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Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound MK-6892
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 8j6i
Q-score: 0.443
Zhu S, Yuan Q, Li X, He X, Shen S, Wang D, Li J, Cheng X, Duan X, Xu HE, Duan J
Cell Rep (2023) 42 pp. 113406-113406 [ Pubmed: 37952153 DOI: doi:10.1016/j.celrep.2023.113406 ]
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Complex of hydroxycarboxylic acid receptor 2 with mk-6892 (Complex from Homo sapiens)
- 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (36 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound niacin
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 8j6l
Q-score: 0.4
Zhu S, Yuan Q, Li X, He X, Shen S, Wang D, Li J, Cheng X, Duan X, Xu HE, Duan J
Cell Rep (2023) 42 pp. 113406-113406 [ Pubmed: 37952153 DOI: doi:10.1016/j.celrep.2023.113406 ]
- Complex of hydroxycarboxylic acid receptor 2 with mk-6892 (Complex from Homo sapiens)
- Nicotinic acid (123 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2,hydroxycarboxylic acid receptor 2 (56 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Svf16 (26 kDa, Protein from Homo sapiens)
Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound with GSK256073
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8j6j
Q-score: 0.425
Zhu S, Yuan Q, Li X, He X, Shen S, Wang D, Li J, Cheng X, Duan X, Xu HE, Duan J
Cell Rep (2023) 42 pp. 113406-113406 [ Pubmed: 37952153 DOI: doi:10.1016/j.celrep.2023.113406 ]
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Scfv16 (Complex)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Complex of hydroxycarboxylic acid receptor 2 with gsk256073 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein (Complex)
- Hydroxycarboxylic acid receptor 2,hydroxycarboxylic acid receptor 2 (56 kDa, Protein from Homo sapiens)
- 8-chloranyl-3-pentyl-7h-purine-2,6-dione (256 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
local structure of hu33 and spike
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7wb5
Q-score: 0.471
Duan X, Shi R, Liu P, Huang Q, Wang F, Chen X, Feng H, Huang W, Xiao J, Yan J
Signal Transduct Target Ther (2022) 7 pp. 23-23 [ Pubmed: 35078968 DOI: doi:10.1038/s41392-022-00879-2 ]
- Hu33 light chain (11 kDa, Protein from Homo sapiens)
- Local structure of r33 and rbd (Complex from Homo sapiens)
- Surface glycoprotein (20 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Hu33 heavy chain (13 kDa, Protein from Homo sapiens)
overall structure of hu33 and spike
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7wbh
Q-score: 0.366
Duan X, Shi R, Liu P, Huang Q, Wang F, Chen X, Feng H, Huang W, Xiao J, Yan J
Signal Transduct Target Ther (2022) 7 pp. 23-23 [ Pubmed: 35078968 DOI: doi:10.1038/s41392-022-00879-2 ]
- Spike glycoprotein (123 kDa, Protein from Severe acute respiratory syndrome-related coronavirus)
- Light chain of hu33 (11 kDa, Protein from Homo sapiens)
- Spike glycoprotein (124 kDa, Protein from Severe acute respiratory syndrome-related coronavirus)
- Heavy chain of hu33 (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Overall structure of hu33 and spike (Complex from Homo sapiens)
Structure of SUR2B in complex with Mg-ATP/ADP
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7vlr
Q-score: 0.468
Ding D, Wu JX, Duan X, Ma S, Lai L, Chen L
Nat Commun (2022) 13 pp. 2675-2675 [ Pubmed: 35562524 DOI: doi:10.1038/s41467-022-30428-y ]
- Atp-binding cassette sub-family c member 9, isoform b (174 MDa, Complex from Rattus norvegicus)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Isoform sur2b of atp-binding cassette sub-family c member 9 (174 kDa, Protein from Rattus norvegicus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
Structure of SUR2B in complex with MgATP/ADP and P1075
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7vls
Q-score: 0.494
Ding D, Wu JX, Duan X, Ma S, Lai L, Chen L
Nat Commun (2022) 13 pp. 2675-2675 [ Pubmed: 35562524 DOI: doi:10.1038/s41467-022-30428-y ]
- Atp-binding cassette sub-family c member 9, isoform b (174 MDa, Complex from Rattus norvegicus)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Isoform sur2b of atp-binding cassette sub-family c member 9 (174 kDa, Protein from Rattus norvegicus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- 1-cyano-2-(2-methylbutan-2-yl)-3-pyridin-3-yl-guanidine (231 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
Structure of SUR2B in complex with Mg-ATP/ADP and levcromakalim
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7vlt
Q-score: 0.52
Ding D, Wu JX, Duan X, Ma S, Lai L, Chen L
Nat Commun (2022) 13 pp. 2675-2675 [ Pubmed: 35562524 DOI: doi:10.1038/s41467-022-30428-y ]
- (3s,4r)-2,2-dimethyl-3-oxidanyl-4-(2-oxidanylidenepyrrolidin-1-yl)-3,4-dihydrochromene-6-carbonitrile (286 Da, Ligand)
- Atp-binding cassette sub-family c member 9, isoform b (174 MDa, Complex from Rattus norvegicus)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Isoform sur2b of atp-binding cassette sub-family c member 9 (174 kDa, Protein from Rattus norvegicus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
Structure of SUR2A in complex with Mg-ATP/ADP and P1075
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7vlu
Q-score: 0.487
Ding D, Wu JX, Duan X, Ma S, Lai L, Chen L
Nat Commun (2022) 13 pp. 2675-2675 [ Pubmed: 35562524 DOI: doi:10.1038/s41467-022-30428-y ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Atp-binding cassette sub-family c member 9 (174 kDa, Protein from Rattus norvegicus)
- 1-cyano-2-(2-methylbutan-2-yl)-3-pyridin-3-yl-guanidine (231 Da, Ligand)
- Atp-binding cassette sub-family c member 9, isoform a (174 MDa, Complex from Rattus norvegicus)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)