Do data resources managed by EMBL-EBI and our collaborators make a difference to your work? Please take 10 minutes to fill in our annual user survey, and help us make the case for why sustaining open data resources is critical for life sciences research. We appreciate your responses prior to closing of the survey on Monday 17th June.
Cryo-EM structure of the CAK-THZ1 complex
Cushing VI, Koh AF, Feng J, Jurgaityte K, Bondke A, Kroll SHB, Barbazanges M, Scheiper B, Bahl AK, Barrett AGM, Ali S, Kotecha A, Greber BJ
Nat Commun (2024) 15 [ DOI: 10.1038/s41467-024-46375-9 Pubmed: 38480681 ]
Image sets:
Cryo-EM structure of the CAK-CT7030 complex
Cushing VI, Koh AF, Feng J, Jurgaityte K, Bondke A, Kroll SHB, Barbazanges M, Scheiper B, Bahl AK, Barrett AGM, Ali S, Kotecha A, Greber BJ
Nat Commun (2024) 15 [ DOI: 10.1038/s41467-024-46375-9 Pubmed: 38480681 ]
Image sets:
Cryo-EM of the human CAK: Data for 1.73 Å-resolution reconstruction
Cushing VI, Koh AF, Feng J, Jurgaityte K, Bondke A, Kroll SHB, Barbazanges M, Scheiper B, Bahl AK, Barrett AGM, Ali S, Kotecha A, Greber BJ
Nat Commun (2024) 15 [ DOI: 10.1038/s41467-024-46375-9 Pubmed: 38480681 ]
Image sets:
- EER movies, CAK-ICEC0942, grid VC13-1
- EER movies, CAK-BS181, grid VC8-1
- EER movies, CAK-dinaciclib, grid VC4-3
- EER movies, CAK-ICEC0942, grid VC14-1
- EER movies, CAK-ICEC0943, grid VC1-1
- EER movies, CAK-ICEC0768, grid VC2-4
Cushing VI, Koh AF, Feng J, Jurgaityte K, Bondke A, Kroll SHB, Barbazanges M, Scheiper B, Bahl AK, Barrett AGM, Ali S, Kotecha A, Greber BJ
Nat Commun (2024) 15 [ DOI: 10.1038/s41467-024-46375-9 Pubmed: 38480681 ]
Image sets:
Cryo-EM structure of CAK in complex with nucleotide analogue ATPgS
Cushing VI, Koh AF, Feng J, Jurgaityte K, Bondke A, Kroll SHB, Barbazanges M, Scheiper B, Bahl AK, Barrett AGM, Ali S, Kotecha A, Greber BJ
Nat Commun (2024) 15 [ DOI: 10.1038/s41467-024-46375-9 Pubmed: 38480681 ]
Image sets:
Cryo-EM structure of CAK in complex with inhibitor BS-181
Resolution: 1.9 Å
EM Method: Single-particle
Fitted PDBs: 8p6w
Q-score: 0.727
Cushing VI, Koh AF, Feng J, Jurgaityte K, Bondke A, Kroll SHB, Barbazanges M, Scheiper B, Bahl AK, Barrett AGM, Ali S, Kotecha A, Greber BJ
Nat Commun (2024) 15 pp. 2265-2265 [ DOI: doi:10.1038/s41467-024-46375-9 Pubmed: 38480681 ]
- Cdk-activating kinase assembly factor mat1 (10 kDa, Protein from Homo sapiens)
- ~{n}5-(6-azanylhexyl)-~{n}7-(phenylmethyl)-3-propan-2-yl-pyrazolo[1,5-a]pyrimidine-5,7-diamine (380 Da, Ligand)
- Cdk-activating kinase (85 kDa, Complex from Homo sapiens)
- Cyclin-dependent kinase 7 (39 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Cyclin-h (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of CAK in complex with inhibitor BS-194
Resolution: 1.9 Å
EM Method: Single-particle
Fitted PDBs: 8p6x
Q-score: 0.695
Cushing VI, Koh AF, Feng J, Jurgaityte K, Bondke A, Kroll SHB, Barbazanges M, Scheiper B, Bahl AK, Barrett AGM, Ali S, Kotecha A, Greber BJ
Nat Commun (2024) 15 pp. 2265-2265 [ DOI: doi:10.1038/s41467-024-46375-9 Pubmed: 38480681 ]
- Cdk-activating kinase assembly factor mat1 (10 kDa, Protein from Homo sapiens)
- (2s,3s)-3-{[7-(benzylamino)-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-5-yl]amino}butane-1,2,4-triol (385 Da, Ligand)
- Cdk-activating kinase (85 kDa, Complex from Homo sapiens)
- Cyclin-dependent kinase 7 (39 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Cyclin-h (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of CAK in complex with inhibitor ICEC0510-R
Resolution: 2.1 Å
EM Method: Single-particle
Fitted PDBs: 8p6z
Q-score: 0.687
Cushing VI, Koh AF, Feng J, Jurgaityte K, Bondke A, Kroll SHB, Barbazanges M, Scheiper B, Bahl AK, Barrett AGM, Ali S, Kotecha A, Greber BJ
Nat Commun (2024) 15 pp. 2265-2265 [ DOI: doi:10.1038/s41467-024-46375-9 Pubmed: 38480681 ]
- Cdk-activating kinase assembly factor mat1 (10 kDa, Protein from Homo sapiens)
- Cdk-activating kinase (85 kDa, Complex from Homo sapiens)
- N7-(phenylmethyl)-3-propan-2-yl-n5-[(3r)-pyrrolidin-3-yl]pyrazolo[1,5-a]pyrimidine-5,7-diamine (350 Da, Ligand)
- Cyclin-dependent kinase 7 (39 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Cyclin-h (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of CAK in complex with inhibitor ICEC0510-S
Resolution: 2.0 Å
EM Method: Single-particle
Fitted PDBs: 8p70
Q-score: 0.68
Cushing VI, Koh AF, Feng J, Jurgaityte K, Bondke A, Kroll SHB, Barbazanges M, Scheiper B, Bahl AK, Barrett AGM, Ali S, Kotecha A, Greber BJ
Nat Commun (2024) 15 pp. 2265-2265 [ DOI: doi:10.1038/s41467-024-46375-9 Pubmed: 38480681 ]
- Cdk-activating kinase assembly factor mat1 (10 kDa, Protein from Homo sapiens)
- Cdk-activating kinase (85 kDa, Complex from Homo sapiens)
- N7-(phenylmethyl)-3-propan-2-yl-n5-[(3s)-pyrrolidin-3-yl]pyrazolo[1,5-a]pyrimidine-5,7-diamine (350 Da, Ligand)
- Cyclin-dependent kinase 7 (39 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Cyclin-h (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of CAK in complex with inhibitor ICEC0574
Resolution: 2.0 Å
EM Method: Single-particle
Fitted PDBs: 8p71
Q-score: 0.678
Cushing VI, Koh AF, Feng J, Jurgaityte K, Bondke A, Kroll SHB, Barbazanges M, Scheiper B, Bahl AK, Barrett AGM, Ali S, Kotecha A, Greber BJ
Nat Commun (2024) 15 pp. 2265-2265 [ DOI: doi:10.1038/s41467-024-46375-9 Pubmed: 38480681 ]
- Cdk-activating kinase assembly factor mat1 (10 kDa, Protein from Homo sapiens)
- Cdk-activating kinase (85 kDa, Complex from Homo sapiens)
- (3r,4s)-4-[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]pyrrolidin-3-ol (366 Da, Ligand)
- Cyclin-dependent kinase 7 (39 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Cyclin-h (37 kDa, Protein from Homo sapiens)