit)
- 40s ribosomal protein es10 (11 kDa, Protein from Rabbit)
- 40s ribosomal protein es25 (13 kDa, Protein from Rabbit)
- 40s ribosomal protein es19 (15 kDa, Protein from Rabbit)
- 40s ribosomal protein us9 (15 kDa, Protein from Rabbit)
- 40s ribosomal protein us7 (21 kDa, Protein from Rabbit)
- 40s ribosomal protein es26 (12 kDa, Protein from Rabbit)
- 40s ribosomal protein es6 (27 kDa, Protein from Rabbit)
- 40s ribosomal protein es28 (7 kDa, Protein from Rabbit)
- Beta-globin mrna (13 kDa, RNA from Homo sapiens)
- 40s ribosomal protein es30 (14 kDa, Protein from Rabbit)
- 40s ribosomal protein us15 (17 kDa, Protein from Rabbit)
- Eukaryotic translation initiation factor 2 subunit gamma (45 kDa, Protein from Rabbit)
- 40s ribosomal protein es21 (8 kDa, Protein from Rabbit)
- 40s ribosomal protein us12 (15 kDa, Protein from Rabbit)
- 40s ribosomal protein us8 (14 kDa, Protein from Rabbit)
- Magnesium ion (24 Da, Ligand)
Mammalian 48S late-stage translation initiation complex (LS48S+eIF3 IC) with beta-globin mRNA
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6yam
Q-score: 0.257
Simonetti A, Guca E, Bochler A, Kuhn L, Hashem Y
Cell Rep (2020) 31 pp. 107497-107497 [ Pubmed: 32268096 DOI: doi:10.1016/j.celrep.2020.03.061 ]
- Eukaryotic translation initiation factor 3 subunit h (39 kDa, Protein from Rabbit)
- 40s ribosomal protein us3 (25 kDa, Protein from Rabbit)
- 40s ribosomal protein es19 (16 kDa, Protein from Rabbit)
- Ribosomal protein us14 (6 kDa, Protein from Rabbit)
- 40s ribosomal protein us11 (16 kDa, Protein from Rabbit)
- Ribosomal protein es31 (8 kDa, Protein from Rabbit)
- 40s ribosomal protein us4 (21 kDa, Protein from Rabbit)
- 40s ribosomal protein us17 (18 kDa, Protein from Rabbit)
- Eukaryotic translation initiation factor 3 subunit a (163 kDa, Protein from Rabbit)
- Atp-binding cassette sub-family e member 1 (abce1) (66 kDa, Protein from Rabbit)
- 40s ribosomal protein us19 (17 kDa, Protein from Rabbit)
- Beta-globin mrna (Complex from Homo sapiens)
- Ribosomal protein es7 (21 kDa, Protein from Rabbit)
- 40s ribosomal protein us7 (21 kDa, Protein from Rabbit)
- 40s ribosomal protein es27 (9 kDa, Protein from Rabbit)
- 40s ribosomal protein es4 (29 kDa, Protein from Rabbit)
- Ribosomal protein es25 (8 kDa, Protein from Rabbit)
- 40s ribosomal protein us10 (13 kDa, Protein from Rabbit)
- Ls48s+eif3 ic (Complex from Oryctolagus cuniculus)
- Eukaryotic translation initiation factor 3 subunit m (42 kDa, Protein from Rabbit)
- Ribosomal protein rack1 (34 kDa, Protein from Rabbit)
- Phosphoaminophosphonic acid-guanylate ester (522 Da, Ligand)
- Iron/sulfur cluster (351 Da, Ligand)
- 18s ribosomal rna (601 kDa, RNA from Rabbit)
- 40s ribosomal protein us13 (17 kDa, Protein from Rabbit)
- 40s ribosomal protein es8 (23 kDa, Protein from Rabbit)
- Eukaryotic translation initiation factor 2 subunit alpha (30 kDa, Protein from Rabbit)
- Eukaryotic translation initiation factor 1a (16 kDa, Protein from Rabbit)
- 40s ribosomal protein es17 (15 kDa, Protein from Rabbit)
- Eukaryotic translation initiation factor 3 subunit k (25 kDa, Protein from Rabbit)
- Eukaryotic translation initiation factor 3 subunit c (105 kDa, Protein from Rabbit)
- 40s ribosomal protein us5 (24 kDa, Protein from Rabbit)
- 40s ribosomal protein es12 (14 kDa, Protein from Rabbit)
- 40s ribosomal protein es30 (6 kDa, Protein from Rabbit)
- Eukaryotic translation initiation factor 3 subunit f (30 kDa, Protein from Rabbit)
- 40s ribosomal protein es24 (15 kDa, Protein from Rabbit)
- Initiator methionylated trna (24 kDa, RNA from Rabbit)
- 40s ribosomal protein us2 (23 kDa, Protein from Rabbit)
- 40s ribosomal protein es1 (29 kDa, Protein from Rabbit)
- 40s ribosomal protein es10 (11 kDa, Protein from Rabbit)
- Eukaryotic translation initiation factor 2 subunit gamma (45 kDa, Protein from Rabbit)
- 40s ribosomal protein us9 (15 kDa, Protein from Rabbit)
- 40s ribosomal protein es26 (12 kDa, Protein from Rabbit)
