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Cryo EM structure of the type 3B polymorph of alpha-synuclein at low pH.
Frey L, Ghosh D, Qureshi BM, Rhyner D, Pokharna A, Guerrero-Ferreira R, Kwiatkowski W, Serdiuk T, Picotti P, Riek R, Greenwald J
eLife (2023) [ DOI: doi:10.7554/eLife.93562.1 ]
- Water (18 Da, Ligand)
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Alpha-synuclein amyloid fibril (Complex from Homo sapiens)
- Chloride ion (35 Da, Ligand)
Cryo EM structure of the type 3C polymorph of alpha-synuclein at low pH.
Frey L, Ghosh D, Qureshi BM, Rhyner D, Pokharna A, Guerrero-Ferreira R, Kwiatkowski W, Serdiuk T, Picotti P, Riek R, Greenwald J
eLife (2023) [ DOI: doi:10.7554/eLife.93562.1 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Alpha-synuclein amyloid fibril (Complex from Homo sapiens)
Cryo EM structure of the type 3D polymorph of alpha-synuclein E46K mutant at low pH.
Resolution: 2.31 Å
EM Method: Helical reconstruction
Fitted PDBs: 8pjo
Q-score: 0.672
Frey L, Ghosh D, Qureshi BM, Rhyner D, Pokharna A, Guerrero-Ferreira R, Kwiatkowski W, Serdiuk T, Picotti P, Riek R, Greenwald J
eLife (2023) [ DOI: doi:10.7554/eLife.93562.1 ]
- Water (18 Da, Ligand)
- Alpha-synuclein amyloid fibril (Complex from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
Cryo EM structure of the type 1m polymorph of alpha-synuclein
Frey L, Ghosh D, Qureshi BM, Rhyner D, Pokharna A, Guerrero-Ferreira R, Kwiatkowski W, Serdiuk T, Picotti P, Riek R, Greenwald J
eLife (2023) [ DOI: doi:10.7554/eLife.93562.1 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Alpha-synuclein amyloid fibril (Complex from Homo sapiens)
Cryo EM structure of the type 5A polymorph of alpha-synuclein.
Frey L, Ghosh D, Qureshi BM, Rhyner D, Pokharna A, Guerrero-Ferreira R, Kwiatkowski W, Serdiuk T, Picotti P, Riek R, Greenwald J
eLife (2023) [ DOI: doi:10.7554/eLife.93562.1 ]
- Alpha-synuclein amyloid fibril (Complex from Homo sapiens)
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
Cryo EM map of the type 2A polymorph of alpha-synuclein at pH 7.0.
Frey L, Ghosh D, Qureshi BM, Rhyner D, Pokharna A, Guerrero-Ferreira R, Kwiatkowski W, Serdiuk T, Picotti P, Riek R, Greenwald J
eLife (2023) [ DOI: doi:10.7554/eLife.93562.1 ]
Cryo EM map of the type 2B polymorph of alpha-synuclein at pH 7.0.
Frey L, Ghosh D, Qureshi BM, Rhyner D, Pokharna A, Guerrero-Ferreira R, Kwiatkowski W, Serdiuk T, Picotti P, Riek R, Greenwald J
eLife (2023) [ DOI: doi:10.7554/eLife.93562.1 ]
Structure of Gabija AB complex
Resolution: 2.79 Å
EM Method: Single-particle
Fitted PDBs: 8tjy
Q-score: 0.534
Yang XY, Shen Z, Xie J, Greenwald J, Marathe I, Lin Q, Xie WJ, Wysocki VH, Fu TM
Nat Struct Mol Biol (2024) [ Pubmed: 38627580 DOI: doi:10.1038/s41594-024-01283-w ]
- Tetramer of gabija protein a (Complex from Bacillus cereus)
- Gabija protein gajb (57 kDa, Protein from Bacillus cereus)
- Endonuclease gaja (67 kDa, Protein from Bacillus cereus)
Structure of Gabija AB complex
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8tk0
Q-score: 0.496
Yang XY, Shen Z, Xie J, Greenwald J, Marathe I, Lin Q, Xie WJ, Wysocki VH, Fu TM
Nat Struct Mol Biol (2024) [ Pubmed: 38627580 DOI: doi:10.1038/s41594-024-01283-w ]
- Tetramer of gabija protein a (Complex from Bacillus cereus)
- Endonuclease gaja (67 kDa, Protein from Bacillus cereus)
Structure of Gabija AB complex 1
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8tk1
Q-score: 0.453
Yang XY, Shen Z, Xie J, Greenwald J, Marathe I, Lin Q, Xie WJ, Wysocki VH, Fu TM
Nat Struct Mol Biol (2024) [ Pubmed: 38627580 DOI: doi:10.1038/s41594-024-01283-w ]
- Tetramer of gabija protein ab (4:4) (Complex from Bacillus cereus)
- Gabija protein gajb (57 kDa, Protein from Bacillus cereus)
- Endonuclease gaja (67 kDa, Protein from Bacillus cereus)