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Resolution: 2.74 Å
EM Method: Single-particle
Fitted PDBs: 8smv
Q-score: 0.572
Hoppe N, Harrison S, Hwang SH, Chen Z, Karelina M, Deshpande I, Suomivuori CM, Palicharla VR, Berry SP, Tschaikner P, Regele D, Covey DF, Stefan E, Marks DS, Reiter J, Dror RO, Evers AS, Mukhopadhyay S, Manglik A
bioRxiv (2023) [ Pubmed: 37292845 DOI: doi:10.1101/2023.05.23.540554 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody 35 (Complex from Lama glama)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (30 kDa, Protein from Homo sapiens)
- G-protein coupled receptor 161, guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- G-protein coupled receptor 161 (59 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Gpr161 gs heterotrimeric complex with nb35 (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2, guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
5-HT2B receptor bound to LSD obtained by cryo-electron microscopy (cryoEM)
Cao C, Barros-Álvarez X, Zhang S, Kim K, Dämgen MA, Panova O, Suomivuori CM, Fay JF, Zhong X, Krumm BE, Gumpper RH, Seven AB, Robertson MJ, Krogan NJ, Hüttenhain R, Nichols DE, Dror RO, Skiniotis G, Roth BL
Neuron (2022) 110 pp. 3154-3167.e7 [ DOI: 10.1016/j.neuron.2022.08.006 Pubmed: 36087581 ]
Image sets:
Cao C, Barros-Álvarez X, Zhang S, Kim K, Dämgen MA, Panova O, Suomivuori CM, Fay JF, Zhong X, Krumm BE, Gumpper RH, Seven AB, Robertson MJ, Krogan NJ, Hüttenhain R, Nichols DE, Dror RO, Skiniotis G, Roth BL
Neuron (2022) 110 pp. 3154-3167.e7 [ DOI: 10.1016/j.neuron.2022.08.006 Pubmed: 36087581 ]
Image sets:
Cao C, Barros-Álvarez X, Zhang S, Kim K, Dämgen MA, Panova O, Suomivuori CM, Fay JF, Zhong X, Krumm BE, Gumpper RH, Seven AB, Robertson MJ, Krogan NJ, Hüttenhain R, Nichols DE, Dror RO, Skiniotis G, Roth BL
To Be Published
Image sets:
Resolution: 2.74 Å
EM Method: Single-particle
Fitted PDBs: 8ta2
Q-score: 0.557
Xu M, Neelands T, Powers AS, Liu Y, Miller SD, Pintilie GD, Bois JD, Dror RO, Chiu W, Maduke M
eLife (2024) 12 [ Pubmed: 38345841 DOI: doi:10.7554/eLife.90648 ]
- Chloride channel protein 2 with inhibitor ak-42 (Complex from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- Chloride channel protein 2 (52 kDa, Protein from Homo sapiens)
- 2-[[2,6-bis(chloranyl)-3-phenylmethoxy-phenyl]amino]pyridine-3-carboxylic acid (389 Da, Ligand)
Resolution: 2.46 Å
EM Method: Single-particle
Fitted PDBs: 8ta3
Q-score: 0.635
Xu M, Neelands T, Powers AS, Liu Y, Miller SD, Pintilie GD, Bois JD, Dror RO, Chiu W, Maduke M
eLife (2024) 12 [ Pubmed: 38345841 DOI: doi:10.7554/eLife.90648 ]
- Chloride channel protein 2 (Complex from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- Chloride channel protein 2 (95 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with symmetric C-terminal
Resolution: 2.75 Å
EM Method: Single-particle
Fitted PDBs: 8ta4
Q-score: 0.59
Xu M, Neelands T, Powers AS, Liu Y, Miller SD, Pintilie GD, Bois JD, Dror RO, Chiu W, Maduke M
eLife (2024) 12 [ Pubmed: 38345841 DOI: doi:10.7554/eLife.90648 ]
- Chloride channel protein 2 (98 kDa, Protein from Homo sapiens)
- Chloride channel protein 2 (Complex from Homo sapiens)
- Chloride ion (35 Da, Ligand)
Resolution: 2.76 Å
EM Method: Single-particle
Fitted PDBs: 8ta5
Q-score: 0.36
Xu M, Neelands T, Powers AS, Liu Y, Miller SD, Pintilie GD, Bois JD, Dror RO, Chiu W, Maduke M
eLife (2024) 12 [ Pubmed: 38345841 DOI: doi:10.7554/eLife.90648 ]
- Chloride channel protein 2 (98 kDa, Protein from Homo sapiens)
- Chloride channel protein 2 (Complex from Homo sapiens)
Cryo-EM structure of the human CLC-2 chloride channel C-terminal domain
Resolution: 4.03 Å
EM Method: Single-particle
Fitted PDBs: 8ta6
Q-score: 0.37
Xu M, Neelands T, Powers AS, Liu Y, Miller SD, Pintilie GD, Bois JD, Dror RO, Chiu W, Maduke M
eLife (2024) 12 [ Pubmed: 38345841 DOI: doi:10.7554/eLife.90648 ]
- Chloride channel protein 2 (98 kDa, Protein from Homo sapiens)
- Chloride channel protein 2 (Complex from Homo sapiens)
The potassium-selective channelrhodopsin HcKCR1 and HcKCR2 in lipid nanodisc
Tajima S, Kim YS, Fukuda M, Jo Y, Wang PY, Paggi JM, Inoue M, Byrne EFX, Kishi KE, Nakamura S, Ramakrishnan C, Takaramoto S, Nagata T, Konno M, Sugiura M, Katayama K, Matsui TE, Yamashita K, Kim S, Ikeda H, Kim J, Kandori H, Dror RO, Inoue K, Deisseroth K, Kato HE
Cell (2023) [ Pubmed: 37652010 DOI: 10.1016/j.cell.2023.08.009 ]
Image sets: