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5-HT1A-Gi in complex with compound (R)-IHCH-7179
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8jt6
Q-score: 0.542
Chen Z, Yu J, Wang H, Xu P, Fan L, Sun F, Huang S, Zhang P, Huang H, Gu S, Zhang B, Zhou Y, Wan X, Pei G, Xu HE, Cheng J, Wang S
Cell (2024) 187 pp. 2194-2208.e22 [ DOI: doi:10.1016/j.cell.2024.02.034 Pubmed: 38552625 ]
- 5-ht1a-gi in complex with compound (r)-ihch-7179 (Complex from Homo sapiens)
- 1-(4-fluorophenyl)-4-[(7r)-2,5,11-triazatetracyclo[7.6.1.0^2,7.0^12,16]hexadeca-1(15),9,12(16),13-tetraen-5-yl]butan-1-one (377 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 1a (60 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- [(2r)-1-[oxidanyl-[(2r,3r,5s,6r)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5e,8e)-hexadeca-5,8,11,14-tetraenoate (854 Da, Ligand)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
High resolution cryoEM structure of huntingtin in complex with HAP40
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 6x9o
Q-score: 0.579
Harding RJ, Deme JC, Hevler JF, Tamara S, Lemak A, Cantle JP, Szewczyk MM, Begeja N, Goss S, Zuo X, Loppnau P, Seitova A, Hutchinson A, Fan L, Truant R, Schapira M, Carroll JB, Heck AJR, Lea SM, Arrowsmith CH
Commun Biol (2021) 4 pp. 1374-1374 [ DOI: doi:10.1038/s42003-021-02895-4 Pubmed: 34880419 ]
- Huntingtin (349 kDa, Protein from Homo sapiens)
- 40-kda huntingtin-associated protein (41 kDa, Protein from Homo sapiens)
- Human huntingtin-hap40 complex (Complex from Homo sapiens)
Resolution: 4.9 Å
EM Method: Single-particle
Fitted PDBs: 6pom
Q-score: 0.28
Li S, Su Z, Lehmann J, Stamatopoulou V, Giarimoglou N, Henderson FE, Fan L, Pintilie GD, Zhang K, Chen M, Ludtke SJ, Wang YX, Stathopoulos C, Chiu W, Zhang J
Nat Struct Mol Biol (2019) 26 pp. 1094-1105 [ Pubmed: 31740854 DOI: doi:10.1038/s41594-019-0326-7 ]
- T-box-trnagly complex (75 kDa, Complex from Bacillus subtilis)
- T-box glyqs leader (155-mer) (54 kDa, RNA from Bacillus subtilis)
- Trnagly (75-mer) (24 kDa, RNA from Bacillus subtilis)