- 40s ribosomal protein es6 (27 kDa, Protein from Rabbit)
- 40s ribosomal protein us12 (15 kDa, Protein from Rabbit)
- Eukaryotic translation initiation factor 3 subunit e (52 kDa, Protein from Rabbit)
- 40s ribosomal protein es28 (7 kDa, Protein from Rabbit)
- 60s ribosomal protein l41 (3 kDa, Protein from Rabbit)
- Eukaryotic translation initiation factor 3 subunit d (64 kDa, Protein from Rabbit)
- Ribosomal protein us15 (17 kDa, Protein from Rabbit)
- Eukaryotic translation initiation factor 3 subunit l (66 kDa, Protein from Rabbit)
- Ls48s+eif3 ic with beta-globin mrna (Complex)
- 40s ribosomal protein es21 (8 kDa, Protein from Rabbit)
- 40s ribosomal protein us8 (14 kDa, Protein from Rabbit)
- Beta-globin mrna (14 kDa, RNA from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
Mammalian 48S late-stage translation initiation complex with histone 4 mRNA
Resolution: 3.48 Å
EM Method: Single-particle
Fitted PDBs: 6yan
Q-score: 0.351
Simonetti A, Guca E, Bochler A, Kuhn L, Hashem Y
Cell Rep (2020) 31 pp. 107497-107497 [ Pubmed: 32268096 DOI: doi:10.1016/j.celrep.2020.03.061 ]
- Ribosomal protein us14 (6 kDa, Protein from Rabbit)
- Ribosomal protein es31 (8 kDa, Protein from Rabbit)
- Ribosomal protein s11 (18 kDa, Protein from Rabbit)
- Ribosomal protein es7 (21 kDa, Protein from Rabbit)
- Ribosomal protein es25 (8 kDa, Protein from Rabbit)
- 40s ribosomal protein sa (23 kDa, Protein from Rabbit)
- Ribosomal protein es28 (7 kDa, Protein from Rabbit)
- Ribosomal protein rack1 (34 kDa, Protein from Rabbit)
- Ribosomal protein s15 (15 kDa, Protein from Rabbit)
- 40s ribosomal protein s4 (29 kDa, Protein from Rabbit)
- 18s ribosomal rna (601 kDa, RNA from Rabbit)
- Ls48s ic (Complex from Oryctolagus cuniculus)
- 40s ribosomal protein us13 (16 kDa, Protein from Rabbit)
- 40s ribosomal protein us11 (14 kDa, Protein from Rabbit)
- Ribosomal protein es17 (14 kDa, Protein from Rabbit)
- 40s ribosomal protein es26 (11 kDa, Protein from Rabbit)
- 40s ribosomal protein us5 (24 kDa, Protein from Rabbit)
- Histone 4 mrna (Complex from Mus musculus)
- 40s ribosomal protein es30 (6 kDa, Protein from Rabbit)
- Ribosomal protein s9 (predicted) (21 kDa, Protein from Rabbit)
- Eukaryotic translation initiation factor 2 subunit 1 (30 kDa, Protein from Rabbit)
- 40s ribosomal protein s21 (8 kDa, Protein from Rabbit)
- Initiator methionylated trna (24 kDa, RNA from Rabbit)
- Ribosomal protein s15a (14 kDa, Protein from Rabbit)
- 40s ribosomal protein es10 (11 kDa, Protein from Rabbit)
- Eukaryotic translation initiation factor 2 subunit gamma (45 kDa, Protein from Rabbit)
- 40s ribosomal protein s6 (27 kDa, Protein from Rabbit)
- 40s ribosomal protein es19 (15 kDa, Protein from Rabbit)
- Ls48s ic with histone 4 mrna (Complex)
- 40s ribosomal protein s12 (13 kDa, Protein from Rabbit)
- Ribosomal protein s5 (21 kDa, Protein from Rabbit)
- Histone 4 (h4) mrna (11 kDa, RNA from Mus musculus)
- 40s ribosomal protein us12 (15 kDa, Protein from Rabbit)
- 60s ribosomal protein l41 (3 kDa, Protein from Rabbit)
- Ribosomal protein us15 (17 kDa, Protein from Rabbit)
- Ribosomal_s10 domain-containing protein (11 kDa, Protein from Rabbit)
- Ribosomal protein us9 (15 kDa, Protein from Rabbit)
- 40s ribosomal protein s24 (14 kDa, Protein from Rabbit)
- Ribosomal protein s3 (25 kDa, Protein from Rabbit)
- Ribosomal protein es1 (24 kDa, Protein from Rabbit)
- 40s ribosomal protein s27 (9 kDa, Protein from Rabbit)
- 40s ribosomal protein s8 (23 kDa, Protein from Rabbit)
Mammalian late-stage translation initiation complex with beta-globin mRNA in presence of ATP
Simonetti A, Guca E, Bochler A, Kuhn L, Hashem Y
Cell Rep (2020) 31 pp. 107497-107497 [ Pubmed: 32268096 DOI: doi:10.1016/j.celrep.2020.03.061 ]
Mammalian late-stage translation initiation complex with beta-globin mRNA in presence of ATP
Simonetti A, Guca E, Bochler A, Kuhn L, Hashem Y
Cell Rep (2020) 31 pp. 107497-107497 [ Pubmed: 32268096 DOI: doi:10.1016/j.celrep.2020.03.061 ]