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CryoEM structure of human orphan GPCR GPR179 in complex with extracellular matrix protein pikachurin
Resolution: 3.57 Å
EM Method: Single-particle
Fitted PDBs: 8d1b
Q-score: 0.476
Patil DN, Pantalone S, Cao Y, Laboute T, Novick SJ, Singh S, Savino S, Faravelli S, Magnani F, Griffin PR, Singh AK, Forneris F, Martemyanov KA
Sci Signal (2023) 16 pp. eadd9539-eadd9539 [ Pubmed: 37490546 DOI: doi:10.1126/scisignal.add9539 ]
- Complex of gpr179 with pikachurin (Complex from Homo sapiens)
- Pikachurin (25 kDa, Protein from Homo sapiens)
- Probable g-protein coupled receptor 179 (81 kDa, Protein from Homo sapiens)
Negative stain EM assembly of MYC, JAZ, and NINJA complex
Resolution: 10.4 Å
EM Method: Single-particle
Fitted PDBs: 8t2i
Q-score: 0.038
Zhou XE, Zhang Y, Yao J, Zheng J, Zhou Y, He Q, Moreno J, Lam VQ, Cao X, Sugimoto K, Vanegas-Cano L, Kariapper L, Suino-Powell K, Zhu Y, Novick S, Griffin PR, Zhang F, Howe GA, Melcher K
Plant Commun. (2023) 4 pp. 100639-100639 [ DOI: doi:10.1016/j.xplc.2023.100639 Pubmed: 37322867 ]
- Maltose/maltodextrin-binding periplasmic protein (44 kDa, Protein from Escherichia coli)
- Protein tify 10a (27 kDa, Protein from Arabidopsis thaliana)
- Transcription factor myc3 (20 kDa, Protein from Arabidopsis thaliana)
- Afp homolog 2 (44 kDa, Protein from Arabidopsis thaliana)
- Mbp fused myc jaz ninja complex (Complex from Arabidopsis thaliana)
Wei G, Iqbal N, Courouble VV, Francis AC, Singh PK, Hudait A, Annamalai AS, Bester S, Huang SW, Shkriabai N, Briganti L, Haney R, KewalRamani VN, Voth GA, Engelman AN, Melikyan GB, Griffin PR, Asturias F, Kvaratskhelia M
Nat Commun (2022) 13 pp. 5879-5879 [ DOI: doi:10.1038/s41467-022-33662-6 Pubmed: 36202818 ]
Wei G, Iqbal N, Courouble VV, Francis AC, Singh PK, Hudait A, Annamalai AS, Bester S, Huang SW, Shkriabai N, Briganti L, Haney R, KewalRamani VN, Voth GA, Engelman AN, Melikyan GB, Griffin PR, Asturias F, Kvaratskhelia M
Nat Commun (2022) 13 pp. 5879-5879 [ DOI: doi:10.1038/s41467-022-33662-6 Pubmed: 36202818 ]
Wei G, Iqbal N, Courouble VV, Francis AC, Singh PK, Hudait A, Annamalai AS, Bester S, Huang SW, Shkriabai N, Briganti L, Haney R, KewalRamani VN, Voth GA, Engelman AN, Melikyan GB, Griffin PR, Asturias F, Kvaratskhelia M
Nat Commun (2022) 13 pp. 5879-5879 [ DOI: doi:10.1038/s41467-022-33662-6 Pubmed: 36202818 ]
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8cvp
Q-score: 0.465
Watson ER, Novick S, Matyskiela ME, Chamberlain PP, H de la Pena A, Zhu J, Tran E, Griffin PR, Wertz IE, Lander GC
Science (2022) 378 pp. 549-553 [ DOI: doi:10.1126/science.add7574 Pubmed: 36378961 ]
- Dna damage-binding protein 1 (127 kDa, Protein from Homo sapiens)
- Cereblon~ddb1 in the apo form (177 kDa, Complex from Homo sapiens)
- Protein cereblon (50 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
Cereblon~DDB1 bound to CC-92480 with DDB1 in the linear conformation
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8d7u
Q-score: 0.515
Watson ER, Novick S, Matyskiela ME, Chamberlain PP, H de la Pena A, Zhu J, Tran E, Griffin PR, Wertz IE, Lander GC
Science (2022) 378 pp. 549-553 [ DOI: doi:10.1126/science.add7574 Pubmed: 36378961 ]
- Cereblon~ddb1 bound to cc-92480 with ddb1 in the linear conformation (177 kDa, Complex from Homo sapiens)
- Protein cereblon (50 kDa, Protein from Homo sapiens)
- Dna damage-binding protein 1 (127 kDa, Protein from Homo sapiens)
- Mezigdomide (567 Da, Ligand)
- Zinc ion (65 Da, Ligand)
Cereblon~DDB1 bound to CC-92480 with DDB1 in the twisted conformation
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8d7v
Q-score: 0.45
Watson ER, Novick S, Matyskiela ME, Chamberlain PP, H de la Pena A, Zhu J, Tran E, Griffin PR, Wertz IE, Lander GC
Science (2022) 378 pp. 549-553 [ DOI: doi:10.1126/science.add7574 Pubmed: 36378961 ]
- Cereblon~ddb1 bound to cc-92480 with ddb1 in the twisted conformation (177 kDa, Complex from Homo sapiens)
- Protein cereblon (50 kDa, Protein from Homo sapiens)
- Dna damage-binding protein 1 (127 kDa, Protein from Homo sapiens)
- Mezigdomide (567 Da, Ligand)
- Zinc ion (65 Da, Ligand)
Cereblon~DDB1 bound to CC-92480 with DDB1 in the hinged conformation
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8d7w
Q-score: 0.476
Watson ER, Novick S, Matyskiela ME, Chamberlain PP, H de la Pena A, Zhu J, Tran E, Griffin PR, Wertz IE, Lander GC
Science (2022) 378 pp. 549-553 [ DOI: doi:10.1126/science.add7574 Pubmed: 36378961 ]
- Cereblon~ddb1 bound to cc-92480 with ddb1 in the hinged conformation (177 kDa, Complex from Homo sapiens)
- Protein cereblon (50 kDa, Protein from Homo sapiens)
- Dna damage-binding protein 1 (127 kDa, Protein from Homo sapiens)
- Mezigdomide (567 Da, Ligand)
- Zinc ion (65 Da, Ligand)
Cereblon~DDB1 in the Apo form with DDB1 in the hinged conformation
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8d7x
Q-score: 0.488
Watson ER, Novick S, Matyskiela ME, Chamberlain PP, H de la Pena A, Zhu J, Tran E, Griffin PR, Wertz IE, Lander GC
Science (2022) 378 pp. 549-553 [ DOI: doi:10.1126/science.add7574 Pubmed: 36378961 ]
- Dna damage-binding protein 1 (127 kDa, Protein from Homo sapiens)
- Cereblon~ddb1 in the apo form with ddb1 in the hinged conformation (177 kDa, Complex from Homo sapiens)
- Protein cereblon (50 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)